griseofulvin / Generic mfg. - LARVOL DELTA

Efficiency of griseofulvin and plumbagin in mitigating N-nitrosodiethylamine-induced hepatocellular carcinoma. (PubMed, Biotech Histochem) - "Animals were randomly assigned to seven groups, including normal control, NDEA control (200 mg/kg), and treatment groups receiving PL (2 mg/kg and 6 mg/kg, intraperitoneally), GF (225 mg/kg and 450 mg/kg, orally), or the reference drug sorafenib (30 mg/kg, orally) for 14 days. In conclusion, PL and GF exhibited substantial hepatoprotective and anticancer effects in the NDEA-induced HCC model, primarily by restoring liver function, reducing oxidative stress, and improving histological outcomes. These findings support their potential as complementary therapeutic agents in liver cancer management."

Journal • Fibrosis • Hematological Disorders • Hepatocellular Cancer • Hepatology • Immunology • Liver Cancer • Liver Failure • Oncology • Solid Tumor

Antimicrobial activity of Vepris salicifolia leaf essential oil and δ-cadinene: in vitro evaluation and in silico mechanistic insights into δ-cadinene. (PubMed, Trop Med Health) - "The findings of this study indicate that V. salicifolia leaf EO, particularly δ-cadinene, represents a promising source of antimicrobial agents for future medicinal applications. Nevertheless, the predicted molecular mechanisms of δ-cadinene should be validated through enzyme inhibition assays."

Journal • Preclinical • Cardiovascular • Infectious Disease

Clinical, Dermoscopic, and Mycological Characteristics of Tinea Capitis in Children (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Sohag University

New trial • Dermatology • Infectious Disease

Pooled Effectiveness of Terbinafine Versus Griseofulvin in the Management of Tinea Capitis: A Systematic Review and Meta-Analysis. (EADV 2026) - No abstract available

Retrospective data • Review • Dermatology

Topical griseofulvin as a therapeutic treatment in a nurseling (EADV 2026) - No abstract available

Dermatology • Pediatrics

Discovery of Forvisirvat (DS-7830a/SP-624), a Brain-Penetrant Sirtuin 6 Activator Derived from Griseofulvin with Antidepressant-Like Effects. (PubMed, ACS Med Chem Lett) - "SAR studies focused on C-6 modification yielded forvisirvat with markedly improved pharmacokinetic properties and CNS exposure. Forvisirvat selectively activated SIRT6 over other sirtuin isoforms and exhibited robust antidepressant-like effects in mouse models, supporting the therapeutic potential of SIRT6 activation in depression."

Journal • CNS Disorders • Depression • Psychiatry • SIRT6

A solid-state-dependent correlation between drug-polymer hot melt extrudate mechanical behavior and milled extrudate tablet tensile strength. (PubMed, Int J Pharm) - "Griseofulvin (GF), a poorly water-soluble BCS class II drug prone to crystallization, was selected as the model drug...Notably, this work uncovers a thermodynamic-mechanical paradox: the marginally miscible GF/HPC system antiplasticized while the strongly miscible GF/PVPVA system plasticized in bulk, contrary to what the Flory-Huggins interaction parameter and Tg would predict. This paradox is explained by polymer chain architecture and free-volume (hole-filling) effects rather than thermodynamic interaction strength alone."

Journal

Griseofulvin as a dual-action agent against glioblastoma: anti-tumor effect and enhancement of 5-ALA photodynamic diagnosis in stem-like cells. (PubMed, Cancer Treat Res Commun) - "These preclinical findings identify GF as a candidate dual-action agent for GBM treatment. Whether the fluorescence enhancement translates into improved intraoperative detection, extent of resection, or patient survival remains to be determined through future in vivo and clinical studies."

Journal • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor • CCNB1 • CCND1 • FECH

Pure but Not Simple: Supersaturation from Excipient-Free, Vapor-Generated, Amorphous Griseofulvin Nanoparticles. (PubMed, Mol Pharm) - "Using experiments and modeling, we establish how initial dissolution rate, peak concentration, and area under the concentration-time curve scale with dose, distinguishing between dose regimes in which supersaturation behavior is monotonic and nonmonotonic. The roles of local surface crystallization, particle aggregation, and nonequilibrium crystallization at high supersaturation are elucidated, providing a framework for attaining excipient-free supersaturation and guiding the development of improved dissolution models."

Journal

Severe Adult Kerion Celsi With Rapid Improvement During Systemic Antifungal and Adjunctive Secretome Therapy: A Case Report. (PubMed, Cureus) - "The patient received oral griseofulvin, topical miconazole, structured wound care, empirical ciprofloxacin for clinically suspected secondary bacterial infection, and adjunctive intramuscular administration of a human umbilical cord-derived mesenchymal stromal cell conditioned-medium secretome preparation. Because several interventions were initiated concurrently, the specific contribution of secretome could not be determined. Systemic antifungal therapy remains the cornerstone of treatment, and the safety and efficacy of secretome in active inflammatory dermatophyte infection require further study."

