Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead - LARVOL DELTA

Assessing the dose of regadenoson required to transiently alter blood-brain barrier integrity in patients with infiltrating gliomas. (PubMed, Neurooncol Adv) - P1 | "Noninvasive quantification of BBB permeability in patients is feasible and could evaluate different regadenoson schedules, combination therapies, and other approaches to modify BBB permeability which is critical to improving outcomes in patients with brain tumors. NCI Protocol #: Adult brain tumor consortium 1804, ClinicalTrials.gov Identifier: NCT03971734, Agent(s): Regadenoson, NSC # 811401, commercially available."

Journal • Brain Cancer • CNS Tumor • Glioma • Oncology • Solid Tumor

Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment. (PubMed, Small Sci) - "Herein, a novel strategy involving the synthesis of p28 peptide-conjugated, lexiscan (LEX)-loaded, bardoxolone methyl (BM) self-assembled nanoparticles, designated as p28-LBM NPs, is introduced. The successful penetration of brain tumors by the p28-LBM NPs after intravenous administration is demonstrated, with BM delivered as part of the NPs significantly inhibiting GBM tumor growth and extending the survival of mice with tumors. In conclusion, the p28-LBM NPs present a promising approach for GBM treatment, with potential for effective and safe clinical applications in the future."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Fully Quantitative Cardiovascular Magnetic Resonance Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy (ISHLT 2025) - "Quantitative short-axis perfusion maps were acquired using single bolus of gadolinium contrast (0.05 mmol/kg), dual sequence perfusion imaging at rest and during stress using adenosine or regadenosone vasodilation...The MP at rest, stress and MPR in the respective groups are shown in Figure 1. The MPR could discriminate CAV2-3 (ROC AUC 0.82, 95% CI[0.69-0.96]) and using a cutoff of 2.2 the sensitivity was 100%, specificity was 69%, positive and negative predictive value was 17% and100%.Conclusion In this multi-center retrospective study MPR assessed by CMR could discriminate CAV2-3 with both high sensitivity and negative predictive value."

Cardiovascular • CACNA1E • CACNG3 • CAV1 • CAV2

AUTOMATED AI-ENABLED ASSESSMENT OF SPLENIC RESPONSE IN CARDIAC PET: A MULTI-SITE STUDY - Piotr Slomka (ACC 2025) - "AI-based automated derivation of SSR could enhance image-based risk assessment. 15,044 consecutive patients undergoing Rb-82 and NH3 regadenoson stress cardiac PET from 5 sites were evaluated... Automated AI-based SSO assessment could significantly enhance clinical risk assessment for cardiac PET."

MYOCARDIAL FLOW AND RESTING CONTRACTILITY MODULATE THE PROGNOSTIC VALUE OF CONTRACTILE RESERVE - Ahmed Sayed (ACC 2025) - "This analysis assesses whether the prognostic value is modified by myocardial blood flow reserve and resting EF. Consecutive patients who underwent Rb-82 PET MPI with Regadenoson stress testing were included... Resting EF and MFR markedly impact the prognostic value of EFR. These results suggest that a low EFR may be particularly helpful in identifying high-risk patients with a normal/high MFR or resting EF."

Cardiovascular • Congestive Heart Failure • Heart Failure

DIFFERENTIAL IMPACT OF REST AND STRESS MYOCARDIAL BLOOD FLOW ON CARDIOVASCULAR OUTCOMES - Ahmed Sayed (ACC 2025) - "Background: There is scarce data on the incremental value of absolute stress and rest myocardial blood flow (MBF) over their ratio (MFR). Patients undergoing Rb-82 positron emission tomography (PET) scans with Regadenoson stress testing were included... MBFstress may be a better marker for ischemic outcomes (MI or revascularization) whereas MBFrest may be a better marker for myocardial dysfunction-related outcomes (death or HFH)."

Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

CARDIAC FIBROMA: RARE TUMOR, COMPLEX DECISIONS - Tahreem Iqbal (ACC 2025) - "Current work up included Regadenoson SPECT stress test, transthoracic echocardiogram (TTE), and cMRI... A multidisciplinary team approach and multimodality imaging is needed in management adults with large symptomatic cardiac fibroma."

Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Oncology • Pain • Pulmonary Disease • Solid Tumor

QUANTITATIVE MYOCARDIAL PERFUSION BY STRESS CARDIAC MAGNETIC RESONANCE IN WOMEN WITH ANGINA WITH NO OBSTRUCTIVE CORONARY ARTERY DISEASE - Bishow M. Paudel (ACC 2025) - "All participants underwent stress cardiac magnetic resonance imaging (CMR) using a 1.5T scanner with regadenoson as a stress vasodilator... Findings suggest that women with ANOCA may have normal MPR, indicating the need for further research into this specific endotype. Understanding these dynamics is essential for developing tailored therapeutic approaches to improve patient outcomes in this population."

Clinical • Cardiovascular • Coronary Artery Disease

ATYPICAL CHEST PAIN IN A PATIENT ON DUPILUMAB: INVESTIGATING DRUG-INDUCED CHEST PAIN - Gedion Yilma Amdetison (ACC 2025) - "The chest pain was not relieved by nitroglycerin and had no identifiable triggers or relieving factors...An extensive cardiovascular workup, including an ECG, echocardiogram, regadenoson nuclear medicine stress test, and CT pulmonary angiography, was performed... While dupilumab is generally well tolerated, with most patients experiencing only mild side effects, physicians should be aware of the potential for serious adverse events as the use of monoclonal antibodies becomes more widespread. This case highlights the importance of monitoring for rare but significant complications, such as vasospastic angina, which may not be fully understood."

Clinical • Acute Coronary Syndrome • Asthma • Atopic Dermatitis • Cardiovascular • Coronary Artery Disease • Dermatitis • Dermatology • Dyslipidemia • Hypertension • Immunology • Pain • Pulmonary Embolism • Respiratory Diseases • Vasculitis • IL13 • IL4

DIAGNOSIS OF CORONARY MICROVASCULAR DISEASE IN A 25-YEAR-OLD USING QUANTITATIVE PERFUSION CARDIAC MAGNETIC RESONANCE IMAGING - Eric E. Morgan (ACC 2025) - "Suspecting MVD, diltiazem (180 mg bd) and ranolazine (500 mg bd) was started empirically.Decision-making: Quantitative perfusion CMR was performed to assess for MVD. This case highlights the utility of quantitative perfusion MRI to assess coronary MVD and guide management."

MRI • Atherosclerosis • Cardiovascular • Endocrine Disorders • Genetic Disorders • Obesity • Pain

HEART RATE RESPONSE INDEPENDENTLY PREDICTS FUTURE DEATH OR HF HOSPITALIZATION IN PATIENTS UNDERGOING PET REGEDENOSON STRESS TESTING - Ahmed Sayed (ACC 2025) - "HRR in Regadenoson PET stress testing is prognostic for death or HFH, particularly in patients with higher EFs."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

A CASE OF ST ELEVATION MYOCARDIAL INFARCTION (STEMI) SECONDARY TO VASOSPASM FOLLOWING REGADENOSON (LEXISCAN) STRESS TESTING - Jacob Sanchez (ACC 2025) - "STEMI secondary to coronary vasospasm during Lexiscan stress testing is rare, but a severe adverse reaction that should be acknowledged. This phenomenon has not been well documented and researched in current literature. There is a need for further research and investigation to understand this phenomenon and reduce its occurrence."

Clinical • Cardiovascular • Myocardial Infarction

CARDIAC PET-DERIVED LEFT VENTRICULAR STRAIN AMONG HEART TRANSPLANT RECIPIENTS - Brandon M. Davis (ACC 2025) - "Background: Regadenoson 82Rb PET myocardial perfusion imaging (MPI) is increasingly being used in adult heart transplant recipients to screen for cardiac allograft vasculopathy (CAV)... This study reports normal PET-derived left ventricular strain values among orthotopic heart transplant patients. Routine PET-derived strain analysis among heart transplant recipients that undergo PET surveillance is feasible and may provide additional prognostic information."

Clinical • Cardiovascular • Transplantation • CAV1

FEASIBILITY OF PARAMETRIC MAPPING AND REGADENOSON STRESS PERFUSION WIDEBAND CMR IN PATIENTS WITH IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS - Hena Patel (ACC 2025) - "Modified WB stress CMR is a safe, promising tool for myocardial tissue characterization and ischemia detection in patients with ICDs. Adjusting bandwidth reduces device related artifacts, and yields diagnostic stress perfusion images in this patient population."

