flurbiprofen / Generic mfg. - LARVOL DELTA

Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Fudan University

New trial • Anesthesia • Colorectal Cancer • Oncology • Solid Tumor

To Determine the Effect of CYP Induction Following Administration of Nirogacestat in Healthy Adult Male Participants (clinicaltrials.gov) - P1 | N=16 | Recruiting | Sponsor: SpringWorks Therapeutics, Inc.

New P1 trial

Flurbiprofen@ZIF-8 nanoformulation with potential for analgesia. (PubMed, BMC Anesthesiol) - "The biosafety assessment confirmed the excellent biocompatibility and safety of FP@ZIF-8 nanoparticles. These findings suggest that FP@ZIF-8 is a promising drug delivery system for treating inflammatory pain conditions."

Journal • Inflammation • Pain

Early detection and management of mesenteric traction syndrome using the hypotension prediction index: a case report. (PubMed, JA Clin Rep) - "Recognition of facial flushing subsequently confirmed the diagnosis of MTS, and intravenous flurbiprofen stabilized the circulation. This case suggests that HPI monitoring may assist in the early identification of vasodilatory changes associated with MTS and support timely intervention before severe hypotension develops."

Journal • Anesthesia • Cardiovascular • Hypotension

Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. (clinicaltrials.gov) - P=N/A | N=220 | Completed | Sponsor: Changhai Hospital | Enrolling by invitation ➔ Completed

Trial completion • Pancreatitis

Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=28 | Recruiting | Sponsor: Institut de Recherches Internationales Servier (I.R.I.S.)

New P1 trial • Breast Cancer • Oncology • Solid Tumor

Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy (clinicaltrials.gov) - P=N/A | N=216 | Recruiting | Sponsor: Beijing Tiantan Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

Novel Ruthenacarborane-NSAID Conjugates. (PubMed, Molecules) - "Herein, we report the synthesis of a series of ruthenacarborane-(η6-p-cymene)-NSAID conjugates (4a, 4b, 5b, and 6b) by linking NSAIDs (flurbiprofen, fenoprofen, and ibuprofen) to ruthenacarborane complexes using methylene and ethylene spacers, while maintaining the integrity of the sensitive ester groups present in the system. Notably, the conjugates demonstrated low COX inhibition and no cytotoxic potential against different cancer cell lines, probably due to oxidative deactivation confirmed by cyclic voltammetry (CV). This indicates that the conjugation of this type of ruthenacarborane with NSAIDs does not result in novel anticancer drugs."

Journal • Oncology

Efficacy and Safety Comparison of Ulinastatin Versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial. (PubMed, J Pain Res) - "Total knee arthroplasty (TKA) poses a significant challenge for acute pain. Single preoperative UTI significantly reduced postoperative morphine consumption (~48%) and adverse reaction risks compared with FA and control by modulating the balance of proinflammatory and anti-inflammatory factors (IL-6 and IL-10). UTI provides an efficient and safe alternative, supporting its inclusion in enhanced recovery after surgery (ERAS) analgesia strategies."

Clinical • Journal • CNS Disorders • Gastrointestinal Disorder • Orthopedics • Pain • IL10 • IL6

Choline chloride-malic acid Natural Deep Eutectic Solvent containing hydrophobic drugs: Insights into solubility and permeability behavior in digestive tract models. (PubMed, Int J Pharm) - "The selected APIs included weak bases (domperidone, cinnarizine, olanzapine), weak acids (nimesulide, flurbiprofen), and a pH-independent compound (carbamazepine). Nevertheless, its ability to improve bioavailability is highly dependent on the molecular characteristics of each API + NaDES system. Upon dilution in biorelevant media, performance is governed by a delicate interplay of hydrogen bonding, hydrophobic interactions and competition with solubilizing agents present in gastrointestinal fluids."

Journal

Development and evaluation of an in situ gelling flurbiprofen throat spray for enhanced mucosal drug delivery and throat inflammation treatment. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "By extending the duration of drug contact with the throat mucosa, this formulation presents a promising alternative for delivering drugs to treat throat inflammation effectively. However, the present study is limited to in vitro and ex vivo evaluations, and clinical validation is warranted to confirm its therapeutic applicability."

Journal • Inflammation • Pain

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=32 | Not yet recruiting | Sponsor: Bristol-Myers Squibb

New P1 trial

Effects of Different Inhaled Oxygen Concentrations Combined with Flurbiprofen Ester Pretreatment on Pulmonary Function in Patients Undergoing Thoracoscopic Lobectomy: A 2×2 Factorial Design Randomized Controlled Trial (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: The Fourth Hospital of Hebei Medical University; The Fourth Hospital of Hebei Medical University

New trial • Lung Cancer • Oncology • Solid Tumor

The influence of laparoscopic combined with flurbiprofen axetil and TAPB on the postoperative rehabilitation of elderly patients undergoing laparoscopic colorectal surgery (ChiCTR) - P=N/A | N=120 | Recruiting | Sponsor: The Second Hospital of Hebei Medical University; The Second Hospital of Hebei Medical University

