Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead - LARVOL DELTA

SUPRAVENTRICULAR TACHYCARDIA AS A COMPLICATION OF REGADENOSON NUCLEAR STRESS TESTING: A CALL FOR CAUTION (CHEST 2025) - No abstract available

Cardiovascular • Ventricular Tachycardia

Network and pharmacophore guided and BCL2 and HSP90AA1 targeted drug repurposable approaches against rheumatoid arthritis mediated diffuse large B-cell lymphoma. (PubMed, Int J Biol Macromol) - "Pharmacophore-based screening revealed lapatinib and itraconazole as superior BCL2 inhibitors [-7.621 and -7.075] kcal/mol compared to FDA-approved venetoclax [-6.546] kcal/mol, while voriconazole and regadenoson demonstrated robust HSP90AA1 binding [-7.279 and -7.268] kcal/mol, outperforming FDA-approved cromolyn [-5.304] kcal/mol. These findings establish BCL2 and HSP90AA1 as promising dual-purpose therapeutic targets, providing a foundation for addressing both RA management and RA-mediated DLBCL prevention."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Rheumatoid Arthritis • Rheumatology • BCL2 • CDC37 • HSP90AA1

Early quantitative stress-CMR identifies microvascular dysfunction as a potential mechanism of myocardial injury in patients with working diagnosis MINOCA and otherwise normal CMR scan. (ESC-WCC 2025) - " Since 2021, consecutive patients with a working diagnosis of MINOCA, referred for CMR have undergone perfusion CMR after pharmacological provocation with regadenosone and at rest, using dual sequence technique... Early performed quantitative stress perfusion CMR scan revealed significant impairment of maximal myocardial blood flow during stress and perfusion reserve in patients with a working diagnosis of MINOCA and otherwise normal CMR scans, compared with healthy controls. More than one third of these patients fulfilled the criteria for microvascular dysfunction as a potential pathomechanism of myocardial injury."

Clinical • Cardiovascular • Dyslipidemia • Hypertension • Myocardial Infarction

Dynamic CT perfusion to identify hemodynamically significant coronary artery disease- preliminary results of a one-stop-shop approach (ESC-WCC 2025) - "Perfusion scans were performed on a 192-slice scanner, using regadenoson as stressor agent... Performing stress CTP in patients with ≥50% stenosis on CCTA seems to streamline diagnosis by decreasing downstream ischemia testing, negative invasive angiographies, and time to diagnosis. After accounting for these, the overall effective radiation dose is not increased by using this strategy."

Cardiovascular • Coronary Artery Disease

Residual myocardial hyperemia in regadenoson stress/rest quantitative perfusion cardiac magnetic resonance. (PubMed, Radiol Med) - "Despite the use of euphylline to counteract the vasodilator effect, MBF does not completely revert to resting values and MBFrecovery cannot be used as a substitute for MBFrest when regadenoson is used. Consequently, a rest/stress protocol is advised for quantitative CMR perfusion to obtain accurate MBF and MPR parameters."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Infarction

Reserve of global constructive work for early diagnosis of myocardial ischemia and risk stratification in chronic coronary syndrome. (PubMed, Front Cardiovasc Med) - "All patients underwent regadenoson stress echocardiography, with early ischemia indicated by coronary flow velocity reserve (CFVR) <2.5...The incorporation of △GCW and hemoglobin into the prediction model enhances its ability to estimate myocardial ischemia risk. △GCW offered higher sensitivity and incremental diagnostic value in detecting myocardial ischemia in the heterogeneous CCS population."

Journal • Cardiovascular • Myocardial Ischemia

Blunted Hemodynamic Response to Pharmacological Stress is Predictive of Mortality in Liver Transplant Candidates. (PubMed, J Nucl Cardiol) - "In this retrospective cohort analysis, LTCs exhibited a reduced hemodynamic response detected as lower delta HR, SBP and DBP as well as fewer symptoms in response to regadenoson during stress testing. Reduced hemodynamic response was significantly associated with mortality and provided incremental prognostic value in addition to MELD score. Further prospective studies are required to validate these findings."

Journal • Cardiovascular • CNS Disorders • Coronary Artery Disease • Hepatology • Transplantation

AI-Derived Splenic Response in Cardiac PET Predicts Mortality: A Multi-Site Study. (PubMed, medRxiv) - "To evaluate the prognostic value of artificial intelligence (AI)-derived SR in a large multicenter 82 Rb-PET cohort undergoing regadenoson stress testing...Incorporating automated SR into PET MPI interpretation may enhance risk stratification and identify patients who could benefit from intensified preventive care, particularly when traditional imaging markers appear reassuring. These findings support SR as a clinically meaningful, easily integrated biomarker in stress PET imaging."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Preventive care

Hemiplegic Migraine in a Patient With Neurologic Symptoms After Regadenoson Administration. (PubMed, Clin Case Rep) - "Regadenoson may be associated with hemodynamic instability and lowering of the seizure threshold. Patients should be screened for neurologic risk factors prior to receiving regadenoson to determine if alternate modalities for ischemic evaluation are more suitable."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Migraine • Pain • ADORA2A

Raising Awareness of ST-Segment Elevation Myocardial Infarction Triggered by Intravenous Regadenoson for Cardiac Stress Testing. (PubMed, JACC Case Rep) - "Attention should also be paid to potential late occurring STEMI. When used in cardiac stress testing, discussing potential serious side effects of regadenoson including STEMI should be part of informed consent."

