cefuroxime / Generic mfg. - LARVOL DELTA

Analysis of the Type VI secretion system and microbiological characteristics of hypervirulent Klebsiella pneumoniae causing urinary tract infections. (PubMed, J Infect Dev Ctries) - "T6SS-positive hvKP exhibits lower antimicrobial resistance but stronger virulence, playing a major role in bacterial competition."

Journal • Observational data • Retrospective data • Cardiovascular • Hematological Disorders • Infectious Disease • Nephrology • Pneumonia • Thrombosis

Antimicrobial resistance of bacteria isolated in a resource-limited region: the experience of the North Kivu Provincial Reference Laboratory in the Democratic Republic of the Congo. (PubMed, Front Med (Lausanne)) - "In E. coli, resistance exceeded 60% to ampicillin, amoxicillin/clavulanate, and ciprofloxacin...pneumoniae showed uniform resistance to ampicillin and high resistance to cefuroxime, cefotaxime, gentamicin, and colistin...Recommended actions include participation in WHONET/GLASS program and antibiotic stewardship. In the interim, empiric strategies should favor nitrofurantoin for uncomplicated cystitis, judicious aminoglycoside use where appropriate, early culture, and prompt de-escalation, reserving carbapenems for severe ESBL-risk presentations."

Journal • Infectious Disease • Pneumonia

Distribution and antibiotic resistance of Gram-negative bacteria from blood cultures before and during the COVID-19 pandemic. (PubMed, J Infect Dev Ctries) - "K. pneumoniae remained the most frequently isolated bacterium in both periods, while A. baumannii showed a significant increase during the pandemic. The 2.6-fold increase in A. baumannii may have been caused by the increased use of broad-spectrum antibiotics during the pandemic. These findings reflect data from a single hospital and should be validated by further multicenter studies."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Efficacy analysis of a bismuth-containing quadruple therapy with vonoprazan for Helicobacter pylori infection. (PubMed, Scand J Gastroenterol) - "The eradication rates for each subgroup were: Clarithromycin + Amoxicillin 93.3% (714/765), Furazolidone + Amoxicillin 93.5% (87/93), Clarithromycin + Furazolidone 73.7% (42/57), Levofloxacin + Cefuroxime 81.3% (39/48), Clarithromycin + Cefuroxime 100% (24/24), Levofloxacin + Clarithromycin 80.0% (12/15), and Levofloxacin + Furazolidone 40.0% (6/15). The vonoprazan-based bismuth-containing quadruple therapy is a highly effective and safe regimen for Hp eradication, achieving a high overall success rate. It represents a preferred strategy for clinical treatment, especially for Hp-infected patients with peptic ulcers."

Journal • Addiction (Opioid and Alcohol) • Gastroenterology • Infectious Disease • Peptic Ulcer

Failure of Endophthalmitis Prophylaxis: A Laboratory Model Comparing Antibiotics and Bacterial Loads. (PubMed, J Cataract Refract Surg) - "High bacterial loads can multiply uncontrollably in the presence of antibiotics which are effective when the bacterial load is lower; this underscores the importance of uncontaminated equipment and ocular surface antisepsis. Broadest coverage against common postoperative endophthalmitis pathogens was demonstrated by moxifloxacin and ceftazidime."

Journal • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumococcal Infections • Pneumonia

A case report of congenital anterior urethral diverticulum: Is parental consanguinity a possible risk factor? (PubMed, Urol Case Rep) - "A clean catch urine sample was positive for E. coli and was sensitive to Cefuroxime...The penis was degloved, the cavity of the anterior urethral diverticulum was opened, the edges were excised, and the mouth of the diverticulum was closed. Consanguinity as a risk factor remains to be explored."

