Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead - LARVOL DELTA

AI-Derived Splenic Response in Cardiac PET Predicts Mortality: A Multi-Site Study. (PubMed, medRxiv) - "To evaluate the prognostic value of artificial intelligence (AI)-derived SR in a large multicenter 82 Rb-PET cohort undergoing regadenoson stress testing...Incorporating automated SR into PET MPI interpretation may enhance risk stratification and identify patients who could benefit from intensified preventive care, particularly when traditional imaging markers appear reassuring. These findings support SR as a clinically meaningful, easily integrated biomarker in stress PET imaging."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Preventive care

Hemiplegic Migraine in a Patient With Neurologic Symptoms After Regadenoson Administration. (PubMed, Clin Case Rep) - "Regadenoson may be associated with hemodynamic instability and lowering of the seizure threshold. Patients should be screened for neurologic risk factors prior to receiving regadenoson to determine if alternate modalities for ischemic evaluation are more suitable."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Migraine • Pain • ADORA2A

Raising Awareness of ST-Segment Elevation Myocardial Infarction Triggered by Intravenous Regadenoson for Cardiac Stress Testing. (PubMed, JACC Case Rep) - "Attention should also be paid to potential late occurring STEMI. When used in cardiac stress testing, discussing potential serious side effects of regadenoson including STEMI should be part of informed consent."

Journal • Acute Coronary Syndrome • Cardiovascular • CNS Disorders • Depression • Myocardial Infarction • Psychiatry

SUPRAVENTRICULAR TACHYCARDIA AS A COMPLICATION OF REGADENOSON NUCLEAR STRESS TESTING: A CALL FOR CAUTION (CHEST 2025) - No abstract available

Cardiovascular • Ventricular Tachycardia

Diagnostic Odyssey of Microvascular Abnormalities in INOCA: 13N-Ammonia and Gadolinium Synchronous Dual-Perfusion PET/MR Approach (SNMMI 2025) - "Under resting conditions and stress states induced by regadenoson, these patients simultaneously received injections of gadolinium contrast agent and 13N - Ammonia on a PET/MR scanner, followed by MR imaging and PET myocardial perfusion imaging examinations... Global CFR (1.47 ± 0.55 vs. 4.04 ± 1.69; P < 0.001) was significantly lower in patients with INOCA than in those with no INOCA. ROC curve analysis was performed and the Youden Index was calculated to determine the best cut-off value with the highest sensitivity and specificity."

Cardiovascular

Differential Association of PET-Derived Rest and Stress Myocardial Blood Flow with Cardiovascular Outcomes. (PubMed, J Nucl Med) - " Consecutive patients undergoing 82Rb PET imaging with regadenoson stress testing at a tertiary care center between August 2019 and August 2024 were included in this study... Measurements of absolute myocardial blood flow offer complementary prognostic value to MFR. A diminished MBFstress may signal a greater risk of future ischemic outcomes, whereas an elevated MBFrest may signal a greater risk of future death or HF hospitalization."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

Quantifying ventricular synchrony and diastolic function to predict patients who will develop pharmacological induced myocardial ischaemia in a diagnostic setting (Euroanaesthesia 2025) - "These were assessed for their association with inducible ischaemia defined as MBF<1.5mL/g/min under hyperaemic stress (400µg regadenoson).Results and Inducible ischaemia was identified in 44% of the patients... We demonstrate in awake patients with suspected cardiovascular disease that modern strain markers for quantifying ventricular contractile synchrony and diastolic function from cardiac images acquired at rest predicted the onset of myocardial ischaemia induced by pharmacological hyperaemia. These measures can be acquired in standard exams with both CMR and echocardiography, and these insights could be helpful to enhance perioperative risk assessment to detect patients prone to hypoperfusion."

Clinical • Cardiovascular • Coronary Artery Disease • Heart Failure

The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI (clinicaltrials.gov) - P=N/A | N=47 | Completed | Sponsor: Emory University | Recruiting ➔ Completed | N=20 ➔ 47 | Trial completion date: Dec 2024 ➔ Sep 2024 | Trial primary completion date: Dec 2024 ➔ Sep 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics (clinicaltrials.gov) - P=N/A | N=68 | Active, not recruiting | Sponsor: University of Cincinnati | Trial completion date: Jun 2024 ➔ Jul 2025 | Trial primary completion date: Jun 2024 ➔ Jul 2025

Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Feasibility and safety of stress perfusion CMR in patients with severe HFrEF and cardiac implantable electronic devices (HEART FAILURE 2025) - "Imaging protocol included standard cine sequences, perfusion study with bolus administration of regadenoson 400 mcg and late gadolinium enhancement (LGE) study with use of gadobutrol...All results are summarised in detail in Table 1. Conclusion pCMR is feasible and safe in HFrEF patients with CIEDs, and should be considered as routine part of the clinician's armamentarium for ischaemia assessment."

