griseofulvin / Generic mfg. - LARVOL DELTA

The Evolving Landscape of Dermatophytosis in the UAE: Trichophyton indotineae and Related Genotypes. (PubMed, Mycoses) - "This study provides baseline evidence of endemic terbinafine-resistant T. indotineae in the UAE, underscoring urgent needs for molecular diagnostics, routine susceptibility testing and antifungal stewardship programs to guide effective management strategies."

Journal • Dermatology • Infectious Disease • SQLE

Revisiting Onychomycosis: Etiological agents and Antifungal susceptibility profile. (PubMed, Med Mycol) - "Over the years, the treatment of onychomycosis has been shifted from griseofulvin to terbinafine and itraconazole as has been proven by the study too that MIC values for griseofulvin were very high. It is important to study and generate data regarding the prevalence and antifungal susceptibility profile of not only dermatophytes but also NDMs and yeast which are increasingly isolated, for not only epidemiological purposes but also to plan targeted treatment at optimum doses of antifungals."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

Lead Optimization: Synthesis and Biological Evaluation of Griseofulvin Derivatives as Novel SIRT6 Activators. (PubMed, ACS Med Chem Lett) - "Compounds bearing para-substituted phenyl rings exhibited excellent retention of activity at lower concentrations, with para-tolyl derivative 24 being the most potent at 10 μM. Retention of activity at pharmacologically relevant concentrations underscores their potential as potent SIRT6 activators and provides a rationale for continued development as drug candidates."

Journal • SIRT6

Clinicomycological Profile and In Vitro Antifungal Activity of Terbinafine and Griseofulvin against Clinical Isolates of Dermatophytes in a Tertiary Care Hospital. (PubMed, J Assoc Physicians India) - "This study highlights the increased resistance of T. mentagrophytes to terbinafine and T. violaceum to griseofulvin, stressing the critical role of routine susceptibility profiling. The findings highlight the growing challenge of antifungal resistance in dermatophytes and the importance of optimizing diagnostic and treatment strategies to improve patient outcomes."

Journal • Preclinical • Dermatology

Mechanistic insight into the effect of tacticity of poly(methyl methacrylate) on crystallization of amorphous griseofulvin: excluding monomer and end-group effects. (PubMed, Acta Crystallogr B Struct Sci Cryst Eng Mater) - "However, the crystal growth rate curves of GSF in the system containing 10 wt% s-PMMA did not overlap with those of the pure GSF system. These results suggest that liquid dynamics is not a main contributor to the inhibitory effect of s-PMMA during drug crystallization."

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Synthesis, in vitro antimicrobial activity and docking studies of novel 1,2,4-oxadiazol based piperidin-1-yl-methanone analogues. (PubMed, Bioorg Med Chem Lett) - "Most of the evaluated compounds displayed exceptional antimicrobial activity, when compared with standard Ampicillin, Griseofulvin. The synthesized compounds exhibited favorable binding interactions within the active site of PBP through H-bonds and hydrophobic interactions, supported by stable binding energies, with crucial residues. These results suggest that the developed 1,2,4-oxadiazol based piperidin-1-yl-methanone analogues favorable stability, have potential as effective antibacterial agents against targeting PBP inhibition."

Journal • Preclinical • Infectious Disease

Reduced-Resistances Model for Enhanced Drug Permeation via a Solubilizing Receiver Medium: A Mechanistic Study with Hollow Fiber Membranes. (PubMed, Mol Pharm) - "The impact of nine solubilizing receiver additives, including surfactants, cyclodextrins, and bovine serum albumin, on the flux of griseofulvin was investigated. Additional drug cocktail permeability studies with antipyrine, phenytoin, and meloxicam confirmed the broader applicability of this model. These findings provide a framework for informed receiver selection in permeability assays and underscore the importance of considering the receiver medium when comparing results across experiments."

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Impact of disintegrants on the structure and disintegration of hydroxypropyl methylcellulose-based amorphous solid dispersion tablets. (PubMed, J Pharm Sci) - "This study investigates the influence of disintegrant characteristics on disintegration behavior of hydroxypropyl methylcellulose (HPMC)-based ASD tablets containing griseofulvin (GRF)...Tablets without disintegrants showed significant disintegration delay, highlighting the critical role of disintegrant selection in ensuring effective drug absorption through rapid disintegration. These findings underscore the importance of understanding the disintegrant mechanisms for optimizing ASD formulations for improved bioavailability."

