Temziva (tocilizumab biosimilar) / AryoGen Pharmed - LARVOL DELTA

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach. (PubMed, Int Immunopharmacol) - "There are two classes of approved IL-6 inhibitors: anti-IL-6 receptor monoclonal antibodies (e.g., tocilizumab) and anti-IL-6 monoclonal antibodies (i.e., siltuximab)...JAK/STAT pathway blockers were also successfully used in dampening IL-6 signal transduction. A better understanding of different mechanisms that modulate IL-6 expression will provide the much-needed solution with excellent safety and efficacy profiles for the treatment of autoimmune and inflammatory diseases in which IL-6 derives their pathogenesis."

Journal • Review • Idiopathic Arthritis • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Novel Coronavirus Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • IL6 • TGFB1

CAR T-cell toxicity: CRS, ICANS and prolonged cytopenias (YouTube) - "Marion Subklewe...discusses recognition and treatment of CAR T-cell therapy-related side effects, including novel insights into the pathophysiology of long-term cytopenias. Close monitoring and timely intervention with tocilizumab with or without corticosteroids remain the best management strategies for cytokine release syndrome (CRS). The pathogenesis of neurotoxicity is not fully understood and it remains very challenging to manage. Similar to CRS management, neurotoxicity needs to be promptly recognized. Additionally, Prof. Subklewe shares the latest updates regarding prolonged cytopenias."

Interview • Video

Biocare Lifesciences Inc. launches Tocilizumab (Temziva) (MSN News) - "Biocare Lifesciences Inc (BLI)...announced the launched of the first branded generic of Tocilizumab (Temziva) 400mg/20mL Solution for infusion. Temziva (Tocilizumab)...has received approval from the Philippines Food and Drug Administration (FDA) to treat severe Covid-19 patients with Cytokine Release Syndrome."

Generic launch • Infectious Disease • Novel Coronavirus Disease

Tocilizumab in hospitalized COVID-19 patients (YouTube) - "Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. List of authors...Gerard J. Criner..."

Video • Novel Coronavirus Disease