floxuridine / Generic mfg. - LARVOL DELTA

Establishment of a stable replicon cell line of Tembusu virus (TMUV) for high-throughput antiviral screening. (PubMed, Poult Sci) - "Using the Vero-TMUV replicon system, three compounds, Panobinostat, Floxuridine, and 5-Fluorouracil were screened out as promising antiviral candidates, along with the known flavivirus inhibitor, Lycorine. The development of this stable replicon cell line for TMUV cluster 3 may provide a versatile platform for screening antiviral drugs and also for understanding the host-virus interaction."

Journal • Preclinical • CNS Disorders • Infectious Disease

Identification of Cepharanthine as a Potential Therapy of Acid Sphingomyelinase Deficiency by Reducing Cellular Sphingosylphosphorylcholine. (PubMed, J Inherit Metab Dis) - "Eight compounds, floxuridine, dexamethasone, indacaterol maleate, triethylenethiophosphoramide, cytarabine, doramectin, cepharanthine (CEP), and tetrandrine (TE), were identified to abate the accumulation of SPC in ASMD cells. Additionally, CEP could improve mitochondrial morphology and function, and stimulated lysosome biogenesis by promoting TFEB nuclear translocation in ASMD cells. These results suggest that CEP could potentially be developed as a promising candidate for treating ASMD."

Journal • Frontotemporal Lobar Degeneration • Genetic Disorders • Lysosomal Storage Diseases • Metabolic Disorders • Rare Diseases • TFEB

Drug-induced liver injury: a real-world pharmacovigilance study using the FDA adverse event reporting system database 2004-2024. (PubMed, Ann Hepatol) - "Our study summarized a reported culprit-drug list of DILI by comprehensively reviewing the liver injury-related reports in the FAERS database, and highlighted the prominent position of antineoplastic agents in reporting frequency, risk signal strength ranking, number of positive signal drugs, and high-risk drug distribution, suggesting that we may need to pay more attention to the liver injury risk of antineoplastic agents in clinical practice."

Adverse events • Journal • Real-world evidence • Hepatology • Liver Failure • Oncology

Preparation and Characterization of New pH-Sensitive Polyurethane Hydrogels as Anti-Cancer Drug Delivery Systems for 5-Fluorouracyl and Fluorodeoxyuridine. (PubMed, Int J Mol Sci) - "The findings indicate that these PU hydrogels are suitable for use as intelligent DDSs for the targeted delivery of 5-FU or FUdR. We expect that the hydrogel DDSs developed will be utilized in the treatment of pancreatic cancer."

Journal • Oncology • Pancreatic Cancer • Solid Tumor

Hepatic Artery Infusion Pump Therapy in Unresectable and Resectable Liver Tumors. (PubMed, Hematol Oncol Clin North Am) - "Hepatic artery infusion (HAI) chemotherapy is a regional, intra-arterial treatment of hepatic malignancies, delivering high-dose floxuridine directly to the liver...Although HAI chemotherapy is most commonly used among patients with colorectal liver metastases, it is now being more frequently employed for other disease processes such as intrahepatic cholangiocarcinoma and hepatocellular carcinoma as well. In addition, HAI chemotherapy is most often used in the setting of unresectable hepatic malignancies."

Journal • Review • Biliary Cancer • Cholangiocarcinoma • Colorectal Cancer • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

ASO Visual Abstract: Hepatic Recurrence Rate Based on Extent of Adjuvant Floxuridine Exposure After Resection of Colorectal Liver Metastases. (PubMed, Ann Surg Oncol) - No abstract available

Journal • Oncology

Germline regulation of the intestinal mitochondrial unfolded protein response. (PubMed, Geroscience) - "We find that pharmacological inhibition of germline proliferation by 5-fluoro-2-deoxyuridine (FUdR), a DNA synthesis inhibitor, potently inhibits activation of the intestinal UPRmt as well as reverses lifespan effects induced by mitochondrial dysfunction...These findings suggest that FOXO/daf-16 acts to limit UPRmt activation in the intestine. These findings also suggest that late-stage reproductive signals that include the maturation of oocytes and fertilization may play a critical role in cell non-autonomous intestinal UPRmt activation."

