cefuroxime / Generic mfg. - LARVOL DELTA

Expression of Deiodinase Type II in Cancer-Associated Fibroblasts (ATA 2025) - "DIO2 mRNA expression and enzyme activity were measured in primary CAF cultures and in tumors from TBP mice treated with cefuroxime (DIO2 inhibitor) alone or in combination with lenvatinib (multikinase inhibitor). CAF-specific DIO2 expression is observed across many human tumor types and is associated with a pCAF transcriptome profile. Our in vivo and in vitro DIO2-expressing CAF models enable us to study the functional role of CAF DIO2 in tumor progression. Targeting DIO2 may represent a novel strategy for selectively inhibiting or reprogramming pCAFs while preserving tumor-restraining CAF populations, addressing a major challenge in CAF-directed therapy."

Oncology • Solid Tumor • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma • CAFs

An Unusual Culprit in Cholecystitis: R. Ornithinolytica in a Cirrhotic Patient (ACG 2025) - "Blood cultures grew R. ornithinolytica sensitive to third-generation cephalosporins; antibiotics were narrowed to ceftriaxone and metronidazole...The patient improved and was discharged on day 7 with a cholecystostomy tube and 7-day oral cefuroxime and metronidazole.Four weeks later, he re-presented with RUQ discomfort and change in catheter output to orange-brown, concerning for acute-on-chronic cholecystitis...Awareness of its pathogenicity is essential in high-risk patients.Figure: Figure 1. HIDA scan images (0–35 minutes) showing normal hepatic uptake and biliary excretion with persistent non-visualization of the gallbladder, consistent with cystic duct obstruction and acute cholecystitis."

Clinical • Anemia • Fibrosis • Gastroenterology • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Leukopenia • Liver Cirrhosis • Metabolic Disorders • Septic Shock • Thrombocytopenia

FLUOROSCOPIC GUIDED TRANSBRONCHIAL LUNG BIOPSY UNMASKS METASTATIC ADENOCARCINOMA MIMICKING NONRESOLVING PNEUMONIA (MTS 2025) - "Case Report A 73-year-old Malay man, an ex-smoker, 10 pack-years, presented with a one-month productive cough and progressive exertional dyspnoea despite four weeks of oral cefuroxime for sputum cultureproven Klebsiella pneumoniae pneumonia treated at a different centre...While awaiting molecular profiling, the patient received dexamethasone for lymphangitis carcinomatosis and was referred to oncology...This case underscores three key points: (1) persistent consolidation after appropriate antibiotics demands re-evaluation; (2) diffuse infiltrates with sclerotic bone lesions should raise suspicion of metastatic malignancy; and (3) fluoroscopic-guided trans-bronchial lung biopsy remains a simple, low-cost, high-yield technique when bronchoscopic visual cues are absent and advanced navigation tools are unavailable. Early biopsy-driven diagnosis accelerates molecular testing, avoids therapeutic delay, and streamlines palliative oncology care."

Biopsy • Metastases • Cough • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Tuberculosis • Napsin A • NKX2-1

Perioperative Gentamicin Prophylaxis in Robot-Assisted Prostatectomy Increases Acute Kidney Injury Risk. (PubMed, Urol Int) - "The risk of AKI was significantly higher after PAP with gentamicin compared to PAP with cefuroxime (OR: 6.25, 95% CI: 2.095-18.664, p = 0.001), suggesting that PAP with gentamicin should be avoided in RARP."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study. (PubMed, Antibiotics (Basel)) - "A MD catheter was inserted into the joint during explantation of the infected inlying implant and implantation of a custom-made static spacer coated with COPAL cement (0.5 g gentamicin (G) and 2 g vancomycin (V)). Over 72 h postoperatively, samples were collected and analyzed for spacer-eluted antibiotics, intravenously administered antibiotics (e.g., cefazolin and cefuroxime), metabolic markers (glucose and lactate), and Interleukin-6 (IL-6)...Differentiating infection from surgical response using metabolic and immunological markers remains challenging. Prolonged in vivo studies with MD are required to evaluate extended antibiotic release in two-stage exchanges."

