Synera (lidocaine 70 mg/tetracaine 70 mg/heated Topical Patch) / Miravo, Eurocept, Galen, Samaritan Pharma - LARVOL DELTA

The use of the S-Caine patch is safe and feasible in children younger than three: a nonrandomised clinical trial. (PubMed, Eur J Pediatr) - P=N/A | " In this clinical trial including 67 children, the S-Caine patch was safe and feasible for use in patients under three, with plasma lidocaine concentrations well below strict clinically relevant thresholds and adverse events only occurring locally, supporting its role as a non-invasive analgesic for procedural pain. Future studies are needed to confirm safety in larger paediatric populations."

Clinical • Journal • Anesthesia • Dermatology • Pain • Pediatrics

Topical analgesia during needle-related procedures in children: a clinical practice guideline. (PubMed, Arch Dis Child) - "There is, however, uncertainty about the type of local anaesthetic (ie, eutectic mixture of topical analgesia (EMLA) or tetracaine-containing creams (eg, Rapydan) that should be used.Therefore, a clinical practice guideline (CPG) was developed to establish a comprehensive, evidence-based overview and provide recommendations for clinical practice.A comprehensive multidisciplinary panel was assembled, comprising 16 professionals and patient representatives in the Netherlands. We suggest the use of tetracaine-containing creams only when rapid cannulation/puncture (ie, within 30-60 min) is required (weak recommendation, very low-quality evidence).In this CPG, we provide recommendations regarding the choice of local anaesthetic for needle-induced pain during minor procedures in children. With these recommendations, we aim to reduce procedural pain and thereby contribute to improving care for children."

Clinical guideline • Journal • Anesthesia • Pain • Pediatrics

Diatom-Inspired Structural Adaptation According to Mode Shapes: A Study on 3D Structures and Software Tools. (PubMed, Biomimetics (Basel)) - "The created software tools, encompassing various components, were successfully tested on the example structures demonstrating the versatility and practicality of implementing biomimetic strategies in engineering designs. Thus, the present investigation does not only highlight the noteworthiness of the structural adaptation method inspired by diatoms in maximizing eigenfrequencies, but also originate software tools permitting different users to easily apply the method to distinct structures that have to be optimized, e.g., lightweight structures in the mobility or aerospace industry that are susceptible toward vibrations."

Journal

Effects of transdermal lidocaine or lidocaine with prilocaine or tetracaine on mechanical superficial sensation and nociceptive thermal thresholds in horses. (PubMed, Vet Anaesth Analg) - "Eutectic mixtures of lidocaine with either prilocaine or tetracaine led to a reduction in thermal nociception and mechanical sensation for up to 2 hours."

Journal • Biosimilar

Nuvo Research Inc. completes reorganization into two publicly traded companies (PRNewswire) - "Nuvo Pharmaceuticals...formerly known as Nuvo Research Inc. and Crescita Therapeutics ...today announced the completion of the reorganization of Nuvo Research Inc. into two separate publicly traded companies (the Reorganization)....Effective with the Reorganization, Nuvo Pharma...is a commercial healthcare company...Nuvo Pharma has three commercial products that are available in a number of countries; Pennsaid 2%, Pennsaid and the heated lidocaine/tetracaine patch."

Commercial • Pain

Nuvo Research announces scientific presentations at Annual Painweek 2013 Meeting (Nuvo research Press Release) - P4, N=52; NCT01525043; "Nuvo Research...announced today that researchers are presenting scientific data related to the heated lidocaine/tetracaine patch (HLT Patch)...clinically important reduction in average pain scores (defined as ≥30% reduction from baseline) were experienced by more patients treated with the HLT Patch 4 hr BID (56%) and the HLT Patch 12 hr QD (53%)..."; P2, N=60; NCT01544283; "Both groups demonstrated a significant (P<.001) reduction in average pain scores at 2 weeks compared with baseline (–35%±29% and –42%±36% in the HLT Patch and injection groups, respectively)..."

P2 data • P4 data • Pain

Economic Evaluation of Lidocaine/Tetracaine Patch Versus Lidocaine/Prilocaine Cream for Topical Anaesthesia Before Vascular Access In Egypt. (PubMed) - Value Health - No abstract available.

Journal • Biosimilar

Drug approval reports (FDA) - Synera label revised on 10th Mar, 2014.

FDA event • Pain

Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection (clinicaltrials.gov) - P4; N=120; Recruiting; Sponsor: The University of Texas Health Science Center, Houston; Trial primary completion date: Feb 2015 ➔ Feb 2016

Trial primary completion date • Biosimilar • Pain

Polymodal Mechanism for TWIK-Related K+ Channel Inhibition by Local Anesthetic. (PubMed, Anesth Analg) - "We propose a mechanism of TREK-1 inhibition comprised of (1) primarily indirect PLD2-dependent inhibition of lipid catalysis and (2) limited direct inhibition for select local anesthetics through partial open pore block. The inhibition through PLD2 explains how the C terminus can regulate the channel despite being devoid of structure and putative binding sites for local anesthetics."

Journal

Pain management for children needing laceration repair. (PubMed, Can Fam Physician) - "In instances where lidocaine-adrenaline-tetracaine is not sufficient, additional injected lidocaine or bupivacaine can be used. Buffering lidocaine with bicarbonate, warming the lidocaine ampule, and injecting the compound slowly at a perpendicular angle to the skin will reduce pain associated with the injection."

Clinical • Journal