BI-2545
/ Boehringer Ingelheim
- LARVOL DELTA
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May 18, 2026
Chronic pain in sickle cell disease: a role for lysophosphatidic acid.
(PubMed, Blood)
- "Blocking LPA synthesis with BI-2545 or blocking LPA1 receptor (LPA1R) function with siRNA or the LPA1R antagonist, AM966, reversed mechanical and heat hyperalgesia in HbSS mice...All these parameters were normalized by pretreatment of HbSS mice with LPA1R siRNA. Our results suggest that LPA signaling may be a promising target for treating pain in SCD."
Clinical • Journal • Review • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease
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