griseofulvin / Generic mfg. - LARVOL DELTA

Research on secondary metabolites of the oyster endophytic fungus Penicillium griseofulvum QDYM-3 and their anti-Alzheimer's disease activity. (PubMed, Nat Prod Res) - "Five compounds were isolated from the fermentation broth of the oyster endophytic fungus Penicillium griseofulvum QDYM-3, including 1,6-dihydroxy-3-methoxy-8-methylxanthone (1), (+)-griseofulvin (2), (4 R,5R,6R)-4,5-dihydroxy-6-(6'-methylsalicyloxy)-2-methyl-2-cyclohexen-1-one (3), 3-hydroxybenzyl alcohol (4), and epigriseofulvin (5)...Notably, 1 µg/mL of compound (3) reduced ROS levels by 26.87%, the enzymatic activities of SOD, CAT, and GSH were elevated by 13.97%, 20.74%, and 82.27% respectively, while the level of MDA was reduced by 20.42%. Additionally, the expression of intracellular proteins p-Akt, p-GSK-3β and β-catenin were up-regulated by 57.9%, 50.8% and 40.4%, respectively, at a sample concentration of 5 μg/ml compared with the injury group."

Journal • Alzheimer's Disease • CNS Disorders • CTNNB1

GD06 Terbinafine-resistant Trichophyton indotineae: an analysis of confirmed cases in our regional National Health Service board. (PubMed, Br J Dermatol) - "Of the 10 positive mycological culture samples, three were terbinafine resistant (three of 10, 30%), 10 of 10 were itraconazole sensitive, seven of 10 were micoconazole sensitive, two of 10 were voriconazole sensitive and one of 10 was griseofulvin sensitive. Our findings confirm that terbinafine-resistant T. indotineae has been detected in our regional NHS board, and identified strains appeared to be sensitive in vitro to alternative antimycotics (although they may still be clinically resistant in practice). Globally, all dermatologists should be aware of this emerging organism, perform mycological testing if suspecting a dermatophytosis and liaise with local microbiology teams where terbinafine resistance is confirmed, to allow correct treatment and national monitoring."

Journal • Dermatology • Human Immunodeficiency Virus • Infectious Disease

Particle-Size-Determined Crystallization and Dissolution Behavior of Amorphous Griseofulvin. (PubMed, Pharm Res) - "Particle size was found to play dominant role in the dissolution kinetics, whereas the difference in the dissolution rates of the crystalline and amorphous particles was rather negligible. This is a beneficial finding, considering the very low stability of finely powdered amorphous griseofulvin, but at the same time, it negates the primary purpose of amorphization. Main benefit is thus that of the coarse amorphous griseofulvin powder, which can be utilized to fine-tune the dissolution profile due to its delayed dissolution."

Journal • Gastrointestinal Disorder

A Cross-sectional Study Comparing the in vitro Biofilm Optical Density of Dermatophytic Isolates with Clinical Profile, Risk Factors, and Antifungal Susceptibility. (PubMed, Indian J Dermatol) - "mentagrophytes ITS genotype VII" exhibits widespread resistance to terbinafine due to mutations in the squalene epoxidase gene...Biofilm density was also significantly associated with antifungal resistance, particularly against fluconazole and griseofulvin (P < 0.001)...Biofilm density correlates significantly with antifungal resistance, which may hinder clinical outcomes. These results highlight the need for tailored treatment strategies targeting biofilm-associated resistance to improve the management of chronic dermatophytosis."

Journal • Observational data • Preclinical • Dermatology

The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism. (PubMed, Mycoses) - "Drug-resistant T. rubrum has emerged in China, indicating the possibly increasing severity of antifungal resistance. The complex mechanism of multidrug-resistant dermophytes poses challenges to clinical treatment, needing more attention."

