cefuroxime / Generic mfg. - LARVOL DELTA

Association of antibiotics with Stevens-Johnson syndrome and toxic epidermal necrolysis: a real-world pharmacovigilance study. (PubMed, Int J Antimicrob Agents) - "Antibiotics including penicillins, cephalosporins, azithromycin, sulfamethoxazole, trimethoprim, vancomycin, doxycycline, and gentamicin are associated with an increased risk of SJS/TEN, with sulfamethoxazole presenting the highest risk. Patients with pneumonia, urinary tract infections, and sepsis are particularly vulnerable. These findings highlight the need for personalized antibiotic regimens based on infection site and patient gender."

Adverse events • Journal • Real-world evidence • Allergy • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases • Septic Shock • Steven-Johnson Syndrome

A Systematic Review and Meta-Analysis on the Presence of Escherichia coli O157:H7 in Africa from a One Health Perspective. (PubMed, Microorganisms) - "The pooled prevalence of antibiotic resistance was observed to be 96.5%, 82.8%, 76.8%, 70.7%, 62.1%, 50.4%, and 40.2% for cefoxitin, ampicillin, cefuroxime, nitrofurantoin, amikacin, amoxiclav, and ciprofloxacin, respectively. This distribution highlights the interconnectedness between animals, the environment, and human populations in the transmission and persistence of this pathogen and the need to implement a suitable and appropriate One Health pathogenic and antimicrobial resistance surveillance system in the African region."

Journal • Retrospective data • Review

Sickle Cell Disease and Antimicrobial Resistance: A Systematic Review and Meta-Analysis. (PubMed, Infect Dis Rep) - "For S. aureus, the pooled resistance was highest for penicillins (ampicillin = 100%; penicillin = 93.64%; and amoxicillin = 77.82%) followed by cefuroxime (51.23%)...SCD patients had 2.89 and 2.47 times higher odds of being colonized or infected with penicillin-resistant and erythromycin-resistant S. aureus strains, respectively...SCD patients have an increased risk of resistance to penicillin and co-trimoxazole across several bacterial pathogens. The limited geographical distribution of the included studies underscores the urgent need for expanded AMR research on the subject, especially in regions with high SCD burden."

Journal • Retrospective data • Review • Genetic Disorders • Hematological Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Sickle Cell Disease

Bacteriological Profile of Diabetic Foot Ulcer With Special Reference to Biofilm Formation. (PubMed, Cureus) - "On antibiotic sensitivity of organisms tested against each antibiotic, more than 75% of tested samples were resistant to ampicillin, cefuroxime, and erythromycin, and around 70% and more of tested samples were sensitive to ertapenem, meropenem, amikacin, gentamicin, benzylpenicillin, vancomycin, and clindamycin. Conclusion The ability to form biofilms adds immensely to the virulence and antibiotic resistance. Detection of biofilm formers is non-invasive and convenient to measure and would help provide insight into antibiotics to be administered to the patient, thereby reducing development of MDROs and reducing healing time."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia

RETRACTION: Effect of Cefuroxime Intracameral Injection Antibiotic Prophylactic on Postoperative Endophthalmitis Wound Post-Cataract: A Meta-Analysis. (PubMed, Int Wound J) - "The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction."

Journal • Retrospective data • Cataract • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases • Tuberculosis

RETRACTION: Effect of Cefuroxime Intracameral Injection Antibiotic Prophylactic on Postoperative Endophthalmitis Wound Post-Cataract: A Meta-Analysis. (PubMed, Int Wound J) - "The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction."

Journal • Retrospective data • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison of Cefuroxime-Based Dual Therapy With Quadruple Therapy in Helicobacter pylori-Infected Treatment-Naive Patients: A Prospective, Multicenter, Randomized Controlled Trial. (PubMed, Helicobacter) - P=N/A | "CQT Was More Effective Than CDT for H. pylori Eradication, Which Might Be Recommended for Penicillin-Allergic Patients. If There Were Contraindications or Intolerance of CQT, CDT Would Be an Alternative."