Journal • Metabolic Disorders

Volvulus With a Twist: A Case of Domestic Body Retrieval (ACG 2025) - "Case Description/ A 53-year-old male with stage 4 splenic flexure adenocarcinoma status post diversion with transverse colostomy followed by splenic flexure colectomy and transverse-descending anastomosis on FOLFIRI, bevacizumab, and floxuridine, presented with subacute abdominal pain...Second tissue material being retrieved (1e), gross view of the second tissue material (1f).Figure: Figure 2. Histology demonstrating fibrinoinflammatory exudate with no viable tissue at 4x magnification (2a) and 20x magnification (2b)."

Clinical • Gastrointestinal Disorder • Neutropenia

Hepatic Recurrence Rate Based on Extent of Adjuvant Floxuridine Exposure After Resection of Colorectal Liver Metastases. (PubMed, Ann Surg Oncol) - "In adjuvant HAI therapy for CRLM, neither the number of FUDR cycles nor the dose density of FUDR is associated with hepatic recurrence."

Journal • Oncology

Hepatic artery infusion chemotherapy for colorectal liver metastasis in low resource setting: Dawn of a new modality in India (ESSO 2025) - "The aim of this study was to determine the feasibility, safety and short-term outcomes of HAIC for high-risk resected CRLM and HCC delivered using repeated femoral puncture and delivering 5-fluorouracil infusional chemotherapy with or without systemic adjuvant chemotherapy.Material and methods This is a retrospective study of a prospectively maintained database...The median follow up was … and …% of the patients were disease free at the time of follow up.Conclusions (For surgical proposals, write down NA) Conventional HAIC has various challenges such as unavailability of the agent floxuridine and the specialized HAIC pump. Percutaneous HAIC has a lower chance of infection. The delivery of HAIC using repeated femoral punctures and 5FU chemotherapy was successful in over 90% of the patients making it a feasible, safe and replicable option in the treatment of CRLM."

Hepatocellular Cancer • Infectious Disease • Solid Tumor

Hepatic Arterial Infusion Pump Chemotherapy in Patients With Unresectable Intrahepatic Cholangiocarcinoma-PUMP-2 Trial. (PubMed, J Clin Oncol) - "Combining HAIP chemotherapy with floxuridine and systemic gem-cis in patients with unresectable liver-confined iCCA had a 1- and 3-year OS superior to gem-cis alone in historical cohorts."

Journal • Biliary Cancer • Cholangiocarcinoma • Hepatology • Infectious Disease • Novel Coronavirus Disease • Oncology • Solid Tumor

One-pot enzyme cascade production of therapeutic deoxyribonucleoside analogs from glycerol and acetaldehyde. (PubMed, Int J Biol Macromol) - "Using this approach, we successfully synthesized four commercially relevant therapeutic deoxyribonucleosides-floxuridine, idoxuridine, decitabine, and cladribine-by varying the nucleobases and nucleoside phosphorylases. These findings highlight the potential of this biocatalytic platform for the sustainable and cost-effective production of deoxyribonucleoside analogs from simple, renewable feedstocks."

Journal

Toward Safer Floxuridine Dosing in an Era of Resurgent Hepatic Artery Infusion Pump Chemotherapy. (PubMed, Ann Surg Oncol) - No abstract available

Journal

The Landmark Series: Hepatic Arterial Infusion Pump Chemotherapy for Colorectal Liver Metastases and Intrahepatic Cholangiocarcinoma. (PubMed, Ann Surg Oncol) - "Hepatic arterial infusion pump floxuridine is an effective locoregional treatment that improves survival in patients with liver-confined CRLM and iCCA. Confirmation from ongoing RCTs is awaited to define its role alongside evolving systemic therapies."

Journal • Review • Biliary Cancer • Cholangiocarcinoma • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Condition-dependent effects of knockdown of autophagy on C. elegans longevity. (PubMed, bioRxiv) - "Factors varied included daf-2 mutant allele class, atg gene, temperature and presence of 5-fluoro-2'-deoxyuridine (FUDR)...The lack of suppression of Age by atg RNAi in most cases raises questions about the importance of autophagy in daf-2 Age. Moreover, condition dependence of effects creates a risk of possible condition selection bias."

