Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead - LARVOL DELTA

Artificial intelligence-derived splenic response in cardiac positron emission tomography is associated with major adverse cardiovascular events: a multi-site study. (PubMed, Cardiovasc Res) - "Elevated AI-derived SR was independently associated with adverse cardiovascular outcomes, including among patients with preserved MFR. These findings support SR as a novel, automated imaging biomarker for risk stratification in 82Rb PET MPI."

Adverse events • Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders

HEMODYNAMIC INSTABILITY AFTER REGADENOSON STRESS TESTING: A QUALITY IMPROVEMENT CASE REPORT (CHEST 2026) - No abstract available

Case report • Clinical • Cardiovascular

Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics (clinicaltrials.gov) - P=N/A | N=68 | Active, not recruiting | Sponsor: University of Cincinnati | Trial completion date: Jul 2026 ➔ Jul 2027 | Trial primary completion date: Jul 2026 ➔ Jul 2027

Trial completion date • Trial primary completion date • Cardiovascular • Coronary Artery Disease

Clinical stress markers vs. quantitative myocardial blood flow for assessing adequate hyperemia during stress CMR (ESC 2026) - "Introduction Accurate detection of myocardial ischemia with vasodilator stress cardiovascular magnetic resonance imaging (S-CMR) relies on adequate hyperemia, typically induced pharmacologically with adenosine or regadenoson...Notably, the vast majority (88–90%) of clinical non-responders were adequately stressed according to quantitative MBF. These findings support the routine integration of quantitative perfusion analysis into clinical S-CMR protocols to verify adequate hyperemia."

Clinical • Cardiovascular • Myocardial Ischemia

Optimising quantitative myocardial perfusion CMR with regadenoson: effects of post-stress timing and protocol design (ESC 2026) - "Although regadenoson provides stress MBF comparable to adenosine, standard stress-first protocols with short post-stress pauses substantially overestimate resting MBF and underestimate MPR due to persistent residual hyperaemia. For accurate quantitative perfusion CMR, regadenoson protocols should incorporate either a substantially prolonged post-stress pause or a rest–stress–rest acquisition strategy."

Clinical • Cardiovascular

Early quantitative stress-perfusion cardiac magnetic resonance reveals perfusion abnormalities consistent with coronary microvascular dysfunction in MINOCA patients with otherwise normal cardiac magnetic resonance findings. (PubMed, Sci Rep) - "All participants underwent dual-sequence first-pass perfusion CMR at rest and during regadenoson stress...43% of MINOCA patients had quantitative perfusion findings consistent with CMD according to previously proposed CMR thresholds, compared with none of the controls. In conclusion, early Q-CMR identifies reduced stress MBF and MPR in MINOCA patients with otherwise normal conventional CMR findings and reveals perfusion abnormalities consistent with CMD in nearly half of these patients, suggesting that microvascular dysfunction may contribute to myocardial injury in a subset of MINOCA patients."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Infarction

Stress CT myocardial perfusion imaging after arterial switch operation for transposition of the great arteries. (PubMed, Eur Heart J Imaging Methods Pract) - "Consecutive adults referred for clinically indicated coronary CT angiography (CCTA) underwent regadenoson stress CT-MPI using either dynamic energy-integrating detector CT (EID-CT) with quantitative myocardial blood-flow mapping or static photon-counting detector CT (PCCT) with qualitative and semiquantitative iodine-map assessment...Stress CT-MPI combined with CCTA was feasible and demonstrated high diagnostic performance for detecting myocardial ischaemia after arterial switch operation. Larger prospective studies are needed to confirm these findings and define its clinical role."

Journal • Cardiovascular • Coronary Artery Disease

Inter-Observer Reliability in Myocardial Blood Flow Measurement Using Rb-82-PET/CT. (PubMed, Tomography) - "Stress conditions were simulated using 400 µg Regadenoson... Measurement of MBF, MFR and EF in Rb-82-PET/CT is highly robust with a very low inter-observer variability. A slightly higher inter-observer reliability was found for more experienced physicians."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia

Two-Dimensional Speckle-Tracking Echocardiography Combined With Stress Echocardiography in the Assessment of Coronary Artery Disease Patients Without Regional Wall Motion Abnormality. (PubMed, J Clin Ultrasound) - "Parameters obtained from 2D-STE combined with regadenoson SE demonstrate favorable diagnostic value for identifying severe CAD in patients without RWMA at rest. This approach may be particularly useful for special populations who are unable to undergo exercise stress testing or have chronic respiratory diseases and warrants further validation as a potential screening tool for significant coronary artery lesions in this patient cohort. Furthermore, the logical diagnostic combination based on ΔGLS and stress WMSI shows preliminary promise, although larger studies are needed to confirm its clinical applicability across diverse scenarios."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia • Respiratory Diseases

Anomalous Origin of the Right Coronary Artery From the Pulmonary Artery: Case Series and Review. (PubMed, JACC Case Rep) - "Nuclear Regadenoson stress test demonstrated anterior wall/anterolateral wall peri-infarctional ischemia...Computed tomography angiography of the chest/abdomen/pelvis was performed in the emergency department that was suspicious for anomalous RCA. Left heart catheterization revealed large RCA, with anomalous origin from the PA."

