Undisclosed Interleukin 6 inhibitor / Evotec, Interprotein Corp - LARVOL DELTA

From Mouse to Clinic: Non-Invasive Swab-Based Profiling of Inflammatory and Barrier Markers in Atopic Dermatitis (IMMUNOLOGY 2026) - "AD-like lesions were induced by chronic oxazolone application on the back or repeated MC903 treatment on the ear.Weekly samples were collected using cotton-tipped swabs for multiplex cytokine assays and ceramide profiling, while glass beads were rolled over the skin for lipid extraction and LC-MS/MS quantification...Key cytokines (IL-4, IL-6, TNF, IL-1β) and ceramides were consistently detectable on the skin surface and correlated with tissue levels. This dual-parameter, minimally invasive approach enables longitudinal monitoring of both immune and barrier markers in preclinical AD models. It aligns with clinical strategies, supports the 3Rs principles and enhances the translational value of murine studies."

Non-invasive • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • IL1B • IL4 • IL6

Impact of mesenchymal stromal/stem cell infusions on circulating inflammatory biomarkers in COVID-19 patients: analysis of a phase I-IIa trial. (PubMed, Cytotherapy) - "MSC in COVID-19 patients resulted safe and feasible, effectively modulating inflammatory cytokines, in particular mitigating brain damage related biomarker, suggesting both reduced inflammation and a potential neurological protection."

Biomarker • Journal • P1/2 data • Acute Respiratory Distress Syndrome • CNS Disorders • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Vascular Neurology • IL18 • IL1R1 • IL6 • NEFL

Cytokine Profiling Reveals Distinctive Immune Responses in Dengue, Zika, Chikungunya and Mayaro Virus Infections (ASTMH 2024) - "Cytokine quantification was carried out by ELISA assays for IL-2, IL-6, IL-10, TNF-α, and IFN-γ...TNF-α and IFN-γ showed a similar pattern, with DENV and ZIKV patients expressing the highest levels. Understanding the distinct immunological signatures of these arboviruses is crucial for effective diagnostic and therapeutic approaches in high-risk regions."

Chikungunya • Dengue Fever • Infectious Disease • Musculoskeletal Pain • Pain • IFNG • IL10 • IL2 • IL6 • TNFA

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis. (PubMed, Gut) - "Novel biomarkers, including IL-6, uNGAL and copeptin, can probably improve prognostication of patients with decompensated cirrhosis compared with MELD alone."

Biomarker • Journal • Retrospective data • Review • Acute Kidney Injury • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Nephrology • Renal Disease • IL6 • LCN2

Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells. (PubMed, Front Pharmacol) - "We treated fresh human peripheral blood mononuclear cells isolated from six healthy volunteers with different concentrations of the RES-010 compound and assessed its proinflammatory effects by quantifying IL-1β, IL-6, IFN-γ, TNF-α, IFN-α2a, IFN-β, IL-10, and IL-17A in the supernatants collected 24 h of treatment with RES-010. The T-cell activation markers, CD69, HLA-DR, and CD25 were evaluated by flow cytometry after 24 and 144 h of treatment, respectively, whereas cell viability was assessed after 24 h of treatment with RES-010. Our results show that RES-010 compound does not induce any significant immunostimulatory responses in human PBMCs in vitro compared to controls, implying that the proinflammatory potential of RES-010 is low."

Journal • Genetic Disorders • Hepatology • Non-alcoholic Fatty Liver Disease • Obesity • CD69 • IFNA1 • IFNB1 • IFNG • IL10 • IL17A • IL1B • IL2RA • IL6 • MIR22 • TNFA

Impact of soluble tumor necrosis factor-related apoptosis-inducing ligand released by engineered adipose mesenchymal stromal cells on white blood cells. (PubMed, Cytotherapy) - "In summary, this study demonstrates the immunological safety and thus the clinical feasibility of an anticancer approach based on AD-MSC expressing the proapoptotic molecule sTRAIL."

Journal • Stroma • Gastrointestinal Cancer • Gene Therapies • Hepatology • Immune Modulation • Immunology • Infectious Disease • Oncology • Pancreatic Cancer • Solid Tumor • IFNG • IL10 • IL6 • TNFRSF10C

Discovery of a Novel Small-Molecule Interleukin-6 Inhibitor through Virtual Screening Using Artificial Intelligence. (PubMed, Med Chem) - "Our screening compound demonstrated an inhibitory effect on IL-6 stimulus. These findings may serve as a basis for the further development of small-molecule IL-6 inhibitors."

Journal • Immunology • Infectious Disease • Inflammation • IL6