VS-5095 / Verastem - LARVOL DELTA

Sex Steroid Hormone Serum Concentrations in Pregnant Women with Epilepsy in MONEAD (AAN 2024) - "Participants were categorized into the EIASM group if on at least one EIASM (carbamazepine, oxcarbazepine, topiramate, felbamate, phenobarbital, phenytoin, clobazam, perampanel) or non-EIASM group if not using any EIASM...Estrone concentrations for the EIASM group appeared consistently lower, most notably in the second [median: 1572pg/mL (IQR: 621, 2690) vs 3030 (1820, 5040)] and third trimesters [3025 (1460, 4510) vs 5095 (3605, 7025)].EIASM regimens in PWWE did not notably affect progesterone and estradiol concentrations. EIASM regimens in PWWE did not notably affect progesterone and estradiol concentrations. However, estrone concentrations were lower in the second and third trimesters. Future studies will include investigation of potential implications for maternal and child outcomes."

Clinical • CNS Disorders • Epilepsy