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November 08, 2023
Type I interferon responsepropagates TDP-43 pathogenesisin ALS
(ALS-MND 2023)
- "While deletionof IFNa/breceptor subunit 1 (Ifnar1) has been characterisedin SOD1 mutant mouse model, this rare genetic conditiondoes not display TDP-43 pathology... We demonstrate a rationale to target type I IFNsingalling to intervene in immune-mediated neurodegenera-tive cascades in the context of TDP-43. This will be founda-tional for development of brain penetrant therapeutics tonew clinical trials for TDP-43 proteinopathies"
Alzheimer's Disease • Amyotrophic Lateral Sclerosis • CNS Disorders • Frontotemporal Lobar Degeneration • Inflammation • Proteinopathy • IFNAR1 • SOD1 • STAT1 • TARDBP
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