TPC-2 / Warren Pharma - LARVOL DELTA

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. (PubMed, Nature) - "...Mammalian TPC1 and TPC2 are localized at the endolysosomal membrane, and have critical roles in regulating the physiological functions of these acidic organelles...Structural comparisons between the apo and PtdIns(3,5)P-bound structures show the interplay between voltage and ligand in channel activation. These MmTPC1 structures reveal lipid binding and regulation in a 6-TM voltage-gated channel, which is of interest in light of the emerging recognition of the importance of phosphoinositide regulation of ion channels."

Journal • Biosimilar