Journal • Alopecia • Dermatology • Immunology • Infectious Disease • Inflammation • Pain • Pruritus

Microsporum canis Complex Infections in the United Arab Emirates: Clinical, Molecular, and Antifungal Susceptibility Profiles. (PubMed, Med Mycol) - "All isolates showed low MICs (terbinafine MIC₅₀/₉₀ 0.015/0.03; itraconazole ≤0.03/0.06; voriconazole ≤0.03/≤0.03; griseofulvin 0.125/0.25; fluconazole 4/8 µg/mL). This first molecular and antifungal characterization of M. canis complex infections in the UAE over three decades showed that ITS sequencing corrected phenotypic identification in nearly 10% of cases. High recurrence despite low MICs suggests limited predictive value of in vitro susceptibility, supporting species directed management, molecular confirmation, species-directed management, and One Health strategies."

Journal • Dermatology • Infectious Disease • Pediatrics

Comparative Efficacy of Terbinafine, Itraconazole, and Griseofulvin in Treatment of Steroid-Modified Tinea. (PubMed, Indian Dermatol Online J) - "Itraconazole appears to be the most effective for steroid-modified tinea, with superior clinical and quality-of-life outcomes. Steroid misuse, driven by pharmacist recommendations, underscores the need for public health interventions."

Journal • Dermatology

In vitro susceptibility and provisional epidemiological cutoff values for eight antifungal agents against Trichophyton mentagrophytes and Trichophyton interdigitale: a multicenter study from China. (PubMed, J Clin Microbiol) - "The remaining seven agents yielded ECVs of 1 µg/mL for ciclopirox olamine and griseofulvin, 0.5 µg/mL for itraconazole, 0.06 µg/mL for voriconazole, 0.25 µg/mL for posaconazole and amorolfine, and 0.016 µg/mL for terbinafine. For T. interdigitale, fluconazole showed a complex non-unimodal distribution, whereas itraconazole and posaconazole showed unstable low-MIC shoulders precluding ECV estimation...In this multicenter study, we established provisional epidemiological cutoff values for most tested species-agent combinations and showed that these two closely related species differ in MIC distribution profiles and in the detection of non-wild-type isolates. These data provide practical laboratory thresholds for recognizing isolates with reduced susceptibility, highlight the limitations of complex-level interpretation, establish a contemporary baseline for dermatophyte susceptibility surveillance in China, and may help support laboratory-informed..."

Clinical • Journal • Preclinical • Dermatology • Infectious Disease

Treatment of tinea capitis in China: a multicenter prospective real-world study. (PubMed, J Am Acad Dermatol) - "All four antifungal drugs have shown good efficacy and were well tolerated. More attention should be paid to the relatively low success rate of oral terbinafine in treating gray patch and M. canis tinea capitis."

Journal • Real-world evidence • Dermatology

Trichophyton indotineae in New York: A Case Series Highlighting Diagnostic Pitfalls and Therapeutic Considerations. (PubMed, J Clin Aesthet Dermatol) - "T. indotineae presents diagnostic and therapeutic challenges due to its atypical clinical features and antifungal resistance. Early recognition and appropriate systemic antifungal therapy are critical. Itraconazole remains the preferred first-line agent based on current clinical experience. Greater clinician awareness and further research are urgently needed to address the rising burden of this infection."

Journal • Dermatology • Infectious Disease • Pruritus

Consensus-based Guideline on tinea capitis. (PubMed, J Dtsch Dermatol Ges) - "In pediatric patients, the choice of systemic antifungal therapy is primarily guided by the identified pathogen, with Trichophyton infections preferably treated with terbinafine (off-label) and Microsporum/Nannizzia infections with itraconazole (off-label) or griseofulvin. In adult patients, terbinafine is recommended as first-line therapy irrespective of the causative species. In addition, the guideline addresses measures to interrupt chains of infection, including the treatment of asymptomatic carriers, implementation of hygiene measures, and management of outbreak situations in community settings."

Journal • Dermatology • Infectious Disease • Pediatrics

Experimentally Derived Hansen Solubility Parameters as a Screening Tool for the Formulation of Amorphous Solid Dispersions. (PubMed, ACS Omega) - "Notably, the release of amorphous griseofulvin increased by up to 235% in ASD formulations exhibiting minimal intermolecular interactions compared to the crystalline API. Collectively, these results demonstrate the reliability of experimentally derived HSP for predicting ASD miscibility and API loading capacity, while complementary physicochemical characterization provides mechanistic insight into dissolution behavior. This integrated framework enables the rational design of high API-loaded, high-performance ASD formulations."