Journal • Dermatology • Infectious Disease

Synthesis, in vitro antimicrobial activity, and in silico studies of 1-aminoalkyl-2-naphthols. (PubMed, Sci Rep) - "Compound 3 also demonstrated superior efficacy against Staphylococcus aureus MDR strains, with an MIC of 100 µg/mL, compared to ciprofloxacin, which had an MIC of 200 µg/mL...Compound 2 showed strong antifungal activity against Penicillium notatum and P. funiculosum, with an MIC of 400 µg/mL, outperforming griseofulvin (MIC = 500 µg/mL). Molecular docking further supported these findings, with compound 3 displaying strong binding affinities to E. coli DNA gyrase (‒6.755 kcal/mol; PDB ID: 5MMN) and Candida albicans lanosterol 14α-demethylase (‒7.813 kcal/mol; PDB ID: 5V5Z). Overall, these results underscore the potential of 1-aminoalkyl-2-naphthol derivatives as promising candidates for combating drug-resistant infections."

Journal • Preclinical • Infectious Disease • ABCB1

Identification of Lung Adenocarcinoma Subtypes Based on Nicotinamide Metabolism-Related Genes to Assess Prognosis and Immunotherapy. (PubMed, J Environ Pathol Toxicol Oncol) - "We successfully developed a predictive model for the survival and immunotherapy response of LUAD patients."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

The impact of solid and liquid lipids and their lipolysis on Griseofulvin bioavailability. In vitro dissolution, in vivo and ex vivo porcine model study. (PubMed, Eur J Pharm Sci) - "The use of the swine model to investigate lipid-enhanced bioavailability should be further explored, paying attention to the differences between different swine breeds. The results from in vitro experiments suggest that solid lipids are not expected to affect the bioavailability of BCS class II drugs."

Journal • Preclinical • Gastrointestinal Disorder

Emerging Antifungal Resistance in Dermatophytosis: A Clinicomycological Study From North India. (PubMed, Cureus) - "Resistance was seen to fluconazole (77; 85.6%) and terbinafine (54; 60%), while itraconazole, ketoconazole, and griseofulvin were sensitive. Conclusion Dermatophytosis continues to be a significant public health concern due to its chronicity and recurrence. Irrational use of medications and emerging resistance to commonly used antifungals highlight the need for better treatment compliance and periodic monitoring of resistance patterns."

Journal • Dermatology • Infectious Disease

SyrSpend® SF PH 4 as a Safe Vehicle for Extemporaneous Oral Suspensions: Microbiological Stability of Seven APIs. (PubMed, Int J Pharm Compd) - "This study aimed to evaluate the microbiological stability of oral suspensions containing dapsone, griseofulvin, levofloxacin, terbinafine, indometacin, naproxen, and paracetamol in SyrSpend® SF PH4, under both room temperature and refrigerated conditions...SyrSpend® SF PH4 effectively preserved the microbiological integrity of all tested formulations without added preservatives. These findings complement existing chemical stability data and support the use of SyrSpend® SF PH4 as a safe and effective vehicle for extemporaneous oral suspensions, particularly in populations requiring preservative-free formulations."

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Brief Primer on the Discovery of New Antifungal Drugs from Plant Sources. (PubMed, Mycopathologia) - "Adherence to core methodological standards, along with suggested advanced analyses where feasible, will help identify promising plant-derived antifungal leads and support a more inclusive and effective discovery pipeline."

Journal • Review • Candidiasis • Infectious Disease

Excipient variability critically impacts crystallization propensity of spray-dried amorphous solid dispersions. (PubMed, Eur J Pharm Sci) - "Polyvinylpyrrolidone-vinyl acetate (PVPVA) and griseofulvin (GSV) were selected as model stabilizer and drug, respectively...The learnings of this study will be beneficial to ensure robust performance of spray-dried ASDs containing other poorly soluble drug(s) and water soluble polymer(s). Due attention should be paid to ensure compliance to the proposed FRCs of the stabilizer from different batches and sources, during the manufacturing of spray-dried ASD, to ensure consistent quality and performance."