New trial

Clinical Study on the Efficacy and Safety of Teglidine Fumarate for Postoperative Analgesia in Orthopedic Surgery (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Ningbo Medical Center Lihuili Hospital; Ningbo Medical Center Lihuili Hospital

New trial • Orthopedics

Effect of perioperative multimodal analgesia based on enrikefon on postoperative fatigue syndrome in patients undergoing thoracoscopic pneumonectomy: a randomized controlled trial (ChiCTR) - P4 | N=130 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Anhui Medical University

New P4 trial • Fatigue

Comparison of the analgesic effect, incidence of delirium, anxiety and depression between bupivacaine liposome intercostal nerve block and PCIA in patients undergoing thoracoscopic surgery (ChiCTR) - P4 | N=280 | Recruiting | Sponsor: The Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University

New P4 trial • CNS Disorders • Depression • Pain • Psychiatry

Effect of Penehyclidine Combined with Flurbiprofen Axetil on Catheter-Related Bladder Discomfort after General Anesthesia (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Shandong Second Medical University Affiliated Hospital; Shandong Second Medical University Affiliated Hospital

New trial • Anesthesia

Analgesic Efficacy and Psychological State Evaluation of Dezocine Combined with Sufentanil and Flurbiprofen in Postoperative Analgesia for Elderly Patients Undergoing Spinal Surgery (ChiCTR) - P4 | N=150 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of Southern Medical University; The Third Affiliated Hospital of Southern Medical University

New P4 trial • Pain

Effect of perioperative polarised light stellate ganglion irradiation on postoperative stress disorder in emergency trauma patients: protocol for a randomised controlled trial. (PubMed, BMJ Open) - P=N/A | "All patients will receive multimodal analgesia, consisting of intraoperative flurbiprofen axetil, ropivacaine infiltration at the end of surgery and postoperative patient-controlled sufentanil. The results of this study will be published in a peer-reviewed journal. ChiCTR2300070852."

Clinical protocol • Journal • Allergy • Anesthesia • Cardiovascular • CNS Disorders • Hypertension • Hypotension • Immunology • Otorhinolaryngology • Pain • Post-traumatic Stress Disorder • Psychiatry • Pulmonary Disease

Preemptive flurbiprofen axetil for sleep-pain-inflammation modulation after laparoscopic gynecological surgery: a prospective, parallel-group randomized controlled trial. (PubMed, Front Pharmacol) - P1 | "Incorporating flurbiprofen axetil into preemptive multimodal analgesia protocols could provide a straightforward yet effective approach to optimizing recovery following laparoscopic gynecological surgery. clinicaltrials.gov, identifier NCT04611763."

Journal • CNS Disorders • Gynecology • Immunology • Inflammation • Insomnia • Pain • Sleep Disorder • Systemic Inflammatory Response Syndrome

The Effect of Prophylactic Use of NSAIDs on Acute Phase Reactions Induced by First-Time Zoledronic Acid Treatment for Osteoporosis. (PubMed, Ann Pharmacother) - "Prophylactic NSAIDs significantly reduce zoledronic acid-induced APRs, especially pain, but have no significant effect on preventing fever. The 3 NSAIDs also have comparable efficacy."

Journal • Musculoskeletal Pain • Osteoporosis • Pain • Rheumatology

Exploring the Population Pharmacokinetic and Pharmacogenetics Characteristics of Flurbiprofen Isomers in Selective Joint Replacement Patients with Postoperative Pain. (PubMed, Drug Des Devel Ther) - "Key covariates of S (+)-flurbiprofen was ABCB1 gene polymorphisms and R-flurbiprofen was POR gene polymorphisms and BSA. The findings may provide support for future dose optimization and the development of novel therapeutic approaches."

Biomarker • Clinical • Journal • PK/PD data • Orthopedics • Pain • ABCB1 • CYP2C9 • POR • UGT1A9

Effects of Perioperative Ketorolac and NSAIDs on Cancer Outcomes (ASA 2025) - "Other NSAIDs used include aspirin, ibuprofen, flurbiprofen, and celecoxib.Patients in the ketorolac and NSAIDs group had significantly greater OS (HR = 0.83, 95% CI 0.74 to 0.92, I2 = 57%, p = 0.0007). Patients in the ketorolac and NSAIDs group had lower recurrence rate (HR = 0.70, 95% CI 0.56 to 0.88, I2 = 79%, p = 0.002). Patients in the ketorolac and NSAIDs group also had significantly greater RFS/DFS (HR = 0.89, 95% CI 0.81 to 0.98, I2 = 76%, p = 0.01).ConclusionPerioperative ketorolac and other NSAIDs were shown to have a positive effect on OS, RFS/DFS, and recurrence rates."

Breast Cancer • Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor

Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy (clinicaltrials.gov) - P=N/A | N=300 | Not yet recruiting | Sponsor: Beijing Tiantan Hospital

New trial • Pain