Undisclosed Interleukin 6 inhibitor / Evotec, Interprotein Corp - LARVOL DELTA

Impact of mesenchymal stromal/stem cell infusions on circulating inflammatory biomarkers in COVID-19 patients: analysis of a phase I-IIa trial. (PubMed, Cytotherapy) - "MSC in COVID-19 patients resulted safe and feasible, effectively modulating inflammatory cytokines, in particular mitigating brain damage related biomarker, suggesting both reduced inflammation and a potential neurological protection."

Biomarker • Journal • P1/2 data • Acute Respiratory Distress Syndrome • CNS Disorders • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Vascular Neurology • IL18 • IL1R1 • IL6 • NEFL

Cytokine Profiling Reveals Distinctive Immune Responses in Dengue, Zika, Chikungunya and Mayaro Virus Infections (ASTMH 2024) - "Cytokine quantification was carried out by ELISA assays for IL-2, IL-6, IL-10, TNF-α, and IFN-γ...TNF-α and IFN-γ showed a similar pattern, with DENV and ZIKV patients expressing the highest levels. Understanding the distinct immunological signatures of these arboviruses is crucial for effective diagnostic and therapeutic approaches in high-risk regions."

Chikungunya • Dengue Fever • Infectious Disease • Musculoskeletal Pain • Pain • IFNG • IL10 • IL2 • IL6 • TNFA

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis. (PubMed, Gut) - "Novel biomarkers, including IL-6, uNGAL and copeptin, can probably improve prognostication of patients with decompensated cirrhosis compared with MELD alone."

Biomarker • Journal • Retrospective data • Review • Acute Kidney Injury • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Nephrology • Renal Disease • IL6 • LCN2

Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells. (PubMed, Front Pharmacol) - "We treated fresh human peripheral blood mononuclear cells isolated from six healthy volunteers with different concentrations of the RES-010 compound and assessed its proinflammatory effects by quantifying IL-1β, IL-6, IFN-γ, TNF-α, IFN-α2a, IFN-β, IL-10, and IL-17A in the supernatants collected 24 h of treatment with RES-010. The T-cell activation markers, CD69, HLA-DR, and CD25 were evaluated by flow cytometry after 24 and 144 h of treatment, respectively, whereas cell viability was assessed after 24 h of treatment with RES-010. Our results show that RES-010 compound does not induce any significant immunostimulatory responses in human PBMCs in vitro compared to controls, implying that the proinflammatory potential of RES-010 is low."

Journal • Genetic Disorders • Hepatology • Non-alcoholic Fatty Liver Disease • Obesity • CD69 • IFNA1 • IFNB1 • IFNG • IL10 • IL17A • IL1B • IL2RA • IL6 • MIR22 • TNFA

Impact of soluble tumor necrosis factor-related apoptosis-inducing ligand released by engineered adipose mesenchymal stromal cells on white blood cells. (PubMed, Cytotherapy) - "In summary, this study demonstrates the immunological safety and thus the clinical feasibility of an anticancer approach based on AD-MSC expressing the proapoptotic molecule sTRAIL."

Journal • Stroma • Gastrointestinal Cancer • Gene Therapies • Hepatology • Immune Modulation • Immunology • Infectious Disease • Oncology • Pancreatic Cancer • Solid Tumor • IFNG • IL10 • IL6 • TNFRSF10C

Discovery of a Novel Small-Molecule Interleukin-6 Inhibitor through Virtual Screening Using Artificial Intelligence. (PubMed, Med Chem) - "Our screening compound demonstrated an inhibitory effect on IL-6 stimulus. These findings may serve as a basis for the further development of small-molecule IL-6 inhibitors."

Journal • Immunology • Infectious Disease • Inflammation • IL6