flurbiprofen / Generic mfg. - LARVOL DELTA

A Dissolving Microneedle Design for Poorly Water-Soluble Drugs for Enhanced Skin Permeation and Transdermal Delivery Fabricated Using 3D Printing. (PubMed, Micromachines (Basel)) - "These optimized structures served as templates for flurbiprofen (FLU)-loaded dissolving MNs (DMNs) fabricated via a bilayered casting method...Consequently, star-type DMNs achieved the highest cumulative drug permeation (86.9 ± 9.9% in 12 h), outperforming pyramidal (77.8 ± 9.0%) and conical (64.4 ± 10.2%) designs. These findings underscore geometric design as a critical determinant of clinical efficacy, providing a robust framework for precision manufacturing of task-specific MNs for poorly soluble drugs."

Journal

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=30 | Completed | Sponsor: Bristol-Myers Squibb | Recruiting ➔ Completed

Trial completion

The Association Between Body Mass Index and Acute Postoperative Pain in Bariatric Surgery Patients: A Prospective Cohort Study. (PubMed, Pain Ther) - P=N/A | "BMI may be considered as a factor for stratifying postoperative analgesia, favoring multimodal, opioid-sparing strategies in patients with severe obesity who demonstrate higher pain tolerance and lower analgesic requirements."

Journal • Gastrointestinal Disorder • Genetic Disorders • Obesity • Oncology • Pain • TNFA

A Case of Toxic Epidermal Necrolysis-Like Dermatosis Associated With Contact Exposure to a Flurbiprofen Plaster. (PubMed, Cureus) - "The patient was treated with methylprednisolone pulse therapy followed by systemic corticosteroids and supportive care, achieving complete re-epithelialization after two months. This case demonstrates that severe contact dermatitis caused by topical NSAIDs can clinically mimic TEN and underscores the critical importance of histopathologic evaluation in establishing an accurate diagnosis."

Journal • Contact Dermatitis • Dermatitis • Dermatology • Dermatopathology • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Rheumatology • Steven-Johnson Syndrome

Bifunctional Analgesic-Pro-Healing Hydrogel Dressing for Postoperative Analgesia and Wound Healing in Mice. (PubMed, ACS Biomater Sci Eng) - "In vitro and in vivo experiments have confirmed that hCMPG-FP can exert dual functions of wound healing promotion and analgesia, which is associated with the antibacterial activity, coagulation-promoting effect, and cell migration-promoting ability of carboxymethyl chitosan hydrogel, as well as the analgesic and anti-inflammatory properties of flurbiprofen. In conclusion, when acting on incisions, hCMPG-FP regulates multiple pathways such as wound healing and inflammation modulation, exerts ideal dressing functions, and provides a theoretical basis and experimental evidence for the further development of innovative wound treatment strategies."

Journal • Preclinical • Inflammation • Pain

Low-dose dexmedetomidine improves postoperative sleep and pain in gynecological surgery: a randomized trial. (PubMed, Front Pharmacol) - P=N/A | "Secondary outcomes included PSQI scores on the first and second postoperative nights, Visual Analogue Scale (VAS) pain scores assessed at 6, 12, 24, and 48 h postoperatively, total postoperative sufentanil consumption, the number of PCA button presses recorded by the infusion pump, and the incidence of adverse events-specifically bradycardia (heart rate <50 bpm), hypotension (mean arterial pressure <60 mmHg), postoperative nausea and vomiting (PONV), and the use of rescue analgesia with intravenous flurbiprofen axetil. Collectively, our findings support that this low-dose regimen is a safe and effective multimodal analgesic strategy, offering a valuable therapeutic option to simultaneously improve sleep and alleviate pain in female patients during the postoperative period. https://www.chictr.org.cn, identifier ChiCTR2500108204."

Clinical • Journal • Cardiovascular • CNS Disorders • Gynecology • Hypotension • Pain • Sleep Disorder

FLURBI-POST: Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation (clinicaltrials.gov) - P=N/A | N=58 | Active, not recruiting | Sponsor: Kittitorn Supphapipat, MD | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Intubation • Otorhinolaryngology

Repurposing flufenamic acid as a putative PmrB-directed adjuvant to restore colistin activity in Klebsiella pneumoniae. (PubMed, Microbiol Spectr) - "High-throughput virtual screening of DrugBank using integrated ligand- and structure-based approaches shortlisted five approved drugs (mebendazole, flurbiprofen, tirbanibulin, flufenamic acid, and netarsudil) for experimental evaluation. Mechanistically, our findings are consistent with modulation of the PmrB/PmrA resistance pathway, supporting bacterial histidine-kinase signaling as a promising direction for antibiotic adjuvant development. Overall, this study highlights a practical and scalable framework for discovering resistance-targeted adjuvants to help protect last-resort antibiotics and improve treatment options for difficult-to-treat infections."