Journal • Preclinical • Infectious Disease • Inflammation • Orthopedics • Pain • IL6

Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb. (PubMed, Pathogens) - "This study revealed an epidemic spread of carbapenemase-producing P. mirabilis in two wards in a psychiatric hospital. Due to the extensively resistant phenotype (XDR), therapeutic options were limited. This is the first report of carbapenemase-producing P. mirabilis in Croatia."

Journal • Infectious Disease • Psychiatry

Risk of conjunctival colonization by cefuroxime-resistant bacteria in cataract surgery patients younger than 75 years and aged 75 or older. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients < 75 years more than they actually do in patients ≥ 75."

Journal • Cataract • Diabetes • Genetic Disorders • Infectious Disease • Metabolic Disorders • Obesity • Ocular Infections • Ocular Inflammation • Ophthalmology

Prolongation of oral antibiotic for prevention of periprosthesis joint infection after aseptic revision: a single center, prospective, randomized controlled trial (ChiCTR) - P=N/A | N=108 | Recruiting | Sponsor: First Affiliated Hospital of Xinjiang Medical University; First Affiliated Hospital of Xinjiang Medical University | -> Recruiting

Enrollment open • Infectious Disease

Acute onset Capgras syndrome after upper respiratory tract infection: a case report on the possible role of inflammation and drug exposure. (PubMed, BMC Psychiatry) - "The etiology and treatment of Capgras syndrome are still unclear and more studies are needed. This case contributes to the limited literature on Capgras syndrome by highlighting a potential temporal link between an acute upper respiratory tract infection, medication exposure, and the onset of delusional misidentification."

Journal • CNS Disorders • Infectious Disease • Inflammation • Psychiatry • Respiratory Diseases

Genomic Signatures of Beta-Lactam Resistance and Reversion in Staphylococcus aureus from Bovine Mastitis. (PubMed, Lett Appl Microbiol) - "aureus ATCC 25923 through serial in vitro exposure to ampicillin sodium salt, cefapirin, cefuroxime sodium salt, and cefquinome. These isolates shared the same resistance-associated mutations as in vitro-selected strains. These findings demonstrate that resistance mutations identified through in vitro selection are also present in clinical isolates, highlighting the clinical applicability of in vitro selection for understanding antimicrobial resistance in mastitis-associated S. aureus."

Journal

Effects of the february 6 earthquake on the agents growing in urine cultures and antibiotic resistance rates. (PubMed, North Clin Istanb) - "The results of our study show that the conditions in communal living areas after the February 6 earthquake had an increasing impact on antibiotic resistance rates and antibiotic resistance rates of certain groups of antibiotics, especially the Enterobacterales group were higher in the first half of 2023."

Journal • Infectious Disease • Nephrology • Urology

Characterizing Antibiotic Practices in Cranial Vault Remodeling Surgery (PSTM 2025) - "The most commonly used primary antibiotics were Cefazolin (92.1%), Clindamycin (2.4%), Cefuroxime (1.5%), and Vancomycin (1.1%). We found that prophylactic IV antibiotic use did not significantly alter the rates of 30-day surgical site infections in pediatric cranial vault remodeling procedures. Results from this study can serve as the basis for further investigation to standardize antibiotic use and stewardship in pediatric craniofacial care."

Surgery • Infectious Disease • Pediatrics

Antimicrobial Resistance Profile of Escherichia coli Isolated from Raw Chicken Meat in a Selected Wet Market in Manila City, Philippines. (PubMed, Acta Med Philipp) - "High resistance rates were observed against ampicillin (92%), tetracycline (88%), trimethoprim-sulfamethoxazole (83%), chloramphenicol (79%), ampicillin-sulbactam (75%), amoxicillin-clavulanic acid (67%), fosfomycin (67%), and streptomycin (54%). The majority of the E. coli isolates were still susceptible to a wide range of selected antimicrobial agents, including carbapenems (100%), ceftriaxone (100%), cefepime (100%), cefuroxime (96%), cefotaxime (96%), ceftazidime (96%), piperacillin-tazobactam (96%), aztreonam (96%), cefoxitin (92%), and nitrofurantoin (83%), among others...This study suggests that chickens in wet markets can potentially serve as reservoir hosts for drug-resistance genes, which could transfer to other bacteria and contaminate humans, animals, and the environment within the food production and supply chain. These findings emphasize the need for AMR surveillance and strategies to combat AMR in the Philippines through the One Health approach."