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Synthesis, spectroscopic characterization, and DFT-assisted molecular docking analysis of novel 1,3,4-oxadiazole-1,2,3-triazole hybrids with antimicrobial and cytotoxicity potential. (PubMed, RSC Adv) - "Additionally, compound 10i showed significant EGFR inhibition (IC50 = 0.93 ± 0.25 µM), comparable to doxorubicin, whereas 11c displayed excellent EGFR inhibition (IC50 = 0.33 ± 0.06 µM), approaching erlotinib's potency. Furthermore, 11b exhibited potent and broad-spectrum antimicrobial activity (MICs of 1.89-4.61 µg mL-1), surpassing those of ciprofloxacin and griseofulvin. The combined computational and experimental findings highlight the significance of nitrogen- and oxygen-rich heteroaromatic functionalities, which enhance electronic distribution, molecular stability, and target recognition. Overall, compounds 10i, 11b, and 11c emerged as promising lead candidates with cytotoxicity and antimicrobial activities, with 10i demonstrating particularly remarkable broad-spectrum cytotoxicity efficacy, providing a rational framework for the design and development of next-generation multifunctional therapeutic agents."

Journal • Liver Cancer • Oncology • Solid Tumor

Optimizing Antifungal Therapy for Pediatric Tinea Capitis: A Narrative Review of Species-Specific Efficacy, Dosing Strategies, and Clinical Implications. (PubMed, Paediatr Drugs) - "This narrative review synthesizes the existing literature to emphasize contemporary dosing regimens and species-directed efficacy on four widely used agents: griseofulvin, terbinafine, itraconazole, and fluconazole. Empirical treatment without microbiologic confirmation risks reduced cure rates and may contribute to emerging antifungal resistance. Future investigations should prioritize long-term follow-up and the potential role of combination therapy to refine and sustain effective management strategies for pediatric tinea capitis."

Journal • Review • Dermatology • Infectious Disease • Pediatrics

Detection of Penicillium-Toxins in Nuts Commercialized in Italy Through LC-MS/MS Analyses. (PubMed, Toxins (Basel)) - "Specifically, secondary metabolites produced by Penicillium spp., including ochratoxin A, patulin, citrinin, cyclopiazonic acid, citreoviridin, griseofulvin, meleagrin, mycophenolic acid, penitrem A, roquefortine C, penicillins G and V, sulochrin, andrastin A, asterriquinone, chaetoglobosin A, cyclopenin, cyclopenol, and viridicatin, were investigated. Besides Penicillium-toxins, aflatoxins were also analyzed with another validated LC-MS/MS method, but they were not detected in any sample. Although most Penicillium-toxins, and in particular patulin in nuts, are not currently regulated in the international legislation, they exert toxic effects on humans and animals, and their occurrence can represent a food safety risk."

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From Fungistatic to Cytotoxic: Nano-Engineered Griseofulvin Triggers Redox-Mediated Apoptosis in Colon Cancer. (PubMed, Eur J Pharm Sci) - "Most surprisingly, the study revealed an unexpected reduction in reactive oxygen species (ROS) levels, challenging conventional therapeutic paradigms and highlighting novel "redox paradox" mechanisms in cancer treatment. This comprehensive investigation highlights the remarkable apoptotic potential of nanosized griseofulvin, driven by enhanced cellular uptake, superior selectivity, and robust activation of multiple apoptotic pathways."

Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • BAX • BCL2 • CASP3

Improving Leishmania isolation in field conditions: Efficacy of caspofungin against yeasts contamination l. (PubMed, Acta Trop) - "Five antifungal drugs: griseofulvin (GRF), caspofungin diacetate (CSF), 5-fluorocytosine (5-FC), po(ly)vidone-iodine (PVI), and undecylenic acid (UCA) were assessed in vitro for their effects on promastigote forms of L. major...Under continuous CSF exposure, L. major promastigotes demonstrated substantial survival, with only a modest reduction in maximum parasite growth curves (peak of 2.65 × 10⁶ parasites/mL) compared to untreated controls (4.31 × 10⁶ parasites/mL maximum growth). These findings suggest that caspofungin diacetate could be used in the field to decontaminate Leishmania cultures from yeasts without significant parasite loss, facilitating L. major isolation and epidemiological investigations in endemic regions."

