cenderitide (CD-NP) / Capricor - LARVOL DELTA

Multimodality mapping of immunotherapy distribution as a prognostic marker in glioma (SNO 2025) - "We find that in contrast to the susceptible Gl261 glioma model, SB28 gliomas are characterized by poor immunogenicity due to low MHC expression and resistance to Toll-like receptor (TLR) 7 targeted therapy by CDNP-R848 nanoparticles...In a translational analysis of the multicenter N2M2/NOA20 trial we validate that edema and microvascular pathology are also associated with poor prognosis in glioblastoma patients treated with anti-PD-L1 immunotherapy and that patients without edema have increased progression free survival (PFS). In summary, we develop a customizable imaging platform (3D-MR-LSM) to three-dimensionally map drug delivery to the central nervous system (CNS) with broad applicability in neuroscience and oncology."

Biomarker • IO biomarker • Brain Cancer • Glioblastoma • Glioma • Solid Tumor • CD8 • IL12A • IL13

Assessing the immune microenvironment in glioma models by correlative high field MRI and light sheet microscopy (SNO 2025) - "To induce a proinflammatory shift in the TME, we used the Toll-like receptor 7 agonist CDNP-R848, which effectively treated preclinical Gl261 glioma...TME complexity appeared to develop prior to therapy. These findings indicate that the recruitment pathways of myeloid and T cells are crucial for understanding potential resistance to glioma immunotherapy."

Brain Cancer • Glioma • Solid Tumor

Advanced imaging, immune profiling and nanoparticle immunotherapy distribution in H3K27M-mutated Diffuse Midline Glioma models: identifying and translating MRI signatures (SNO 2025) - "Additionally, we assessed the biodistribution of fluorescently labeled cyclodextrin (CDNP)-nanoparticle therapy upon intravenous administration in the tumor microenvironment by light sheet microscopy. MRI data indicate unique imaging signatures associated with different primary tumor locations. We found strong infiltration along white matter tracts and distinct immune profiles. SE-DTI tractography was utilized to reconstruct white matter tracts to further identify DMG infiltration pathways."

IO biomarker • Metastases • Brain Cancer • Diffuse Midline Glioma • Glioma • Solid Tumor

Assessing the immune microenvironment in glioma models by correlative high field MRI and light sheet microscopy (WFNOS 2025) - "To induce a proinflammatory shift in the TME, we used the Toll-like receptor 7 agonist CDNP-R848, which effectively treated preclinical Gl261 glioma...TME complexity appeared to develop prior to therapy. These findings indicate that the recruitment pathways of myeloid and T cells are crucial for understanding potential resistance to glioma immunotherapy."

Brain Cancer • Glioma • Oncology • Solid Tumor

Advanced imaging, immune profiling and nanoparticle immunotherapy distribution in H3K27M-mutated Diffuse Midline Glioma models:  identifying and translating MRI signatures (WFNOS 2025) - "Additionally, we assessed the biodistribution of fluorescently labeled cyclodextrin (CDNP)-nanoparticle therapy upon intravenous administration in the tumor microenvironment by light sheet microscopy. MRI data indicate unique imaging signatures associated with different primary tumor locations. We found strong infiltration along white matter tracts and distinct immune profiles. SE-DTI tractography was utilized to reconstruct white matter tracts to further identify DMG infiltration pathways."

IO biomarker • Metastases • Brain Cancer • Diffuse Midline Glioma • Glioma • Solid Tumor

Multimodality mapping of immunotherapy distribution as a prognostic marker in glioma (WFNOS 2025) - "We find that in contrast to the susceptible Gl261 glioma model, SB28 gliomas are characterized by poor immunogenicity due to low MHC expression and resistance to Toll-like receptor (TLR) 7 targeted therapy by CDNP-R848 nanoparticles...In a translational analysis of the multicenter N2M2/NOA20 trial we validate that edema and microvascular pathology are also associated with poor prognosis in glioblastoma patients treated with anti-PD-L1 immunotherapy and that patients without edema have increased progression free survival (PFS). In summary, we develop a customizable imaging platform (3D-MR-LSM) to three-dimensionally map drug delivery to the central nervous system (CNS) with broad applicability in neuroscience and oncology."

Biomarker • IO biomarker • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oncology • Solid Tumor • CD8 • IL12A • IL13

Metformin attenuates coal dust nanoparticle-induced pulmonary fibrosis by modulating inflammation and epithelial-mesenchymal transition. (PubMed, Int Immunopharmacol) - "Coal worker pneumoconiosis is an occupational pulmonary fibrosis (PF) caused by prolonged exposure to respirable coal dust (CD), with limited therapeutic options. These findings indicate that Met attenuates CD-NP-induced PF by inhibiting oxidative stress, inflammation, and EMT, potentially by targeting IGF1/IGF1R, AKT/GSK3β, and NF-κB/NLRP3 signaling. Its preventive efficacy highlights promising translational value for occupational PF intervention."

