cefuroxime / Generic mfg. - LARVOL DELTA

An Injectable, Self-Expanding Hemostatic Foam for Field-Compatible Postpartum Hemorrhage Management. (PubMed, Adv Sci (Weinh)) - "Incorporation and controlled release of tranexamic acid and cefuroxime show versatility in topical drug delivery. Beyond extensive ex vivo testing, rapid, controlled deployment in vivo in a swine model is demonstrated. By integrating mechanical and chemical mechanisms, this injectable foam provides effective bleeding control, with a design well suited to low-resource settings."

Journal • Hematological Disorders • Postpartum Hemorrhage

ANTIBIOTIC PROPHYLAXIS IN CHOLANGIOSCOPY: A MULTICENTER REAL-WORLD COHORT (UEGW 2026) - "A periprocedural single-dose strategy was used in 65 procedures, with ciprofloxacin being the most frequent agent (n=36, 55.4%). An extended post-procedural course was used in 41 procedures, with a median duration of 5 days (range 2-14), most commonly cefuroxime combined with metronidazole (n=16, 39%)... Prolonged antibiotic prophylaxis did not demonstrate superiority over a periprocedural single-dose strategy in preventing post-procedural cholangitis following cholangioscopy. The higher complication rates observed in the extended course group likely reflect confounding by indication, as more complex procedures may have prompted prolonged prophylaxis rather than representing a true causal effect. The retrospective design and heterogeneity of antibiotic agents across centers are the main limitations."

Clinical • Real-world • Real-world evidence • Hepatology

Antibiotic Consumption Patterns in Three Romanian Hospitals: A Five-Year Retrospective Study. (PubMed, Antibiotics (Basel)) - "Cefuroxime accounted for the highest cumulative consumption, followed by ceftriaxone, meropenem, vancomycin, ciprofloxacin, and metronidazole. Antibiotic consumption differed among the participating hospitals and study years. Monitoring antibiotic consumption provides valuable information on hospital antibiotic utilization patterns and can support evidence-based antimicrobial stewardship in hospitals."

Journal • Retrospective data

Aseptic Pulmonary Abscesses: A Rare Extraintestinal Manifestation of Crohnâs Disease (ACG 2026) - "In early 2013, the patient was evaluated for dyspnea and cough and was treated with cefuroxime for URI...Adalimumab was discontinued during this time due to concern for infection...She was initiated on infliximab and high-dose prednisone with improvement of respiratory symptoms; however, infliximab was discontinued due to an infusion reaction...Figure: Figure 1. CT Chest demonstrating a right lower lobe cavitary lesion."

Cough • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Musculoskeletal Diseases • Pulmonary Disease • Respiratory Diseases

Prevalence and Antimicrobial Resistance Profiles of Enterococci Isolated From Humans, Animals, and Environment in Bangladesh: A Systematic Review and Meta-Analysis. (PubMed, Int J Microbiol) - "High resistance rates were observed against cefuroxime (77.1%) and ceftriaxone (73.4%), whereas resistance to vancomycin was 20.9%. The findings underscore the urgent need for rational antimicrobial use, strengthened infection prevention and control measures, improved environmental hygiene, and integrated One Health surveillance across human, animal, and environmental settings to mitigate the burden of antimicrobial-resistant enterococci."

Journal • Retrospective data • Review • Infectious Disease

Unilateral lower limb cellulitis-like edema as an atypical cutaneous manifestation of antisynthetase syndrome: a case report and targeted literature review. (PubMed, Front Med (Lausanne)) - "Moderate-dose oral prednisone was added and cefuroxime sodium was discontinued...After discharge, mycophenolate mofetil(MMF) and nintedanib were added...Notably, this case highlights that ASyS may mimic infectious cellulitis and cause misdiagnosis. Inflammatory myopathy should be considered when atypical skin lesions are accompanied by elevated muscle enzymes and ILD."