Clinical • Cardiovascular

Drug-induced cardiac arrest: a pharmacovigilance study from 2004-2024 based on FAERS database. (PubMed, Front Cardiovasc Med) - "The top five drugs identified by ROR were: carisoprodol [ROR (95% CI): 34.13 (29.62-39.32)], sugammadex [ROR (95% CI): 26.93 (22.56-32.16)], regadenoson [ROR (95% CI): 20.00 (17.69-22.60)], alprazolam [ROR (95% CI): 12.82 (12.19-13.48)], and propofol [ROR (95% CI): 11.93 (10.61-13.41)]. This study identifies over 40 drugs potentially associated with an elevated risk of CA based on FAERS data. Healthcare professionals should be particularly vigilant when prescribing these drugs, especially to patients with a history of heart disease, and ensure rigorous monitoring of their cardiac health."

Adverse events • Journal • Cardiovascular • Heart Failure • Musculoskeletal Diseases • Oncology

Assessing the dose of regadenoson required to transiently alter blood-brain barrier integrity in patients with infiltrating gliomas. (PubMed, Neurooncol Adv) - P1 | "Noninvasive quantification of BBB permeability in patients is feasible and could evaluate different regadenoson schedules, combination therapies, and other approaches to modify BBB permeability which is critical to improving outcomes in patients with brain tumors. NCI Protocol #: Adult brain tumor consortium 1804, ClinicalTrials.gov Identifier: NCT03971734, Agent(s): Regadenoson, NSC # 811401, commercially available."

Journal • Brain Cancer • CNS Tumor • Glioma • Oncology • Solid Tumor

Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment. (PubMed, Small Sci) - "Herein, a novel strategy involving the synthesis of p28 peptide-conjugated, lexiscan (LEX)-loaded, bardoxolone methyl (BM) self-assembled nanoparticles, designated as p28-LBM NPs, is introduced. The successful penetration of brain tumors by the p28-LBM NPs after intravenous administration is demonstrated, with BM delivered as part of the NPs significantly inhibiting GBM tumor growth and extending the survival of mice with tumors. In conclusion, the p28-LBM NPs present a promising approach for GBM treatment, with potential for effective and safe clinical applications in the future."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Fully Quantitative Cardiovascular Magnetic Resonance Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy (ISHLT 2025) - "Quantitative short-axis perfusion maps were acquired using single bolus of gadolinium contrast (0.05 mmol/kg), dual sequence perfusion imaging at rest and during stress using adenosine or regadenosone vasodilation...The MP at rest, stress and MPR in the respective groups are shown in Figure 1. The MPR could discriminate CAV2-3 (ROC AUC 0.82, 95% CI[0.69-0.96]) and using a cutoff of 2.2 the sensitivity was 100%, specificity was 69%, positive and negative predictive value was 17% and100%.Conclusion In this multi-center retrospective study MPR assessed by CMR could discriminate CAV2-3 with both high sensitivity and negative predictive value."

Cardiovascular • CACNA1E • CACNG3 • CAV1 • CAV2

AUTOMATED AI-ENABLED ASSESSMENT OF SPLENIC RESPONSE IN CARDIAC PET: A MULTI-SITE STUDY - Piotr Slomka (ACC 2025) - "AI-based automated derivation of SSR could enhance image-based risk assessment. 15,044 consecutive patients undergoing Rb-82 and NH3 regadenoson stress cardiac PET from 5 sites were evaluated... Automated AI-based SSO assessment could significantly enhance clinical risk assessment for cardiac PET."

MYOCARDIAL FLOW AND RESTING CONTRACTILITY MODULATE THE PROGNOSTIC VALUE OF CONTRACTILE RESERVE - Ahmed Sayed (ACC 2025) - "This analysis assesses whether the prognostic value is modified by myocardial blood flow reserve and resting EF. Consecutive patients who underwent Rb-82 PET MPI with Regadenoson stress testing were included... Resting EF and MFR markedly impact the prognostic value of EFR. These results suggest that a low EFR may be particularly helpful in identifying high-risk patients with a normal/high MFR or resting EF."

Cardiovascular • Congestive Heart Failure • Heart Failure

DIFFERENTIAL IMPACT OF REST AND STRESS MYOCARDIAL BLOOD FLOW ON CARDIOVASCULAR OUTCOMES - Ahmed Sayed (ACC 2025) - "Background: There is scarce data on the incremental value of absolute stress and rest myocardial blood flow (MBF) over their ratio (MFR). Patients undergoing Rb-82 positron emission tomography (PET) scans with Regadenoson stress testing were included... MBFstress may be a better marker for ischemic outcomes (MI or revascularization) whereas MBFrest may be a better marker for myocardial dysfunction-related outcomes (death or HFH)."

Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

CARDIAC FIBROMA: RARE TUMOR, COMPLEX DECISIONS - Tahreem Iqbal (ACC 2025) - "Current work up included Regadenoson SPECT stress test, transthoracic echocardiogram (TTE), and cMRI... A multidisciplinary team approach and multimodality imaging is needed in management adults with large symptomatic cardiac fibroma."

Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Oncology • Pain • Pulmonary Disease • Solid Tumor

QUANTITATIVE MYOCARDIAL PERFUSION BY STRESS CARDIAC MAGNETIC RESONANCE IN WOMEN WITH ANGINA WITH NO OBSTRUCTIVE CORONARY ARTERY DISEASE - Bishow M. Paudel (ACC 2025) - "All participants underwent stress cardiac magnetic resonance imaging (CMR) using a 1.5T scanner with regadenoson as a stress vasodilator... Findings suggest that women with ANOCA may have normal MPR, indicating the need for further research into this specific endotype. Understanding these dynamics is essential for developing tailored therapeutic approaches to improve patient outcomes in this population."

Clinical • Cardiovascular • Coronary Artery Disease

ATYPICAL CHEST PAIN IN A PATIENT ON DUPILUMAB: INVESTIGATING DRUG-INDUCED CHEST PAIN - Gedion Yilma Amdetison (ACC 2025) - "The chest pain was not relieved by nitroglycerin and had no identifiable triggers or relieving factors...An extensive cardiovascular workup, including an ECG, echocardiogram, regadenoson nuclear medicine stress test, and CT pulmonary angiography, was performed... While dupilumab is generally well tolerated, with most patients experiencing only mild side effects, physicians should be aware of the potential for serious adverse events as the use of monoclonal antibodies becomes more widespread. This case highlights the importance of monitoring for rare but significant complications, such as vasospastic angina, which may not be fully understood."

Clinical • Acute Coronary Syndrome • Asthma • Atopic Dermatitis • Cardiovascular • Coronary Artery Disease • Dermatitis • Dermatology • Dyslipidemia • Hypertension • Immunology • Pain • Pulmonary Embolism • Respiratory Diseases • Vasculitis • IL13 • IL4

DIAGNOSIS OF CORONARY MICROVASCULAR DISEASE IN A 25-YEAR-OLD USING QUANTITATIVE PERFUSION CARDIAC MAGNETIC RESONANCE IMAGING - Eric E. Morgan (ACC 2025) - "Suspecting MVD, diltiazem (180 mg bd) and ranolazine (500 mg bd) was started empirically.Decision-making: Quantitative perfusion CMR was performed to assess for MVD. This case highlights the utility of quantitative perfusion MRI to assess coronary MVD and guide management."

MRI • Atherosclerosis • Cardiovascular • Endocrine Disorders • Genetic Disorders • Obesity • Pain

HEART RATE RESPONSE INDEPENDENTLY PREDICTS FUTURE DEATH OR HF HOSPITALIZATION IN PATIENTS UNDERGOING PET REGEDENOSON STRESS TESTING - Ahmed Sayed (ACC 2025) - "HRR in Regadenoson PET stress testing is prognostic for death or HFH, particularly in patients with higher EFs."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

A CASE OF ST ELEVATION MYOCARDIAL INFARCTION (STEMI) SECONDARY TO VASOSPASM FOLLOWING REGADENOSON (LEXISCAN) STRESS TESTING - Jacob Sanchez (ACC 2025) - "STEMI secondary to coronary vasospasm during Lexiscan stress testing is rare, but a severe adverse reaction that should be acknowledged. This phenomenon has not been well documented and researched in current literature. There is a need for further research and investigation to understand this phenomenon and reduce its occurrence."

Clinical • Cardiovascular • Myocardial Infarction

CARDIAC PET-DERIVED LEFT VENTRICULAR STRAIN AMONG HEART TRANSPLANT RECIPIENTS - Brandon M. Davis (ACC 2025) - "Background: Regadenoson 82Rb PET myocardial perfusion imaging (MPI) is increasingly being used in adult heart transplant recipients to screen for cardiac allograft vasculopathy (CAV)... This study reports normal PET-derived left ventricular strain values among orthotopic heart transplant patients. Routine PET-derived strain analysis among heart transplant recipients that undergo PET surveillance is feasible and may provide additional prognostic information."

Clinical • Cardiovascular • Transplantation • CAV1

FEASIBILITY OF PARAMETRIC MAPPING AND REGADENOSON STRESS PERFUSION WIDEBAND CMR IN PATIENTS WITH IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS - Hena Patel (ACC 2025) - "Modified WB stress CMR is a safe, promising tool for myocardial tissue characterization and ischemia detection in patients with ICDs. Adjusting bandwidth reduces device related artifacts, and yields diagnostic stress perfusion images in this patient population."

Clinical • Cardiovascular