Clinical • Journal • Infectious Disease

Efficacy and Safety of Cefuroxime-Tetracycline-Containing Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Penicillin-Allergic Patients: A Multicenter Randomized Controlled Trial. (PubMed, Helicobacter) - P4 | "BQT containing cefuroxime and tetracycline is efficacious and safe for the first-line eradication of H. pylori in penicillin-allergic patients. This regimen provides a viable alternative to circumvent the antimicrobial resistance concerns associated with levofloxacin-based regimens."

Clinical • Journal • Allergy • Immunology • Infectious Disease

Structural and Functional Insight into Intracameral Cefuroxime Ocular Toxic Syndrome (ICOTS) in Eyes with Disrupted Intraocular Barrier. (PubMed, Ophthalmol Ther) - "Intracameral cefuroxime ocular toxic syndrome may induce persistent retinal changes despite fluid resolution in eyes with a disrupted intraocular barrier due to prior vitrectomy. Early OCT assessment can help to identify this condition. Further investigation, incorporating UWF-OCTA and ERG for a comprehensive assessment of ICOTS, along with revised informed consent protocols for patients undergoing cataract surgery with this antibiotic prophylaxis, may be indicated when risk factors are identified."

Journal • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

DO THE REDEFINED EUCAST DEFINITIONS WARRANT ADJUSTMENT OF PAEDIATRIC ANTIBIOTIC DOSAGES? A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELLING APPROACH (ESPID 2025) - "Method For amoxicillin, ceftazidime, cefuroxime, and ciprofloxacin, we used existing PBPK models and verified them with adult and paediatric clinical pharmacokinetic data. Conclusions/Learning Points In contrast to adults, there is no need to increase currently recommended paediatric antibiotic dosages for the included drugs. At the same time, further simulations showed that, in case of therapy failure, individualization of doses should be considered in both adults and children, especially in severe infections with micro-organisms with known relatively high minimal inhibitory concentrations."

PK/PD data • Infectious Disease • Pediatrics

PROPENSITY-SCORE MATCHED COMPARATIVE STUDY OF PARENTERAL PENICILLIN G VS. CEFUROXIME/CEFTRIAXONE FOR THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN HOSPITALIZED CHILDREN IN THE POST-PNEUMOCOCCAL CONJUGATE VACCINE ERA (ESPID 2025) - "Multivariate analysis showed that penicillin G was associated with reduced LOS [4.2 days (95% CI: 3.8-4.6) vs. 4.8 days (95% CI: 4.5-5.0); p<0.001]. Conclusions/Learning Points Parenteral penicillin G demonstrated equivalent clinical efficacy to cefuroxime/ceftriaxone in children hospitalized for non-complicated CAP and was associated with a shorter LOS, potentially facilitating an earlier transition to oral therapy."

Clinical • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases • CRP

Cataracts: A Review. (PubMed, JAMA) - "Systemic α1-adrenergic antagonists for symptomatic benign prostatic hyperplasia, such as tamsulosin, increase the risk of surgical complications and some ophthalmologists temporarily discontinue the drug preoperatively. Intraocular antibiotics, such as moxifloxacin or cefuroxime, delivered intraoperatively have reduced the rates of sight-threatening postsurgical endophthalmitis from 0.07% to 0.02%...Cataracts are common among older adults and may cause visual disability and blindness without treatment. Cataract surgery reverses and prevents progressive vision loss, and advanced technology lens implants facilitate reduced dependence on eyeglasses."

Journal • Alzheimer's Disease • Anesthesia • Benign Prostatic Hyperplasia • Cataract • CNS Disorders • Dementia • Developmental Disorders • Diabetes • Genetic Disorders • Infectious Disease • Inherited Retinal Dystrophy • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Retinitis Pigmentosa • Rubella

Genomic characterization and drug resistance of Bordetella pseudohinzii first isolated from wild niviventer. (PubMed, BMC Microbiol) - "The first isolation of B. pseudohinzii from the lung tissue of wild niviventer was reported, and the limitations of traditional methods for identifying B. pseudohinzii were demonstrated. We highlight the superiority of WGS for accurate species identification. The findings reveal a complex pathogenic profile and notable antibiotic resistance, providing important insights for the future prevention and treatment of B. pseudohinzii infections in humans, as well as underscoring the need for monitoring B. pseudohinzii in rodent populations."

Journal • Infectious Disease

Basophil activation test and lymphocyte transformation test in cefuroxime-induced anaphylactic reactions. (PubMed, Front Allergy) - "Our analysis highlights the importance of cefuroxime-associated anaphylactic reactions, as almost all of the spontaneous reports were classified as serious. Neither a negative BAT nor LTT can rule out a sensitization in cefuroxime-induced anaphylactic reactions."

Journal • Allergy • Immunology

Green synthesis of selenium nanoparticles, and its conjugation with antibacterial proteins for enhancing their antibacterial activity. (PubMed, Bioorg Chem) - "The highest percentages of resistance were found for Amikacin (AK; 43 %), Cefuroxime (CXM; 42 %), Gatifloxacin (GAT; 38 %), Clindamycin (DA; 38 %), Ciprofloxacin (CIP; 36 %), Ceftriaxone (CRO; 35 %), Cefoperazone/Sulbactam (CES; 34 %), Nitrofurantoin (F; 31 %), Piperacillin (PRL; 26 %), and Amoxicillin/Clavulanic acid (AMC; 23 %). Results showed that 11S globulin had the highest antibacterial activity of 7S globulin and isolated protein, recording the MIC at 125 μg/mL. Conjugation between Se-NPs with antibacterial proteins (protein isolates, 7S, and 11S) has MBC (125 μg/mL) and MIC (125 μg/mL) values against tested bacteria."

Journal • Infectious Disease • Nephrology • Pneumonia

Surgical Antibiotic Prophylaxis Dosing in Adult Patients with Obesity: A Comprehensive Review of Pharmacokinetic and Pharmacodynamic Data. (PubMed, Anesthesiology) - "Thirty studies investigating cefazolin, cefoxitin, cefuroxime, piperacillin/tazobactam, meropenem, ertapenem, metronidazole, vancomycin, ciprofloxacin, and gentamicin were included in this analysis. Except for metronidazole, cefoxitin, and gentamicin, there is currently no evidence suggesting the need for dosing adjustments."

Journal • PK/PD data • Genetic Disorders • Infectious Disease • Obesity

Whole-genome sequencing of extended spectrum beta lactamases (ESBLs)-producing Klebsiella pneumoniae (kp) isolates from selected hospitals in Malaysia. (PubMed, BMC Genomics) - "The study showed that 46(46%) of the 100 isolates were positive for ESBL production and antibiotic susceptibility testing revealed significant resistance to β-lactam antibiotics including monobactam especially ampicillin/sulbactam (40%), cephalosporin groups (cefuroxime, cefotaxime, and ceftriaxone) stood at 51%, 49% and 48% respectively and aztreonam with 49%. The WGS analysis of the representative strains revealed genes encoding resistance to aminoglycoside (StrA4, StrB1, aac(3')-IIa, aac(6')-1b, aac(6')1b-cr-1, aadA16, aph(3')-VIa and aadA15), trimethoprim (dfrA14 and dfrA27), sulphonamide (sul1_11, sul2_2 and sul2_3), quinolone (QnrB40-1, QnrB10, QnrS2, OqxA and OqxB), tetracycline (tet(A)_4), fosfomycin (fosA3, floR2 and fosA7), macrolid (mph(A)_1), rifampicin (ARR-3), β-lactam (blaCTX-M-15_23, blaCTX-M-55, blaSHV-1_22, blaSHV11_18, blaSHV-11, blaSHV-1_1.1, blaSHV-11_3, blaSHV-11_19, blaTEM-1_1, blaTEM-1_5, blaOXA-51_10, blaOXA-30_1, blaNDM-1,..."