Journal • Cardiovascular • Dermatology • Dermatomyositis • Immunology • Interstitial Lung Disease • Melanoma • Musculoskeletal Pain • Myositis • Oncology • Pain • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Solid Tumor • CRP • IFIH1

Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections (clinicaltrials.gov) - P=N/A | N=2278 | Recruiting | Sponsor: Helsinki University Central Hospital | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial primary completion date • Gynecology • Infectious Disease

Osimertinib Induced Bone Marrow Aplasia Case Report (IASLC-WCLC 2026) - "Initially, she began treatment with carboplatin and pemetrexed while awaiting next-generation sequencing results...She was treated empirically with cefuroxime due to concurrent respiratory illness within her household...Therapy was switched to erlotinib (Tarceva), and supportive agents including eltrombopag and darbepoetin were initiated...Despite these interventions, her cytopenias persisted, and her blood counts did not recover. Conclusions : This case highlights that osimertinib induced bone marrow aplasia is a rare adverse event but it is important to monitor patients for hematological toxicities closely while on osimertinib therapy."

Case report • Clinical • Anorexia • Aplastic Anemia • Cardiovascular • Cough • Infectious Disease • Interstitial Lung Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Pneumonia • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Cefuroxime combined with metronidazole alleviates sepsis-induced cognitive dysfunction. (PubMed, Neuroscience) - "Furthermore, administration of HDAC2 inhibitor vorinostat (SAHA) similarly attenuated sepsis-associated cognitive dysfunction. Additionally, the treatment normalized the dysregulated expression of TrkB, PD-1, and PD-L1, which are critical regulators of synaptic plasticity and immune responses. Collectively, this study highlights the therapeutic potential of targeting inflammation and synaptic integrity in SAE and provides a rationale for further exploring the role of antibiotics in cognitive recovery among sepsis survivors."

IO biomarker • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Infectious Disease • Inflammation • Septic Shock • HDAC2 • NTRK2 • PD-1 • SYP

Mycoplasma pneumoniae-associated reactive infectious mucocutaneous eruption (RIME) confirmed by multiplex PCR: a case-based review. (PubMed, Ir J Med Sci) - "The eruption developed five days after initiation of oral cefuroxime for a presumed respiratory tract infection. The patient improved with intravenous corticosteroids, azithromycin, and supportive care, with complete resolution at one-month follow-up. This case-based review summarises diagnostic clues, highlights the role of multiplex PCR in aetiologic attribution, and outlines pragmatic management principles to reduce morbidity and avoid misclassification as a severe drug reaction."

Journal • Review • Dermatology • Infectious Disease • Mucositis • Ophthalmology • Pneumonia • Respiratory Diseases • Steven-Johnson Syndrome

Adverse events associated with cefuroxime ocular administration: potential demographic and dose-dependent heterogeneity assessment. (PubMed, Cutan Ocul Toxicol) - "What this study addsThis represents a pharmacovigilance study to evaluate cefuroxime ocular administration-associated adverse events.88.7% of the cases resulted in severe outcomes.There may be potential difference in reporting cefuroxime ocular administration-associated adverse events across continents, sexes and doses. How this study might affect research, practice or policyThis study emphasizes the need for careful attention to ocular adverse events when cefuroxime was administered ocular.The findings underscore the need for future confirmatory studies into the potential demographic and dose differences in adverse events associated with cefuroxime ocular administration."

Adverse events • Heterogeneity • Journal • Inflammation • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology

Diffuse-Type Tenosynovial Giant Cell Tumor of the Hip With Acetabular Bone Involvement: A Case Report With Radiologic-Pathologic Correlation. (PubMed, Cancer Rep (Hoboken)) - "Hip D-TGCT should be considered when an intra-articular hip lesion shows synovial proliferation with acetabular erosion, even when inflammatory findings raise concern for alternative diagnoses. Magnetic resonance imaging and computed tomography are complementary for defining soft-tissue extent and osseous involvement, but definitive diagnosis depends on clinicopathologic correlation. This case highlights the diagnostic value of histopathology and immunohistochemistry in destructive-appearing hip lesions."