Journal • IGF1

ASO Author Reflections: Optimizing the Dose of Floxuridine for the Adjuvant Treatment of Resected Colorectal Cancer Liver Metastases. (PubMed, Ann Surg Oncol) - No abstract available

Journal • Colorectal Cancer • Oncology • Solid Tumor

ASO Visual Abstract: Reduced Floxuridine Dose Limits Hepatobiliary Toxicity Without Negatively Impacting Survival After Resection of Colorectal Cancer Liver Metastases. (PubMed, Ann Surg Oncol) - No abstract available

Journal • Colorectal Cancer • Oncology • Solid Tumor

Reduced Floxuridine Dose Limits Hepatobiliary Toxicity Without Negatively Impacting Survival After Resection of Colorectal Cancer Liver Metastases. (PubMed, Ann Surg Oncol) - "A reduced starting floxuridine dose (0.08 mg/kg/day) is associated with lower hepatobiliary toxicity without compromising survival after complete resection of CRLM. These findings support adopting the reduced dose as a new standard in the adjuvant treatment of resected CRLM."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases (clinicaltrials.gov) - P2 | N=14 | Active, not recruiting | Sponsor: Spectrum Health Hospitals | Trial completion date: Dec 2027 ➔ Dec 2025 | Trial primary completion date: Dec 2027 ➔ Dec 2025

Trial completion date • Trial primary completion date • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Solid Tumor

Molecular mechanisms related to NETs in DVT using single cell combined with Mendelian randomization. (ISTH 2025) - "Analysis of relationship between expression levels and disease immune infiltration show that the gene Srgn has a significant positive correlation with Neutrophil Cells, etc.; the gene Plekho2 has a significant negative correlation with T Cells CD8 Memory, Gamma Delta T Cells, etc. GSVA results showed that high expression of Acta2 was mainly enriched in signaling pathways such as ADIPOGENESIS and MYOGENESIS; high expression of Plekho2 was mainly enriched in signaling pathways such as IL2 STAT5 SIGNALING and ANGIOGENESIS; high expression of Srgn was mainly enriched in signaling pathways such as APICAL SURFACE and HYPOXIA(Figure 2).Drug target prediction analysis showed that the expression profiles perturbed by drugs such as aminopurvalanol-a, angiogenesis-inhibitor, cladribine, floxuridine, and pyrimethamine are closely related to disease perturbations. Table or Figure Upload"

Cardiovascular • Hematological Disorders • Inflammation • Thrombosis • ACTA2 • CD8 • IL2 • SRGN • STAT5

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery (clinicaltrials.gov) - P2 | N=164 | Recruiting | Sponsor: Memorial Sloan Kettering Cancer Center | Trial completion date: May 2025 ➔ May 2026 | Trial primary completion date: May 2025 ➔ May 2026

Trial completion date • Trial primary completion date • Biliary Cancer • Cholangiocarcinoma • Oncology • Solid Tumor

Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment. (PubMed, Small) - "These findings underscore the transformative potential of targeting endothelial cell membrane proteins for drug delivery. This study paves the way for innovative targeted therapies, promising significant advancements in treatment strategies and improves outcomes for patients with metastatic cancers."

Biomarker • Journal • Melanoma • Oncology • Solid Tumor

Fox Chase Cancer Center Physicians Open New Trial For Patients With Colorectal Cancer That Has Spread to the Liver (OncLive) - "Physicians at Fox Chase Cancer Center have begun accepting patients for a new clinical trial looking at the effectiveness of a hepatic artery infusion (HAI) pump along with standard chemotherapy. Fox Chase is the only local hospital offering this trial, which is designed for patients with colorectal cancer that has spread to the liver and cannot be treated with surgery. HAI is a specially designed chemotherapy pump that uses a catheter to carry a tumor-killing drug called floxuridine directly into the liver."

Trial status • Colorectal Cancer

N6-methyladenosine in DNA promotes genome stability. (PubMed, Elife) - "To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic agent that incorporates uracil and fluorouracil into DNA. METTL3 and 6mA were required for repair of lesions driven by additional base-damaging agents, including raltitrexed, gemcitabine, and hydroxyurea. Our results establish a role for METTL3 and 6mA in promoting genome stability in mammalian cells, especially in response to base damage."

Journal • Oncology • METTL3

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer (clinicaltrials.gov) - P1 | N=38 | Completed | Sponsor: Memorial Sloan Kettering Cancer Center | Active, not recruiting ➔ Completed

Trial completion • Colorectal Adenocarcinoma • Colorectal Cancer • Oncology • Solid Tumor • TYMS