cefuroxime / Generic mfg. - LARVOL DELTA

Investigation of interactions between LDPE containers and ingredients of oil-based ophtalmic formulations. (PubMed, Polim Med) - "The study confirmed the necessity of comprehensive compatibility testing between ophthalmic formulations and their packaging materials. A thorough understanding of these interactions is essential to ensure product stability, safety, and quality during storage and use."

Journal • Ophthalmology

Analysis of Antibiotic Consumption Trends and Pathogens' Epidemiological Profile Within a Multidisciplinary Clinical Hospital from Romania. (PubMed, Antibiotics (Basel)) - "For Reserve antibiotics, only slight annual fluctuations were observed, but there was an important reduction in colistin consumption. The most used were cephalosporins (cefazolin, cefuroxime and ceftriaxone), carbapenems (meropenem and ertapenem), vancomycin and linezolid... The analysis was carried out using tools recommended by the World Health Organisation (Access Watch Reserve antibiotics classification (AWaRe); Bacterial Priority Pathogen List (BBPL); Defined Daily Dose (DDD)), Average Annual Percent Change (AAPC) calculation and ESKAPE classification (bacteria group: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.). Relatively stable trends in bacterial isolates and resistant strains over five years (2020-2024) are consistent with effective antimicrobial stewardship practices."

Journal • Infectious Disease • Pneumonia

FROM RASH TO RENAL RUIN: A CASE REPORT ON RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS SECONDARY TO IMMUNOGLOBULIN A VASCULITIS IN AN ELDERLY FEMALE (ISN-WCN 2026) - "She later developed hypogastric pain and dysuria, for which she was treated with cefuroxime 500 mg tablet twice daily for two days for urinary tract infection (UTI)...Ceftriaxone was discontinued, renal replacement therapy was initiated, and pulse methylprednisolone therapy followed by oral prednisone was given...While not a substitute for renal biopsy, skin biopsy may be a valuable tool in selected vasculitis cases especially in resource-limited settings. Early intervention is critical to prevent irreversible renal damage and to improve long-term outcomes.This abstract was also submitted in the 45th Annual Meeting of the Korean Society of Nephrology."

Case report • Clinical • Chronic Kidney Disease • Glomerulonephritis • IgA Nephropathy • Infectious Disease • Lupus Nephritis • Musculoskeletal Pain • Nephrology • Vasculitis

Case Report: Maculopathy following standard dose intracameral cefuroxime injection during ICL surgery. (PubMed, Front Ophthalmol (Lausanne)) - "Unlike typical post-cataract inflammatory edema, ICOTS presents acutely on day 1. Surgeons should maintain a high index of suspicion and utilize early OCT imaging for unexpected postoperative visual disturbances."

Journal • Age-related Macular Degeneration • Cataract • Diabetes • Macular Degeneration • Macular Edema • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing. (PubMed, J Antimicrob Chemother) - "Prediction of oral second-generation cephalosporins may warrant cefazolin MIC ≤2 mg/L, despite limitations regarding false resistance and susceptibility discordant. Ceftriaxone/cefotaxime demonstrates a more reliable surrogate for predicting oral third-generation cephalosporins susceptibility. Future investigations are necessary to clinically corroborate these findings."

Journal • Infectious Disease

Cephalosporins Versus Non-Cephalosporin Antibiotics for Perioperative Prophylaxis in Primary Arthroplasty: A Systematic Review and Meta-Analysis. (PubMed, Clin Infect Dis) - "Cephalosporins, particularly cefazolin or cefuroxime, remain the preferred prophylactic agents for primary arthroplasty. This quantitative synthesis reinforces their protective association against prosthetic joint infection and supports adherence to guideline-endorsed prophylaxis."

