DermaVax (IR-444) / Immune Response BioPharma - LARVOL DELTA

Circulating exosomal microRNA profiling to depict mechanisms of chemotherapy resistance among triple negative breast cancer (ESMO 2018) - "... We isolated exosomes and analyzed exosome-carried miRNA signatures in several TNBC cells lines sensitive or resistant to adariamycin, docetaxel or cisplatin...Exosomal miR-222, miR-4443, miR-100, miR-17, miR-210 were found significantly upregulated from chemotherapy-resistant cells... Exosomes from chemotherapy-resistant TNBC cells could transfer drug resistance to sensitive cells via exosomal miRNAs. A circulating exosomal microRNA profiling was estabilished for potential biomarkers and therapeutic target identification."

Hormone Receptor Breast Cancer • Triple Negative Breast Cancer

Origin and evolution of MIR1444 genes in Salicaceae. (PubMed) - Sci Rep - "A copy of MIR1444 gene was lost in Salix through DNA segment deletion during chromosome rearrangements. The results provide significant information for the origin of plant miRNAs and the mechanism of Salicaceae gene evolution and divergence."

Journal • Biosimilar

miR-4443 Participates in the Malignancy of Breast Cancer. (PubMed) - PLoS One - "We revealed that miR-4443 induced malignancy of breast cancer mainly in chemo-resistance aspect for the very first time, providing a novel biomarker in breast cancer diagnosis and therapy."

Biomarker • Journal • Biosimilar • Breast Cancer • Oncology

Comparative analysis of microRNA expression profiles between A549, A549/DDP and their respective exosomes. (PubMed) - Oncotarget - "The expression level of 5 microRNAs (miR-197-5p, miR-4443, miR-642a-3p, miR-27b-3p and miR-100-5p) with the most differential expression were verified by qRT-PCR. And the prediction of their association with diseases found that most of these microRNAs was associated with lung cancer. We could draw a preliminary conclusion that microRNAs in exosomes may be involved in the drug resistance of lung cancer cells to cisplatin."

Journal • Biosimilar • Lung Cancer • Oncology

Comprehensive bioinformatics analyses of Crohn's disease. (PubMed) - Mol Med Rep - "The miRNA-gene network showed that miR‑149‑3p and miR‑4447 regulated the most differentially expressed genes. These findings extend current understanding of the mechanisms underlying CD, and the differentially expressed genes and regulator miRNAs identified may be used as potential biomarkers and therapeutic targets for CD."

Biomarker • Journal • Biosimilar • Crohn's disease • Immunology • Inflammatory Bowel Disease

miR-4443 Regulates Mast Cell Activation By T Cell - Derived Microvesicles. (PubMed, J Allergy Clin Immunol) - No abstract available.

Journal