Journal • Infectious Disease

Simple and robust analysis of cefuroxime in human plasma and bone tissues by LC-MS/MS. (PubMed, Anal Methods) - "Upon stability assessment under varying storage conditions, all samples exhibited a difference of less than 15.0%. The method was successfully applied to the determination of cefuroxime in plasma and bone tissues of actual patients."

Journal • Immunology • Infectious Disease • Orthopedics • Osteoarthritis • Pain • Rheumatology

A ptsH mutation suppresses growth defects and antibiotic sensitivity in a cpgA mutant defective in metabolite proofreading. (PubMed, J Bacteriol) - "This mutant HPr protein increases carbon catabolite repression to restrict import of intoxicating gluconate. These studies highlight the ability of mutations in HPr to rewire carbon catabolism to help avoid the toxic effects of metabolic dysregulation."

Journal • Infectious Disease • Metabolic Disorders • GAPDH

Preoperative Stand-Alone Intraosseous Cefuroxime in Total Knee Arthroplasty: A Randomized Trial Demonstrating Superior Tissue Concentrations and Improved Efficiency. (PubMed, J Arthroplasty) - "Intraosseous cefuroxime (750 or 1,500 mg) achieved higher local tissue concentrations than intravenous 1,500 mg in TKA. Preoperative intraosseous 750 mg cefuroxime alone minimized systemic exposure while maintaining effective concentrations, suggesting its safety and potential as a preferred prophylactic strategy."

Journal • Infectious Disease • Orthopedics • Pain

Analysis of pathogenic features of mucoid Haemophilus influenzae infection in children (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "The in vitro drug susceptibility test results of 23 strains of mucoid Hib showed that the resistance rates to ampicillin, cefuroxime, and Trimethoprim-sulfamethoxazole were 13.0%(3 strains), 13.0%(3 strains), and 87.0%(20 strains), respectively. All the 23 strains of mucoid Haemophilus influenzae infected children were Hib, and the main ST types were ST386 and ST18. It is very important to advocate Hib vaccination."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Exploring the Association of Antimicrobial Use with Serratia marcescens Resistance Rates via Multiple Linear Regression. (PubMed, Infect Drug Resist) - "The strains showed sensitivity to cefoperazone-sulbactam, cefepime, ertapenem, imipenem, meropenem, amikacin, trimethoprim-sulfamethoxazole, and tigecycline, with resistance rates <10%...Resistance to cefoperazone-sulbactam and imipenem had independent negative linear relationships with gentamicin DDDs; resistance to cefoxitin correlated negatively with piperacillin-tazobactam DDDs; resistance to cefepime showed a negative association with cefuroxime DDDs...Additionally, amoxicillin-clavulanic resistance positively correlated with meropenem DDDs, and levofloxacin resistance positively correlated with gentamicin DDDs...The significant associations between S. marcescens resistance rates and prior antimicrobial consumption patterns underscore the critical impact of antibiotic use on resistance development. This highlights the need for better antimicrobial stewardship to delay resistance and guide prescribing."

Journal

Association between fluoroquinolones and retinal detachment: insights from a large German health claims-based cohort study. (PubMed, BMC Ophthalmol) - "This large German cohort study found no meaningful real-world evidence for the association between fluoroquinolones and retinal detachment compared to a group of active comparator antibiotics."

HEOR • Journal • Retinal Disorders

Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains. (PubMed, Sci Rep) - "The isolates displayed their highest resistance rate to sulfamethoxazole-trimethoprim (94.5%), erythromycin, imipenem (94.1% each), penicillin, ampicillin, streptomycin, gentamycin (90.7% each), ampicillin/sulbactam (89.9%), cefuroxime and cefepime (85.8%), nalidixic acid (85.1%), and tetracycline (78.9%). Remarkably, none of the strains were resistant to meropenem...Our results also show that in order to combat multidrug resistance, new medications and antibiotic substitutes are required. The importance of conducting more surveys to better understand the prevalence of C. perfringens infection under strict management circumstances for various flock purposes cannot be overstated."

