lamotrigine liquid oral suspension / OWP Pharma - LARVOL DELTA

Pembrolizumab-induced Multifocal, Musicogenic, Autoimmune Epilepsy due to GAD65 Autoantibodies in a Patient Treated for Triple Negative Breast Cancer (AAN 2026) - "Design/ The patient was a 34-year-old, right-handed female with a past medical history of type 1 diabetes mellitus, hypogammaglobulinemia, systemic lupus erythematosus and triple-negative breast cancer due to the BRAC1 mutation who underwent a clinical trial with a neoadjuvant regimen of pembrolizumab plus carboplatin and docetaxel...She was maintained on intravenous immunoglobulin, hydroxychloroquine and mycophenolic acid for immunotherapy and clobazam, lamotrigine, levetiracetam, lorazepam and cenobamate for antiseizure medications. This case report describes a phenotypic evolution of GAD65 disease from adult-onset, type 1 diabetes mellitus to multifocal, musicogenic, drug-resistant autoimmune epilepsy after pembrolizumab use."

Clinical • IO biomarker • Breast Cancer • CNS Disorders • Diabetes • Epilepsy • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders • Oncology • Solid Tumor • Systemic Lupus Erythematosus • Triple Negative Breast Cancer • Type 1 Diabetes Mellitus

Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a systematic review of causative agents, management strategies, and long-term outcomes (AAD 2026) - "Antiepileptics were the most frequent causative agents (phenobarbital 13.8%, carbamazepine 7.2%, lamotrigine 6.5%), followed by antibiotics (sulfamethoxazole-trimethoprim 7.2%, amoxicillin 3.7%) and analgesics (acetaminophen 6.5%, ibuprofen 2.2%). Our findings highlight antiepileptics and antibiotics as the main causative agents in pediatric SJS/TEN. In-hospital mortality, along with both short- and long-term complications are significant concerns. Future multicenter studies with standardized outcome reporting are needed to guide pediatric-specific clinical protocols."

Clinical • Review • Infectious Disease • Ocular Infections • Pediatrics • Steven-Johnson Syndrome

Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a systematic review of causative agents, management strategies, and long-term outcomes. (AAD 2026) - "Among causative agents, antiepileptics were most frequent (phenobarbital 13.8%, carbamazepine 7.2%, and lamotrigine 6.5%), followed by antibiotics (sulfamethoxazole–trimethoprim 7.2%, amoxicillin 3.7%) and analgesics (acetaminophen 6.5%, ibuprofen 2.2%). We highlight antiepileptics and antibiotics as the main causative agents in pediatric SJS/TEN. Oral and ocular mucosal involvement were the most frequent extracutaneous organs involved and treatment strategies varied. Future multicenter studies with standardized outcome reporting are needed to guide pediatric-specific clinical protocols."

Clinical • Review • Infectious Disease • Ocular Infections • Pediatrics • Steven-Johnson Syndrome

A case of steroid-induced mania following lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): a cautionary tale. (PubMed, SAGE Open Med Case Rep) - "We present a case of a 21-year-old female patient with bipolar disorder who was treated with prednisone for lamotrigine-induced drug reaction with eosinophilia and systemic symptoms, and subsequently experienced steroid-induced mania, exacerbated by an unopposed antidepressant medication. This resulted in involuntary hospital admission under psychiatry, which was profoundly distressing for the patient. We present this case as a reminder to screen for risk of mania in patients receiving systemic corticosteroids, and to carefully assess concurrent antidepressant use when discontinuing mood stabilizers like lamotrigine."

Journal • Bipolar Disorder • CNS Disorders • Eosinophilia • Mood Disorders • Psychiatry

Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study. (PubMed, BMJ) - "The findings strengthen the evidence for increased neurodevelopmental risks among children with prenatal valproate exposure and suggest the need for further evaluation of zonisamide. Signals for other antiseizure drugs, observed in the context of several comparisons and rare outcomes, require confirmation as data accumulate."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • Behavior Disorders • CNS Disorders • Cognitive Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Mental Retardation • Psychiatry

Focal evolution following apparent interictal period on scalp electroencephalography in generalized epilepsy: a three-case study. (PubMed, Seizure) - "In the seizure pattern of focal evolution in generalized epilepsy, an apparent interictal period may occasionally appear on scalp EEG before focal evolution, which warrants careful consideration in diagnostic interpretation."

