thiocolchicoside / Generic mfg. - LARVOL DELTA

A phase III, randomized, double blind, controlled trial to evaluate the efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg, compared to diclofenac 75 mg monotherapy and placebo, in the treatment of acute low back pain. (PubMed, Minerva Med) - "IM diclofenac + thiocolchicoside FDC was significantly more effective than diclofenac and placebo in the relief of pain and improvement of mobility in patients with acute moderate-severe LBP, and was well tolerated."

Journal • Monotherapy • P3 data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Potential of Thiocolchicoside as an Antimicrobial Repurposing Agent: An In Vitro Study. (PubMed, Cureus) - "Standard antibacterial and antifungal controls were provided by gentamicin (GN) and fluconazole (FZ). THC exhibited lower activity compared to GN and FZ, yet it showed initial promise as an adjunct antimicrobial agent; nonetheless, this assessment is tentative due to the comparatively elevated MIC values and the constraints of in vitro data lacking mechanistic or in vivo corroboration. In order to improve its therapeutic profile, additional mechanistic studies, synergistic evaluations, and nanotechnology-based formulations are necessary."

Journal • Preclinical • Infectious Disease • Oncology • Pneumonia

Thiocolchicoside: A Focused Review of Its Pharmacological, Therapeutic, and Toxicological Profile. (PubMed, Cureus) - "Thiocolchicoside remains a valuable agent in pain and spasm management, but its expanding therapeutic spectrum suggests opportunities for drug repurposing, especially in oncology and infectious disease. Future research ought to concentrate on safety optimization, chronic toxicity studies, and the development of novel delivery platforms to maximize therapeutic efficacy while minimizing risks."

Journal • Review • Anesthesia • Infectious Disease • Musculoskeletal Diseases • Oncology • Pain

Anticancer Potential of Thiocolchicoside: An In-Vitro MTT Assay Study. (PubMed, Cureus) - "Nonetheless, its structural resemblance to colchicine indicates possible anticancer attributes. This shows THC has moderate cytotoxic activity. THC showed a dose-dependent decrease in cell viability and can be selected as a repurposing agent."

Journal • Preclinical • Breast Cancer • Gastric Adenocarcinoma • Gastric Cancer • Oncology • Solid Tumor

Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial. (PubMed, Turk J Phys Med Rehabil) - "The second group received oral meloxicam 15 mg once daily and thiocolchicoside 8 mg twice daily for seven days. We found mesotherapy to be as effective as oral combination therapy. Mesotherapy can be preferred as it allows the use of low-dose medication to relieve acute and subacute neck pain."

Journal • Musculoskeletal Pain • Pain

Non-Randomized Trial of Bruxism-Related TMD Treatments (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Recep Tayyip Erdogan University

New P4 trial • Dental Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Systematic review of the literature and evaluation of the effectiveness of muscle relaxants in acute low back pain according to REB method (PubMed, Therapie) - "According to the REB method, none of the three molecules demonstrated efficacy in acute low back pain with or without radiculopathy."

Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

DITH-II/VER: A Study Comparing the Efficacy and Tolerability of a Combination of Diclofenac and Thiocolchicoside Versus Diclofenac Monotherapy in Patients with Low Back Pain. (clinicaltrialsregister.eu) - P2/3 | N=110 | Not yet recruiting | Sponsor: Verisfield Single Member S.A.

Head-to-Head • Monotherapy • New P2/3 trial • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Comparative effects of thiocolchicoside and etodolac on fracture healing in a rat femur model. (PubMed, J Orthop Surg Res) - No abstract available

Journal • Preclinical • Musculoskeletal Diseases • Orthopedics

The impact of tizanidine, thiocolchicoside, and cyclobenzaprine on vascular function in ovariectomized rats. (PubMed, Turk J Med Sci) - "Vascular reactivity was assessed using increasing concentrations of phenylephrine, acetylcholine, and sodium nitroprusside, as well as potassium chloride at a concentration of 40 mM. In high doses and for longer periods, TCC and CBZ might also have deleterious effects on vascular reactivity. These findings are noteworthy from the perspective of rational drug therapy."