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Characterization of Different Copovidone Grades as Carrier Materials in Hot Melt Extrusion of Amorphous Solid Dispersions. (PubMed, Pharmaceutics) - "The two model drugs itraconazole and griseofulvin were used to examine drug dissolution and degradation during HME via in-line UV-vis spectroscopy. When comparing both polymers, PS-630U offers various advantages due to the improved powder feeding behavior and reduced yellowing of extruded products while maintaining similar melt properties and drug compatibility compared to PS-630. These findings support the use of PS-630U as an optimized copovidone grade for ASD manufacturing, facilitating improved processing characteristics and best product qualities without the requirement of significant formulation adjustments."

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Voriconazole is effective in totally drug resistant cases of dermatophytosis (EADV 2025) - "Dermatologists in India routinely advise higher dose & longer duration of currently available oral antifungals like terbinafine, fluconazole, griseofulvin & itraconazole. Voriconazole is effective even in the totally drug-resistant cases of dermatophytosis. If used consistently in a greater number of cases, the price of the drug may come down & morbidity is reduced."

Clinical • Dermatology

Tackling resistant dermatophytosis: A rising challenge (EADV 2025) - "The patient was initially put on local and oral Terbinafine 250 mg/d for 2 months, then switched to Griseofulvin 1 g/d, with no improvement, prompting the introduction of Itraconazole 400 mg/d...Voriconazole has also demonstrated efficacy, while terbinafine has shown reduced response rates... Classic dermatophytosis manifest as erythematosquamous lesions, typically localized on the face, trunk, limbs, and large folds. However, the emergence of Trichophyton indotineae, a terbinafine-resistant strain, complicates the diagnosis and treatment of these infections. Initially identified in India and Nepal, this species' resistance is due to mutations in the squalene epoxidase gene, leading to extensive and refractory dermatophytosis, often following inappropriate self-medication with corticosteroids and/or antifungals."

Dermatitis • Dermatology • Immunology • Infectious Disease

Clinical and Laboratory Characteristics of Trichophyton Indotineae Infection in a National Tertiary Dermatology Centre (EADV 2025) - "Among patients without relapses, treatment included varied combinations of oral terbinafine, itraconazole and griseofulvin (Table 2). In this study, we report the largest cohort of patients with T. indotineae infection in Singapore to date. Patients were predominantly young, with common sites of involvement being the groin and buttocks, and the majority were not immunocompromised. Considering the increasing resistance of T. indotineae to oral antifungals, we propose using distinct culture morphology features to aid its identification when advanced molecular diagnostics are unavailable."

Clinical • Dermatology • Infectious Disease

Co-occurrence of Varicella and Tinea Capitis in an 8-year-old child: A diagnostic challenge (EADV 2025) - "Management included systemic antifungal therapy with oral griseofulvin (20 mg/kg/day) for six weeks, topical antiseptic care for varicella lesions, and monitoring for secondary bacterial infection... This report illustrates the rare overlapping of varicella and tinea capitis, emphasizing the necessity for thorough dermatological examination, including scalp assessment, even during acute viral illnesses. Dermoscopy proves valuable in diagnosing pediatric mycological infections, highlighting the importance of avoiding attribution of all skin lesions to a single etiology without mycological confirmation. Clinicians should broaden their diagnostic approach in similar clinical scenarios, particularly during epidemic periods or in community settings."

Clinical • Alopecia • Dermatology • Herpes Zoster • Immunology • Pediatrics • Pruritus • Varicella Zoster

Annular eyebrow plaque: an entity to recognize (EADV 2025) - "Tinea faciei is a relatively uncommon dermatophyte infection that causes atypical clinical symptoms, affecting non bearded areas of the face. Microsporum audouinii is an anthropophilic dermatophyte developing outside the hair shaft, a type of hair damage known as ectothrix. This dermatophyte has resurged recently, mostly in prepubertal children manifesting by specific clinical and trichoscopic signs, such as comma and corkscrew hairs."