Journal • CNS Disorders • Epilepsy • Movement Disorders

Unexpected Relief of Trigeminal Neuralgia With Memantine: A Case Report (AAN 2026) - "First-line therapies are carbamazepine and oxcarbazepine; alternatives include gabapentin, lamotrigine, and baclofen, with procedural or surgical options for refractory disease. While carbamazepine/oxcarbazepine remain first-line for TN and should be prioritized when effective and tolerated, this single case suggests memantine may have therapeutic potential in select patients, particularly when standard agents are contraindicated or poorly tolerated. The rapid response and reproducibility with withdrawal and re-exposure strengthen the temporal association but do not establish causality. Prospective studies are needed to evaluate efficacy, safety, dose–response, and patient selection, and any use should be considered off-label within shared decision-making."

Case report • Clinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • Hypertension • Migraine • Neuralgia • Pain

Adult Lennox Gastaut Syndrome: Clinic Characteristics and Therapeutic Patterns (AAN 2026) - "The most commonly used ASM were Levetiracetam(55.5%), Cannabidiol (40.7%), Lacosamide (33.3%), Lamotrigine (29.6%), and Brivaracetam (29.6%). Adult LGS can remain in refractory despite medical and surgical intervention. Medications used in our cohort differed from Tier 1 pediatric agents. In addition, findings suggest a possible trend in which patients with lower seizure frequency were more likely to exhibit agitation, without reaching statistical significance."

Clinical • CNS Disorders • Epilepsy

The Efficacy of Lacosamide in the Treatment of Delirium Complicated With Ileus: Four Cases. (PubMed, Neuropsychopharmacol Rep) - "Drug-induced eruptions are rare compared to other antiepileptics, such as carbamazepine and lamotrigine. The mechanisms of ileus have been suggested; to involve antagonism of the cholinergic, histaminergic, and serotonergic systems. Since lacosamide is not related to these antagonists, it may be one of the helpful options for treating delirium tremens in elderly patients."

Journal • CNS Disorders • Geriatric Disorders • Psychiatry

Trends in paediatric antiseizure-medication use and costs in France, 2014-2023: a nationwide population-based analysis. (PubMed, Lancet Reg Health Eur) - "Prescriptions by private psychiatrists and use of gabapentin, pregabalin, lamotrigine, and levetiracetam independently predicted generic uptake. Targeted substitution strategies could release funds for innovative therapies without compromising seizure control. None."

Journal • CNS Disorders • Epilepsy • Pediatrics • Psychiatry

Unique Case of GABRA4-Related Neurodevelopmental Disorder with a Novel Frameshift Variant (ACMG 2026) - "He showed early developmental regression in motor and speech skills and was on lamotrigine for a long period...Outcome and Follow-Up The patient's tremor improved with primidone...These findings provide crucial evidence to support reclassification of this novel variant and underscore the utility of genome sequencing in diagnosing patients with complex NDDs. Further reporting of individuals with similar variants is essential to delineate the clinical spectrum and establish definitive genotype-phenotype corelations."

Clinical • Neurodevelopmental • Autism Spectrum Disorder • CNS Disorders • Depression • Developmental Disorders • Diabetes • Epilepsy • Genetic Disorders • Gestational Diabetes • Gynecology • Mental Retardation • Metabolic Disorders • Movement Disorders • Psychiatry • Schizophrenia

Autoimmune encephalitis associated with anti-recoverin antibodies. (PubMed, J Med Case Rep) - "Our case illustrated the value of testing anti-recoverin antibodies in CSF and provides insights into management and prognosis through a longitudinal 2-year follow-up. Anti-recoverin antibody-related AE is a rare but treatable cause of adult subacute encephalopathy and epilepsy. Prompt and optimized management associating appropriate anti-epileptic drugs and immunotherapies is essential to alleviate sequelae."

IO biomarker • Journal • CNS Disorders • Cognitive Disorders • Epilepsy • Immunology • Insomnia • Mental Retardation • Oncology • Psychiatry • Retinal Disorders • Sleep Disorder

Age- and sex-associated variability in lamotrigine prescription patterns and clearance. (PubMed, Epilepsia) - "Prescription rates for lamotrigine varied between patients with epilepsy and those with non-epilepsy conditions. Age and sex differences in pharmacokinetics suggest the need for lamotrigine dose adjustments, highlighting the importance of therapeutic drug monitoring in personalized epilepsy care. Lamotrigine use was less frequent in postmenopausal women compared to younger women but higher compared to older men. Postmenopausal women were prescribed lamotrigine as monotherapy to a lesser extent than younger women and older men."