Journal • Acute Coronary Syndrome • Cardiovascular • CNS Disorders • Depression • Myocardial Infarction • Psychiatry

Diagnostic Odyssey of Microvascular Abnormalities in INOCA: 13N-Ammonia and Gadolinium Synchronous Dual-Perfusion PET/MR Approach (SNMMI 2025) - "Under resting conditions and stress states induced by regadenoson, these patients simultaneously received injections of gadolinium contrast agent and 13N - Ammonia on a PET/MR scanner, followed by MR imaging and PET myocardial perfusion imaging examinations... Global CFR (1.47 ± 0.55 vs. 4.04 ± 1.69; P < 0.001) was significantly lower in patients with INOCA than in those with no INOCA. ROC curve analysis was performed and the Youden Index was calculated to determine the best cut-off value with the highest sensitivity and specificity."

Cardiovascular

Differential Association of PET-Derived Rest and Stress Myocardial Blood Flow with Cardiovascular Outcomes. (PubMed, J Nucl Med) - " Consecutive patients undergoing 82Rb PET imaging with regadenoson stress testing at a tertiary care center between August 2019 and August 2024 were included in this study... Measurements of absolute myocardial blood flow offer complementary prognostic value to MFR. A diminished MBFstress may signal a greater risk of future ischemic outcomes, whereas an elevated MBFrest may signal a greater risk of future death or HF hospitalization."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

Quantifying ventricular synchrony and diastolic function to predict patients who will develop pharmacological induced myocardial ischaemia in a diagnostic setting (Euroanaesthesia 2025) - "These were assessed for their association with inducible ischaemia defined as MBF<1.5mL/g/min under hyperaemic stress (400µg regadenoson).Results and Inducible ischaemia was identified in 44% of the patients... We demonstrate in awake patients with suspected cardiovascular disease that modern strain markers for quantifying ventricular contractile synchrony and diastolic function from cardiac images acquired at rest predicted the onset of myocardial ischaemia induced by pharmacological hyperaemia. These measures can be acquired in standard exams with both CMR and echocardiography, and these insights could be helpful to enhance perioperative risk assessment to detect patients prone to hypoperfusion."

Clinical • Cardiovascular • Coronary Artery Disease • Heart Failure

The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI (clinicaltrials.gov) - P=N/A | N=47 | Completed | Sponsor: Emory University | Recruiting ➔ Completed | N=20 ➔ 47 | Trial completion date: Dec 2024 ➔ Sep 2024 | Trial primary completion date: Dec 2024 ➔ Sep 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics (clinicaltrials.gov) - P=N/A | N=68 | Active, not recruiting | Sponsor: University of Cincinnati | Trial completion date: Jun 2024 ➔ Jul 2025 | Trial primary completion date: Jun 2024 ➔ Jul 2025

Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Feasibility and safety of stress perfusion CMR in patients with severe HFrEF and cardiac implantable electronic devices (HEART FAILURE 2025) - "Imaging protocol included standard cine sequences, perfusion study with bolus administration of regadenoson 400 mcg and late gadolinium enhancement (LGE) study with use of gadobutrol...All results are summarised in detail in Table 1. Conclusion pCMR is feasible and safe in HFrEF patients with CIEDs, and should be considered as routine part of the clinician's armamentarium for ischaemia assessment."

Clinical • Cardiovascular

Drug-induced cardiac arrest: a pharmacovigilance study from 2004-2024 based on FAERS database. (PubMed, Front Cardiovasc Med) - "The top five drugs identified by ROR were: carisoprodol [ROR (95% CI): 34.13 (29.62-39.32)], sugammadex [ROR (95% CI): 26.93 (22.56-32.16)], regadenoson [ROR (95% CI): 20.00 (17.69-22.60)], alprazolam [ROR (95% CI): 12.82 (12.19-13.48)], and propofol [ROR (95% CI): 11.93 (10.61-13.41)]. This study identifies over 40 drugs potentially associated with an elevated risk of CA based on FAERS data. Healthcare professionals should be particularly vigilant when prescribing these drugs, especially to patients with a history of heart disease, and ensure rigorous monitoring of their cardiac health."