Journal • Gene Therapies • Infectious Disease • Pneumonia

First-time cefuroxime target tissue concentrations in long-lasting spine surgery: Continuous evaluation after repeated weight-dosed administrations. (PubMed, Br J Clin Pharmacol) - "Repeated weight-dosed intravenous cefuroxime administrations (20 mg/kg) provided homogenous and sufficient intraoperative target tissue exposure of cefuroxime (100% fT>MIC4) in long-lasting spine surgery with hypotensive anaesthesia and postoperative exposure (>4 μg/mL) for 5.5-7.5 h."

Journal • Anesthesia • Infectious Disease • Orthopedics

Pharmacokinetic/pharmacodynamic target attainment of cefuroxime in adult patients on general wards with different degrees of renal function: a prospective observational cohort study (ESCMID Global 2025) - No abstract available

Clinical • Observational data • PK/PD data

A pooled population pharmacokinetic study of intravenous cefuroxime in neonates and infants: renal function dependent underexposure (ESCMID Global 2025) - No abstract available

Clinical • PK/PD data

Unraveling the bone pharmacokinetics of cefuroxime in periprosthetic joint infection (ESCMID Global 2025) - No abstract available

PK/PD data • Infectious Disease

β-lactam antibiotics to prevent ventilator-associated pneumonia (VAP) in coma patients: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Med Intensiva (Engl Ed)) - "In adult patients in coma due to ABI, intravenous β-lactam antibiotics reduce EO-VAP and all-VAP risk."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Infectious Disease • Pneumonia • Respiratory Diseases • Vascular Neurology

Klebsiella pneumoniae urinary tract infection: A multicentric study highlights significant regional variations in antimicrobial susceptibility across India. (PubMed, IJID Reg) - "Overall, low susceptibility (<60%) was observed for the standard oral antibiotics prescribed for cystitis: co-trimoxazole, 54% (36-68%); ciprofloxacin, 52% (29-55%); amoxicillin-clavulanic acid, 46%, (35-82%); nitrofurantoin, 39% (19-78%); and cefuroxime, 30% (15-62%)...Piperacillin-tazobactam 74% (65-87%), amikacin 76% (45-91%), and meropenem 81% (61-87%) exhibited higher activity...Good susceptibility to fosfomycin was observed (89%). The empirical use of fluoroquinolones, cephalosporins, and amoxicillin-clavulanic acid has been discouraged. Piperacillin-tazobactam and aminoglycosides are carbapenem-sparing agents."

Journal • Infectious Disease • Nephrology • Pneumonia

In and Outpatients Bacteria Antibiotic Resistances in Positive Urine Cultures from a Tertiary Care Hospital in the Western Part of Romania-A Cross-Sectional Study. (PubMed, Diseases) - "susceptibility. Bacteria identified in inpatients' positive urine cultures present higher resistance rates to several antibiotics. Our study could be a foundation for a local or even national guideline for the antibiotic treatment of urinary tract infections."

Journal • Observational data • Infectious Disease • Nephrology

Bacteriuria profile and antimicrobial sensitivity among pregnant women attending antenatal care at Jazan and Sabyia general hospitals, Jazan Region, KSA: A cross-sectional study. (PubMed, Int J Gynaecol Obstet) - "The study revealed a significant prevalence of bacteriuria among pregnant women in Jazan Region, highlighting the importance of routine screening and targeted interventions for high-risk groups. Effective antibiotic stewardship programs are essential to managing resistance patterns."

Journal • Observational data • Infectious Disease • Nephrology • Obesity • Pneumonia