Journal • CNS Disorders • Epilepsy

Early Institution of Immunotherapy Alters the Course of Temporal Lobe Epilepsy With GAD65 Antibody: A Clinical Report. (PubMed, Neurologist) - "In patients presenting with new-onset seizures characterized by unusual semiology and frequent focal aware seizures, it is crucial to consider GAD65-TLE in the list of potential diagnoses. Delayed diagnosis may lead to resistance to both ASMs and immunotherapy. This case report emphasizes how prompt identification and early initiation of immunotherapy can significantly impact the course of the disease."

Journal • CNS Disorders • Cognitive Disorders • Epilepsy • Immunology

Unaware and unrestrained: binge-eating behavior in epileptic absence seizures. (PubMed, Eat Weight Disord) - "This case highlights the critical importance of neurological evaluation in eating disorder patients presenting with altered consciousness or memory lapses. The temporal relationship between seizures and binge episodes, coupled with treatment response, suggests potential neurobiological mechanisms linking epileptic activity to disinhibited eating behaviors. Clinicians should maintain heightened awareness of possible epilepsy-eating disorder comorbidity and consider integrated treatment approaches addressing both neurological and psychiatric components."

Journal • Absence Seizure Disorder • Binge Eating Disorder • CNS Disorders • Epilepsy • Psychiatry

Toward needle-free lamotrigine monitoring: Proof-of-concept for saliva and dried saliva spot analysis by LC-MS/MS - a short communication. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "This technique improves patient comfort and accessibility through a non-invasive sampling method while ensuring accuracy. These findings provide a foundation for broader clinical implementation of alternative-matrix TDM, representing a significant step toward patient-centred, accessible pharmacotherapy and enabling improved LTG monitoring in ambulatory and remote settings."

Journal • CNS Disorders • Epilepsy

Seizure medications and interictal spiking: Implications for cognition and behavior. (PubMed, Epilepsia) - "The use of sodium channel blockers, such as lamotrigine and oxcarbazepine, produces cognitive improvements. Additionally, γ-aminobutyric acidergic agents, including clobazam and diazepam, are effective in treating developmental epileptic encephalopathies. Emerging therapies, including cannabidiol and perampanel, show promising IED and behavioral outcomes...Targeted reduction of IEDs may lead to improved cognitive and behavioral outcomes. This can be achieved by testing and recognizing ASMs in carefully designed prospective trials in animals and humans."

Journal • Review • CNS Disorders • Epilepsy

Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation. (PubMed, Neurooncol Adv) - "Nf1 OPG mice were treated with standard of care (SOC; carboplatin), clinically evaluated (everolimus, mirdametinib), and investigational (pexidartinib, HBS-101, lamotrigine) drugs during the period of most rapid tumor growth (6-12 weeks of age). This referential preclinical study design affords direct head-to-head comparisons of investigational therapies relative to SOC treatment using clinically meaningful outcomes (OPG growth and RNFL thickness). Using this strategy, lamotrigine emerged as the most promising therapy for limiting tumor progression and vision loss in Nf1-OPG mice, relevant to clinical translation for children with NF1-OPG."

Head-to-Head • Journal • Preclinical • Brain Cancer • Genetic Disorders • Glioma • Neurofibromatosis • Oncology • Pediatrics • Solid Tumor • CCL2 • CCL3 • NF1

Benign episodic unilateral mydriasis and headache: More than meets the eye (EHF-EHC 2025) - "Indomethacin and oral corticosteroids were not useful. Lamotrigine 100mg BD resulted in resolution of the pain, but with ongoing episodes of mydriasis... These two cases highlight the likely association of headache with BEUM, suggesting possible shared biological pathways."