Clinical • Cardiovascular

Use of Stress-CMR Using Regadenoson and GE-267 in Adult Patients with Known or Suspected Coronary Artery Disease (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: German Heart Institute | Trial completion date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Nov 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Assessing the Real-World Safety of Regadenoson for Myocardial Perfusion Imaging: Insights from a Comprehensive Analysis of FAERS Data. (PubMed, J Clin Med) - " This study provides preliminary safety data on Regadenoson's real-world use, corroborating known adverse effects while uncovering new potential risks. These findings offer valuable safety insights for clinicians when prescribing Regadenoson for the use of MPI."

Journal • Real-world evidence • CNS Disorders • Movement Disorders • Pain • Psychosomatic Disorders • Pulmonary Disease • ADORA2A

Feasibility and Safety of Regadenoson Stress Perfusion Protocol in Pediatric Transplant Patients under General Anesthesia. (PubMed, J Cardiovasc Magn Reson) - "Regadenoson stress CMR is safe and feasible in PHTR under GA. While hypotension was frequently seen, it improved in all cases with phenylephrine. Semi-quantitative myocardial perfusion analysis by MPRI is feasible in these young patients, however further studies are needed to assess its clinical utility in this population."

Journal • Anesthesia • Hypotension • Pediatrics • Transplantation

Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. (PubMed, JACC Adv) - "In patients with normal single-photon emission computed tomography/CT MPI, CAC is strongly associated with adverse outcomes independent of ischemic ECG changes with low event rates in patients without CAC on attenuation CT irrespective of ischemic stress ECG changes."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Infarction

Allograft Dysfunction in Heart Transplant (clinicaltrials.gov) - P4 | N=376 | Recruiting | Sponsor: Paul Kim | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • Cardiovascular • Transplant Rejection • Transplantation

A2A Adenosine Receptor as a Potential Therapeutic Target in Cystitis-Induced Bladder Pain: Insights from a Transgenic Autoimmune Cystitis Murine Model. (PubMed, Int Urogynecol J) - "A2AR downregulation correlates with increased inflammation in the URO-OVA model of BPS. Activation of A2AR via regadenoson significantly suppresses inflammatory responses and bladder pain, suggesting A2AR is a promising therapeutic target for BPS."

IO biomarker • Journal • Preclinical • Immunology • Inflammation • Interstitial Cystitis • Musculoskeletal Pain • Pain • GFAP • HMGB1 • IL6 • ITGAM • PD-1 • TGFB1 • TNFA

Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: St. Jude Children's Research Hospital | Trial completion date: Sep 2026 ➔ Sep 2028 | Trial primary completion date: Sep 2025 ➔ Sep 2027

Trial completion date • Trial primary completion date • Cardiovascular • Genetic Disorders • Hematological Disorders • Sickle Cell Disease

Regadenoson R-T Perfusion Imaging Trial (clinicaltrials.gov) - P1 | N=100 | Completed | Sponsor: University of Nebraska | Phase classification: P=N/A ➔ P1

Phase classification • Cardiovascular • Coronary Artery Disease

Differences in coronary microcirculation measurements during regadenoson vs. adenosine - induced hyperemia. (PubMed, Cardiol J) - "Regadenoson may be a feasible alternative to adenosine in coronary microcirculation assessment, as it produces similar outcomes. Selected factors were found to be predictors of greater differences in IMR, CFR and FFR values according to the agent used for coronary hyperemia."

Journal • Cardiovascular

Diagnostic Accuracy of Dynamic Stress Myocardial CT Perfusion Compared with Invasive Physiology in Patients with Stents: The Advantage 2 Study. (PubMed, Radiology) - "Purpose To compare the diagnostic performance of regadenoson-stress dynamic CTP with that of CCTA, using fractional flow reserve (FFR) and the index of microvascular resistance (IMR) as reference standards for epicardial coronary circulation and coronary microcirculation, respectively.."

Clinical • Journal • Cardiovascular • Coronary Artery Disease

State of the art of CT myocardial perfusion. (PubMed, Radiol Med) - "For both, CTP acquisition hyperemia is reached using stressor agents such as adenosine or regadenoson. CTP in addition to CCTA acquisition shows good diagnostic accuracy compared to invasive fractional flow reserve (FFR). Furthermore, the evaluation of late iodine enhancement (LIE) could be performed allowing the detection of myocardial infarction."

Journal • Review • Cardiovascular • Coronary Artery Disease • Myocardial Infarction • Myocardial Ischemia