Journal

Genomic Basis of Zoonotic Transmission and Antifungal Resistance in Microsporum canis. (PubMed, J Fungi (Basel)) - "Terbinafine exhibited the highest activity, while itraconazole, voriconazole, posaconazole, griseofulvin, and ciclopirox olamine showed higher MICs; 11 isolates showed a multidrug high-MIC phenotype. Notably, copy number variation in the ABC transporter gene CDR1 was positively correlated with MICs of multiple antifungal agents (p<0.05). This study provides a genomic basis for optimized antifungal therapy, resistance surveillance and transmission control of zoonotic M. canis."

Journal • Dermatology

Norlichexanthone, a shunt product of Griseofulvin, disrupts spindle assembly checkpoint and nucleocytoplasmic transport by targeting TPR in the nuclear pore complex. (PubMed, Bioorg Chem) - "This novel dual mechanism-disrupting SAC assembly and nucleocytoplasmic transport-renders norlichexanthone a superior cytotoxic agent. Our findings position norlichexanthone as a promising chemotherapeutic candidate that promotes cancer cell death by targeting TPR-mediated pathways across both interphase and mitosis."

Journal • Oncology • BUB1B

Antifungal products and associated mechanisms of action in the fight against Didymella segeticola responsible for tea and tobacco leaf spot diseases. (PubMed, Pestic Biochem Physiol) - "The products include (1) ergosterol synthesis inhibitor jiahuangxianjunzuo, (2) protein translation inhibitor zhongshengmycin, (3) succinate dehydrogenase inhibitor boscalid, (4) nitrate reductase inhibitor kasugamycin, (5) β-tubulin binder griseofulvin, (6) DNA-binding agent carvacrol, (7) pyruvate dehydrogenase inhibitor phenazine-1-carboxamide, (8) threonine dehydratase inhibitor wuyiencin, (9) glucose regulator erlvejunzuo, and (10) phosphoenolpyruvate carboxykinase inhibitor ningnanmycin...The diversity of products and their molecular targets underline the multiplicity of approaches currently investigated to tackle leaf spot disease. On this basis, novel products and combinations can be proposed and the battle is going again."

Journal • Review

TCC-France: Epidemiological and Molecular Analysis of Scalp Ringworm in France (clinicaltrials.gov) - P=N/A | N=701 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris

Biomarker • New trial

SEVERE KERION CELSI IN HEALTHY PEDIATRIC PATIENTS: DIAGNOSTIC AND THERAPEUTIC CHALLENGES (ESPID 2026) - "Initial treatment with griseofulvin failed, and she developed a large purulent scalp mass...Our multidisciplinary team initiated intravenous fluconazole, broad-spectrum antibiotics, and systemic corticosteroids, followed by surgical drainage...However, in our cases, surgical drainage proved decisive once marked inflammation and abscess formation developed. Subsequent clinical monitoring contributed to minimize the risk of permanent scarring alopecia and long-term sequelae."

Clinical • Infectious Disease

THE IMPORTANCE OF ULTRAVIOLET-ENHANCED FLUORESCENCE DERMOSCOPY (UEFD) IN THE MANAGEMENT OF TINEA (ESPID 2026) - "Systemic treatment with fluconazole, griseofulvine or terfinafine was initiated, associated with anti-inflammatory therapy, as well as isoconasole cream...It is also important to perform paraclinical exam, so we may differentiate between kerion celsi and bacterial scalp infections, as the treatment is different. On the other hand, because of the delay of the mycological exam, therapy could be initiated late; so, UEFD is helpful for a "blitz" diagnosis."

Infectious Disease

Design, synthesis, and biological evaluation of novel imidazole-morpholinone hybrids as broad-spectrum antimicrobial agents: molecular docking, DFT, and ADMET studies. (PubMed, RSC Adv) - "albicans, A. niger) strains revealed compound 10c as the most potent analogue, matching chloramphenicol (MIC 7.81 µg mL-1) and griseofulvin (MIC 15.62 µg mL-1) reference standards. Molecular docking against S. aureus DNA gyrase (2XCT) and E. coli GyrB24 (7P2M), corroborated by DFT analysis (B3LYP/6-311++G(d,p)) and ADMET profiling, confirmed DNA gyrase inhibition as the primary mechanism and established 10c as a promising drug-like lead for further development."

Journal

Clinical description and management of two terbinafine-resistant cases of tinea caused by Trichophyton indotineae from Finland. (PubMed, Skin Health Dis) - "In some reports, itraconazole has been suggested as a drug of choice to treat these cases. Here, we report two cases in which griseofulvin was used successfully."

Journal • Dermatology • Infectious Disease