flurbiprofen / Generic mfg. - LARVOL DELTA

Interleukin-1β-Induced Inflammatory Signaling and Myelin-Related Alterations in Oligodendroglia and Schwann Cells in Multiple Sclerosis: Modulatory Effects of Ibuprofen and Flurbiprofen. (PubMed, Curr Issues Mol Biol) - "In contrast, treatment with Ibuprofen and Flurbiprofen effectively countered the harmful effects of IL-1β in MS. These in vitro studies show that IL-1β can play a possible detrimental role in facilitating neuropathogenesis, as seen in Alzheimer's and Parkinson's disease, and anti-inflammatory drugs Ibuprofen and Flurbiprofen have a potential role in modulating the neuroinflammation in MS."

Journal • Alzheimer's Disease • Brain Cancer • CNS Disorders • Glioma • Inflammation • Movement Disorders • Multiple Sclerosis • Oligodendroglioma • Oncology • Parkinson's Disease • Solid Tumor • IL1B • IL6 • MBP • MYD88 • SYP • TNFA

High-performance adhesive eutectogel based on polyacrylate-carboxylated cellulose nanofibers double networks for efficient transdermal drug delivery. (PubMed, Int J Biol Macromol) - "Compared to conventional hydrogels, the prepared eutectogel demonstrated superior performance in TDDS, including an excellent elongation rate (> 1400%), high tensile strength (0.89 MPa), strong skin adhesion (> 60 kPa), strong self-healing capacity, and outstanding stability across the temperature range of -20 to 60 °C due to the multiple hydrogen bond interactions and metal coordination. Meanwhile, owing to the enhanced drug solubilizing effects of DES solvents and acrylate polymers, eutectogel significantly enhanced flurbiprofen drug loading and demonstrated excellent therapeutic effects through in vivo pharmacodynamics experiments, highlighting its potential as an efficient platform to facilitate transdermal therapy for chronic diseases, including arthritis, offering an effective way to develop transdermal patches for low-solubility drugs."

Journal • Immunology • Rheumatology

Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Laparoscopic Hepatectomy (clinicaltrials.gov) - P2 | N=108 | Not yet recruiting | Sponsor: Tianjin Medical University Cancer Institute and Hospital

New P2 trial • Pain

ARK-PCNL: A Randomized, Double-Blind, Placebo-Controlled Trial of Anrikefon for Postoperative Analgesia After Percutaneous Nephrolithotomy (clinicaltrials.gov) - P4 | N=160 | Not yet recruiting | Sponsor: Beijing Tsinghua Chang Gung Hospital

New P4 trial • Nephrology • Pain • Renal Calculi

A Study on the Efficacy Tegileridine Fumarate Injection in Combination with Adductor Canal Block for Postoperative Analgesia afler Total Knee Arthroplasty (ChiCTR) - P4 | N=58 | Recruiting | Sponsor: The Eighth Affiliated Hospital, SunYat-Sen University; The Eighth Affiliated Hospital, SunYat-Sen University

New P4 trial • Orthopedics

Biased μ-opioid receptor agonist tegileridine for postoperative analgesia after gynecologic laparoscopy or abdominal surgery: a prospective, double-blind, randomized controlled trial (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Maternal and Child Health Hospital of Jiangxi Province; Maternal and Child Health Hospital of Jiangxi Province

New trial

Flurbiprofen axetil attenuates myocardial ischemia-reperfusion injury and suppresses NLRP3 inflammasome signaling. (PubMed, Eur J Pharmacol) - "Furthermore, postconditioning tended to exhibit greater protective effects than preconditioning in attenuating inflammatory responses and myocardial injury markers, whereas both strategies showed comparable effects on cardiomyocyte death. In conclusion, flurbiprofen axetil attenuates myocardial I/R injury, and these cardioprotective effects are associated with attenuation of NLRP3 inflammasome-related and downstream pyroptotic signaling, accompanied by reduced inflammatory responses."

Journal • Cardiovascular • Inflammation • Myocardial Ischemia • Reperfusion Injury • IL18 • IL1B • NLRP3 • TNFA

Comparative Effects of Flurbiprofen and Benzydamine on COX-2/PGE2 and Inflammatory Cytokine Release in Polyinosinic:polycytidylic Acid-Stimulated Human Tonsil and Bronchial Epithelial Cells. (PubMed, Int J Mol Sci) - "Benzydamine showed limited or no effect and less inhibition of caspase-1. With rapid suppression of the COX-2/PGE2 pathway, rapid onset and a broad inhibition spectrum, flurbiprofen more comprehensively modulates inflammatory processes in epithelial respiratory models."