Journal • Gastrointestinal Disorder • Infectious Disease

Tough, Antibacterial, and Antithrombogenic Hydrogel Coatings for Blood-Contacting Silicone Medical Devices. (PubMed, ACS Appl Mater Interfaces) - "The strong hydration characteristics of poly(sulfobetaine) (pSB) endow the hydrogel-coated surface with excellent repulsion against coagulation, shielding the interaction of xylitol and cefuroxime sodium...Promisingly, the pXASBCS coating not only showed low toxicity and high hemocompatibility but also prevented the formation of thrombi. The New Zealand white rabbits' arteriovenous shunt model shows that the surface-induced coagulation tendency is reduced when using a pXASBCS-coated catheter in ex vivo rabbit blood circulation."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Thrombosis

Topical antibiotics for treating bacterial keratitis: a network meta-analysis. (PubMed, Cochrane Database Syst Rev) - "In our NMA, mostly moderate- to very low-certainty evidence suggests that vancomycin + ceftazidime combination therapy, moxifloxacin monotherapy, and cefazolin + tobramycin combination therapy may be the most effective treatments for BK in terms of corneal healing time, whereas ciprofloxacin monotherapy is the least effective. Given that most evidence was not of high certainty, the results of this NMA should be interpreted with caution, and future research could potentially alter these findings."

Journal • Retrospective data • Review • Conjunctivitis • Corneal Abrasion • Glaucoma • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Trends of Antibiotic Resistance Patterns and Bacteriological Profiles of Pathogens Associated with Genitourinary Infections in Secondary Healthcare Facilities in the Volta Region of Ghana. (PubMed, Pathogens) - "The isolates were mostly resistant to amoxicillin/clavulanic acid (n = 75, 95% CI [91.8-99.9]), meropenem (n = 61, 95% CI [87.6-99.4]), cefuroxime (n = 54, 95% CI [78.9-96.5]), ampicillin (n = 124, 95% CI [61.2-77.9]), and piperacillin (n = 43, 95% CI [82.9-99.2]). Multidrug-resistant (MDR, 70 (34.1%)), extensively drug-resistant (XDR, 63 (30.7%)), and pandrug-resistant (PDR, 9 (4.3%)) strains of S. aureus, E. coli, and Pseudomonas aeruginosa were identified from the patient samples. The study highlights the presence of high-priority resistant urogenital pathogens of public health significance to varied antibiotic groups."

Journal • Retrospective data • Infectious Disease • Urology

Gram Negative Antibiotic Resistance in the Deceased Donor Setting (WTC 2025) - "Over 90% of E. cloacae were resistant to Cefoxitin (2nd generation Cephalosporin) and >34% of isolates were resistant to Nitrofurantoin...cloacae was also resistant to 2nd and 3rd generation cephalosporin, Cefuroxime (>30% resistence) and Ceftriaxone (>20%)...pneumoniae was resistant to Ampicillin and Cephalothin but sensitive to most commonly prescribed antibiotics including Tigecycline (used to treat multi-drug resistant strains of K. pneumonia)...aeruginosa recovered isolates were responsive to most antibiotics with the highest resistance to Aztreonam (14%).* Our data demonstrates the antibiotic susceptibility of GNB recovered from the deceased donor population and the variability of resistance across antibiotics. Our data demonstrates the antibiotic susceptibility of GNB recovered from the deceased donor population and the variability of resistance across antibiotics. This information is useful in establishing prophylactic donor antibiotic selections when..."

Gram negative • Infectious Disease • Pneumonia • Respiratory Diseases

Canine Pyoderma and Otitis Externa: A Retrospective Analysis of Multidrug-Resistant Bacterial Carriage in Hong Kong. (PubMed, Antibiotics (Basel)) - "High resistance rates were observed for orbifloxacin (61.3% in pyoderma; 76.7% in otitis externa), doxycycline (59.3%; 69.2%), clindamycin (62%; 68.9%), and enrofloxacin (50%; 55.5%). Most isolates were sensitive to ofloxacin, ticarcillin-clavulanate, tobramycin, ciprofloxacin, cefpodoxime, cefuroxime, and cefixime...A higher focus should be placed on topical antiseptic therapy, with oral antibiotics used only in exceptional cases and after susceptibility testing. From a One Health perspective, the potential transmission of MDR bacteria between companion animals and humans underscores the importance of a coordinated approach to antimicrobial stewardship across both veterinary and human medicine."

Journal • Retrospective data • Dermatology • Infectious Disease • Otorhinolaryngology