Journal

A retrospective assessment of antimicrobial resistance patterns in WHO-access, watch, and reserve-classified antibiotics across two large hospitals in a resource-limited setting. (PubMed, Sci Rep) - "For the Access category, highest resistance was reported for Doxycycline at 100% resistance while the lowest resistance was reported for Amikacin at 24.63%. For the Watch category, the highest resistance was reported for Cefuroxime at 85.71% while the lowest resistance was reported for ticarcillin/clavulanic acid and Netilmicin, both with 0% resistance...More than 70% of multi-drug resistance was observed in frequently used antibiotics such as Cefuroxime, Ceftazidime, and Meropenem. Additionally, over 60% resistance was found in antibiotics like Ertapenem, Aztreonam, and Teicoplanin even though they are not readily available in Nigeria...Across gender, positive isolates were found more in women than men across almost all the microbes identified. These results, based on real patient data, highlight the urgent need for an institutionalized AWaRe Antibiotics framework across healthcare facilities in addition to broader strategies of antimicrobial stewardship, pharmaceutical..."

Journal • Retrospective data

Complex Management of an Infected Pancreatic Collection With Walled-Off Necrosis in Acute Pancreatitis: A Case Report. (PubMed, Cureus) - "Endoscopic transluminal drainage (ETD) was performed, followed by empiric antibiotics, later adjusted to cefuroxime based on collection fluid cultures. The patient developed septic shock with Pseudomonas aeruginosa isolation in blood cultures, prompting targeted ceftazidime therapy. Repeat ETD with necrosectomy addressed the ongoing infection, with polymicrobial cultures necessitating an extended course of targeted antibiotics and antifungals. Clinical improvement ensued, culminating in discharge home. This case underscores the challenges in managing severe NP and highlights the efficacy of a multidisciplinary approach for improved patient outcomes."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Pain • Pancreatitis • Septic Shock • Thrombosis

Thoracic surgeons' practice and attitude towards surgical antimicrobial prophylaxis in VATS lung surgery: A survey within a large medical consortium. (PubMed, PLoS One) - "The study underscores the need for updated, multidisciplinary guidelines for VATS lung surgery, emphasizing the importance of a collaborative approach among healthcare professionals to optimize individualized SAP."

Journal • Infectious Disease

Coccydynia caused by anatomical variation of the first coccygeal vertebra: a case report. (PubMed, J Med Case Rep) - "This case provides new insights into the etiology and pathogenesis of coccydynia."

Journal • Anesthesia • Infectious Disease • Mood Disorders • Pain • Pediatrics

First report of extended-spectrum beta lactamase (ESBL) and carbapenemase-producing MDR Klebsiella pneumoniae from Fuchka. (PubMed, PLoS One) - "All showed resistance to amoxicillin and cefuroxime (100%), while most were sensitive to cefepime (96.7%), norfloxacin (96.7%), imipenem (93.3%) and meropenem (83.3%). Moreover, other resistance determinants (aadA1, aac3IV was most prevalent (40%) but aadA1, qnrA were not detected. The presence of multidrug-resistant, ESBL- and carbapenemase-producing K. pneumoniae in fuchka represents a critical threat to public health."

Journal • Infectious Disease • Pneumonia

High prevalence of class 1 integron, biofilm formation, and antimicrobial resistance profiles of Escherichia coli isolated from cattle, water, and soil in Bangladesh. (PubMed, BMC Microbiol) - "This study reveals a high prevalence of class 1 integron and the mcr-1 gene in MDR E. coli from food animals in Bangladesh, highlighting their role in resistance dissemination and the public health risk of colistin resistance. The strong association of integron with MDR and mcr-1 underscores the need for prudent antibiotic use, routine surveillance, and stronger antimicrobial stewardship in livestock to limit the spread of resistance to humans."

Journal

Do the redefined EUCAST susceptibility categories warrant adjustment of paediatric antibiotic dosages? Pragmatic physiologically based pharmacokinetic modelling of four commonly used agents. (PubMed, J Antimicrob Chemother) - "In contrast to adults, there is no need to increase the currently recommended paediatric dosages for the tested antibiotics. At the same time, further simulations showed that the PTA varies by drug-micro-organism combination and age, providing a potential opportunity to tailor doses to individual patients."