Alopecia • Atopic Dermatitis • Dermatology • Herpes Simplex • Immunology • Infectious Disease • Pruritus

Tinea Imbricata: a diagnosis to consider for an annular dermatosis (EADV 2025) - "The treatment of choice is oral antifungals, such as terbinafine (250 mg) or griseofulvin (1000 mg daily) for 4 weeks... Concentric lesions present a diagnostic challenge. Despite its geographic limitations, Tinea imbricata should be considered. This case underscores the importance of diagnostic vigilance and appropriate therapy to prevent exacerbation under unsuitable treatment."

Dermatology • Infectious Disease

Surgical Excision as a Therapeutic Option for Recalcitrant Oral Lichen Planus (EADV 2025) - "Topical treatment with high potency steroids, as well as systemic treatments with methothrexate, acitretin, griseofulvin and dapsone were also tried, without success. Surgical removal of the lesion not only reduced the local inflammatory burden and facilitated healthy tissue regeneration but also ruled out malignancy as a sustaining factor. Importantly, it addressed a behavioral component, emphasizing the need to consider mechanical and behavioral influences when formulating therapeutic strategies for chronic or recurrent lesions."

Cardiovascular • Dermatology • Dermatopathology • Hypertension • Immunology • Lichen Planus • Psoriasis

Generalized Bullous Fixed Drug Eruption Mimicking Toxic Epidermal Necrolysis Caused by Griseofulvin (EADV 2025) - "Common causative agents include paracetamol, NSAIDs, trimethoprim-sulfamethoxazole, systemic antifungals, antibiotics, and psychotropic medications...Treatment included intravenous dexamethasone 6 mg every 6 hours which was given for 48 hours, oral co- amoxiclav, and topical steroids and antibiotic ointments... GBFDE is a rare but potentially severe drug reaction that may closely mimic SJS/TEN. A detailed history of prior drug exposure and lesion recurrence at the same sites is crucial for diagnosis. Histopathology plays an important role in distinguishing GBFDE from SJS/TEN."

Dermatitis • Immunology • Steven-Johnson Syndrome • CRP

Deciphering the role of amphiphilic polymer combinations in the formation of ternary griseofulvin amorphous solid dispersions. (PubMed, J Pharm Sci) - "Overall, this work advances the understanding of how amphiphilic polymer combinations influence the physical and biopharmaceutical performance of ternary GRF ASDs. The findings provide a rational framework for designing synergistic polymer matrices that enable high drug loading while ensuring stability and dissolution enhancement, critical factors for next-generation oral dosage forms of challenging APIs like GRF."

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Utility of MALDI-ToF MS for Recognition and Antifungal Susceptibility of Nannizzia, an Underestimated Group of Dermatophytes. (PubMed, Mycoses) - "Diagnostic coverage of Nannizzia remains incomplete. Expanding commercial MALDI-ToF MS libraries with spectra from rare species and performing routine susceptibility testing are essential to optimise patient management."

Journal • Infectious Disease

Management of Tinea Capitis in children under 10 kg : Results from a French multicentre study. (PubMed, J Eur Acad Dermatol Venereol) - No abstract available

Journal • Dermatology

Prevalence, safety evidence, and determinants of medicine use during breastfeeding among women in Kampala, Uganda. (PubMed, BMC Womens Health) - "The overall prevalence of medicine use among breastfeeding women was high, with frequent self-medication using over-the-counter drugs. There is urgent need for strengthened regulatory frameworks, enhanced healthcare provider training, with community based education to promote rational medicine use and improve public health literacy. Further pharmacokinetic research is critical to generate safety data on commonly used medications, hence informing clinical guidelines and supporting evidence-based decision-making among breastfeeding women."

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