Journal • Fibrosis • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • IGF1 • NLRP3

Molecular Basis of Cadmium Cardiotoxicity: Chamber-Specific Effects of CdO Nanoparticles and Soluble CdCl2 Exposure. (PubMed, Food Chem Toxicol) - "Thus, exposure to CdNP could exhibit greater cardiotoxicity than CdCl2, with opposite effects on the right ventricle. Therefore, molecular mechanisms of cadmium's influence on specific heart chambers should be considered when developing strategies for heart disease management."

Journal • Cardiovascular • Heart Failure

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations. (PubMed, Microbiol Spectr) - "Furthermore, the detailed structural insights and inhibitory mechanisms elucidated through molecular dynamics simulations provide valuable knowledge for rational drug design. This research bridges natural product discovery with computational biology to address the urgent need for novel TB treatments, especially against drug-resistant strains, presenting a significant advancement toward more effective therapeutic interventions for this persistent global health threat."

Journal • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • STING

Review on the utilization of metal organic frameworks (MOFs) for eliminating ibuprofen and naproxen from water sources. (PubMed, Environ Sci Pollut Res Int) - "This study demonstrated that MOFs, including Pd@MIL-100(Fe), UiO-67@β-CD-NP, HSO₃-MIL-53(Fe), and UiO-66-MOF, are capable of achieving complete removal of the targeted pharmaceuticals. This review concludes that MOFs, particularly those following the Langmuir adsorption isotherm model and PSO adsorption kinetics, are promising for the effective removal of IBU and NPX. These results highlight the potential of MOFs in addressing pharmaceutical contamination and suggest further research, particularly in optimizing MOF structures for environmental applications."

Journal • Review

Cyclodextrin Nanoparticles and Injectable Polymer-Nanoparticle Hydrogels for Macrophage-Targeted Delivery of Small-Molecule Drugs. (PubMed, Methods Mol Biol) - "We have, therefore, developed a macrophage-targeted nanoparticulate carrier (cyclodextrin nanoparticle [CDNP]) that can house a variety of hydrophobic small-molecule drugs for systemic delivery through the body. This system has further been manipulated to formulate an injectable polymer-nanoparticle (iPNP) hydrogel for local delivery, with the goal of concentrating drug effects at the target site while perpetuating sustained delivery and minimizing off-target effects. Herein, we describe the strategy for preparing these CDNPs and iPNP hydrogels for a wide range of therapeutic applications."

Journal • Immune Modulation • Immunology • Oncology

Enhanced bioaccessibility of cyclolinopeptides via zein-cyclodextrin nanoparticles: Simulated gastrointestinal digestion and cellular uptake study. (PubMed, Food Chem) - "Z-CD NP had a smaller diameter (Dh) and better encapsulation effect on CLS...Z-CD NPs also enhanced absorption and reduced secretion of CLS after digestion. Overall, this study provides a simple approach to enhance the oral delivery efficiency of CLS by modulating Z-based NPs with CD."

Journal • Gastrointestinal Disorder

Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS-Triggered Cross-Linker Release. (PubMed, Adv Sci (Weinh)) - "1718 intra-links reveal dynamic conformations involving chaperones with ATP-dependent conformation cycles, and 385 inter-links reveal dynamic interactions involving OXPHOS complexes and 27 pairs of possible potential interactions. These results signify that R-CDNP can achieve dynamic conformation and interaction analysis of mitochondrial proteins in living cells, thereby contributing to a better understanding of their biological functions."

Journal

Metal Ion-Condensed DNA Nanoparticle Library: Phase Separation and Transition and Antisense Therapy Applications. (PubMed, ACS Appl Mater Interfaces) - "In addition, the Mn+-controlled anticancer therapeutic efficiency of the Mn+-CDNP library as a state-of-the-art gene delivery platform was demonstrated even for unmodified antisense oligonucleotides in association with the potential toxicity of the Mn+s released from the Mn+-CDNPs. This comprehensive study of the Mn+-dependent condensation of nucleic acids provides profound insights into the chemistry of the nucleic acid-Mn+ interactions and the reliable theragnostic applications of Mn+-CDNPs as functional nucleic acid nanostructures."

Journal • Gene Therapies • Oncology

Macrophage-targeted drug delivery for systemic and local immunotherapy (ACS-Fall 2024) - "Hydrogels released CDNP-celastrol for >14 days with >80% inhibition of inflammatory response (Fig 1C). In sum, small-molecules can potently modulate MF-state and their efficacy is improved through cell- and tissue-targeted delivery to aid clinical translation."

Oncology

Interfacial engineering method to regulate the performances of bilayer emulsions co-stabilized by casein/butyrylated dextrin nanoparticles and chitosan. (PubMed, Int J Biol Macromol) - "In present study, bilayer emulsions with different interfacial structures stabilized by casein/butyrylated dextrin nanoparticles (CDNP), chitosan (CS) and chitosan nanoparticles (CSNP) were prepared to overcome the limitations of conventional emulsions...This study also provides a new material for the preparation of delivery systems that protect biologically active compounds. Bilayer emulsions are promising for applications in traditional and manufactured food products."