Journal • PK/PD data • Infectious Disease • Pediatrics

Prevalence, Characterization and Genetic Diversity of Listeria monocytogenes in Ready-to-Eat Raw Salmon (Salmo salar) and Trout (Oncorhynchus mykiss) Products. (PubMed, Foods) - "All isolates were resistant to cefuroxime sodium, ceftriaxone, cefepime and nalidixic acid, and 13% showed resistance to sulphamethoxazole-trimethoprim. The five highly virulent isolates exhibited the highest genetic similarity to J2-031 (GCA_000438645.1) and C1-387 (GCA_000438605.1). The results provided valuable information for Chinese regulatory authorities to strengthen the risk monitoring of L. monocytogenes in ready-to-eat raw salmon and trout products."

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A Retrospective Study on the Aetiology of Clinical Bovine Mastitis and Its Antibiotic Resistance Profiles in Western Australia Dairy Farms. (PubMed, Microorganisms) - "The antimicrobial profiles revealed high susceptibilities towards cefuroxime (95.7%), clavulox (89.4%), and oxytetracycline (89%), whilst showing high resistance towards novobiovin (70%). There is a need to consider surveillance programmes that determine the patterns of on-farm antimicrobial usage and further characterise the pathogens based on the presence of resistance antimicrobial genes. Data on antimicrobial surveillance represent an important component of antimicrobial stewardship."

Journal • Retrospective data

Thermally Stable Naphthalenediimide Alkali-MOFs Exhibiting Photo-Thermochromism for Cefuroxime Detection and Information Encryption. (PubMed, Inorg Chem) - "Based on this, a dynamic information encryption system was successfully established, which can generate specific passwords within a certain period of time, and a color-based encryption strategy was developed by using an 8888-type mold to brush the powder to encrypt specific four-digit numbers. Moreover, both AMOFs can be used as fluorescent sensors for the detection of the antibiotic cefuroxime, demonstrating good application potential in the fields of medicine and ecological protection."

Journal

Safe Surgery Checklist Reduces Infections and Costs in Spine, Hip, and Knee Procedures. (PubMed, Surg Infect (Larchmt)) - "Implementation of the Safe Surgery Program was associated with reduced SSI incidence and hospital costs in complex orthopedic procedures. Blood transfusion remained an important risk factor, highlighting the value of optimization of peri-operative management and adherence to surgical safety practices."

Journal • Infectious Disease • Orthopedics

Prior culture-guided prediction of antibiotic susceptibility in recurrent respiratory tract infections: a retrospective cohort analysis. (PubMed, Front Cell Infect Microbiol) - "Prior cultures had good predictive value (>70%) for detecting future resistance to 22 antibiotics, with ciprofloxacin, levofloxacin, cefuroxime, cefotaxime, ampicillin, ampicillin/sulbactam, and ceftriaxone showing excellent predictive values (≥85%). Additionally, prior cultures had excellent predictive value (≥85%) for detecting future susceptibility to imipenem, amikacin, tobramycin, meropenem, minocycline, and tigecycline. Considerable antibiotic resistance was detected among isolates in patients with RRTIs. Using a prior culture as a guide can enhance the probability of selecting an effective empirical agent."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Antimicrobial susceptibility and risk factors of asymptomatic bacteriuria among pregnant women attending antenatal care at public health facilities in Debre Markos town, Northwest Ethiopia. (PubMed, BMC Microbiol) - "ASB prevalence was 16.2%; E. coli was the predominant isolate; the MDR rate was 40%. Diabetes, vaginal douching, catheterization, and prior UTI were associated with ASB. Routine urine culture should be considered for targeted screening and culture-guided therapy for high-risk groups. Further studies are needed to evaluate prophylaxis and treatment outcomes."