Journal • Infectious Disease • Pneumonia

nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity. (PubMed, J Inorg Biochem) - "Furthermore, the nido-carborane conjugates with ibuprofen, flurbiprofen or fenoprofen incorporating propylene spacers 3b, 6b, and 9b, respectively, displayed the most potent activity against A549 lung cancer cells and in comparison to other tested molecules exhibited better selectivity towards malignant cells, as evidenced by selectivity index values. The main mechanism of action of these NSAID conjugates includes caspase dependent apoptosis synchronized by inhibited cell division and hyperproduction of superoxide anions, hydrogen peroxide and peroxynitrites."

Journal • Lung Cancer • Oncology • Solid Tumor

A predictive release kinetic model guiding the rational design of sustained release solid dispersions with insoluble carriers. (PubMed, Int J Pharm) - "Flurbiprofen (FBU) is a nonsteroidal anti-inflammatory drug with short half-life, requiring frequent dosing and leading to potential gastrointestinal side effects...The model was further utilized to predict the release behavior for varying carrier compositions and particle sizes successfully, demonstrating its ability in guiding the rational design of formulations based on insoluble polymeric carriers. This work underscores the critical role of mechanistic modeling in transitioning from empirical formulation screening to rational design."

Journal

Ionic liquid-assisted synthesis of triazine covalent organic frameworks for selective enrichment and sensitive detection of nonsteroidal anti-inflammatory drugs in urine and river water. (PubMed, Anal Chim Acta) - "This study presents an alternative strategy to enhance the adsorption performance and selectivity of COFs for NSAIDs by introducing functional groups and increasing the specific surface area and pore size. Moreover, it offers an efficient HPLC-UV method for the selective enrichment and sensitive detection of NSAIDs in environmental and biological samples."

Journal

Formulation and Optimization of Chitosan-Based Flurbiprofen Nanoparticles for Ocular Delivery: A Design of Experiments Approach. (PubMed, Assay Drug Dev Technol) - "In vitro studies showed a controlled release of flurbiprofen over 20 h. The optimized chitosan-based nanoparticle system demonstrated favorable physicochemical stability, high encapsulation efficiency, and sustained release of flurbiprofen. Compared with conventional ocular formulations, this structured nanoparticle delivery system offers superior drug retention and extended therapeutic action."

Journal • Ophthalmology

Comparing the Effect of Drug, Sodium Carboxymethyl Cellulose and Other Excipients on Shape, Size and Drug Release from the Matrices. (PubMed, Int J Pharm Compd) - "The swelling rate of the different matrices was constrained only by NaCMC. The ratio of anionic NaCMC primarily controlled the release rate of drugs. The shape and size of the matrices, according to the solubility and charge of these drugs. Other excipients, such as surfactants, lactose, and magnesium stearate, affected the release rate of the drugs, shape and size of the matrices but did not influence their swelling rate."

Clinical • Journal

Effects of electroacupuncture combined with flurbiprofen axetil on postoperative pain and early functional recovery after breast cancer surgery. (PubMed, World J Clin Oncol) - "EA combined with flurbiprofen FA can reduce the occurrence of postoperative pain and complications, improve early postoperative functional recovery after breast cancer surgery."

Journal • Anesthesia • Anorexia • Breast Cancer • Oncology • Pain • Solid Tumor

A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery (clinicaltrials.gov) - P=N/A | N=110 | Recruiting | Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University | Not yet recruiting ➔ Recruiting

Enrollment open • Head-to-Head • Pain

KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism (clinicaltrials.gov) - P=N/A | N=12 | Completed | Sponsor: Helsinki University Central Hospital | Not yet recruiting ➔ Completed

Trial completion • Congestive Heart Failure

A multiphasic core-shell flurbiprofen and ciprofloxacin-loaded nanofibrous dressing cures infected burns via dual control of infection and inflammatory response. (PubMed, Biomater Sci) - "Also, evidence from IHC staining confirmed secondary skin organ formation. The PCL-CS-based dual drug delivery system provides synergistic enhanced therapeutic efficacy and could be a solution to the simultaneous challenges in burn wounds."

