RIG-301 / RIGImmune - LARVOL DELTA

CFTR mRNA delivery with a novel non-LNP nanoemulsion formulation to cystic fibrosis differentiated human airway epithelium and airway organoid (ERS 2025) - "RIG-301 also showed an increased forskolin-induced swelling of CF-airway organoid, which effects were comparable to those of a triple combinations of CFTR modulators (VX-661/VX- 445/VX-770). Our data demonstrate the capability of the NEED TM platform to deliver optimised CFTR mRNA in airway cells. These preclinical data warrant further investigations of CFTR delivery in vivo ."

Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • CFTR

CFTR mRNA delivery with a revolutionary non-LNP nanoemulsion formulation to differentiated primary human airway epithelium and airway organoid (ECFS 2025) - "Our results demonstrate the capability of the NEEDTM platform to deliver optimised CFTR mRNA in ALI hAE and hBE cultures, as well as CF organoid. These preclinical data warrant further investigation of CFTR delivery and functional rescue in cells derived from CF patients."

Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • CFTR