Journal • Diabetes • Metabolic Disorders • Nephrology

Synthesis, characterization, and performance of the Fe-HApBio heterogeneous catalyst for electro-Fenton degradation of cefuroxime sodium. (PubMed, RSC Adv) - "Moreover, heterogeneous EF treatment enhanced the biodegradability of the solution after 90 minutes, and therefore, allowed its subsequent low-cost biological treatment. After 17 days, aerobic biological post-treatment achieved almost complete mineralization, which indicated the overall efficiency, sustainability, and less energy consumption of the process."

Heterogeneity • Journal

Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures (clinicaltrials.gov) - P=N/A | N=174 | Recruiting | Sponsor: Olawumi Olajide

New trial • Gastroenterology • Infectious Disease • Pediatrics

Comparative Evaluation of Efficacy of Transdermal Buprenorphine Patch versus Intraoperative Cocktail Injection for Post-operative Pain Relief in Total Hip Arthroplasty. (PubMed, J Orthop Case Rep) - "At the same time, Group 2 (n = 22) received an intraoperative periarticular cocktail injection composed of 0.2% ropivacaine, cefuroxime, triamcinolone, ketorolac, adrenaline, and normal saline (45 mL). Tailoring the choice of analgesic strategy to patient-specific needs and surgical context may optimize pain management in hip arthroplasty. To the best of our knowledge, this is the first study directly comparing transdermal buprenorphine patches with periarticular cocktail infiltration for post-operative pain management in THA."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

Anaphylaxis and Cardiac Arrest Induced by Initial Intravenous Ceftriaxone: A Case Report. (PubMed, Am J Case Rep) - "She had been taking cefuroxime and aminophylline, with no known antibiotic allergies. No complications were noted at 1-month follow-up. CONCLUSIONS An initial intravenous dose of ceftriaxone may trigger rare but serious anaphylactic reactions, even in patients without a history of drug allergy, underscoring the need for vigilant monitoring during administration."

Journal • Allergy • Cardiovascular • Cough • Critical care • Dermatology • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases • Urticaria

Bacterial Profile and Antimicrobial Susceptibility Patterns in Diabetic Foot Ulcers: A Cross‑Sectional Study in Bangladesh. (PubMed, Cureus) - "In the Gram‑positive panel, erythromycin showed the highest resistance (S. aureus 92.9%; Enterococcus spp. 83.3%), with ampicillin/vancomycin/linezolid also high. In the Gram-negative panel, ampicillin, ciprofloxacin and cefuroxime carried heavy resistance burdens (reaching 100% in P. aeruginosa). By contrast, resistance to piperacillin-tazobactam and imipenem was low in E. coli (10.7% and 14.3%, respectively); in K. pneumoniae it was higher for piperacillin-tazobactam than imipenem (41.7% vs 16.7%); and in P. aeruginosa the pattern was reversed, with 10.0% resistant to piperacillin-tazobactam and 40.0% resistant to imipenem...Tigecycline showed the best preserved activity. Empirical treatment should be guided by local data, prioritise agents with retained activity against both Gram‑positive and Gram‑negative pathogens, and be promptly narrowed once susceptibilities are available. Continued local surveillance and strong antimicrobial stewardship are..."

Journal • Observational data • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia

Cephalosporin-induced hemolytic anemia: a case study. (PubMed, Immunohematology) - "The patient's condition improved rapidly after stopping cephalosporins and starting ciprofloxacin/levofloxacin and clindamycin, which resulted in an Hb increase to 9.1 g/dL within 48 hours and the absence of hemoglobinuria. This case shows why health care professionals must identify DIIHA early through diagnostic testing even when patients have shown previous tolerance to antibiotics. This case report also shows that both cefuroxime and ceftriaxone were the drugs responsible for the DIIHA."

Journal • Anemia • Cardiovascular • Hematological Disorders • Infectious Disease • Nephrology • Renal Disease