Journal • Giant Cell Tumor of Bone • Oncology • Orthopedics • Pain • Tenosynovial Giant Cell Tumor

Integrating a multistage DoE strategy using Plackett-Burman screening and Box-Behnken optimization to develop cefuroxime transfersomal patch for diabetic ulcer biofilm eradication. (PubMed, Int J Pharm) - "This patch platform with transferosomal technology significantly improves the skin permeation of Cef and the eradication of BF, offering new therapeutic possibilities for the treatment of DUs linked with BF."

Journal

Differential risk signals of cutaneous adverse drug reactions among β-lactam antibiotics: ceftriaxone shows increased signals for SJS/TEN in clinical and real-world cohorts. (PubMed, Front Med (Lausanne)) - "Separate analyses were conducted comparing ceftriaxone with aminopenicillins, cefazolin, cefuroxime, and allopurinol, which was included as a positive control. While both datasets need to be interpreted within the context of their respective limitations, our analysis, are in line with previous studies, suggesting that ceftriaxone may have an SJS/TEN risk profile that exceeds the class-wide risk observed among cephalosporins. This underscores the importance of substance-specific, rather than purely class-based approaches in both clinical research and pharmacovigilance."

Adverse drug reaction • Journal • Real-world evidence • Steven-Johnson Syndrome

Antibiotic use in bronchiolitis at a tertiary hospital in Sokoto, Nigeria: clinical audit highlighting predictors of prescription (ERS 2026) - "Majority (90.5%) received antibiotics, with the most prescribed being intravenous cefuroxime (93.2%), intravenous ceftriaxone (86.7%) and oral azithromycin (41.7%). Antibiotic overuse is high in children admitted for bronchiolitis, hence the need for antibiotic stewardship."

Clinical • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Perioperative antibiotic prophylaxis in trauma surgery and orthopedics (PubMed, Unfallchirurgie (Heidelb)) - "The standard is cefazolin 2 g i.v. or cefuroxime 1.5 g i.v., administered approximately 30 min before skin incision. Prolonged antibiotic administration should be avoided."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Antibiotic prophylaxis in shoulder arthroplasty - increased number of early infection revisions in patients treated with clindamycin compared to cefuroxime. (PubMed, JSES Int) - "Clindamycin antibiotic prophylaxis may result in more early infection revisions in shoulder arthroplasty when compared to cefuroxime prophylaxis. This finding suggests that cefuroxime may be preferred over clindamycin for routine prophylaxis, although missing data warrant cautious interpretation."

Journal • Infectious Disease • Orthopedics

Antibacterial consumption in four paediatric inpatient facilities in Sri Lanka in 2023: a cross-sectional descriptive study. (PubMed, BMJ Open) - "High use of broad-spectrum and Watch-group antibacterials was observed across the four paediatric inpatient facilities. The findings highlight targets for antibacterial stewardship programmes and demonstrate the feasibility of ABC surveillance in Sri Lanka."

Journal • Pediatrics

Prevalence, genomic characterization, and biofilm-forming capacity of extended-spectrum β-lactamase-producing Escherichia coli from faecal samples of broiler chickens in Jinan City, China. (PubMed, Poult Sci) - "Antimicrobial susceptibility testing revealed markedly more severe resistance among ESBL-producing isolates, with complete ampicillin resistance (100 %) and high-level resistance to sulfamethoxazole/trimethoprim (94.37 %), streptomycin (87.32 %), chloramphenicol (78.87 %), and tetracycline (70.42 %). Resistance to extended-spectrum cephalosporins cefuroxime and ceftriaxone reached 43.66 % and 36.62 %, respectively, while amoxicillin/clavulanic acid susceptibility declined to 61.97 %...The plasmid-mediated colistin resistance gene mcr-1 was detected in 25.35 % of ESBL-producing isolates, indicating a substantial reservoir of last-resort antibiotic resistance determinants, though physical linkage between mcr-1 and ESBL-encoding genes remains undetermined due to short-read sequencing limitations...These findings demonstrate that broiler chickens in the sampled Jinan farms constitute a significant reservoir of multidrug-resistant, biofilm-forming ESBL-producing E. coli..."