Journal • Retrospective data • Allergy • Immunology • Infectious Disease • Orthopedics

Empirical antibiotic use, resistance patterns, and their impact on clinical outcomes in a Yemeni tertiary hospital. (PubMed, New Microbes New Infect) - "The most commonly prescribed antibiotics were Ceftriaxone, Vancomycin, Levofloxacin, Meropenem, Imipenem/Cilastatin, and Metronidazole. Significant resistance (>50%) was observed against Moxifloxacin, Clindamycin, and all tested beta-lactam agents except Cefuroxime (42%)...These findings underscore the need for effective interventions to optimize antibiotic use and mitigate the growing threat of resistance in Yemen. Strategies such as enhanced diagnostic capabilities, improved stewardship programs, and rational prescribing practices are essential to improve patient outcomes and preserve the effectiveness of antibiotics."

Clinical data • Journal

Analysis of the efficacy of fosfomycin trometamol in preventing biofilm bacterial infection in double-J stents among diabetic patients and the factors associated with infection. (PubMed, Int Urol Nephrol) - "When administered with equivalent dosing frequency (three doses total), FMT was associated with a significantly lower detection rate of biofilm-forming bacteria in double-J stent specimens compared with LFX among diabetic patients. These findings support the preferential use of FMT over LFX for targeted prophylaxis in high-risk diabetic populations and underscore the importance of integrating antimicrobial stewardship-particularly agent selection aligned with local resistance patterns-with proactive management of modifiable risk factors to optimize infection prevention and clinical outcomes."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

Multi-drug-resistant organisms are the main pathogens of surgical-site infection after colorectal surgery: a retrospective study. (PubMed, Infect Prev Pract) - "coli isolates showed high levels of resistance to cefazolin and cefuroxime but low resistance to imipenem, piperacillin and tazobactam. MDROs were the most common pathogens of SSIs after colorectal surgery. Prior antibiotic use, blood transfusion and pre-operative ICU admission are key independent risk factors for SSIs and MDRO infections."

Journal • Retrospective data • Critical care • Infectious Disease

Re-examining cephalosporin activity against methicillin-susceptible Staphylococcus aureus among clinical isolates from southern Taiwan. (PubMed, JAC Antimicrob Resist) - "Non-susceptibility rates ranged from 4.9% to 6.2% for cefazolin, cefuroxime, ceftriaxone, and cefepime. Although elevated oxacillin MICs were associated with higher MICs for several cephalosporins, this relationship was less predictive for ceftaroline. These findings highlight microbiological variability in MSSA cephalosporin susceptibility and may inform situations where direct MIC testing provides additional clarity."

Journal

OmpK35/36 absence does not confer carbapenem-resistance alone nor ceftazidime-avibactam resistance with one bla KPC-2. (PubMed, Front Cell Infect Microbiol) - "As to ΔompK36, the minimum inhibitory concentrations (MICs) of piperacillin, cefoxitin, cefazolin, cefuroxime, and imipenem increased to 4, 4, 4, 8, and 4 times respectively compared with those against NTUH-K2044; the MICs of piperacillin, cefoxitin, cefazolin, cefuroxime, imipenem, and meropenem increased to 8, 32, 32, 16, 8, and 8 times in ΔompK35/36 respectively. The loss of OmpK35/36 confers increased resistance to certain β-lactams, with OmpK36 being dominant. Moreover, OmpK35/36 loss is a contributor but not a determinant in the formation of carbapenem-resistance under the absence of bla KPC-2, as well as in the formation of CZA-resistance with one bla KPC-2."

Journal • Infectious Disease • Pneumonia

Antibiotic therapy in adult patients with infectious mononucleosis in the prehospital period - a single-center experience. (PubMed, Otolaryngol Pol) - "The most common choices were amoxicillin/clavulanate (46.2%), cefuroxime (27.7%), and macrolides (26.1%). Broad-spectrum ATBs are often prescribed. Meticulous clinical evaluation supported by simple and widely available diagnostic tools could reduce the use of antimicrobials in such a patient population."

