lamotrigine liquid oral suspension / OWP Pharma - LARVOL DELTA

Case Report: Seizure freedom after resection of a temporal choroidal fissure cyst in drug-resistant epilepsy. (PubMed, Front Neurosci) - "Postoperatively, she continued lacosamide 150 mg twice daily and lamotrigine 100 mg twice daily. The available histopathological specimens showed no definite evidence of hippocampal sclerosis or ILAE-classifiable focal cortical dysplasia (FCD). These findings suggest that, in certain cases, choroidal fissure cysts may act as independent epileptogenic triggers, with implications for epilepsy diagnosis and management."

Journal • CNS Disorders • Epilepsy

Cross national pharmacovigilance analysis of drug-induced delirium: a comparative study using the US FAERS, Japanese JADER, and canadian CVAR datasets. (PubMed, Front Pharmacol) - "Duloxetine, lamotrigine, pregabalin, quetiapine fumarate, and zolpidem demonstrated consistent signals across databases. Time-to-onset analysis demonstrated early-onset clustering, suggesting an acute temporal pattern. Cross-database consistency in drug class signals and early-onset temporal patterns highlights the need for medication review and risk mitigation in high-risk populations."

Adverse events • Journal • CNS Disorders • Cognitive Disorders • Pain

Trends in Use of Antiseizure Medicines in Women With Epilepsy in Pregnancy During 2018-2023 in an Irish Maternity Hospital: A Cohort Study. (PubMed, Obstet Gynecol Int) - "Levetiracetam (60.1%) and lamotrigine (31.5%) were most frequently used overall. Zonisamide use decreased significantly (-0.395, p = 0.029), although this finding should be interpreted cautiously given the small number of exposures (n = 13)...ASMs with safer pregnancy profile were most frequently used in WWE in pregnancy. Additional data are needed to further assess trends and outcomes and to determine the place of newer generation ASMs in WWE in pregnancy."

Journal • CNS Disorders • Epilepsy

Clobazam and Valproate, but Lamotrigine, a Sodium Channel Inhibitor, Reduce the Incidence of Hyperthermia-Induced Clonic Seizures in Dravet Syndrome Mice: Assessment of Anti-Seizure Effects in Mice Using a Stabilized Ambient Temperature System. (PubMed, Neuropsychopharmacol Rep) - "These results reflect clinical findings that CLB and VPA suppress, but LTG does not suppress seizures in patients with DS. Our data demonstrate the validity of our test system to induce hyperthermia-induced seizures and to evaluate the efficacy of antiseizure medications in Scn1a KI/+ mice."

Journal • Preclinical • CNS Disorders • Epilepsy

Implementation of a Pharmacy-Led Psychotropic Stewardship Pilot Program at an Academic Medical Center. (PubMed, J Am Coll Clin Pharm) - "A pharmacist-led PSP was feasible in a general medical inpatient setting and resulted in a high rate of accepted interventions. These findings support the role of pharmacists in improving psychotropic medication safety and highlight opportunities for targeted, system-level interventions. Future work should evaluate clinical outcomes and long-term sustainability of PSPs."

Journal • CNS Disorders • Palliative care • Psychiatry

Topic: Manufacturing Drift, Excipients & System-Level Gaps (WFSBP 2026) - "Second, formulation changes alter dissolution profiles in ways the 80–125% window can hide — polymorph differences in carbamazepine, valproate, and lamotrigine have produced documented neurobehavioral failures despite "passing" BE. JAMA 2008; Schall R & Luus HG. Eur J Clin Pharmacol 1993."

CNS Disorders • Psychiatry

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta-analysis. (PubMed, Epileptic Disord) - "Current recommendations may underestimate ASM effects on exposure to COC components, especially those in newer COCs. Greater caution is recommended with low-dose topiramate. For individuals treated with weak COC inducers without additional contraceptive means, COCs containing levonorgestrel or norethindrone might be preferable given their lower vulnerability to induction."