Journal • Cardiovascular • Myocardial Ischemia • Pulmonary Disease • Ventricular Tachycardia

Dual perfusion imaging with integrated positron emission tomography-magnetic resonance imaging for the detection of coronary microvascular dysfunction in patients with ischemia with no obstructive coronary artery disease: a study on myocardial perfusion imaging and T1 mapping. (PubMed, Quant Imaging Med Surg) - "MRI-derived left ventricular function, native T1, postcontrast T1, extracellular volume (ECV), T2 mapping, and regadenoson stress/rest MPRI were obtained and compared between the CMVD group and the non-CMVD group...Native T1 and MPRI showed nonsignificant differences in their ability to detect CMVD, with consistent and complementary diagnostic value. As a contrast-free method, native T1 may serve as a potential initial screening option, particularly for patients with renal dysfunction."

Journal • Cardiovascular • Coronary Artery Disease • Nephrology • Renal Disease

Unmasking Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy: Multimodality Imaging With Stress Cardiac MRI and Coronary CT Angiography. (PubMed, Case Rep Radiol) - "Cardiac magnetic resonance imaging (CMR) provided more definitive findings: severe asymmetrical left ventricular hypertrophy, most pronounced in the apical inferoseptal wall, alongside subendocardial perfusion defects identified during regadenoson stress perfusion imaging...In summary, this case highlights the crucial role of advanced imaging techniques, such as CMR stress perfusion and T1 mapping, in diagnosing CMD within the context of HCM. These findings underscore the need for tailored management strategies targeting CMD to mitigate its impact on clinical outcomes in HCM patients."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Fatigue • Fibrosis • Heart Failure • Hypertrophic Cardiomyopathy • Immunology • Myocardial Ischemia • Pulmonary Disease

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF) (clinicaltrials.gov) - P1 | N=100 | Recruiting | Sponsor: University of Utah | Trial completion date: Mar 2023 ➔ Mar 2027 | Trial primary completion date: Mar 2022 ➔ Mar 2027

Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure

Reduced regadenoson dose using heart rate-targeted titration in paediatric stress perfusion CMR. (PubMed, Eur Heart J Imaging Methods Pract) - "Heart rate-targeted regadenoson titration for paediatric stress perfusion CMR is feasible, achieving diagnostic-quality images with substantially reduced drug exposure. Consistent haemodynamic responses and positivity rates comparable to published series suggest adequacy of pharmacological stress, though prospective validation with quantitative perfusion measurement is required."

Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Pediatrics

Role of multiparametric cardiac MRI in the assessment of microvascular dysfunction in patients with ischemia and non-obstructive coronary arteries: validation against 13N‑ammonia during co‑injection myocardial perfusion imaging on a hybrid PET/MRI scanner (SNMMI 2026) - "Under resting conditions and stress states induced by regadenoson, all subjects simultaneously received injections of gadolinium-based contrast agent and 13N-ammonia during PET/MRI scanning... This study thoroughly compared CMR parameters in INOCA patients with and without CMVD, highlighting the diagnostic value of native T1 and longitudinal strain for CMVD. In conclusion, this study emphasizes the value of multiparametric MRI for differentiating patients with microvascular dysfunction in INOCA based on changes in the myocardial contractility pattern and tissue structure."

Clinical • Cardiovascular

Prognostic Performance of Quantitative Myocardial Perfusion Imaging Using H2[15O] Positron Emission Tomography in Coronary Artery Disease - The AQUA COR trial (clinicaltrialsregister.eu) - P2/3 | N=40000 | Not yet recruiting | Sponsor: Vaestra Goetalandsregionen

New P2/3 trial • Cardiovascular • Coronary Artery Disease

Blunted Heart Rate Response to Regadenoson Predicts Cardiovascular Risk Beyond Quantitative PET Myocardial Blood Flow. (PubMed, J Nucl Cardiol) - "Blunted HRR to regadenoson is independently associated with higher CV risk and provides incremental prognostic value beyond PET myocardial flow."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • ADORA2A

Total-Body Rb-82 Parametric Imaging on Biograph Vision Quadra with Event-by-Event Motion Correction (SNMMI 2026) - " Five large field of view dynamic Rb-82 rest and regadenoson stress studies acquired on Quadra scanner with visual motion were analyzed... We demonstrated a practical framework for total-body Rb-82 parametric imaging on Biograph Vision Quadra using a fast basis-function 1T model with explicit IDIF delay/dispersion correction. Heart-bounding-box rigid motion correction improves IDIF robustness and downstream MBF quantification in the presence of large motion. This approach supports feasible, reliable whole-body perfusion assessment with Rb-82 in clinical total-body PET workflows."

