influenza A virus H1N1 vaccine (swine flu vaccine) / iBio - LARVOL DELTA

Antibacterial and antiviral potential of harmalacidine hydrochloride, a β-carboline alkaloid, against respiratory tract pathogens: Staphylococcus aureus and H1N1 influenza virus. (PubMed, PLoS One) - "It also showed high affinity for H1N1 neuraminidase and polymerase basic protein 2 (PB2), indicating potential antiviral activity. However, experimental enzyme assays and in vivo studies are required to confirm the proposed antiviral and antibacterial mechanisms."

Journal • Infectious Disease • Influenza • Respiratory Diseases

FATAL TRACHEOBRONCHIAL ASPERGILLOSIS AFTER H1N1 INFLUENZA INFECTION (CHEST 2025) - "The patient was initiated on peramivir and broad-spectrum antibiotics.Despite gradual improvement in renal function, the patient's respiratory status deteriorated, necessitating high-flow nasal cannula oxygen and intermittent noninvasive ventilation. Subsequent sputum cultures grew Aspergillus fumigatus, prompting the initiation of voriconazole therapy... This case highlights the potential for fatal TBA following H1N1 influenza infection, even in patients without classic immunosuppressive risk factors. Clinicians should maintain a high index of suspicion for invasive aspergillosis in critically ill influenza patients, particularly those with underlying pulmonary conditions or a history of substance use. Early recognition and prompt antifungal therapy are crucial to improving outcomes in this population."

Cardiovascular • Hypertension • Infectious Disease • Influenza • Ischemic stroke • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock

Omadacycline in the treatment of severe Q fever pneumonia during an influenza epidemic: a case report with literature review. (PubMed, Front Med (Lausanne)) - "Following antiviral treatment with Maraviroc and antibiotic therapy with omadacycline tosilate (a novel tetracycline-class drug) for Coxiella burnetii infection, the patient's clinical symptoms improved, biochemical markers normalized, and pulmonary imaging showed resolution. This case highlights the potential of tNGS to improve the detection rate of mixed infections in cases of severe pneumonia of unknown etiology. The novel tetracycline drug, such as omadacycline, has demonstrated efficacy against Q fever rickettsial pneumonia, offering a new perspective for clinical diagnosis and treatment."

Journal • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases

Journey from H1N1 to Acute Hemorrhagic Leukoencephalitis. (PubMed, Ann Afr Med) - "Swab for H1N1 influenza was positive. Treatment with intravenous methylprednisolone, ceftriaxone, acyclovir, and oseltamivir resulted in significant recovery."

Journal • CNS Disorders • Diabetes • Epilepsy • Hematological Disorders • Infectious Disease • Influenza • Respiratory Diseases

A BEWILDERING CASE OF ACUTE EOSINOPHILIC PNEUMONIA RELATED TO INFLUENZA A INFECTION (CHEST 2024) - "He was started on a 2-week steroid taper, starting at 40 mg prednisone daily. In conclusion, we recommend including AEP in a differential diagnosis in a patient with recent influenza diagnosis with concern for recurrent symptoms."

Clinical • Allergic Bronchopulmonary Aspergillosis • Asthma • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Fibrosis • Hematological Disorders • Hepatology • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Inflammation • Influenza • Langerhans Cell Histiocytosis • Pneumonia • Rare Diseases • Respiratory Diseases • Vasculitis

SOMETIMES COMMON PROBLEMS ARE DUE TO ZEBRAS: A CASE OF TRACHEITIS FROM SECONDARY SYPHILIS (CHEST 2024) - "She was started on treatment with penicillin G. Following initiation of targeted antibiotics, her vocal cord swelling improved, and she was successfully decannulated prior to discharge. Syphilis can present with non-specific symptoms over a varied time course and is often known as a "Great Imitator" of disease [1]. This case shows that syphilis testing should be considered in patients who present with a prolonged course of upper head/neck symptoms and in those where malignancy is a concern."

Clinical • Cervical Cancer • Cough • Gastrointestinal Disorder • Gynecology • Head and Neck Cancer • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Influenza • Novel Coronavirus Disease • Oncology • Otorhinolaryngology • Respiratory Diseases • Solid Tumor

Clinical and Etiological Profile of Children With Acute Viral Encephalitis in a Tertiary Care Hospital: A Cross-Sectional Study. (PubMed, Cureus) - "Causative agents such as mumps, herpes simplex virus (HSV), dengue, and many other viruses are now more prevalent than the Japanese encephalitis (JE) virus. Bad clinical course and fatal outcomes are observed in patients affected with rabies, HSV, and H1N1 influenza virus. Factors such as GCS scores, shock, and need for ventilation play a significant role in determining patient prognosis. Early detection and prompt treatment may aid in better outcomes for patients."

Journal • Observational data • CNS Disorders • Critical care • Dengue Fever • Epilepsy • Herpes Simplex • Infectious Disease • Influenza • Mumps • Pediatrics • Respiratory Diseases

Mechanism of Jinzhen Oral Liquid against influenza-induced lung injury based on metabonomics and gut microbiome. (PubMed, J Ethnopharmacol) - "JZOL attenuates H1N1 influenza infection induced lung injury by regulating lipid metabolism via the modulation of Lactobacillus. The results support the clinical application of JZOL, and are useful to further understand the mechanism of TCM in the treatment of influenza."