Journal • Retrospective data • CNS Disorders • Epilepsy

Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy. (PubMed, JAMA Neurol) - "ASM monotherapy with levetiracetam, valproate, moderate enzyme-inducing ASMs, or strong enzyme-inducing ASMs (eg, carbamazepine, phenytoin), each vs lamotrigine or lacosamide (1 pooled reference group of patients taking either drug; hereafter referred to as lamotrigine/lacosamide). In VKA-treated adults, thromboembolic risks were near null. Results suggest that in adults with epilepsy who are treated with DOACs, ASM selection was associated with distinct thromboembolic, bleeding, and mortality risks, supporting ASM choice as a modifiable contributor to clinical outcomes."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Ischemic stroke • Myocardial Infarction

Treatment of obesity with liraglutide in bipolar disorder: a case report. (PubMed, Front Psychiatry) - "During the weight-loss intervention, and temporally after liraglutide titration to 1.8 mg/day, he developed a manic episode (YMRS = 30), prompting an increase in risperidone and addition of gabapentin alongside continuation of mood stabilizers. His manic symptoms remitted within one week, allowing discharge with liraglutide 1.8 mg, risperidone 3 mg, valproic acid and lamotrigine. Over subsequent outpatient follow-up at the target liraglutide dose (3 mg/day), he lost 6.5 kg more (total Δ weight = - 7 kg), his HOMA-IR improved to 5.78 and glycemic and lipid parameters stabilized without further mood destabilization. This case illustrates the bidirectional interplay between metabolic regulation and mood stability in BD, highlights the need for close psychiatric monitoring during structured weight-loss interventions in clinically vulnerable patients, and supports integrated multidisciplinary care when initiating anti-obesity treatments in patients with severe mental illness."

Journal • Bipolar Disorder • CNS Disorders • Dyslipidemia • Genetic Disorders • Metabolic Disorders • Mood Disorders • Obesity • Psychiatry

Non-Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof-of-Concept Study. (PubMed, Clin Pharmacol Ther) - "Breath-derived estimates of valproic acid, levetiracetam, lamotrigine, and lacosamide showed moderate concordance with measured serum concentrations, with concordance correlation coefficients ranging from 0.733 to 0.895 across medications. These findings support the feasibility of exhaled breath analysis for non-invasive estimation of systemic drug exposure across pharmacologically distinct medications. Breath analysis should currently be considered complementary to serum-based monitoring, and external multicenter and longitudinal validation is required before clinical implementation."

Journal

Silent refractoriness in epilepsy care: cross-sectoral analysis of prescribing patterns, referrals and workforce capacity in Saxony. (PubMed, Front Neurol) - "Utilization was assessed using Days of Therapy (DOT), with a focus on levetiracetam (LEV) as a proxy for focal epilepsy care...Prescribing patterns showed a persistent preference for LEV across all sectors, with marked regional variation in LEV: lamotrigine ratios that aligned with levels of specialization and proximity to the epilepsy center...Addressing this gap requires implementation of standardized referral criteria, strengthened cross-sectoral networks, and regional accountability mechanisms. These findings provide a scalable framework for aligning decentralized care systems with evidence-based escalation pathways."

Journal • CNS Disorders • Epilepsy

Refractory Temporal Gelastic Seizure: A Case Report. (PubMed, Niger Med J) - "Initial treatment with carbamazepine followed by combination therapy with levetiracetam failed to adequately control seizures. However, seizure frequency improved after substitution of levetiracetam with lamotrigine. This case highlights that gelastic seizures may originate from the temporal lobe even in the absence of hypothalamic hamartoma and may be resistant to first-line therapy. Awareness of this rare presentation may facilitate earlier recognition and optimization of treatment strategies in affected patients."

Journal • Review • CNS Disorders • Epilepsy

The gut microbiome and drug-resistant epilepsy: Microbiome-antiseizure medication interactions and implications for pharmacoresistance. (PubMed, Epilepsia Open) - "The gut microbiome harbors a vast repertoire of drug-metabolizing enzymes capable of directly biotransforming orally administered antiseizure medications (ASMs)-including valproic acid, lamotrigine, carbamazepine, and oxcarbazepine-thereby altering their pharmacokinetics, bioavailability, and therapeutic efficacy. The medications themselves can reshape the microbiome in return, creating a cycle that may sustain treatment failure. Understanding this gut-drug relationship may open new paths to personalized epilepsy care through diet, probiotics, and microbiome-guided prescribing."

