Diractin (ketoprofen) / Pfizer - LARVOL DELTA

Lethal and sublethal effects of selected bacterial and neem-based novel insecticides on cotton aphid, Aphis gossypii and the predator, Coccinella septempunctata. (PubMed, Bull Entomol Res) - "strain A396 as Venerate® XC; Chromobacterium subtsugae strain PRAA4-1 as Grandevo® WDG) and two neem-based insecticides (1.2% azadirachtin A and B as Azatrol and 3% azadiractin as Molt-X) on the cotton aphid, Aphis gossypii, and its natural enemy, Coccinella septempunctata...The development time of predator larvae remained unaffected by treatment. New Betaproteobacteria- and neem-based insecticides except Azatrol seem to be a promising tool to suppress population of Aphis gossypii and integrate pest management programmes."

Journal

Influence of polarized light, disruptive visual patterns, and chemical cues on oviposition in the aquatic midge, Chironomus riparius (Diptera: Chironomidae). (PubMed, Environ Entomol) - "Chemical cues appeared to play a weak role, if any, in oviposition choices. Onlyazadiractin (0.02 and 0.11 ppm) reduced the number of egg ropes deposited, but the mechanism may have been from mechanical trapping and drowning, not deterrence."

Journal

Compatibility of pesticides with the predatory mite Neoseiulus barkeri. (PubMed, Exp Appl Acarol) - "In the present study, the effects of residual exposure to four broad-spectrum insecticides/acaricides (azadiractin, abamectin, chlorfenapyr, and fenpyroximate) on immature (development and survival time) and adult females (longevity, fecundity, and fertility life table parameters) of the predatory mite Neoseiulus barkeri were evaluated...Among the insecticides/acaricides studied, azadirachtin had minimal effects on immature and adult N. barkeri (all non-significant) and was considered harmless based on the classification of toxicity according to the standards/categories proposed by the IOBC. All other insecticides/acaricides affected immature and adult N. barkeri and were considered slightly harmful in terms of toxicity, according to the IOBC."

Journal

The Impact of Systematic Insecticides Against Emerald Ash Borer on Phenology of Urban Ash Trees. (PubMed, J Econ Entomol) - "Given symptoms observed, we posit that delays in these events in untreated trees were due to infestations of EAB and the treatments of emamectin benzoate or azadiractin simply preserved the original phenology. The results from this study suggest that systemic insecticides may mitigate changes in ash tree phenology such as delayed leaf out that may be early symptoms of emerald ash borer."

Journal

Evaluation of the Toxicity of Chemical and Biogenic Insecticides to Three Outbreaking Insects in Desert Steppes of Northern China. (PubMed, Toxins (Basel)) - "The LC values of matrine, azadiractin, and avermectin were more than 1 μg a.i./adult for O. asiaticus and M. palpalis, the LC values of which were higher 2 g/L for G. daurica. Our findings complement information from previous similar studies and will inform future studies relating to the control of outbreaking insects, such as O.asiaticus, M. palpalis, and G. daurica in desert steppes of northern China. This study is also expected to provide basic data on the use of chemical and biogenic insecticides for application in desert steppes."

Journal

Laboratory study of an innovative concept to control aphid pests and mosquito vectors of pathogens to humans. (PubMed, Pest Manag Sci) - "The AGRIAC concept allows for an innovative vector control method which can manage aphid pests and mosquitoes while providing plants with the needed fertilizer."

Journal

Transferosomes as nanocarriers for drugs across the skin: quality by design from lab to industrial scale. (PubMed, Int J Pharm) - "Clinical trials of a licensed topical ketoprofen transferosomal gel have shown promising results in the alleviation of symptons in orthreothritis with non-severe skin and subcutaneous tissue disorders. However, the product was withdrawn from the market which probably was related to the higher cost of the medicine linked to the expensive manufacturing process required in the production of transferosomes compared to other conventional gel formulations. This example brings out the need for a careful formulation design to exploit the best properties of this drug delivery system as well as the development of manufacturing processes easily scalable at industrial level."

Journal • Review • Hematological Malignancies • Immunology • Leukemia • Oncology • Rheumatoid Arthritis • Rheumatology

A 12-week randomized study of topical therapy with three dosages of ketoprofen in Transfersome gel (IDEA-033) compared with the ketoprofen-free vehicle (TDT 064), in patients with osteoarthritis of the knee (J Pain Res) - P=NA, N=NA; “The 100 and 50 mg ketoprofen groups, but not the 25 mg group, showed a superior reduction in the WOMAC pain score versus the TDT 064 group (100 mg: -57.4% [P = 0.0383]; 50 mg: -57.1% [P = 0.0204]; and 25 mg: -53.4% [P = 0.3616] versus TDT 064: -49.5%)...Responder rates were significantly higher for all the IDEA-033 groups versus the TDT 064 group, but were high in all groups (100 mg: 88.6%; 50 mg: 86.8%; 25 mg: 88.6%; and TDT 064: 77.5%)."

Clinical data • Pain

A large randomised, controlled trial comparing the efficacy and safety of topical ketoprofen in transfersome gel with oral celecoxib for osteoarthritis knee pain (EULAR 2012) - P3, N=1,395; NCT00716547; Treatment with 100mg ketoprofen in transfersome was non-inferior to celecoxib; Treatment for 12 wks with topically applied ketoprofen (50mg and 100mg) in transfersome was not statistically superior to treatment with matching NSAID-free transfersome gel

P3 data • Pain

Acetogenin-Based Formulated Bioinsecticides on Anastrepha fraterculus: Toxicity and Potential Use in Insecticidal Toxic Baits. (PubMed, Neotrop Entomol) - "The present study evaluated the lethal toxicity and oviposition deterrence of ethanolic extracts of Annona mucosa Jacq., Annona muricata L., and Annona sylvatica A. St.-Hil on Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae) compared with those of a limonoid-based bioinsecticide (Azamax™ 1.2 EC-azadiractin +3-tigloyl-azadiractol) and a synthetic spinosyn-based insecticide (Delegate™ 250 WG-spinetoram)...In combination with the food attractants Anamed™, 3% Biofruit, and 7% sugarcane molasses, the emulsion of the A. mucosa extract had a residual effect similar to that of the spinetoram insecticide, with a mortality rate of over 80% of A. fraterculus adults up to 14 days after application (DAA) in the absence of rain. Thus, acetogenin-rich formulations, especially from A. mucosa seeds, are useful alternatives for the integrated management of A. fraterculus in agricultural orchards."

Journal