CNS Disorders • Migraine • Musculoskeletal Pain • Ophthalmology • Pain

Migraine and visual snow syndrome: Exploring shared pathways through hallucinogen-induced perceptual disturbances (EHF-EHC 2025) - "She showed no improvement with lamotrigine or gabapentin but responded to valproate 250 mg and cognitive behavioral therapy. Hallucinogens modulate thalamic activity, particularly its inhibitory role in sensory processing, contributing to perceptual disturbances. In migraine, a lowered thalamic threshold may promote visual symptoms, further exacerbated by hallucinogens. These cases suggest overlapping pathophysiological mechanisms between VSS and hallucinogenic effects, highlighting the thalamus as a key structure involved in both conditions."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Endocrine Disorders • Migraine • Ophthalmology • Pain • Polycystic Ovary Syndrome • Retinal Disorders

Trigeminal neuralgia secondary to giant saccular aneurysm/endovascular procedure – Is lidocaine block an old treatment with a new indication? (EHF-EHC 2025) - "Carbamazepine is the standard firstline treatment, although alternatives such as oxcarbazepine, lamotrigine, or pregabalin may be considered in cases of intolerance or poor response...Due to poor control of pain (15 episodes/month) and intolerance to carbamazepine (ataxia, vertigo), eslicarbazepine was introduced. Trials with oxcarbazepine, lamotrigine, pregabalin, and levetiracetam were ineffective and poorly tolerated... Peripheral nerve block with lidocaine is a safe, accessible, and effective option for symptom relief and should be considered in cases of secondary trigeminal neuralgia refractory to pharmacological treatment."

Ataxia • Brain Cancer • Cardiovascular • Movement Disorders • Musculoskeletal Pain • Neuralgia • Otorhinolaryngology • Pain • Solid Tumor • Vertigo

Differential Analysis of Neonatal Adverse Drug Events from Intrauterine and Extrauterine Exposure: Insights into Administration Routes Using the FAERS Database. (PubMed, Z Geburtshilfe Neonatol) - "The top maternal exposure drugs included venlafaxine, sertraline, quetiapine, lamotrigine, and levetiracetam. For intravenous use, levetiracetam, zidovudine, indomethacin, ibuprofen, and vancomycin were most common...Serious AEs were mainly linked to maternal drug exposure during pregnancy.These results showed that the use of antidepressants, antiepileptics, and antivirals during pregnancy represents a significant risk factor for neonatal adverse reactions, particularly congenital malformations. Consequently, it is imperative to implement precise prevention strategies tailored to specific exposure stages and to advocate for the establishment of an international pharmacovigilance network for neonates."

Adverse events • Journal • Perinatal Disorders

Phosphodiesterase-4 Inhibition: An Experimental Approach to Overcome Drug Resistance in a Rotenone-Corneal 6 Hz Kindling Mouse Model of Drug-Resistant Epilepsy. (PubMed, Mol Neurobiol) - "Standard anti-seizure medications (ASMs) such as pregabalin, levetiracetam, carbamazepine, phenytoin, and lamotrigine were used for resistance validation. Roflumilast as PDE4 inhibitor significantly manage DRE as evidenced by reducing seizure severity, improving cognitive functions and restoring neurochemical alterations. Its ability to modulate oxidative stress and provide neuroprotection in RCK mice underscores its promise as a novel adjunct treatment for DRE."

Journal • Preclinical • CNS Disorders • Epilepsy • Inflammation • CAT

Pre-Ictal Asystole in Refractory Epilepsy: A Video Case Report (AES 2025) - "Medications included lacosamide and lamotrigine...The patient was discharged on Perampanel 4 mg daily, and according to the parent's report on a follow up visit, there has been significant improvement, with no new seizures of any type observed. Our case is unique given a long pre-ictal asystole, as most literature regarding ictal asystole suggests it occurs at or following ictal onset... Our case is unique given a long pre-ictal asystole, as most literature regarding ictal asystole suggests it occurs at or following ictal onset. While the asystole in our case occurred during lab draws, the preceding junctional rhythms and pauses suggest a more complex interplay between autonomic instability and this seizure's onset rather than vasovagal response. Also, lack of EEG changes prior to and during asystole suggest against hypoperfusion-induced seizure."

Case report • Clinical • Video • Cardiovascular • CNS Disorders • Epilepsy

Cenobamate and Brivaracetam Use in Pregnancy and Lactation - A Case Report (AES 2025) - "She previously failed multiple ASMs, including clonazepam, gabapentin, oxcarbazepine, levetiracetam, lamotrigine, zonisamide, and phenytoin, due to inadequate seizure control or intolerable side effects. This case describes a normal pregnancy outcome in a young female with intractable localization-related epilepsy on combination cenobamate and brivaracetam. To our knowledge, this is the first reported pregnancy outcome with this specific ASM combination. This offers reassuring, preliminary evidence that cenobamate and brivaracetam may be safely continued in pregnancy when benefits outweigh risks, especially in intractable epilepsy."

Case report • Clinical • Anesthesia • CNS Disorders • Epilepsy