Journal

Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure. (PubMed, Cell Rep Med) - "Three drug target genes show sex-differential effects on HF/HFrEF via influencing LVEF, with NPR2 as the target gene for the HF drug Cenderitide under phase 2 clinical trial. Our study highlights the importance of considering sex-differential genetic effects in sex-balanced diseases such as HF and emphasizes the value of sex-stratified GWASs and MR in identifying putative genetic variants, causal genes, and candidate drug targets for HF, which is not identifiable using a sex-combined strategy."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Uptake of Cyclodextrin Nanoparticles by Macrophages is Dependent on Particle Size and Receptor-Mediated Interactions. (PubMed, ACS Appl Bio Mater) - "Finally, we investigated the cellular bioavailability of drug-loaded CDNPs using a model anti-inflammatory drug, celastrol, which demonstrated that drug bioactivity is improved by CDNP loading relative to free drug alone. This study thus elucidates the interactions between the polyglucose nanoparticles and macrophages, thereby facilitating their application in macrophage-targeted drug delivery that has applications in the context of tissue injury and repair."

Journal • Review

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP. (PubMed, Microbiol Spectr) - "There is strong evidence in tuberculosis and in cancer biology that potentiation of the cGAS-STING-IRF3 pathway leads to improved M.tb clearance and also improved antitumor responses in cancer. In addition to the identification of novel inhibitors and their biochemical characterization, we provide proof-of-concept evidence that our E-3 inhibitor potentiates the cGAS-STING-IRF3 pathway in both macrophage cell lines and also in primary human monocyte-derived macrophages."

Journal • Preclinical • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CGAS

Metal Salts of 4-Chloro-3,5-dinitropyrazole for Promising Eco-Friendly Primary Colors Pyrotechnics. (PubMed, Inorg Chem) - "In this regard, we present the syntheses of novel green primary colors pyrotechnics (red, green, and blue light-generating pyrotechnics) by employing 4-chloro-3,5-dinitropyrazole (CDNP) as a multifunctional raw material...Chromaticity analysis reveals that the three EMSs possess good color purities of 91, 80, and 70%, respectively. Consequently, the three integrated pyrotechnics exhibit exceptional combustion properties, highlighting their potential for use in various pyrotechnic applications."

Journal

A Universal Cyclodextrin-Based Nanovaccine Platform Delivers Epitope Peptides for Enhanced Antitumor Immunity. (PubMed, Adv Healthc Mater) - "Here, we design a cyclodextrin-based polymer nanovaccine platform (CDNP) for the codelivery of peptides with two immune adjuvants [the Toll-like receptor (TLR)7/8 agonist R848 and the TLR9 agonist CpG] that is broadly applicable to epitope peptides with diverse sequences...The immunogenicity of the epitope peptides is significantly enhanced by the codelivery and synergy of the adjuvants, and the CDNP shows the ability to inhibit tumor progression in diverse tumor-bearing mouse models. We conclude that CDNP hold promise as an optimized peptide-based cancer vaccine platform."

Journal • Oncology

Novel cyclodextrin-based nanoparticles delivering alpha-mangostin for the treatment of brain ischemia (ACS-Fall 2023) - "In vivo results indicated that α-M crossed the blood-brain barrier (BBB) with the assistance of CDNP. The released α-M from CDNP interacted with albumin during its prolonged blood circulation, forming an α-M/albumin complex that may cross the BBB through the absorptive-mediated transcytosis pathway."

Cardiovascular

Genomic Distribution of Pro-Virulent cpdB-like Genes in Eubacteria and Comparison of the Enzyme Specificity of CpdB-like Proteins from Salmonella enterica, Escherichia coli and Streptococcus suis. (PubMed, Int J Mol Sci) - "It is structurally related to cell wall-anchored proteins, CdnP and SntA, encoded by the also pro-virulent cdnP and sntA genes of Streptococcus agalactiae and Streptococcus suis, respectively...On the other hand, since CpdB-like proteins are relevant to host-pathogen interactions, the presence of cpdB-like genes was probed in eubacterial taxa by TblastN analysis. The non-homogeneous genomic distribution revealed taxa with cpdB-like genes present or absent, identifying eubacteria and plasmids where they can be relevant."

Journal

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles. (PubMed, Nat Commun) - "Using serial magnetic resonance imaging, we identify a radiomic signature in response to CDNP-R848 treatment and ultrasmall superparamagnetic iron oxide (USPIO) imaging reveals that immunosuppressive macrophage recruitment is reduced by CDNP-R848. In conclusion, CDNP-R848 induces tumor regression in experimental glioma by targeting blood-borne macrophages without requiring adaptive immunity."

Journal • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Immunology • Oncology • Solid Tumor • Thoracic Cancer

Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia. (PubMed, J Control Release) - "Combining an in vitro BBB model and a physicochemical binding assay between α-M and albumin, it is speculated that α-M released from CDNP would interact with albumin during its prolonged circulation in the blood, and the resultant α-M/albumin complex may cross the BBB through the absorptive-mediated transcytosis pathway. These findings suggest the potential clinical application of α-M in ischemic stroke treatment."

Journal • Cardiovascular • CNS Disorders • CNS Tumor • Ischemic stroke • Neuroblastoma • Oncology • Solid Tumor