BCG vaccine / University of Groningen - LARVOL DELTA

Clinical Characteristics and Management of Infective Native Arterial Aneurysms Associated with BCG Therapy for Bladder Cancer. (PubMed, Ann Vasc Surg) - "BCG-induced INAAis a rare but life-threatening complication and early recognition is critical. Optimal management involves targeted antimicrobial therapy and timely surgical intervention, either open or endovascular, based on the patient's condition and aneurysm characteristics."

Journal • Review • Bladder Cancer • Cardiovascular • Genito-urinary Cancer • Oncology • Solid Tumor

Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions. (PubMed, Nat Commun) - "We map genetic effects on gene expression (expression quantitative trait locus, eQTL) using single-cell transcriptomes of 152 samples from 38 healthy individuals, covering baseline state and lipopolysaccharide challenge either before or after Bacillus Calmette-Guerin vaccination...Of note, our results support the pivotal roles of SLFN5 in COVID-19 pathogenesis by incorporating disease-associated loci, chromatin accessibility, and transcription factor binding affinities, aligning with the established functions of SLFN5 in restricting virus replication during viral infection. Our study provides a paradigm to decipher genetic underpinnings of complex traits by integrating single-cell eQTLs with multi-omics data from patients and public databases."

Journal • Infectious Disease • Novel Coronavirus Disease • CD55

Genetic regulators of cytokine responses upon BCG vaccination in children from West Africa. (PubMed, J Genet Genomics) - "Here, we aimed to identify single-nucleotide polymorphisms (SNPs) controlling cytokine responses (cQTLs) after microbial stimulation in infants of West-African ancestry, comprising of low-birth-weight neonates randomized to BCG vaccine-at-birth (intervention) or to the usual delayed BCG (control)...We observed limited overlap of common cQTLs between the West-African infants and cohorts of Western European individuals. These data reveal strong population-specific genetic effects on cytokine production and may indicate new opportunities for therapeutic intervention and vaccine development in African populations."

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