Journal • Epstein-Barr Virus Infections • Inflammation

Use of a Scattered Light Integrating Collector for Point of Care Testing to Detect Bacteria in Fluid Samples from Prosthetic Joint Infections of the Hip (AAOS 2026) - "Six antibiotics typically used in PJIs were selected for testing: vancomycin, gentamicin, flucloxacillin, rifampicin, cefuroxime, and cotrimoxazole. We demonstrate that in organisms typical for PJI, SLIC detects infection rapidly, shows a high PPV for the presence of antimicrobial resistance, and has strong concordance with BMD in defining AST, at 60 and 120 minutes. This timescale compares favourably to the current laboratory standard (culture and colorimetry), which typically returns results in 48h or longer. SLIC also obviates the need for a priori knowledge pertaining to the likely organism, as is often required by rapid molecular methods."

Infectious Disease • Orthopedics • Septic Shock

Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study. (PubMed, J Antimicrob Chemother) - "A daily dose of 4500 mg cefuroxime provides adequate tissue and plasma concentrations with both BI and CI to achieve ≥50%T > MIC in patients undergoing oral cavity cancer surgery with FAMM flap reconstruction. CI provided more consistent exposure and may offer pharmacokinetic advantages in selected high-risk situations/patients."

Journal • Head and Neck Cancer • Infectious Disease • Oncology • Oral Cancer • Solid Tumor

Antimicrobial resistance patterns of Salmonella spp. identified from retail pork and raw side salads from Busia County, Kenya. (PubMed, Trans R Soc Trop Med Hyg) - "The high prevalence of AMR Salmonella in pork and salad samples highlights the risk of transmission to humans in Kenya. These findings underscore the urgent need for strengthened food safety practices, antimicrobial stewardship and integrated AMR surveillance across livestock value chains."

Journal • Infectious Disease

Intracameral Cefuroxime Use in Cataract Surgery After Penicillin Allergy Reclassification. (PubMed, JAMA Ophthalmol) - "Patient receipt of intracameral antibiotics (1.0 mg/0.1 mL of cefuroxime or 0.5 mg/0.1 mL of moxifloxacin), topical antibiotics (eg, erythromycin or moxifloxacin), or no prophylaxis. Evidence-based antibiotic selection policies for patients with a penicillin allergy label may enhance appropriate use of intracameral cefuroxime in cataract surgery. The rapid increase in cefuroxime use after the policy intervention date suggests surgeons may benefit from education and pharmacy support."

Journal • Allergy • Cardiovascular • Cataract • Immunology • Ophthalmology

Drug-Related Uveitis: A Real-World Study Based on the Food and Drug Administration Adverse Event Reporting System Database. (PubMed, J Ocul Pharmacol Ther) - "Preventing DRU is more effective than treatment. Identifying the risk and drug-induced onset times of these drugs could help medication evaluations and, to a certain extent, avoid the occurrence of DRU."

Adverse events • Journal • Real-world evidence • Ocular Inflammation • Oncology • Ophthalmology • Uveitis

Characterization of Clostridium perfringens Causing Liver Abscess Using Whole-Genome Sequencing: A Case Report and Literature Review. (PubMed, Infect Drug Resist) - "The patient was treated empirically with cefuroxime, ornidazole, and cefoperazone-sulbactam, after which the fever gradually resolved and the patient was discharged in stable condition...Among these cases, only six cases were tested for C. perfringens toxin genes: five cases were associated with the plc gene alone, while one case involved concurrent detection of both plc and pfoA. Overall, this study provided important molecular and clinical evidence to support improved diagnosis, risk assessment, and therapeutic management of liver abscesses caused by C. perfringens."

