Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead - LARVOL DELTA

WOLFF-PARKINSON-WHITE SYNDROME UNMASKED BY REGADENOSON DURING MYOCARDIAL PERFUSION IMAGING (ACC 2026) - "Abstract is embargoed at this time."

Cardiovascular • CNS Disorders • Movement Disorders

VISUAL SPLENIC SWITCH-OFF WITH 18F-FLURPIRIDAZ VS 82RB PET DURING REGADENOSON STRESS: A MATCHED COMPARATIVE ANALYSIS (ACC 2026) - "Abstract is embargoed at this time."

The Value of Three-Dimensional Speckle Tracking Echocardiography in the Estimation of Left Ventricular Systolic Function in Patients With Coronary Microvascular Dysfunction. (PubMed, Echocardiography) - "Strain parameters derived from 3D-STE under pharmacologic stress demonstrate excellent benefits in assessing LV systolic function in CMD patients. These parameters, especially ΔGAS, may serve as novel predictive indicators for the clinical assessment of CMD."

Journal • Cardiovascular • Coronary Artery Disease

BLUNTED HEART RATE RESPONSE TO REGADENOSON IS ASSOCIATED WITH HIGH RISK BEYOND PET QUANTITATIVE MYOCARDIAL BLOOD FLOW (ACC 2026) - "Abstract is embargoed at this time."

Relationship between epicardial fat tissue, endothelial function, and coronary flow reserve in coronary microvascular disease patients. (PubMed, Cardiovasc Ultrasound) - "EFT and FMD may serve as potential evaluation methods for CMVD in patients with INOCA. EFT was independently associated with the presence of CMVD in this cohort, offering significant clinical diagnostic insights. EFT is a novel independent predictor of CMVD in this specific population, while FMD provides complementary diagnostic value for risk stratification. These non-invasive markers may help to improve risk stratification in patients with microvascular dysfunction."

Journal • Cardiovascular

Using regadenoson for stress first-pass perfusion cardiac MR imaging: How, when, and why? (PubMed, Diagn Interv Imaging) - "However, regadenoson, which is an adenosine A2A receptor agonist, is a highly suitable alternative for stress cardiac MRI due to its kinetic properties, ease of use, single-dose administration, limited contraindications, and prognostic value. This technical note describes the characteristics and safety profile of regadenoson and discusses its application to cardiac MRI and reimbursement issues."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia • ADORA2A

The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Emory University | N=47 ➔ 20

Enrollment change • Cardiovascular • Coronary Artery Disease

Regadenoson in the rehabilitation of marginal donor lungs on ex vivo lung perfusion: A blinded multicenter randomized controlled clinical trial. (PubMed, JTCVS Open) - P1 | "Regadenoson is a safe ex vivo lung perfusion adjunct. The use rate of the placebo group was greater than the expectation set in the NOVEL trial of 51%, making it difficult for the regadenoson group to have a significant increase in use."

Clinical • Journal • Preclinical • Reperfusion Injury • ADORA2A

Comparison and evaluation of safety, pharmacokinetics, and pharmacodynamics of two regadenoson injections in healthy Chinese subjects. (PubMed, Int J Clin Pharmacol Ther) - "The test drug demonstrated similar pharmacokinetic and pharmacodynamic characteristics as the reference drug. Additionally, it was well-tolerated and safe in healthy Chinese participants. Sex may influence regadenoson pharmacokinetics."

Journal • PK/PD data

Myocardial Perfusion SPECT 2024 in Germany: Results of the 10th Survey. (PubMed, Nuklearmedizin) - "Regadenoson was mostly used...The proportion of departments not scoring decreased to 4% [13%].The MPS 2024 survey indicates that the long-term positive development of MPS imaging is continuing. The procedural and technical details of MPS imaging demonstrate a high level of conformity with guidelines, with a slight improvement observed from 2021 to 2024."

Journal

Exercise versus Regadenoson for Myocardial Perfusion Assessment in Hypertrophic Cardiomyopathy (AHA 2025) - "Preliminary findings suggest that regadenoson, as compared to exercise, overestimates myocardial perfusion defects in HCM, results in frequently impaired CFR (<2.0), and causes frequent symptomatology not reflective of patients' daily symptoms. These results support reevaluating the routine use of supraphysiologic vasodilators in HCM stress testing. Furthermore, CMI use led to higher CFR values, supporting our hypothesis that alleviation of myocyte hypercontractility may improve perfusion in HCM patients."

Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy

Machine learning prediction of myocardial ischemia using quantitative assessment of coronary calcifications in non-contrast CT calcium scoring scans (AHA 2025) - "This study aimed to develop a novel machine learning model that predicts ischemia based solely on the quantitative analysis of coronary calcifications in CTCS scans.Methods We retrospectively analyzed 987 patients who underwent both non-contrast CTCS and regadenoson stress cardiac positron emission tomography (PET) myocardial perfusion imaging with an NH3 tracer within one year at the University Hospitals of Cleveland...Compared to models using only clinical features (precision 13.2±3.7% and F1 score 21.3±5.3%) or clinical features plus the Agatston score (precision 74.7±9.5% and F1 score 76.4±6.7%), the inclusion of calcium-omics features significantly improved predictive performance (p<0.05), particularly by reducing false positives.ConclusionWe developed a novel machine learning approach for predicting myocardial ischemia using non-contrast CTCS imaging. Our findings suggest that calcium-omics features provide additional predictive value beyond..."

Machine learning • Atherosclerosis • Cardiovascular • Myocardial Ischemia

Epicardial Adipose Tissue Biomarkers Are Associated with Myocardial Perfusion in Women with Angina and No Obstructive Coronary Artery Disease: A CMR study (AHA 2025) - "Subjects underwent CMR scan at 1.5T (Aera), including rest and regadenoson stress perfusion with automated inline global rest and stress myocardial blood flow (MBF), myocardial perfusion reserve (MPR)... CMR-derived EAT T1 relaxation time and SFA fraction are associated with CMD in women with ANOCA. Elevated SFA and reduced T1, reflective of a pro-inflammatory adipose phenotype, are independently associated with impaired myocardial perfusion. These findings support a potential mechanistic link between EAT metabolic dysfunction and CMD and underscore the value of multiparametric CMR in the phenotyping at-risk women with ANOCA."

Biomarker • Clinical • Cardiovascular • Coronary Artery Disease • Inflammation • Metabolic Disorders

Heart Rate Response to Regadenoson Stress with PET MPI: Old Marker, New Insights. (PubMed, J Nucl Cardiol) - No abstract available

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Noninvasive Measurement of Coronary Collateral Flow Capacity in Patients with Chronic Total Occlusion: External Counterpulsattion Reduces the Need for High Risk Percutaneous Coronary Intervention (AHA 2025) - "Noninvasive external counterpulsation (ECP) improves invasively measured collateral flow index, angina and walking time in patients with obstructive CAD.We hypothesized that coronary collateral flow capacity can be measured noninvasively in CTO patients by comparing absolute stress perfusion during vasodilator stress (DIP) which reduces supply side pressure in the collateralized ischemic bed, revealing coronary steal, compared with demand ischemic stress (DBT) which maintains supply side pressure. Twenty sequential patients found to have CTO at angiography prompted by abnormal quantitative PET myocardial perfusion imaging with vasodilator stress using dipyridamole or regadenoson (QPET-DIP) underwent 35 one-hour sessions of ECP, rather than PCI, followed by demand ischemic stress PET using dobutamine (QPET-DBT). Coronary collateral flow capacity can be measured noninvasively with quantitative PET myocardial perfusion imaging. Initial treatment of CTO patients with ECP is..."

Clinical • Non-invasive • Cardiovascular

Stress myocardial perfusion imaging with photon-counting CT: Initial validation against reference modalities. (PubMed, Diagn Interv Imaging) - "Stress static PCCT-MPI is feasible and demonstrates excellent diagnostic accuracy for detecting myocardial ischemia. Defect-to-remote iodine ratio from spectral imaging further enhances performance, establishing PCCT as a comprehensive imaging modality that unifies anatomic and functional coronary assessment at a reasonable radiation dose, within a single examination."

Journal • Cardiovascular • Coronary Artery Disease • Ischemic stroke • Myocardial Ischemia

EPIPERICARDIAL FAT NECROSIS: A RARE AND UNDERRECOGNIZED CAUSE OF CHEST PAIN (CHEST 2025) - "He later underwent a regadenoson nuclear stress test which was negative for ischemia... EFN is a rare but benign cause of chest pain that can present similarly to more life-threatening conditions such as ACS, pulmonary embolism, or aortic dissection. With increasing use of CT imaging in the evaluation of acute chest pain, recognition of EFN may improve with time."

Acute Coronary Syndrome • Dyslipidemia • Genito-urinary Cancer • Mood Disorders • Obesity • Pain • Prostate Cancer • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

ACUTE CORONARY SYNDROME IN ACUTE MYELOID LEUKEMIA: A CASE OF MYOCARDIAL INJURY DUE TO HYPERLEUKOCYTOSIS AND COAGULOPATHY (CHEST 2025) - "He had undergone an echocardiogram and Lexiscan nuclear stress test prior to admission, both of which showed no ischemia and normal left ventricular (LV) function...The patient was treated with aspirin, intravenous heparin, furosemide, and allopurinol... This case highlights the unique pathophysiological mechanisms contributing to myocardial injury in patients with AML and hyperleukocytosis, emphasizing the diagnostic and therapeutic challenges in managing ACS outside the traditional framework of atherosclerotic coronary disease. The patient's clinical deterioration despite conventional ACS treatment emphasizes the complex interplay between leukemia-related hyperviscosity, coagulopathy, and myocardial injury. Meanwhile, leukapheresis remains a debated intervention due to its uncertain impact on survival."

Clinical • Acute Coronary Syndrome • Acute Myelogenous Leukemia • Atherosclerosis • Chronic Obstructive Pulmonary Disease • Dyslipidemia • Fatigue • Genito-urinary Cancer • Hematological Malignancies • Hypertension • Immunology • Leukemia • Myocardial Infarction • Oncology • Prostate Cancer • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Thrombosis

SUPRAVENTRICULAR TACHYCARDIA AS A COMPLICATION OF REGADENOSON NUCLEAR STRESS TESTING: A CALL FOR CAUTION (CHEST 2025) - "He was started on amiodarone, initiated on norepinephrine, and transferred to the cardiac care unit (CCU) for monitoring. Regadenoson-induced SVT is a potentially serious but underappreciated complication of nuclear stress testing, particularly in elderly patients with underlying cardiovascular risk factors. Enhanced pre-test risk stratification is crucial to identify high-risk individuals who may benefit from alternative ischemic evaluations. Awareness of these complications allows for prompt recognition and management, ultimately improving patient outcomes."

Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Diabetes • Heart Failure • Hypertension • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Differential Association of Heart Rate Response to Regadenoson with Death and Heart Failure Hospitalizations According to Ejection Fraction in Patients Undergoing PET MPI. (PubMed, J Nucl Cardiol) - "The prognostic value of HRR after pharmacological stress testing for death and HF hospitalization is most pronounced in patients with a preserved EF and is independent of traditional risk factors and PET parameters, including myocardial flow reserve."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Prognostic Significance of Transient Ischemic Dilatation with Adenosine 99mTc Sestamibi SPECT/CT in Diabetic Patients with Normal Myocardial Perfusion (EANM 2025) - "Aim The prognostic value of transient ischemic dilatation (TID) with otherwise normal perfusion in patients undergoing adenosine/regadenoson stress remains controversial with limited data pertaining to diabetic patients...Similarly, cardiac event-free survivals were similar in patients with AC TID ≥ and < 1.18 (2.0% vs. 5.6%, p = .076), ≥ and < 1.21 (2.6% vs. 5.3%, p = .252) and ≥ and < 1.36 (3.2% vs. 4.9%, p = .577). Conclusion TID, whether based on attenuation or non-attenuation corrected scans, does not confer adverse prognosis in diabetic patients with normal perfusion on adenosine stress/rest 99mTc-sestamibi SPECT/CT irrespective of the threshold used for its definition."

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Dyslipidemia • Endocrine Disorders • Heart Failure • Hypertension • Metabolic Disorders

Myocardial Perfusion Scintigraphy with Regadenoson and Correlation with the Findings of Coronary Angiography (EANM 2025) - "Conclusion Regadenoson MPS is a safe, well-tolerated, and effective tool for assessing myocardial ischemia in patients unable to perform exercise testing. Despite statistically significant correlations with CA, the weak association highlights the importance of combining both functional and anatomical imaging techniques for a more comprehensive and reliable CAD evaluation."

Cardiovascular • Coronary Artery Disease • Myocardial Ischemia

Prediction of Cardiac Events in Patients with Diabetes Using Stress Myocardial Blood Flow and Coronary Flow Reserve (EANM 2025) - "Acquisition was performed at rest and after maximal vasodilation with an injection of 400 mg regadenoson over 10 seconds, followed by administration of Tc-99m sestamibi (rest 3 MBq/kg and stress 9 MBq/kg)...However, the addition of CFR to stress MBF did not demonstrate a clearly significant incremental prognostic value in this cohort. These findings may support a potential simplification of the dynamic SPECT protocol, favoring a stress-first or stress-only approach, which could facilitate broader MBF quantification and improve accessibility for a larger patient population."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Heart Failure • Metabolic Disorders • Myocardial Infarction

Myocardial Blood Flow and Ejection Fraction Measurement in Rb82-PET/CT shows high inter-observer reliability (EANM 2025) - "Stress conditions were simulated using 400 µg Regadenoson...Additionally this study first demonstrates an increase in inter-observer reliability as an effect of user experience. Perfusion-PET-based EF evaluation as a parameter of left ventricular function shows a similar reliability as echocardiography."

Cardiovascular • Coronary Artery Disease • Myocardial Ischemia

PET MPI With F-18 FlurpiridazVersus Rb-82: Insights Into Blood Flow and Splenic Switch-Off. (PubMed, JACC Case Rep) - "F-18 flurpiridaz PET MPI demonstrated superior image quality compared with Rb-82 PET MPI. Splenic switch-off was more visually and quantitatively pronounced with F-18 flurpiridaz, potentially improving the ability to distinguish responders to regadenoson from nonresponders. Stress myocardial blood flow and myocardial flow reserve were higher with F-18 flurpiridaz, in part owing to its higher myocardial extraction fraction."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia