lamotrigine liquid oral suspension / OWP Pharma - LARVOL DELTA

Challenging the preclinical paradigm: Adverse effects of antiseizure medicines in male rats with drug-resistant epilepsy. (PubMed, Br J Pharmacol) - "This study highlights the need for preclinical models that better reflect human epilepsy, considering both efficacy and side effects in drug development. Our findings emphasize the complexity of drug responses and underscore the importance of improved models for drug development."

Adverse events • Journal • Preclinical • CNS Disorders • Epilepsy

Case Report: Hematopoietic Stem Cell Transplantation to Treat Severe Acquired Aplastic Anemia in a Pediatric Kidney Transplant Recipient. (PubMed, Pediatr Transplant) - "Despite reported favorable outcomes in children who received allogeneic HSCT after kidney transplantation, there is a lack of evidence on how to overcome numerous challenges in these ultrarare cases."

Journal • Absence Seizure Disorder • Acute Graft versus Host Disease • Anemia • Aplastic Anemia • Atypical Hemolytic Uremic Syndrome • Bone Marrow Transplantation • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Epstein-Barr Virus Infections • Graft versus Host Disease • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Nephrology • Pediatrics • Pulmonary Arterial Hypertension • Solid Organ Transplantation • Transplant Rejection • Transplantation

Varying Lamotrigine Concentrations in Patients Following One Anastomosis Gastric Bypass Surgery: A Case Series. (PubMed, J Pharm Pract) - " This case series shows the complexity of drug treatment after bariatric surgery. The potentially large variability among patients in the effect of the surgery on the bioavailability of lamotrigine, a highly prescribed, life-saving medication, highlights the special care that must be taken with post-bariatric pharmacotherapy in general, and epilepsy treatment in particular."

Journal • CNS Disorders • Diabetes • Epilepsy • Genetic Disorders • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

PTSD and Onset of Cocaine Use Disorder: A Complex Case Report (APA 2025) - "Upon her current admission, she was being treated with Lithium Carbonate 900mg, Quetiapine 200mg, Risperidone 6mg, and Fluoxetine 40mg...Considering the patient's unique situation, the decision was made to continue lithium, reintroduce Lamotrigine (due to a favorable previous response), optimize the dose of fluoxetine, and choose a single atypical antipsychotic for continued treatment (Quetiapine, due to its side effect profile)... This case report expands scientific and clinical knowledge of dual diagnosis. It is relevant to discuss diagnostic challenges, effective therapeutic approaches, and the interaction between these disorders. Additionally, it promotes increased awareness of the importance of integrated care for patients."

Case report • Clinical • Addiction (Opioid and Alcohol) • Borderline Personality Disorder • Cardiovascular • CNS Disorders • Insomnia • Mood Disorders • Personality Disorder • Post-traumatic Stress Disorder • Psychiatry • Pulmonary Disease • Sleep Disorder

Status Epilepticus in Melas; Will There Ever Be a Solution? (ATS 2025) - "Unable to control her seizures with high-dose lorazepam and the addition of oral clobazam, she was transferred to the neurosurgical intensive care unit (ICU), intubated, and started on a continuous midazolam infusion for aggressive seizure control...Our patient achieved 24 hours of seizure-free activity by adding the aforementioned benzodiazepines to her home regimen of levetiracetam, lamotrigine, L-arginine, levocarnitine, cyproheptadine, niacin, riboflavin, coenzyme Q10, and thiamine. Unfortunately, attempts to wean midazolam infusion failed as seizure activity recurred despite the addition of perampanel to her antiepileptic regimen...It is worth wondering whether status epilepticus could have been avoided if her VNS had been active. Unfortunately, given the complexity, mortality remains high with reported mean survival only into the third decade of life."

Cardiovascular • Epilepsy • Genetic Disorders • Metabolic Disorders • Movement Disorders

Psychiatric disorders with antiseizure medications in children: an analysis of the FDA adverse event reporting system database. (PubMed, Acta Epileptol) - "This study highlights psychiatric AEs of ASMs in children, offering critical insights to improve clinical medication practices and enhance treatment safety. Further research with broader clinical data is needed to promote safe and rational medication use."

Adverse events • Journal • CNS Disorders • Epilepsy • Mental Retardation • Psychiatry

The clinical features and 18F-FDG-PET analysis of absence status epilepsy. (PubMed, Front Neurol) - "Seventeen cases (17/20) became seizure-free after treatment with valproate (VPA) and lamotrigine (LTG)...Interictal brain PET imaging may reveal relative hypometabolism in posterior regions, along with decreased thalamic area and metabolic activity, potentially indicating the key role of posterior regions in sustaining wakefulness. Most patients responded well to VPA and LTG."

Journal • CNS Disorders • Epilepsy

Brain dysfunction underlying visual snow syndrome: Insights into therapeutic implications. (PubMed, Brain Dev) - "There has been only sporadic therapeutic success with lamotrigine and cognitive behavioral therapy. Given the complexity of its disease state, multidisciplinary therapeutic approaches appear to be required for more effective symptom management."

Journal • Review • CNS Disorders • Migraine • Ophthalmology • Pain

Autoimmune Encephalitis and Musicogenic Epilepsy: A Case of GAD65 Antibody-Associated Seizure. (PubMed, Clin Case Rep) - "The patient was treated with a combination of antiepileptic medication (Lamotrigine) and corticosteroids and intravenous immunoglobulin. This case contributes to the growing evidence supporting an association between ME and autoimmune mechanisms, particularly GAD65 antibody-mediated autoimmunity. It highlights the importance of screening autoimmune factors in ME patients and highlights the need for further research into targeted treatment strategies."

Journal • CNS Disorders • Epilepsy • Immunology

Pharmacodynamic interactions between seletracetam and antiseizure comedications in the human photosensitivity model. (PubMed, Epilepsia) - "We recently reported that seletracetam (SEL), a highly potent derivative of levetiracetam (LEV), reduces or abolishes the photoparoxysmal electroencephalographic response (PPR) to intermittent photic stimulation (IPS) in patients with epilepsy. Patients comedicated with LEV + lamotrigine or LEV + valproate exhibited significantly lower AUEC (0-8)s than patients without comedication, whereas no significant effects of lamotrigine or valproate alone were found. Despite the significant reduction of AUEC (0-8) in patients on comedication with LEV, SEL still reduced or abolished PPR in the majority (7/9) of exposures."

Journal • PK/PD data • CNS Disorders • Epilepsy

Psychiatric treatment preferences of sports psychiatrists for athlete-patients across competitive levels: a 2024 update. (PubMed, Phys Sportsmed) - "Top choices of psychiatric medications for athletes included: bupropion for depression without anxiety; escitalopram for depression with anxiety, generalized anxiety disorder, and social anxiety disorder; sertraline for obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder; melatonin for insomnia; methylphenidate extended release osmotic-controlled release oral delivery system for attention-deficit/hyperactivity disorder; aripiprazole for bipolar spectrum disorder (manic/hypomanic phase); lamotrigine for bipolar spectrum disorder (depressive and maintenance/prophylaxis phases); and aripiprazole for psychotic disorders. They undertake medical evaluations for their athlete-patients with relatively great frequency. Their preferred psychotherapy types are skills-based and can be completed within relatively short time-frames."

Journal • ADHD (Impulsive Aggression) • Anesthesia • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • CNS Disorders • Depression • General Anxiety Disorder • Insomnia • Mood Disorders • Obsessive-Compulsive Disorder • Post-traumatic Stress Disorder • Psychiatry • Sleep Disorder • Social Anxiety Disorder

The Cultural Perception of Abuse in a Multicultural Context and Its Impact on Mental Health: A Case Report. (PubMed, Cureus) - "She was treated with lamotrigine and Adderall XR, with trauma-informed group therapy and psychoeducation about cultural perceptions of abuse. The patient showed improvement in emotional regulation and investment in the treatment; however, she continued to have difficulties with sleep hygiene and alcohol consumption. This case underlines the importance of culturally sensitive psychiatric care and emphasizes that osteopathic practitioners should further work within the framework of the trauma-informed approach with consideration of cultural influence when managing patients, especially those of migrant backgrounds."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Depression • Mood Disorders • Personality Disorder • Post-traumatic Stress Disorder • Psychiatry

Non-invasive therapeutic drug monitoring: LC-MS validation for lamotrigine quantification in dried blood spot and oral fluid/saliva. (PubMed, J Pharm Biomed Anal) - "By offering a less invasive sampling approach, this method improves the accessibility and safety of pharmacotherapy for epilepsy patients. The results of this study lay the foundation for further clinical applications by implementing alternative matrix TDM, which may significantly advance personalized care in epilepsy management."

Journal • CNS Disorders • Epilepsy

Diagnostic and Management Strategies of Visual Snow Syndrome: Current Perspectives. (PubMed, Eye Brain) - "Based on this review of 27 publications, benzodiazepines and lamotrigine had the best effect (71.4% and 61.5% of patients had an improvement of VS symptoms on each medication, respectively)...FL-41 tinted lenses consistently provide symptom relief, with cognitive behavioral therapy showing promise as an emerging intervention. Due to the small sample size, further research is recommended to enhance the applicability of findings."

Journal • Review • CNS Disorders • Migraine • Pain • Retinal Disorders

Management of a Complex Case of Primary Enuresis in an Adult With Attention-Deficit Hyperactivity Disorder: A Case Report. (PubMed, Cureus) - "She was treated with 10 mg oral escitalopram once daily and a monthly intramuscular injection of 400 mg aripiprazole extended-release, with no reported improvement in her symptoms. Along with her current medications, she was started on 18 mg methylphenidate once daily and lamotrigine, started by 25 mg once daily, titrated to 50 mg. This adjustment led to significant improvement in her symptoms and the resolution of her enuresis. This case report demonstrates the resolution of ADHD symptoms along with the primary enuresis in an adult female patient who was treated with methylphenidate."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • Borderline Personality Disorder • CNS Disorders • Mood Disorders • Personality Disorder • Psychiatry • Urinary Incontinence

The effect of lamotrigine on cortical inhibition and plasticity in Neurofibromatosis type 1: Exploratory analysis of a randomized controlled trial (NF1-EXCEL). (PubMed, Clin Neurophysiol) - P2/3 | "While limited by a small sample size, our study indicates that lamotrigine cannot consistently modulate SICI or PAS in adolescents with NF1, suggesting limited potential for treating the underlying pathophysiological mechanisms."

Journal • Genetic Disorders • Neurofibromatosis • Solid Tumor • NF1

Clinical signatures of SYNGAP1-related disorders through data integration. (PubMed, Genet Med) - "We delineated the seizure, developmental, and behavioral trajectories in SYNGAP1-related disorders, to improve diagnosis, prognosis, and clinical care, as well as facilitating clinical trial readiness."

Journal • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Mental Retardation • Psychiatry

Severe Cutaneous Adverse Reaction to Lamotrigine: A Case of Stevens-Johnson Syndrome in a Psychiatric Patient. (PubMed, Cureus) - "Current treatment strategies remain debated, with corticosteroids, cyclosporine, and tumor necrosis factor α (TNF-α) inhibitors showing potential benefits. Strengthening pharmacovigilance, patient education, and screening for genetic predispositions may help mitigate the risk of drug-induced SJS. Further research into optimal therapeutic strategies is warranted to improve clinical outcomes in affected patients."

Journal • Bipolar Disorder • CNS Disorders • Dermatology • Mood Disorders • Oncology • Psychiatry • Schizophrenia • Steven-Johnson Syndrome

Criteria for medication reconciliation in major orthopedic surgery in high-risk patients: A consensus based on the Delphi method. (PubMed, Farm Hosp) - "We develop and validate a list of 30 criteria to identify patients at high risk of experiencing medication errors undergoing major orthopedic surgery. These may help improve human resource management for clinical pharmacy activities by prioritizing patients who would benefit most."

Journal • CNS Disorders • Glaucoma • Movement Disorders • Myasthenia Gravis • Ophthalmology • Orthopedics • Parkinson's Disease

Development of a PBPK Model for Lamotrigine which Incorporates Metabolism by UGT2B10: Impact of UGT2B10 Poor Metabolizer Phenotype and Pregnancy. (PubMed, AAPS J) - "Information on the prevalence of UGT2B10 poor metabolizer phenotypes and longitudinal changes in UGT1A4 and UGT2B10 expression during pregnancy were incorporated into the PBPK model and the plasma concentrations in subjects with different UGT2B10 phenotypes and in different trimesters of pregnancy were simulated. The simulated concentrations in pregnant subjects were in line with those reported during pregnancy."

Journal • UGT1A4

Antiseizure medications for Lennox-Gastaut Syndrome: Comprehensive review and proposed consensus treatment algorithm. (PubMed, Epilepsy Behav) - "To date, eight anti-seizure medications (ASMs) have been specifically approved by the U.S. Food and Drug Administration (FDA) for the treatment of LGS: clonazepam, felbamate, lamotrigine, topiramate, rufinamide, clobazam, cannabidiol, and fenfluramine. Barriers to access, including economic and regulatory hurdles, are also discussed. The proposed treatment algorithm emphasizes a personalized approach to LGS management, recommending valproate or clobazam as first-line treatments, followed by individualized combinations based on the specific patient profile and associated comorbidities."

Journal • Review • CNS Disorders • Epilepsy

Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (PubMed, Epilepsy Behav) - "Medications such as valproate, lamotrigine, cannabidiol, fenfluramine, levetiracetam, brivaracetam, felbamate, and rufinamide generally support cognitive stability, while topiramate and zonisamide are associated with cognitive challenges. Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes."

Journal • Review • CNS Disorders • Developmental Disorders • Epilepsy • Mental Retardation • Psychiatry

Characterization of lamotrigine disposition changes during and after pregnancy in women with epilepsy. (PubMed, Pharmacotherapy) - "During pregnancy, 91% of PWWE experience a 275% change from nonpregnant baseline in lamotrigine clearance whereas the remaining PWWE experience little to no change. Nonpregnant baseline lamotrigine clearance was higher in both PWWE and NPWWE with the administration of oral estrogen-containing medications. Our results are of clinical importance as they indicate a subpopulation without the need for substantial dose changes during pregnancy and a source of potential difference across nonpregnant individuals."

Biomarker • Journal • Observational data • Retrospective data • Review • CNS Disorders • Epilepsy

Anatomical, behavioral, and cognitive teratogenicity associated with valproic acid: a systematic review. (PubMed, CNS Spectr) - "VPA is significantly associated with anatomical, behavioral, and cognitive teratogenicity. Folic acid supplementation does not abrogate the risk of teratogenicity associated with VPA exposure. Available evidence supports recommendations to reduce VPA exposure in women of reproductive age."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Mental Retardation • Mood Disorders • Psychiatry • Women's Health

Promising therapeutic strategies for lennox-gastaut syndrome: what's new? (PubMed, Expert Rev Neurother) - "Seven antiseizure medications (ASMs) in the US (six in the UK/EU) are licensed for the treatment of seizures in LGS: lamotrigine, topiramate, rufinamide, clobazam, felbamate (not licensed in the UK/EU), cannabidiol and fenfluramine. Although no major breakthroughs have been reported, several established and novel ASMs, some surgical strategies and other treatment approaches are of benefit or are showing promise. Progress remains incremental but any improvements in the management of this resistant epilepsy syndrome are worthwhile."

Journal • CNS Disorders • Epilepsy