Journal • Infectious Disease • Inflammation • Thermal Injury

Peroxymonosulfate activation by a nitrogen-doped multilayer graphene catalyst derived from cotton for enhanced flurbiprofen degradation. (PubMed, RSC Adv) - "Pyridinic nitrogen proved the most potent active site for PMS activation. By incorporating waste cotton fibers into the pharmaceutical wastewater treatment solution, this study offers a practical approach to biomass recycling and an actionable reference for treating waste with waste."

Journal

Fabrication of electrospun nanofibers of flurbiprofen-cyclodextrin inclusion complexes for anti-inflammatory assessment in skin fibroblast cell line. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The FP-CD-IC-NFs demonstrated excellent biocompatibility on CCD-986Sk skin fibroblasts, with cell viability reaching nearly 100% as confirmed by the MTT assay. Therefore, the non-toxic and biocompatible nature of FP-HPβCD-IC-NF and FP-MβCD-IC-NF highlights their potential for use in wound dressing and wound healing applications."

Journal • Preclinical

Top-Down Exfoliation of Ultrathin Chiral 2D Nanosheets for High-Resolution Gas Chromatography. (PubMed, Anal Chem) - "Experiments showed that the stationary phase of 2D nanosheets, prepared by exfoliating BPDS-PBIM, exhibited exceptional separation performance for complex pharmaceutical molecules (e.g., ibuprofen, ketoprofen, flurbiprofen, fenoprofen, mexiletine hydrochloride) and chiral compounds with different polarity. This work not only demonstrates the powerful potential of BPDS-PBIM as a chiral stationary phase but also suggests its broad application prospects in fields such as pharmaceutical analysis, flavor and fragrance quality control, and chemical reaction monitoring."

Journal • CDKN1A

L-Alaninium borneol ester flurbiprofenate: a dual-function ionic carrier for enhanced solubility and transdermal delivery. (PubMed, Eur J Pharm Biopharm) - "Furthermore, in lipopolysaccharide-stimulated monocytes, the derivative reduced interleukin-1β, interleukin-6, and cyclooxygenase-2 expression in a dose-dependent manner, surpassing the anti-inflammatory effects of flurbiprofen. These results suggest that ionic pairing with L-alaninium borneol ester is a promising strategy to enhance solubility, permeability, and therapeutic efficacy of NSAIDs for topical administration."

Journal • IL1B • IL6

Chronic pain after mastectomy: current knowledge and knowledge gaps. (PubMed, Minerva Anestesiol) - "Perioperative preventive strategies, such as topical EMLA cream, pregabalin, PECS II block, i.v. dexmedetomidine and flurbiprofen axetil, show potentially promising effects in reducing the incidence or severity of PMPS. Treatment options for established PMPS with potentially promising effects include topical capsaicin, amitriptyline, venlafaxine, multimodal pharmacological therapy, thermal radiofrequency of the stellate ganglion, and mindfulness-based cognitive therapy...Large-scale well-powered clinical trials on interventions aiming to prevent and treat PMPS are highly needed to inform evidence-based clinical practice. Future clinical studies should also aim to identify biomarkers that predict the efficacy of interventions in individual patients, thereby supporting personalized medicine."

Journal • Breast Cancer • Musculoskeletal Pain • Oncology • Pain • Solid Tumor

Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: Min Kyu Park

New P1 trial

Enhanced transdermal delivery of S-flurbiprofen-lidocaine ionic liquid-loaded emulgel for synergistic anti-inflammation and analgesia. (PubMed, Colloids Surf B Biointerfaces) - "Histopathological examination of SFP-LDC-IL-EMG-treated animals showed minimal inflammatory cell infiltration with tissue morphology closely resembling normal groups. These findings establish SFP-LDC-IL-EMG as a promising topical delivery system combining IL-mediated transdermal enhancement with synergistic pharmacological mechanisms for effective localized inflammation and pain management."

Journal • Inflammation • Pain

The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus. (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Marmara University

New trial • Pain