Journal • Diabetes • Hepatology • Infectious Disease • Metabolic Disorders • Varicose Veins

Antimicrobial resistance dynamics in Mycobacterium tuberculosis coinfection systems: A spatiotemporal strain analysis. (PubMed, Biochem Biophys Rep) - "The drug sensitivity tests results over different years showed that K. pneumoniae exhibited significant resistance rates against doxycycline, ceftazidime, cefepime, cefuroxime, cefazolin, cefotaxime, levofloxacin, ticarcillin/clavulanate, amikacin, and norfloxacin (P < 0.05). The resistance rates of P. aeruginosa to cefazolin and ciprofloxacin were also statistically significant (P < 0.05). The drug sensitivity test results across different regions showed that the resistance rate of K. pneumoniae to minocycline in urban patients was statistically significant (P = 0.012), while the resistance rates of P. aeruginosa to tobramycin and ciprofloxacin in rural patients were statistically significant (P < 0.05)...The rise of new carbapenem-resistant K. pneumoniae strains in 2023 should be monitored. This study provides strong data support to formulate antibiotic treatment plans for patients with tuberculosis and respiratory infections, reduce the risk of resistant..."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

PIVOT: Pivmecillinam as oral step-down treatment for Escherichia coli febrile urinary tract infection versus standard of care; a randomized controlled non-inferiority multicenter trial (clinicaltrialsregister.eu) - P1/2 | N=560 | Recruiting | Sponsor: Uppsala Universitet

Head-to-Head • New P1/2 trial • Infectious Disease • Nephrology

Genomic Characterization of Carbapenemases in Providencia Species from Croatia: The Results of the Multicenter Study. (PubMed, Genes (Basel)) - "Providencia spp., in spite of being a rare pathogen, should be included in the surveillance studies across the medical centers in Croatia."

Clinical • Journal • Infectious Disease

Antimicrobial Resistance, Virulence Factors and Plasmid Replicon Patterns of Klebsiella pneumoniae and Klebsiella grimontii Isolates from Bovine Mastitic Milk in the Northwest of Portugal: Pilot Genomic Characterization. (PubMed, Antibiotics (Basel)) - "pneumoniae-1DH1 (20.0%, 5/25) exhibited phenotypic resistance to amoxicillin-clavulanic acid, ampicillin (AM), cefuroxime, colistin (Cl), and nitrofurantoin (Fd), whereas K. grimontii-2DH2 (8.0%, 2/25) was resistant to AM and nalidixic acid (NA). Novel phenotypic resistance profiles were observed in the BM-associated K. pneumoniae-1DH1 (MDR, Cl and Fd) and K. grimontii-2DH2 (AM and NA) isolates. Notably, K. grimontii-2DH2 harbored a plasmid replicon carrying both the blaCTX-M ARG and the astA VF gene."

Journal • Infectious Disease • Pneumonia

Antibiotic Resistance Patterns in Pancreatic Surgery: A Tailor-Made Antibiotic Prophylaxis in a Secondary Hospital. (PubMed, Cureus) - "In conclusion, our study shows that the frequency of positive bile cultures is much higher in patients previously submitted to biliary drainage, although this did not increase the risk of pancreatic fistula. After subgroup analyses, we concluded that the current standard antibiotic prophylaxis at our institution is inadequate to cover the microbiologic profile observed in our local patient cohort."

Journal • Infectious Disease • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Pneumonia

Diffusion Tensor Imaging in the Diagnosis of Perianal Abscess: Protocol for a Single-Blind Randomized Controlled Trial. (PubMed, JMIR Res Protoc) - "If the patient's blood routine shows infection, cefuroxime sodium combined with metronidazole is being administered intravenously as an anti-infective therapy...DTI technique can be used to gain a deeper understanding of the relationship between internal orifice, the degree of infected infiltration, the extent of the abscess, and the involvement of the perianal tissues and muscles in patients with perianal abscess. Deep pelvic floor DTI reveals the complex 3D structure of the pelvic floor in perianal abscesses through structured reports, which may provide new insights into the diagnosis of perianal abscesses."

Journal • Gastrointestinal Disorder • Infectious Disease • Pain

Bacterial Pathogens and Antibiotic Resistance Patterns in Pediatric Appendicitis: Implications for Antibiotic Choice. (PubMed, Pediatr Infect Dis J) - "In our cohort, cefuroxime/metronidazole seems to be an adequate option for uncomplicated and piperacillin/tazobactam for complicated cases."

Journal • Gastroenterology • Gastrointestinal Disorder • Pediatrics • CRP