Total-Body Rb-82 Parametric Imaging on Biograph Vision Quadra with Event-by-Event Motion Correction (SNMMI 2026) - " Five large field of view dynamic Rb-82 rest and regadenoson stress studies acquired on Quadra scanner with visual motion were analyzed... We demonstrated a practical framework for total-body Rb-82 parametric imaging on Biograph Vision Quadra using a fast basis-function 1T model with explicit IDIF delay/dispersion correction. Heart-bounding-box rigid motion correction improves IDIF robustness and downstream MBF quantification in the presence of large motion. This approach supports feasible, reliable whole-body perfusion assessment with Rb-82 in clinical total-body PET workflows."

Pathophysiologic Study of the Changes of Blood Flow in Portal Vein and Hepatic Artery and the Role of Administration of Regadenoson in Post-hepatectomy Liver Failure. (PubMed, Cureus) - "Conclusion Regadenoson significantly enhanced hepatic arterial perfusion and may be associated with a reduced risk of developing PHLF syndrome compared to surgical modulation alone in the porcine model. These results position regadenoson as a promising therapeutic agent for optimizing liver perfusion in cases where portal venous flow is impaired."

Journal • Cardiovascular • Hepatology • Liver Failure

Effect of attenuation correction on myocardial flow reserve evaluation with novel multi-pinhole collimator on Triple-NaI-Detector SPECT/CT in patients with normal MIBI perfusion (SNMMI 2026) - "Dynamic flow imaging was performed following Regadenoson-induced stress and at rest... Our findings suggest that novel multi-pinhole collimator on Triple-NaI-Detector SPECT/CT provides reliable myocardial flow measurements despite the lack of statistical correlation with extended pretest CAD probability scores, even in the absence of angiographic stenosis. This supports its potential role in risk stratification and early detection of microvascular dysfunction, presenting a cost-effective and widely accessible alternative to PET imaging or dedicated cardiac SPECT in CAD assessment. Further clinical studies are needed to establish 1.5 as a suitable SPECT MFR cut-off value for grouping patients as having significant coronary artery stenosis or not."

Clinical • Cardiovascular • Obesity

Effect of attenuation correction on myocardial flow reserve evaluation with novel multi-pinhole collimator on Triple-NaI-Detector SPECT/CT in patients with normal MIBI perfusion (SNMMI 2026) - "Dynamic flow imaging was performed following Regadenoson-induced stress and at rest... Our findings suggest that novel multi-pinhole collimator on Triple-NaI-Detector SPECT/CT provides reliable myocardial flow measurements despite the lack of statistical correlation with extended pretest CAD probability scores, even in the absence of angiographic stenosis. This supports its potential role in risk stratification and early detection of microvascular dysfunction, presenting a cost-effective and widely accessible alternative to PET imaging or dedicated cardiac SPECT in CAD assessment. Further clinical studies are needed to establish 1.5 as a suitable SPECT MFR cut-off value for grouping patients as having significant coronary artery stenosis or not."

Clinical • Cardiovascular • Obesity

REGAT: Safety and Accuracy of Regadenoson-Atropine Stress Echocardiography in CAD (clinicaltrials.gov) - P=N/A | N=45 | Terminated | Sponsor: Henry Ford Health System | N=110 ➔ 45 | Unknown status ➔ Terminated; Slow recruitment and interim analysis results

Enrollment change • Trial termination • Cardiovascular • Coronary Artery Disease

Noninvasive detection of early coronary allograft vasculopathy using myocardial contrast echocardiography (HEART FAILURE 2026) - "Burst replenishment MCE perfusion was performed at rest and during regadenoson-induced hyperemia...While ICA remains the standard for defining advanced CAV, it frequently misses early, clinically relevant disease. At our institution, MCE demonstrated higher sensitivity for CAV in patients with angiographically normal coronaries, indicating its value in detecting impaired flow reserve and microvascular disease beyond angiographically defined flow obstruction. MCE enhances CAV detection and risk stratification beyond angiography alone, supporting its integration as a complementary tool in routine post-transplant surveillance for more proactive graft preservation."

Non-invasive • Cardiovascular • Congestive Heart Failure • Heart Failure • CAV1

Functional consequences of diminished myocardial oxygen delivery per beat in experimental heart failure. (PubMed, Basic Res Cardiol) - "Coronary flow responses to Regadenoson (0.4 mg) and cardiac pacing (180 beats/min) were significantly attenuated in swine with pacing HF (P ≤ 0.01)...Regional wall thickening and stroke volume declined once myocardial oxygen delivery fell below ~ 1.0 µL O₂/g/beat. These findings indicate that adaptations in the coronary microcirculation in pacing HF attenuate coronary metabolic and autoregulatory capacity and that subsequent functional deficits are related to reductions in the volume of myocardial perfusion and oxygen delivered per beat."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure