cefuroxime / Generic mfg. - LARVOL DELTA

β-Lactam dosing in critically ill children: predictors for target non-attainment. (PubMed, J Antimicrob Chemother) - "This study found an eGFR ≥90 mL/min/1.73 m2 to be associated with target non-attainment, indicating that kidney function should be taken into account when identifying individuals who may require higher dosages. These results may help identify subpopulations of paediatric patients requiring higher dosages or continuous infusion in order to achieve adequate β-lactam exposure."

Journal • Pediatrics

In vitro efficacy of sulbactam/durlobactam combined with β-lactam antibiotics in Australian Mycobacterium abscessus isolates. (PubMed, J Antimicrob Chemother) - "Sulbactam/durlobactam significantly increased susceptibility to oral and intravenous β-lactam antibiotics in the form of cefuroxime, cefuroxime/amoxicillin and meropenem against clinical isolates of M. abscessus. This study also found significant differences in susceptibility to β-lactam antibiotics dependent on the culture media used, highlighting that the optimal culture methods for determining MIC in M. abscessus remains uncertain. Future in vivo studies are required to determine whether the in vitro efficacy of the β-lactam combinations studied could result in clinical efficacy for M. abscessus disease."

Journal • Preclinical

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

A Case Report of Acute Generalized Pustular Bacterid Preceded by Tinea Pedis. (PubMed, Case Rep Dermatol) - "After 1 week of combination therapy with intravenous cefuroxime sodium and topical triamcinolone acetonide and econazole nitrate cream, the skin lesions showed significant improvement. This case highlights that for patients presenting with acute generalized pustular eruptions accompanied by tinea pedis, AGPB should be included in the differential diagnosis. Early recognition and targeted treatment can lead to a favorable prognosis."

Journal • Dermatology • Infectious Disease • Vasculitis

Aetiopathogenesis and Treatment Evaluation of Odontogenic Cellulitis in the Maxillofacial Region: a Retrospective Study. (PubMed, J Oral Maxillofac Res) - "The most frequently detected pathogens - the streptococcus group - are characterized by a high sensitivity to penicillin and clindamycin as well as third-generation cephalosporins. The most effective empirical antibiotic therapy is a combination of cefazolin and metronidazole and cefuroxime and metronidazole. Diabetes mellitus, lung disease, alternating antibiotic therapy and complications prolong the duration of treatment."

Journal • Retrospective data • Review • Critical care • Dermatology • Diabetes • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Antibiotic prophylaxis in trauma and orthopedic surgery : Current practices across 36 German hospitals and comparison with recently published national guidelines. (PubMed, Unfallchirurgie (Heidelb)) - "While guideline adherence is high in routine indications, significant deviations remain in open fractures and distal phalanx fractures of the fingers. Extended prophylaxis beyond 72 h in GA type III fractures and the frequent use of antibiotics in distal phalanx injuries contrast with current recommendations. Stronger implementation of national standards is essential to reduce overtreatment and support antimicrobial stewardship."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Pneumonia with no eschar: an atypical presentation of rickettsial disease. (PubMed, BMJ Case Rep) - "A middle-aged male construction worker presented with a 7-day history of fever, night sweats and malaise, unresponsive to oral cefuroxime. The patient's symptoms and liver function improved with doxycycline, supporting the diagnosis of a systemic rickettsial illness with hepatic and pulmonary involvement. This case is notable for the rare pulmonary involvement in rickettsial infection along with the absence of the typical rickettsial rash or eschar, both of which highlight the diagnostic challenge in this case."

Journal • Hematological Disorders • Hepatology • Infectious Disease • Pain • Pneumonia • Respiratory Diseases • Thrombocytopenia • CRP

Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study. (PubMed, Front Public Health) - "Multivariate logistic regression analysis identified cefuroxime usage [odds ratio (OR) = 0.10, 95% confidence interval (CI) = 0.01-0.92], high WBC count (OR = 0.79, 95% CI = 0.69-0.91), and high neutrophil percentage (OR = 1.49, 95% CI = 1.22-1.82) as independent risk factors for PICU admission (p < 0.05)...Common clinical features of severe pertussis include pneumonia, respiratory failure, elevated WBC count, and decreased neutrophil percentage. Pediatricians should prioritize early recognition and treatment of these clinical indicators to prevent the progression of severe pertussis."

Journal • Retrospective data • Cough • Critical care • Infectious Disease • Pediatrics • Pertussis • Pneumonia • Respiratory Diseases

Clinical Management of Herpes Zoster Complicated by MRSA Infection. (PubMed, Clin Cosmet Investig Dermatol) - "After a clear diagnosis, antiviral treatment with valacyclovir and pain relief with pregabalin was administered...Based on the drug sensitivity results, cefuroxime combined with levofloxacin was administered for anti-infection treatment...Herpes zoster combined with MRSA infection makes the treatment more complicated. This case illustrates the complexities of managing herpes zoster with MRSA and highlights the importance of comprehensive diagnostic and treatment strategies."