Journal • Preclinical • Gynecology • Pain

A Double-Blind Randomized Active-Controlled Trial Evaluating the Short-Term Efficacy of a Single Intramuscular Injection of a Fixed-Dose Combination Product Containing Diclofenac and Thiocolchicoside in Patients with Acute Moderate to Severe Low Back Pain. (PubMed, J Clin Med) - "The combination therapy significantly reduced pain and muscle spasm-related mobility limitations within 1-3 h and was well tolerated. These results support the combined use of an NSAID and muscle relaxant as an effective and safe option for acute moderate-to-severe LBP management."

Clinical • Journal • Back Pain • Inflammation • Lumbar Back Pain • Musculoskeletal Pain • Pain

Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast. (PubMed, Commun Biol) - "Thus, thioactivation of archaeal Urm1 and urmylation-like conjugation are conserved and exchangeable processes between Sulfolobus and Saccharomyces. Our survey underlines that Urm1 likely occupies a key role in the evolution of the ubiquitin-like protein family."

Journal • Targeted Protein Degradation

Therapeutic efficacy of thiocolchicoside-nonsteroidal anti-inflammatory drug combination in pain management: A systematic review and cross-sectional real-world study. (PubMed, World J Orthop) - "Evidence indicates that multimodal therapy, including parenteral TCC with NSAIDs, provides quicker and effective pain relief, reduces muscle spasms, and improves hand-to-floor distance compared to using NSAIDs or TCC alone."

Journal • Real-world evidence • Back Pain • Immunology • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Rheumatology

Autoimmune Hypoglycemia in Type 2 Diabetes: A Case of Thiocolchicoside-Induced Steroid-Refractory Insulin Autoimmune Syndrome. (PubMed, Clin Diabetes) - No abstract available

Journal • Diabetes • Hypoglycemia • Immunology • Metabolic Disorders • Type 2 Diabetes Mellitus

One potential method of recycling expired thiocolchicoside drug is to use an environmental corrosion inhibitor for carbon steel in HCl. (PubMed, Sci Rep) - "DFT-based quantum chemical indices made further understanding of the inhibitory mechanism possible. Results gained for all techniques used are in good agreement."

Journal

MESOCOLO: Mesotherapy Treatment of Irritable Bowel Syndrome (clinicaltrials.gov) - P2 | N=27 | Active, not recruiting | Sponsor: Polyclinique de l'Europe | Trial completion date: Jan 2026 ➔ Jan 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Chemopreventive effects of chitosan nanogel with thiocolchicoside and lauric acid in chemically induced oral carcinogenesis, in a rodent model. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "There was also a significant decrease in the expression of EGFR and VEGFR signaling molecules in the CTL nanogel-treated group (p < 0.05 level). CTL nanogel shows potent chemopreventive efficiency in reducing the occurrence and severity of 4NQO-induced oral cancer in Wistar rats, marking it a promising candidate for further investigation in cancer prevention strategies."

IO biomarker • Journal • Preclinical • Head and Neck Cancer • Oncology • Oral Cancer • Solid Tumor • BAX • BCL2 • CASP3 • CCND1 • CTNNB1 • RAC1 • TNFA

Efficacy and Safety of the Combination of Diclofenac and Thiocolchicoside in the Treatment of Low Back Pain and Other Conditions: Systematic Review of the Literature. (PubMed, Healthcare (Basel)) - "However, there is no clear evidence of its clinical superiority over other available treatments, due to study heterogeneity and potential biases. Rigorous, standardized research with larger sample sizes and consistent methodologies is essential to definitively establish the efficacy and safety of diclofenac-thiocolchicoside, providing clearer guidance for clinical decision-making."

Journal • Review • Back Pain • Gastrointestinal Disorder • Inflammation • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Exploring structural and spectroscopic aspects, solvent effect (polar and non-polar) on electronic properties, topological insights, ADME and molecular docking study of thiocolchicoside: A promising candidate for antiviral and antitumor pharmacotherapy. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "Thiocolchicoside (TCS), a colchicine derivative, was analyzed using experimental and theoretical spectroscopic methods. ADME prediction shows that TCS has low GI absorption and no permeability across the BBB, with five hydrogen bond donors and ten acceptors. Molecular docking analysis confirmed TCS's biological activity, demonstrating binding affinities for COVID-19 main proteases 6LU7, spike protein 6VXX, and SMAD proteins 1U7V (SMAD4) and 1U7F (SMAD3) with binding energies of -9.52, -3.59, -5.18, and -5.85 kcal/mol, indicating its potential antiviral and antitumor effects."