Journal • Dermatology • Infectious Disease

Revolutionizing Ringworm Care: Holistic Advancements and Breakthrough Innovations. (PubMed, Curr Drug Discov Technol) - "A multidisciplinary and integrative approach that combines conventional antifungal therapy with advanced delivery systems and natural remedies yields improved outcomes in the management of dermatophytosis. Understanding the disease's transmission dynamics and epidemiological trends is essential for timely diagnosis, effective treatment, and prevention of recurrence. Preventive strategies, including hygiene education, proper skin care, and early treatment of infections, are critical components in controlling the spread of dermatophyte infections within communities."

Journal • Dermatology • Infectious Disease

Research on secondary metabolites of the oyster endophytic fungus Penicillium griseofulvum QDYM-3 and their anti-Alzheimer's disease activity. (PubMed, Nat Prod Res) - "Five compounds were isolated from the fermentation broth of the oyster endophytic fungus Penicillium griseofulvum QDYM-3, including 1,6-dihydroxy-3-methoxy-8-methylxanthone (1), (+)-griseofulvin (2), (4 R,5R,6R)-4,5-dihydroxy-6-(6'-methylsalicyloxy)-2-methyl-2-cyclohexen-1-one (3), 3-hydroxybenzyl alcohol (4), and epigriseofulvin (5)...Notably, 1 µg/mL of compound (3) reduced ROS levels by 26.87%, the enzymatic activities of SOD, CAT, and GSH were elevated by 13.97%, 20.74%, and 82.27% respectively, while the level of MDA was reduced by 20.42%. Additionally, the expression of intracellular proteins p-Akt, p-GSK-3β and β-catenin were up-regulated by 57.9%, 50.8% and 40.4%, respectively, at a sample concentration of 5 μg/ml compared with the injury group."

Journal • Alzheimer's Disease • CNS Disorders • CTNNB1

GD06 Terbinafine-resistant Trichophyton indotineae: an analysis of confirmed cases in our regional National Health Service board. (PubMed, Br J Dermatol) - "Of the 10 positive mycological culture samples, three were terbinafine resistant (three of 10, 30%), 10 of 10 were itraconazole sensitive, seven of 10 were micoconazole sensitive, two of 10 were voriconazole sensitive and one of 10 was griseofulvin sensitive. Our findings confirm that terbinafine-resistant T. indotineae has been detected in our regional NHS board, and identified strains appeared to be sensitive in vitro to alternative antimycotics (although they may still be clinically resistant in practice). Globally, all dermatologists should be aware of this emerging organism, perform mycological testing if suspecting a dermatophytosis and liaise with local microbiology teams where terbinafine resistance is confirmed, to allow correct treatment and national monitoring."

Journal • Dermatology • Human Immunodeficiency Virus • Infectious Disease

Particle-Size-Determined Crystallization and Dissolution Behavior of Amorphous Griseofulvin. (PubMed, Pharm Res) - "Particle size was found to play dominant role in the dissolution kinetics, whereas the difference in the dissolution rates of the crystalline and amorphous particles was rather negligible. This is a beneficial finding, considering the very low stability of finely powdered amorphous griseofulvin, but at the same time, it negates the primary purpose of amorphization. Main benefit is thus that of the coarse amorphous griseofulvin powder, which can be utilized to fine-tune the dissolution profile due to its delayed dissolution."