Clinical • Journal • Infectious Disease • Oncology • CXCL10 • CXCL8 • IL18 • IL1B • IL6 • PTGS2 • TNFA

Preemptive nalbuphine combined with subcostal transversus abdominis plane block for multimodal analgesia in laparoscopic liver resection: a randomized controlled trial of multimodal analgesia for laparoscopic hepatectomy. (PubMed, Clinics (Sao Paulo)) - "The regimen combining preemptive nalbuphine with subcostal TAPB was associated with better postoperative analgesia, more stable perioperative hemodynamics, and fewer opioid-related adverse events than no regional block and represents a feasible multimodal analgesia strategy for LLR. Because the control group did not receive a sham TAPB, the specific pharmacological contribution of TAPB alone cannot be isolated from a procedural placebo effect."

Journal • Dermatology • Pain • Pruritus

Development of HPTLC method for simultaneous estimation of Gatifloxacin and Flurbiprofen Sodium using 32 factorial design. (PubMed, Drug Dev Ind Pharm) - "RGB12 multi-colour assessment yielded a Whiteness score of 80.5%. A simple, accurate, robust, and AQbD-based HPTLC method was successfully developed and validated for simultaneous determination of gatifloxacin and flurbiprofen sodium in ophthalmic formulations."

Journal • Ophthalmology

Effects of flurbiprofen axetil on postoperative renal function in patients undergoing percutaneous nephrolithotomy: A prospective, randomized, double-blind, controlled clinical study. (PubMed, Medicine (Baltimore)) - "Postoperative administration of 100 mg flurbiprofen axetil may reduce NGAL levels at 6 hours after PCNL, indicating a potential protective effect on renal function."

Clinical • Journal • Acute Kidney Injury • Anesthesia • Nephrology • Renal Calculi • Renal Disease • CST3 • LCN2

Management of Acute Sore Throat in Community Pharmacies: Insights from a Survey of Italian Pharmacists. (PubMed, Pharmacy (Basel)) - "Topical sprays (83.33%) and lozenges (44.69%), especially containing flurbiprofen (94.19%), dominate recommendations, followed by systemic analgesics (45.79%)...The findings inform training outputs prioritizing simplified triage, expanded symptom checklists, spray/lozenge optimization, and 3-5-day call-backs. This work aims to promote pharmacists' antimicrobial stewardship to reduce antibiotic use while enhancing patient-centred sore throat care in Italy's pharmacy network."

Journal • Otorhinolaryngology • Pain

Mesenteric Traction Syndrome during Cesarean Section: Incidence and Prevention with Flurbiprofen (ASA 2026) - "Abstract is embargoed at this time."

Anesthesia

Effects of Preemptive Analgesia Using Wrist-Ankle Acupuncture on Postoperative Pain and Urinary Retention After Haemorrhoidectomy: A Randomised, Three-Arm, Clinical Trial. (PubMed, J Pain Res) - P1 | "In patients stratified by types of basic analgesics (Med1 (Flurbiprofen Esters Injection) and Med2 (Parecoxib sodium for injection) subgroups), the preemptive analgesia group consistently showed significantly lower VAS scores (P < 0.01). It represents a promising non-pharmacological adjunct for multimodal perioperative care; however, multi-centre trials are needed to confirm its generalisability before routine adoption. ChiCTR2400084402."

Clinical • Journal • Gastroenterology • Pain • MBD4 • MED1

Effects of oliceridine-based patient-controlled intravenous administration on postoperative pain and hemodynamic stability in elderly patients undergoing laparoscopic surgery for colorectal cancer. (PubMed, Am J Cancer Res) - "Patients were divided into three groups according to the analgesic regimen: a control group (Group C, fentanyl PCIA), a low-dose oliceridine group (Group O1), and a high-dose oliceridine group (Group O2), each comprising 50 patients. The number of remedial analgesia administrations within 24 hours postoperatively (0.4±0.2 times) and total flurbiprofen axetil consumption (25.0±12.5 mg) were significantly lower in Group O2 than in Groups O1 and C (P<0.05). High-dose Oliceridine PCIA provided better analgesic effects for elderly Laparoscopic Colorectal Cancer Patients after surgery, effectively reduced inflammatory response, and maintained stable Hemodynamic and Respiratory Function."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Colorectal Cancer • Oncology • Pain • Solid Tumor

Therapeutic potential of edaravone and flurbiprofen in valproic acid-induced autism: Targeting oxidative stress and neuroinflammation. (PubMed, IBRO Neurosci Rep) - "This finding suggests that monotherapy with either drug is sufficient to achieve maximal therapeutic effects, a point with significant implications for future treatment strategies in ASD. This study advances neurodevelopmental neuroscience by demonstrating that independently targeting oxidative stress or neuroinflammation achieves maximal behavioral and hippocampal rescue in an autism model, revealing a convergent therapeutic ceiling that challenges combinatorial polypharmacy and refines our understanding of how overlapping pathological pathways govern neural circuit dysfunction and functional recovery."