Journal • Review • CNS Disorders • Epilepsy

Acquired pharmacoresistance in temporal lobe epilepsy is driven by Nav1.6-mediated subicular hyperexcitability. (PubMed, Acta Pharm Sin B) - "Here, using a hippocampal kindling mouse model, we established that prolonged lamotrigine (LTG) treatment-either during or after kindling-induces broad-spectrum resistance to multiple ASMs, effectively recapitulating clinical patterns of acquired pharmacoresistance...Chemogenetic inhibition of subicular pyramidal neurons (mimicking ASM effects) restored drug responsiveness, directly implicating compensatory increases in Nav1.6 offsetting ASM's inhibitory function on subicular excitability in acquired pharmacoresistance. These findings collectively identify Nav1.6 upregulation in subicular pyramidal neurons as a critical driver of acquired pharmacoresistance in TLE, highlighting a novel therapeutic target for refractory epilepsy."

Journal • CNS Disorders • Epilepsy • FOS • NAV1

Interaction Between Direct Oral Anticoagulants and Antiepileptic Drugs: A Multicenter Observational Study (ISTH 2026) - "Apixaban, rivaroxaban, and edoxaban were measured using anti–factor Xa assays, and dabigatran using a thrombin time–based assay...AEDs were classified as enzyme-inducing (carbamazepine, oxcarbamazepin, fenobarbital) or non–enzyme-inducing (levetiracetam, gabapentin, pregabalin, lamotrigine, clonazepam, lacosamide)...These findings support a CYP3A4/P-gp–mediated interaction and underscore the need for careful DOAC selection or the use of non–enzyme-inducing AEDs in patients receiving DOACs. Table or Figure Upload (1) Page 2 Table or Figure Upload (2) DOI*10.1016/j.rpth.2026.105440"

Clinical • Observational data • Atrial Fibrillation • Cardiovascular • Venous Thromboembolism • CYP3A4

Treatment and management approaches for ketamine misuse: A systematic review of medical interventions. (PubMed, J Subst Use Addict Treat) - "Current management of ketamine misuse relies mainly on supportive care, psychotherapy, and off-label pharmacological options, but robust evidence on efficacy is lacking. There is an urgent need for controlled studies and standardized treatment protocols. Integrated, multidisciplinary, models appear most promising in addressing the complex medical and psychiatric consequences of ketamine misuse."

Journal • Review • Anesthesia • CNS Disorders • Depression • Interstitial Cystitis • Psychiatry • Urology

A systematic review of Lamotrigine overdose: from uneventful to ICU admission and cardiac arrest (EAN 2026) - "LTG overdose can result in severe neurotoxicity, coma, status epileptics and death (6%). Cardiac arrest was reported 11% of cases. Suicidal ideation was the most common reason for overdose but also erroneous intake in children and elders."

Review • Bipolar Disorder • Cardiovascular • CNS Disorders • Depression • Epilepsy • Mood Disorders • Suicidal Ideation

Transcutaneous auricular vagus nerve stimulation in adult abdominal epilepsy associated with ketosis-prone diabetes: A case report. (PubMed, Medicine (Baltimore)) - "In diabetic patients with recurrent unexplained abdominal pain, AE should be considered when episodes are stereotyped, abrupt, or accompanied by orofacial automatisms, altered awareness, autonomic instability, or a mismatch between symptom severity and abdominal findings. Early EEG may help reduce diagnostic delay, whereas adjunctive taVNS should be viewed as exploratory."

Journal • CNS Disorders • Diabetes • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypoglycemia • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus

Targeting glutamatergic dysregulation in severe treatment-resistant obsessive-compulsive disorder: integrating serotonergic, dopaminergic, and glutamatergic therapies (CINP 2026) - " Serotonergic optimization remains foundational, with high-dose SSRIs (fluoxetine 80 mg/day, sertraline 200 mg/day, paroxetine 60 mg/day) demonstrating clinical efficacy when trials are of adequate duration (≥12 weeks). Clomipramine, a tricyclic antidepressant with potent serotonergic properties, is effective as monotherapy or combined with SSRIs under careful monitoring.Dopaminergic/antipsychotic augmentation using low-dose atypical antipsychotics — including risperidone (0.5–3 mg/day), aripiprazole (10–20 mg/day), and quetiapine (150–300 mg/day) — yields response in approximately 30–50% of SSRI nonresponders, though metabolic and neurological adverse effects necessitate vigilant monitoring.Glutamatergic modulators, particularly memantine (5–20 mg/day), have shown promising results in open-label and controlled studies, with clinically meaningful reductions in Y-BOCS scores and favorable tolerability. Additional agents under investigation include lamotrigine,..."

CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data. (PubMed, Biosensors (Basel)) - "In contrast, the closed-loop system achieved lower peak concentrations (Cmax ≈ 0.045 mmol/L) and maintained plasma concentrations within the therapeutic range of 0.02-0.03 mmol/L with reduced fluctuations. These findings support further investigation of biosensor-guided closed-loop lamotrigine delivery systems."

Clinical data • Journal • CNS Disorders • Epilepsy

Cerebral X-Linked Adrenoleukodystrophy Associated with Hemophilia A: a case report. (PubMed, Horm Res Paediatr) - "This case highlights the genetic vulnerability of the Xq28 locus and the possible co-occurrence of Hemophilia A and ALD. Physicians should maintain a high index of clinical suspicion for ALD in males with known FVIII deficiency and cognitive signs or concomitant hyperpigmentation as early diagnosis is vital for life-saving therapeutic interventions."

Journal • Absence Seizure Disorder • Alzheimer's Disease • Bone Marrow Transplantation • CNS Disorders • Cognitive Disorders • Endocrine Disorders • Epilepsy • Genetic Disorders • Hematological Disorders • Hemophilia • Hemophilia A • Insomnia • Nephrology • Psychiatry • Rare Diseases • Renal Disease • Sleep Disorder • Transplantation • F8

Multimodal Imaging in the Presurgical Evaluation of Epilepsy - An Educative Case Report (OHBM 2026) - "The epilepsy proved resistant to multiple antiseizure medications, including oxcarbazepine, valproate, zonisamide, levetiracetam, lamotrigine, carbamazepine, eslicarbazepine, and phenytoin. From a neuroimaging perspective, this case illustrates how advanced data integration and visualization strategies can translate complex multimodal information into actionable surgical guidance. Beyond seizure freedom, timely and precise intervention may allow recovery of neurodevelopmental trajectories and long-term functional outcomes."

Case report • Clinical • CNS Disorders • Epilepsy

From Microadenoma to Macro-Energy: A Case of Cabergoline-Associated Mania (ENDO 2026) - "Cabergoline was held, lithium was started along with his prior regimen of quetiapine and lamotrigine...When treatment of hyperprolactinemia is necessary, options include cautious rechallenge with close monitoring, or non-dopaminergic alternatives when feasible. This report underscores the importance of shared decision-making and anticipatory monitoring when prescribing cabergoline to patients with mood disorders."

Clinical • Bipolar Disorder • CNS Disorders • Endocrine Disorders • Mood Disorders • Movement Disorders • Parkinson's Disease • Pituitary Gland Carcinoma • Schizophrenia

Mining and Mapping 25 Years of Medication Use in Child and Adolescent Mental Health Services: Contact-Level Descriptive Analysis of Electronic Health Records. (PubMed, JMIR Med Inform) - "We demonstrated a mining and mapping analytic pipeline for EHRs to analyze diagnoses, comorbidities, and prescribing practices at the individual contact level. In the Norwegian CAMHS, axis I diagnoses are common, often behavioral-emotional disorders. Among the medications, psychostimulants and antidepressants are common. Beyond characterizing diagnoses and medication prescribing patterns, the study presents an approach for mining and mapping EHR data to analyze and provide service-level metrics, as well as clinical practice insights."

Journal • CNS Disorders • Developmental Disorders • Mental Retardation

Laughing before the storm: A case of gelastic migraine (AHS 2026) - "One Sentence Summary: We report a case of gelastic migraine in a 43-year-old woman with acute stereotyped, involuntary laughter with mirth preceding her usual migraine headaches, whose episode resolved with ubrogepant...She is currently on a preventive medication regimen including onabotulinumtoxinA, fremanezumab, acetazolamide, and lamotrigine... This is a rare presentation of gelastic migraine. In the absence of other identifiable etiology for the gelastic symptoms, we believe that this case describes an atypical temporal lobe aura, with the attack aborted by a gepant."

Clinical • CNS Disorders • Epilepsy • Migraine • Pain