Journal • Gastrointestinal Disorder

A Cross-sectional Study Comparing the in vitro Biofilm Optical Density of Dermatophytic Isolates with Clinical Profile, Risk Factors, and Antifungal Susceptibility. (PubMed, Indian J Dermatol) - "mentagrophytes ITS genotype VII" exhibits widespread resistance to terbinafine due to mutations in the squalene epoxidase gene...Biofilm density was also significantly associated with antifungal resistance, particularly against fluconazole and griseofulvin (P < 0.001)...Biofilm density correlates significantly with antifungal resistance, which may hinder clinical outcomes. These results highlight the need for tailored treatment strategies targeting biofilm-associated resistance to improve the management of chronic dermatophytosis."

Journal • Observational data • Preclinical • Dermatology

The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism. (PubMed, Mycoses) - "Drug-resistant T. rubrum has emerged in China, indicating the possibly increasing severity of antifungal resistance. The complex mechanism of multidrug-resistant dermophytes poses challenges to clinical treatment, needing more attention."

Journal • Dermatology • Infectious Disease

Synthesis, in vitro antimicrobial activity, and in silico studies of 1-aminoalkyl-2-naphthols. (PubMed, Sci Rep) - "Compound 3 also demonstrated superior efficacy against Staphylococcus aureus MDR strains, with an MIC of 100 µg/mL, compared to ciprofloxacin, which had an MIC of 200 µg/mL...Compound 2 showed strong antifungal activity against Penicillium notatum and P. funiculosum, with an MIC of 400 µg/mL, outperforming griseofulvin (MIC = 500 µg/mL). Molecular docking further supported these findings, with compound 3 displaying strong binding affinities to E. coli DNA gyrase (‒6.755 kcal/mol; PDB ID: 5MMN) and Candida albicans lanosterol 14α-demethylase (‒7.813 kcal/mol; PDB ID: 5V5Z). Overall, these results underscore the potential of 1-aminoalkyl-2-naphthol derivatives as promising candidates for combating drug-resistant infections."

Journal • Preclinical • Infectious Disease • ABCB1

Identification of Lung Adenocarcinoma Subtypes Based on Nicotinamide Metabolism-Related Genes to Assess Prognosis and Immunotherapy. (PubMed, J Environ Pathol Toxicol Oncol) - "We successfully developed a predictive model for the survival and immunotherapy response of LUAD patients."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

The impact of solid and liquid lipids and their lipolysis on Griseofulvin bioavailability. In vitro dissolution, in vivo and ex vivo porcine model study. (PubMed, Eur J Pharm Sci) - "The use of the swine model to investigate lipid-enhanced bioavailability should be further explored, paying attention to the differences between different swine breeds. The results from in vitro experiments suggest that solid lipids are not expected to affect the bioavailability of BCS class II drugs."

Journal • Preclinical • Gastrointestinal Disorder

Emerging Antifungal Resistance in Dermatophytosis: A Clinicomycological Study From North India. (PubMed, Cureus) - "Resistance was seen to fluconazole (77; 85.6%) and terbinafine (54; 60%), while itraconazole, ketoconazole, and griseofulvin were sensitive. Conclusion Dermatophytosis continues to be a significant public health concern due to its chronicity and recurrence. Irrational use of medications and emerging resistance to commonly used antifungals highlight the need for better treatment compliance and periodic monitoring of resistance patterns."

Journal • Dermatology • Infectious Disease

SyrSpend® SF PH 4 as a Safe Vehicle for Extemporaneous Oral Suspensions: Microbiological Stability of Seven APIs. (PubMed, Int J Pharm Compd) - "This study aimed to evaluate the microbiological stability of oral suspensions containing dapsone, griseofulvin, levofloxacin, terbinafine, indometacin, naproxen, and paracetamol in SyrSpend® SF PH4, under both room temperature and refrigerated conditions...SyrSpend® SF PH4 effectively preserved the microbiological integrity of all tested formulations without added preservatives. These findings complement existing chemical stability data and support the use of SyrSpend® SF PH4 as a safe and effective vehicle for extemporaneous oral suspensions, particularly in populations requiring preservative-free formulations."

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Brief Primer on the Discovery of New Antifungal Drugs from Plant Sources. (PubMed, Mycopathologia) - "Adherence to core methodological standards, along with suggested advanced analyses where feasible, will help identify promising plant-derived antifungal leads and support a more inclusive and effective discovery pipeline."

Journal • Review • Candidiasis • Infectious Disease