MM09 / Inmunotek - LARVOL DELTA

MM09-SIT-023: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites (clinicaltrials.gov) - P3 | N=150 | Recruiting | Sponsor: Inmunotek S.L. | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Jan 2024 ➔ Dec 2026

Trial completion date • Trial primary completion date • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3 | N=18 | Terminated | Sponsor: Inmunotek S.L. | N=140 ➔ 18 | Recruiting ➔ Terminated; Due to the low recruitment rate since the start of the trial

Enrollment change • Monotherapy • Trial termination • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

MM09-SLIM: Clinical Trial to Evaluate the Efficacy and Safety of Polymerized, Mannan-Conjugated Dermatophagoides Allergen Extract (clinicaltrials.gov) - P2/3 | N=90 | Not yet recruiting | Sponsor: Inmunotek S.L. | Trial completion date: Dec 2025 ➔ Dec 2026 | Initiation date: Apr 2023 ➔ Nov 2023 | Trial primary completion date: Jun 2025 ➔ Jun 2026

Trial completion date • Trial initiation date • Trial primary completion date • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

MM09-SLIM: Clinical Trial to Evaluate the Efficacy and Safety of Polymerized, Mannan-Conjugated Dermatophagoides Allergen Extract (clinicaltrials.gov) - P2/3 | N=90 | Not yet recruiting | Sponsor: Inmunotek S.L.

New P2/3 trial • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of HDM Induced Allergic Asthma and Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3 | N=400 | Not yet recruiting | Sponsor: Inmunotek S.L. | Initiation date: Aug 2022 ➔ Dec 2022

Trial initiation date • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3 | N=140 | Recruiting | Sponsor: Inmunotek S.L. | Trial completion date: Sep 2022 ➔ Oct 2023 | Trial primary completion date: Sep 2022 ➔ Oct 2023

Trial completion date • Trial primary completion date • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of HDM Induced Allergic Asthma and Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3 | N=400 | Not yet recruiting | Sponsor: Inmunotek S.L.

New P3 trial • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

MM09-SIT-023: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites (clinicaltrials.gov) - P3 | N=150 | Recruiting | Sponsor: Inmunotek S.L. | Trial completion date: Apr 2022 ➔ Dec 2025 | Trial primary completion date: Jan 2022 ➔ Jan 2024

Trial completion date • Trial primary completion date • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3; N=140; Recruiting; Sponsor: Inmunotek S.L.; Active, not recruiting ➔ Recruiting

Clinical • Enrollment open • Monotherapy • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3; N=140; Active, not recruiting; Sponsor: Inmunotek S.L.; Not yet recruiting ➔ Active, not recruiting

Clinical • Enrollment closed • Monotherapy • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

MM09-SIT-023: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites (clinicaltrials.gov) - P3; N=150; Recruiting; Sponsor: Inmunotek S.L.; Trial primary completion date: Jan 2021 ➔ Jan 2022

Clinical • Trial primary completion date • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis (clinicaltrials.gov) - P3; N=140; Not yet recruiting; Sponsor: Inmunotek S.L.

Clinical • Monotherapy • New P3 trial • Allergic Rhinitis • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases

MM09-SIT-023: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites (clinicaltrials.gov) - P3; N=150; Recruiting; Sponsor: Inmunotek S.L.; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Inflammation • Ophthalmology • Respiratory Diseases

MM09-SIT-023: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites (clinicaltrials.gov) - P3; N=150; Not yet recruiting; Sponsor: Inmunotek S.L.

Clinical • New P3 trial • Allergy • Asthma • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Respiratory Diseases