Journal • Herpes Zoster • Infectious Disease • Musculoskeletal Pain • Pain • Varicella Zoster

Calcite solubilizing, Multi-metal Tolerant Strain Isolated from Dolomite Affected Tea Garden Shows Plant Growth Promoting Activity. (PubMed, Curr Microbiol) - "Also, displayed resistance against antibiotics, including streptomycin, colistin, cefuroxime, methicillin and fosfomycin. Significant increases in plant height, root length, leaf length and biomass were noted for Phaseolus vulgaris and Vigna radiata on its soil application, with similar effects on increases in chlorophyll content. Overall findings displayed the potentiality of this strain may be used as a bioinoculant in dolomite affected tea gardens for sustainable agriculture."

Journal

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus. (PubMed, Front Microbiol) - "Compared with the wild-type strain, the ampH-knockout strain exhibited significantly increased MICs for carbenicillin, piperacillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam, and ertapenem by at least 2-, 4-, 8-, 4-, 4-, 4-, 4-, 4-, 4-, and 2-fold, respectively. Under ceftazidime stress, P. diazotrophicus reduced aldB expression to increase its tolerance to the antibiotic. The discovery of the mechanism by which AcoR regulates aldB expression provides preliminary evidence for subsequent research on drug resistance mechanisms."

IO biomarker • Journal • Infectious Disease • ACACA • PD-1

Environmental Footprint of Antibiotics: A Multi-Source Investigation of Wastewater Systems in UAE. (PubMed, Antibiotics (Basel)) - "Ciprofloxacin concentrations were highest in hospital wastewater, reaching up to 247.9 ng/mL, while cefuroxime and vancomycin ranged between 0.2 and 10.9 ng/mL across samples. Clindamycin was notably prevalent in wastewater treatment plant samples (up to 10.9 ng/mL), whereas vancomycin and cefuroxime were dominant in residential community samples, reflecting diverse antibiotic usage patterns and persistence in treatment systems. The findings reveal substantial antibiotic contamination in United Arab Emirates wastewater systems, underscoring the need for ongoing surveillance and regulatory measures. Continuous monitoring, coupled with effective wastewater treatment and antibiotic stewardship strategies, is critical to mitigating the environmental spread of antimicrobial resistance and safeguarding public and environmental health."

Journal

Impact of an integrated stewardship intervention at a secondary care hospital in Ras Al Khaimah, United Arab Emirates: findings from September 2018-March 2019. (PubMed, Antimicrob Resist Infect Control) - "This study demonstrates that the incorporation of prospective audit and feedback intervention into the newly implemented antimicrobial stewardship program in the hospital enhanced the selection of surgical prophylactic antibiotics and supported the reduction in surgical site infection rates. However, challenges persist, particularly in maintaining adherence to the recommended timing and duration of prophylaxis, which limited overall compliance and led to higher antimicrobial costs. These findings emphasize the importance of continuous cycles of antibiotic stewardship audit-feedback interventions to standardize prescribing practices and enhance surgical prophylaxis outcomes in the UAE healthcare setting."

Journal • Retrospective data • Infectious Disease

Transient maculopathy after intracameral injection of cefuroxime (PubMed, Ophthalmologie) - "These findings completely resolved within 6 days of treatment with prednisolone acetate and nepafenac eye drops, resulting in full visual recovery.Intracameral administration of antibiotics, in Europe as cefuroxime 1 mg/0.1 ml, is recommended for endophthalmitis prophylaxis at the end of cataract surgery. Patients who have undergone pars plana or anterior vitrectomy apparently have an inherently higher risk of developing maculopathy. Transient cefuroxime maculopathy usually has a benign, self-limiting course. Cataract surgeons should be aware of this condition and avoid overdosing that otherwise safe and effective drug."

Journal • Cataract • Macular Degeneration • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

Cefuroxime-related hemorrhagic retinal vasculitis following cataract surgery. (PubMed, BMC Ophthalmol) - "HRV may occur following intracameral cefuroxime at recommended doses in complicated cataract surgery with posterior capsule compromise. Surgeons should be aware of this rare but serious complication, particularly when posterior capsule integrity is compromised and the administered dose may reach the vitreous."

Journal • Retrospective data • Cardiovascular • Cataract • Hematological Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders • Retinal Vein Occlusion • Vasculitis

Patterns of In-patient Antibiotic Use among COVID-19 Patients in a Tertiary Government Hospital: A Retrospective Cross-sectional Survey. (PubMed, Acta Med Philipp) - "The most frequently prescribed antibiotic therapies are azithromycin (250, 45.9%), ceftriaxone (188, 32.2%), and cefuroxime (58, 9.9%). The collection of culture before the start of antibiotic therapy was at 50.2%. The results from the study highlighted the need for antimicrobial surveillance and stewardship efforts among COVID-19 and other viral infections."

Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Coronary Artery Disease • Diabetes • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pulmonary Disease • Renal Disease • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Kuwait and the United Arab Emirates: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Pneumococci were susceptible to fluoroquinolones (>98%), amoxicillin and amoxicillin/clavulanic acid (>79%-94%), ceftriaxone and cefotaxime (>73%-94%). Susceptibility was lower to oral/low-dose penicillin (20%-27%), macrolides (33%-51%), tetracyclines (53%-59%) and trimethoprim/sulfamethoxazole (33%-61%). Susceptibility was generally >80% in H. influenzae except for trimethoprim/sulfamethoxazole (47%-56%)."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Pakistan: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Although antimicrobial resistance was observed, many therapeutic options remain to treat S. pneumoniae and H. influenzae from CA-RTI in Pakistan despite concerns about high levels of inappropriate antibiotic use. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Oncology • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "For H. influenzae, 100% susceptibility (CLSI) was observed to amoxicillin/clavulanic acid, macrolides, most cephalosporins and tetracycline. S. pneumoniae susceptibility was 100% to fluoroquinolones, 90.6%-96.9% to third-generation cephalosporins and 96.9% to amoxicillin and amoxicillin/clavulanic acid. This is consistent with previous resistance surveillance in Ukraine. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Italy and Spain: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Susceptibility of S. pneumoniae to many antibiotics was low in both countries, with susceptibility > 90% observed only with high-dose penicillin and fluoroquinolones (CLSI and EUCAST) and high-dose amoxicillin or amoxicillin/clavulanic acid (PK/PD). Higher susceptibility was seen with H. influenzae in both countries. Continued surveillance of antimicrobial resistance is important for guiding therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Türkiye: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Susceptibility in S. pneumoniae was 90% except for trimethoprim/sulfamethoxazole and ampicillin. These data are similar to recent surveillance of antibiotic resistance data in Türkiye."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in India: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Some therapeutic options against S. pneumoniae and H. influenzae from CA-RTI in India remain, but only ceftriaxone covers both bacterial species using both guidelines. Continued surveillance of antibiotic susceptibility is important to monitor changes and trends in susceptibilities and for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Estimating antibiotic resistance following antibiotic treatment in outpatients: a retrospective study. (PubMed, Clin Microbiol Infect) - "Our study provides novel estimates of the impact of exposure to oral antibiotics on resistance of future urinary pathogens. These estimates are relevant for both antibiotic treatment guidelines and clinical decision-making."

Journal • Retrospective data • Infectious Disease

Microbiological Profile of Sputum Cultures in Patients with Severe Bronchiectasis: A Cross-Sectional Study (APSR 2025) - "Pseudomonas species showed high resistance to tetracycline (94.44%) and cefuroxime (100%), but good susceptibility to colistin (77.78%) and amikacin (83.33%)...Klebsiella species were uniformly resistant to amoxicillin-clavulanate, ceftriaxone, and cefuroxime, but susceptible to colistin (100%). Acinetobacter species showed high resistance to erythromycin (100%), but susceptible to colistin (88.89%)...Enterobacter species showed high resistance to many antibiotics, but sensitivity to collistin (80%), gentamicin (80%), tigecycline (60%) and meropenem (40%). Conclusion : This study highlights the complex microbiological landscape of severe bronchiectasis, emphasizing widespread antibiotic resistance, the potential of colistin, challenges posed by multidrug-resistant organisms, and the need for robust antibiotic stewardship and culture-guided therapy to improve patient outcomes."

Observational data • Bronchiectasis • Infectious Disease • Influenza • Pulmonary Disease • Respiratory Diseases

Repurposing cephalosporins as excellent anticancer agents and chemosensitizers for inflammation-driven cancer therapy. (PubMed, Sci Rep) - "Cefamandole nafate (CAN) and cefuroxime sodium (CUS) demonstrated potent dual efficacy against colorectal cancer model while enhancing cisplatin chemosensitivity. Building on links to inflammation-driven chemosensitization, CUS synergistically potentiated cisplatin and levofloxacin cytotoxicity in colorectal cancer...Crucially, we reveal for the first time that CUS significantly up-regulates HMOX1 expression in HCT116 cells in a dose-dependent manner, establishing this ferroptosis regulator as the central effector governing both intrinsic anticancer activity and chemosensitization. This study unveils the translational potential of repurposing cephalosporins for combinatorial precision oncology strategies targeting inflammation-driven cancers."

Journal • Colorectal Cancer • Oncology • Solid Tumor • CASC19 • DDIT3 • HMOX1 • MUC1