Journal • Immunology • Infectious Disease • Inflammation • Influenza • Metabolic Disorders • Pneumonia • Pulmonary Disease • Respiratory Diseases • IFNG • TNFA

Antibiotic treatment issues in patients with COVID-19. (PubMed, Vnitr Lek) - "Thus, it is clear that a careful assessment of the role of antibiotic treatment in patients hospitalized for COVID-19 is required. According to the current WHO recommendation, the application of antibiotics is especially suitable for patients with severe/critical degree of respiratory insufficiency requiring intensive oxygen therapy, artificial lung ventilation or support by extracorporeal membrane oxygenation."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Break and Poster Viewing (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Conclusions and Remarks (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Break and Poster Viewing (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Lunch (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Q&A (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Q&A (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Welcome and Introduction (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Q&A (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

Q&A (USCAP 2022) - "Presentations 8:00 AM 8:15 AM Welcome and Introduction 8:15 AM 8:45 AM Role of Pathology in One Health Jeannette Guarner, Emory University 8:45 AM 9:15 AM Emergence of Antibacterial Resistance Cynthia E. Flynn, ChristianaCare Health System 9:15 AM 9:30 AM Q&A 9:30 AM 10:30 AM Break and Poster Viewing 10:30 AM 11:00 AM What Is New in Fungal Infections? Daniel Diekema, University of Iowa 11:00 AM 11:30 AM The Changing Landscape of Parasitic Infections Bobbi Pritt, Mayo Clinic 11:30 AM 11:45 AM Q&A 11:45 AM 1:15 PM Lunch 1:15 PM 1:45 PM Flaviviruses in the traveler: Around the World and to Your Stage Gillian Leigh Hale, The University of Utah 1:45 PM 2:15 PM The 2020 Coronavirus Pandemic Michael Mina, eMed 2:15 PM 2:30 PM Q&A 2:30 PM 3:30 PM Break and Poster Viewing 3:30 PM 4:00 PM The Veterinary Pathology Perspective in The Global Eradication of Guinea worm Fernando J. Torres-Velez, The Carter Center 4:00 PM 4:30 PM Teaching Infectious Disease Pathology and..."

Allergy • Dermatopathology • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Novel Coronavirus Disease • Obstetrics • Oncology • Respiratory Diseases • Solid Tumor

[VIRTUAL] ROLE OF VIRAL PATHOGEN IN HOSPITALIZED CHILDREN WITH COMMUNITY ACQUIRED PNEUMONIA IN QATAR; ATTENTION-GRABBING REPORT (ESPID 2021) - "Our study revealed that Rhinovirus was the most common causative agent in hospitalized children with CAP. H1N1 influenza virus plays a major role in PICU admission, adherence to annual influenza vaccine may reduce CAP complications and morbidity."

Clinical • Asthma • Cerebral Palsy • CNS Disorders • Critical care • Immunology • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Disease • Respiratory Diseases

[VIRTUAL] A FUNGUS AMONG US: A RARE CASE OF BLASTOMYCOSIS AND INFLUENZA A H1N1 CO-INFECTION (CHEST 2020) - "He required non-invasive positive pressure ventilation and methimazole, propranolol, high-dose steroids and diuresis for suspected thyroid storm and ceftriaxone and doxycycline for community-acquired pneumonia...Vancomycin, piperacillin/tazobactam, levofloxacin and fluconazole were started...Oseltamivir was started... To our knowledge, this is the first case of blastomycosis and influenza co-infection reported and it indicates a comparable risk of high mortality. Even without superinfection, there are implications for early therapy of acute blastomycosis. Given that it can transition to chronic pneumonia and rarely, ARDS, with a 50%–89% case-fatality rate, it is important to maintain a high index of suspicion for blastomycosis in a patient from an endemic area who has respiratory symptoms."

Clinical • Acute Respiratory Distress Syndrome • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock

[VIRTUAL] MELTING MUSCLES: H1NI INFLUENZA A-INDUCED RHABDOMYOLYSIS (CHEST 2020) - "H1N1 Influenza-A can cause severe rhabdomyolysis and physicians should consider checking a creatine kinase level in adults hospitalized with acute influenza infection."

Acute Kidney Injury • Acute Respiratory Distress Syndrome • Cardiovascular • CNS Disorders • Epilepsy • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Mood Disorders • Myositis • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Swine-influenza (H1N1 influenza) mimicking a case of high altitude pulmonary oedema (HAPO). (PubMed, BMJ Case Rep) - "Oseltamivir was empirically started, in addition to parenteral antibiotics and he was started on inotropic support. In view of severe hypoxaemia, not responding to non-invasive ventilation, he was intubated and placed on mechanical ventilation. The patient turned out to be H1N1 positive and succumbed to his illness 3 days later."

Clinical • Journal • Hypotension • Infectious Disease • Leukopenia • Respiratory Diseases

Necrotizing tracheobronchitis causing airway obstruction complicated by pandemic 2009 H1N1 influenza: A case report. (PubMed, Medicine (Baltimore)) - "We suggest that necrotizing tracheobronchitis be considered in patients with influenza who present with unexplained hypoxemia."

Clinical • Journal

The Utility of Renal Replacement Therapy in Hepatic Encephalopathy (KIDNEY WEEK 2019) - "In this case, our patient was somnolent requiring intubation and had rising ammonia levels despite lactulose and rifaximin therapy. This case sheds light on the utility of renal replacement therapy in the management of critically ill patients, even those without pre-existing kidney dysfunction or end-organ damage. Further studies are needed to quantify the extent to which renal replacement may benefit these patients."

Is weight associated with severity of acute respiratory illness? (PubMed, Int J Obes (Lond)) - "Overweight and obesity were not associated with increased risk of hospitalization during winter respiratory seasons in children or adults."

Journal