Journal • Infectious Disease • Novel Coronavirus Disease • Oncology • SMAD3 • SMAD4

Revolutionizing Drug Delivery: A Design Professional's Approach to Drug-loaded Transferosomal Vesicles for Transdermal Use. (PubMed, Pharm Nanotechnol) - "The study concludes that formulation TDP-8, which incorporates 3g of Aloe vera leaf mucilage (AVLM) and lime oil (LO) as permeability enhancers, demonstrated favorable discharge characteristics. This indicates its potential as an effective transdermal delivery system for LXM and TCS, offering a promising substitute for pain and inflammation relief while minimizing gastric irritation. The study succeeded in developing and evaluating transferosomal transdermal patches for LXM and TCS, providing an alternative delivery method that minimizes gastric irritation."

Journal • Inflammation • Pain

Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, J Clin Med) - " Although thiocolchicoside was found to significantly reduce patient-reported low back pain, the clinical impact was very small, as the pooled effect estimates were below the MID, and the overall certainty of evidence was very low. In light of the safety concerns raised by the European Medicine Agency, an in-depth analysis on the risk-benefit balance of thiocolchicoside is required."

Clinical • Journal • Retrospective data • Review • Back Pain • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A Comparative Study of Skeletal Muscle Relaxant Effects of Thiocolchicoside, Diazepam and Their Combination in Wistar Rats Using the Rotarod Apparatus. (PubMed, Cureus) - "This indicates that the addition of THC did not potentiate the skeletal muscle relaxant activity of DIZ. Conclusion THC didn't show skeletal muscle relaxant properties in both doses and did not potentiate the activity of DIZ."

Journal • Preclinical • Back Pain • CNS Disorders • Immunology • Infertility • Mood Disorders • Movement Disorders • Musculoskeletal Pain • Neuralgia • Orthopedics • Pain • Parkinson's Disease • Rheumatoid Arthritis • Rheumatology • Sexual Disorders

Nicolau Syndrome Associated with Diclofenac Sodium and Thiocolchicoside Injection: A Case Report (EADV 2024) - "NS is a rare condition first described in 1925 following intramuscular bismuth injection to treat syphilis and has been reported to develop after intramuscular, subcutaneous, intravenous, intraarticular and subacromial injections of various drugs. NS is accompanied by dermatological symptoms such as a vivid reticular-type purplish patch and varying degrees of tissue loss and necrosis after injection. The diagnosis of NS is primarily based on the patient ’ s medical history, clinical findings and exclusion of other differential diagnoses."

Case report • Clinical • Anesthesia • Dermatology • Infectious Disease • Oncology • Pain • Vasculitis

QUALITY BY DESIGN-BASED DEVELOPMENT AND IN-VITRO EVALUATION OF DUAL RELEASE TABLET OF ETORICOXIB & THICHOLCHICOSIDE: A NOVEL CHRONOTHERAPEUTIC APPROACH FOR ARTHRITIS PAIN MANAGEMENT. (PubMed, Ann Pharm Fr) - "A high level of patient compliance is ensured through the current design as the patient does not need to get out of bed at night to take the medication."

Journal • Preclinical • Immunology • Musculoskeletal Pain • Pain • Rheumatology

Effectiveness of Mesotherapy in Post-COVID Pain Syndrome: Retrospective Cohort Study of 96 Patients. (PubMed, Clin Ther) - "While both mesotherapy and oral therapy offer benefits in reducing pain and alleviating neuropathic symptoms in post-COVID pain syndrome, mesotherapy stands out as an especially effective and well-tolerated treatment method, surpassing the efficacy of the oral alternative."

Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Novel Coronavirus Disease • Pain • Respiratory Diseases