Adverse events • Journal • Cardiovascular • Heart Failure • Musculoskeletal Diseases • Oncology

Assessing the dose of regadenoson required to transiently alter blood-brain barrier integrity in patients with infiltrating gliomas. (PubMed, Neurooncol Adv) - P1 | "Noninvasive quantification of BBB permeability in patients is feasible and could evaluate different regadenoson schedules, combination therapies, and other approaches to modify BBB permeability which is critical to improving outcomes in patients with brain tumors. NCI Protocol #: Adult brain tumor consortium 1804, ClinicalTrials.gov Identifier: NCT03971734, Agent(s): Regadenoson, NSC # 811401, commercially available."

Journal • Brain Cancer • CNS Tumor • Glioma • Oncology • Solid Tumor

Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment. (PubMed, Small Sci) - "Herein, a novel strategy involving the synthesis of p28 peptide-conjugated, lexiscan (LEX)-loaded, bardoxolone methyl (BM) self-assembled nanoparticles, designated as p28-LBM NPs, is introduced. The successful penetration of brain tumors by the p28-LBM NPs after intravenous administration is demonstrated, with BM delivered as part of the NPs significantly inhibiting GBM tumor growth and extending the survival of mice with tumors. In conclusion, the p28-LBM NPs present a promising approach for GBM treatment, with potential for effective and safe clinical applications in the future."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Fully Quantitative Cardiovascular Magnetic Resonance Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy (ISHLT 2025) - "Quantitative short-axis perfusion maps were acquired using single bolus of gadolinium contrast (0.05 mmol/kg), dual sequence perfusion imaging at rest and during stress using adenosine or regadenosone vasodilation...The MP at rest, stress and MPR in the respective groups are shown in Figure 1. The MPR could discriminate CAV2-3 (ROC AUC 0.82, 95% CI[0.69-0.96]) and using a cutoff of 2.2 the sensitivity was 100%, specificity was 69%, positive and negative predictive value was 17% and100%.Conclusion In this multi-center retrospective study MPR assessed by CMR could discriminate CAV2-3 with both high sensitivity and negative predictive value."

Cardiovascular • CACNA1E • CACNG3 • CAV1 • CAV2

AUTOMATED AI-ENABLED ASSESSMENT OF SPLENIC RESPONSE IN CARDIAC PET: A MULTI-SITE STUDY - Piotr Slomka (ACC 2025) - "AI-based automated derivation of SSR could enhance image-based risk assessment. 15,044 consecutive patients undergoing Rb-82 and NH3 regadenoson stress cardiac PET from 5 sites were evaluated... Automated AI-based SSO assessment could significantly enhance clinical risk assessment for cardiac PET."

MYOCARDIAL FLOW AND RESTING CONTRACTILITY MODULATE THE PROGNOSTIC VALUE OF CONTRACTILE RESERVE - Ahmed Sayed (ACC 2025) - "This analysis assesses whether the prognostic value is modified by myocardial blood flow reserve and resting EF. Consecutive patients who underwent Rb-82 PET MPI with Regadenoson stress testing were included... Resting EF and MFR markedly impact the prognostic value of EFR. These results suggest that a low EFR may be particularly helpful in identifying high-risk patients with a normal/high MFR or resting EF."

Cardiovascular • Congestive Heart Failure • Heart Failure

DIFFERENTIAL IMPACT OF REST AND STRESS MYOCARDIAL BLOOD FLOW ON CARDIOVASCULAR OUTCOMES - Ahmed Sayed (ACC 2025) - "Background: There is scarce data on the incremental value of absolute stress and rest myocardial blood flow (MBF) over their ratio (MFR). Patients undergoing Rb-82 positron emission tomography (PET) scans with Regadenoson stress testing were included... MBFstress may be a better marker for ischemic outcomes (MI or revascularization) whereas MBFrest may be a better marker for myocardial dysfunction-related outcomes (death or HFH)."

Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

CARDIAC FIBROMA: RARE TUMOR, COMPLEX DECISIONS - Tahreem Iqbal (ACC 2025) - "Current work up included Regadenoson SPECT stress test, transthoracic echocardiogram (TTE), and cMRI... A multidisciplinary team approach and multimodality imaging is needed in management adults with large symptomatic cardiac fibroma."

Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Oncology • Pain • Pulmonary Disease • Solid Tumor

QUANTITATIVE MYOCARDIAL PERFUSION BY STRESS CARDIAC MAGNETIC RESONANCE IN WOMEN WITH ANGINA WITH NO OBSTRUCTIVE CORONARY ARTERY DISEASE - Bishow M. Paudel (ACC 2025) - "All participants underwent stress cardiac magnetic resonance imaging (CMR) using a 1.5T scanner with regadenoson as a stress vasodilator... Findings suggest that women with ANOCA may have normal MPR, indicating the need for further research into this specific endotype. Understanding these dynamics is essential for developing tailored therapeutic approaches to improve patient outcomes in this population."

Clinical • Cardiovascular • Coronary Artery Disease