Journal

Detection and antimicrobial susceptibility patterns of Salmonella enterica subsp. arizonae and Proteus spp. associated with gastrointestinal disease in rescued hedgehogs (Erinaceus europaeus). (PubMed, Comp Immunol Microbiol Infect Dis) - "isolates were susceptible to cefotaxime, nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, amikacin, gentamicin, tobramycin, aztreonam, cefoxitin, ceftazidime and fosfomycin. However, resistance was observed to amoxicillin-clavulanic acid, ampicillin, ertapenem, meropenem, trimethoprim-sulfamethoxazole, cefuroxime, piperacillin-tazobactam, colistin and nitrofurantoin, with the latter two showing resistance in all Proteus spp...from hedgehog samples may display relevant antimicrobial resistance (AMR) patterns. Therefore, continuous bacteriological monitoring and antimicrobial susceptibility testing are important in wildlife rehabilitation settings to guide treatment decisions and support One Health surveillance."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Two-day versus three-day systemic antibiotic prophylaxis for Gustilo-Anderson type IIIA and IIIB open tibial fractures (PROACT): a randomised controlled trial. (PubMed, Lancet Reg Health Southeast Asia) - "Adults (≥18 years) with Gustilo-Anderson type IIIA or IIIB open tibial fractures were randomly assigned (1:1) to receive 2 days or 3 days of intravenous cefuroxime and amikacin; metronidazole was added for farm-related contamination. Larger multicentre studies are warranted to confirm these findings. This study received no external funding."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Simulating an intravenous-to-oral cefotaxime-to-cefditoren/cefuroxime switch: an in vitro pharmacodynamic approach against selected Streptococcus pneumoniae strains with defined susceptibility profiles. (PubMed, Front Pharmacol) - "Overall, despite the limitations of the proposed model in reproducing the antimicrobial activity of agents with high plasma protein binding, such as CDN, greater in vitro pharmacodynamic activity was observed with CDN than with CXM in the simulated sequential regimens against the four strains tested, particularly against CTX-susceptible strains. These findings warrant confirmation in clinical studies before any therapeutic recommendation could be made."

Journal • PK/PD data • Preclinical • Infectious Disease • Pneumococcal Infections • Pneumonia

Microbiological spectrum and antimicrobial resistance patterns in pediatric acute appendicitis: implications for evidence-based empirical therapy. (PubMed, Front Pediatr) - "All patients received a standardized preoperative antimicrobial regimen (cefuroxime 50 mg/kg plus metronidazole 7.5 mg/kg, administered intravenously within 30-60 min before surgical incision), which was documented for each case...coli remained highly susceptible to amikacin and imipenem, but showed substantial resistance to co-trimoxazole and ceftriaxone...The findings should be interpreted in the context of the study's aerobic culture methodology, which may have limited recovery of anaerobic organisms. These findings support the use of local resistance surveillance to guide severity-based empirical antibiotic selection, especially in complicated appendicitis."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pediatrics

Changing Trends in the Microbiological spectrum and clinical presentation of Postcataract Endophthalmitis over a 23-year period. (PubMed, Am J Ophthalmol) - "This retrospective comparative cohort study of 234 cases across two periods spanning 23 years was associated with a marked shift in the bacterial spectrum of acute postcataract endophthalmitis, with fewer coagulase-negative staphylococci and more Enterococcus faecalis isolates, alongside increased cefuroxime and methicillin resistance. Continued microbiological surveillance is warranted to guide empiric therapy and future prophylactic strategies."

Journal • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Successful Management of a Massive Second-Trimester Subchorionic Hematoma: A Case Report. (PubMed, Case Rep Med) - "Following written informed consent, intramuscular progesterone was administered to suppress uterine activity, and intravenous cefuroxime was initiated for prophylaxis against infection. The subchorionic hematoma resolved completely by 28 weeks and 3 days' gestation, and a viable female neonate was delivered by cesarean section at 39 weeks and 1 day's gestation. In conclusion, this study provides a detailed, real-world example of managing a high-risk, massive subchorionic hematoma in the absence of standardized guidelines, which lays a practical foundation for future research."

Journal • Infectious Disease • Obstetrics