Journal • Autism Spectrum Disorder • Genetic Disorders • Inflammation • Mood Disorders • Psychiatry • IL6 • TNFA

Comparison of Oliceridine and Hydromorphone for Postoperative Analgesia in Adults Undergoing Lower Limb Fracture Surgery: A Randomized Controlled Non-Inferiority Trial. (PubMed, Drug Des Devel Ther) - "A total of 126 adult patients scheduled for lower limb fracture surgery were enrolled and randomly assigned (1:1) to receive PCIA with either oliceridine or hydromorphone, both combined with flurbiprofen axetil. For post-operative analgesia after lower limb fracture surgery, oliceridine provides analgesic efficacy comparable to hydromorphone. Observations suggest a potential for a lower incidence of PONV with oliceridine, which may offer a favorable opioid option within multimodal analgesic regimens for this population."

Clinical • Head-to-Head • Journal • Dermatology • Musculoskeletal Diseases • Orthopedics • Pain • Pruritus

opioid-free: Opioid Free Anesthesia on the Quality of Early Recovery (clinicaltrials.gov) - P4 | N=160 | Recruiting | Sponsor: Beijing Friendship Hospital | Not yet recruiting ➔ Recruiting | Phase classification: PN/A ➔ P4 | Trial completion date: Dec 2023 ➔ Dec 2026 | Trial primary completion date: Sep 2023 ➔ Oct 2026

Enrollment open • Phase classification • Trial completion date • Trial primary completion date • Anesthesia

Absolute 19F-qNMR Quantification of Fluorinated Pharmaceuticals: Fluorometholone, Flurbiprofen, and Flutamide. (PubMed, Chem Pharm Bull (Tokyo)) - "The average purity values determined by 19F-qNMR were 98.79 ± 0.62% (n = 7) or 98.62 ± 0.34% (n = 6) for FM, 99.84 ± 0.40% (n = 9) for FP, and 99.84 ± 0.48% (n = 9) for FT; these values were in good agreement with those determined by 1H-qNMR (99.23 ± 0.41% (n = 9), 100.04 ± 0.34% (n = 10), and 99.67 ± 0.38% (n = 10), respectively). Collectively, these results indicate that 19F-qNMR is a reliable and reproducible technique for absolute quantification of fluorinated pharmaceuticals, supporting its application in pharmaceutical quality control and regulatory assessment."

Journal

Clove oil in combination with flurbiprofen attenuated imiquimod-induced psoriasis-like skin inflammation in a mouse model: A mechanistic study. (PubMed, Inflammopharmacology) - "Phytochemical analyses confirmed the presence of flavonoids, tannins, phenolic compounds, and saponins in the CO. Overall, these findings suggest that the clove oil-flurbiprofen combination has the potential to reduce skin inflammatory conditions possibly via modulation of oxidative and inflammatory pathways."

Journal • Preclinical • Cardiovascular • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Tegaserod combined with different non-steroidal drugs for postoperative analgesia after laparoscopic cholecystectomy: a 22 factorial randomized controlled trial (ChiCTR) - P4 | N=428 | Not yet recruiting | Sponsor: Shanghai East Hospital; Shanghai East Hospital

New P4 trial • Respiratory Diseases

Analgesic Effect of a Novel Non-pharmacological Electrical Signal-Based Analgesic Device versus Intravenous Flurbiprofen Axetil on Burn Donor Sites: A Prospective, Single-Blind, Randomized Controlled Study (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

New trial

Cobalt(II) and zinc(II) complexes with 2-propionate-based non-steroidal anti-inflammatory drugs. (PubMed, Dalton Trans) - "Three cobalt(II) and three zinc(II) complexes with the non-steroidal anti-inflammatory drugs fenoprofen, loxoprofen and flurbiprofen as ligands were synthesized and characterized with diverse techniques including single-crystal X-ray crystallography...The complexes may interact with calf-thymus DNA via intercalation as revealed from the techniques employed. The affinity of the complexes for bovine and human serum albumins was evaluated by fluorescence emission spectroscopy and the corresponding binding constants revealed reversible binding to both albumins."

Journal

Dexmedetomidine-flurbiprofen axetil-based opioid-free analgesia attenuates postoperative melatonin suppression and improves sleep quality after thyroidectomy: a randomized controlled trial. (PubMed, Front Pharmacol) - P1 | "In this prospective, randomized, double-blind controlled trial, 96 patients undergoing thyroidectomy were randomly assigned to receive either opioid-free PCIA (dexmedetomidine, flurbiprofen axetil, and ondansetron) or opioid PCIA (sufentanil and ondansetron). https://www.chictr.org.cn, identifier ChiCTR2400079949. 01/17/2024."

Clinical • Journal • Anesthesia • Dermatology • Pain • Pruritus • Psychiatry

In reply to: comment on "Effect of flurbiprofen on intraoperative nausea and vomiting during cesarean delivery: a single-center retrospective cohort study". (PubMed, J Anesth) - No abstract available

Journal • Retrospective data