clonazepam intranasal (JZP-8) / Jazz - LARVOL DELTA

Optimizing Rescue Medication Prescribing Practices for Patients with Epilepsy: A Study on Current Trends and Opinions (AES 2025) - "Out of 98 patients, 18% (n=18) were prescribed seizure rescue medications: seven received clonazepam, nine intranasal midazolam and two intranasal diazepam. This study highlights a misalignment between current prescribing patterns for seizure rescue medications and established guideline-based recommendations. Despite high-risk clinical histories, appropriate rescue therapy remains underutilized, influenced by perceived barriers such as caregiver competence, benzodiazepine stewardship concerns, and administrative burden. Optimizing prescribing practices will require targeted provider education, standardized protocols, and strategies to address practical barriers, ensuring that all eligible patients with epilepsy receive timely guideline-concordant rescue treatment."

Clinical • Late-breaking abstract • CNS Disorders • Epilepsy

Preparation, Characterization, and In vivo Biodistribution Study of Intranasal I-Clonazepam-Loaded Phospholipid Magnesome as a Promising Brain Delivery System: Biodistribution and pharmacokinetic behavior of intranasal I-Clonazepam loaded phospholipid magnesome as a potential brain targeting system. (PubMed, Eur J Pharm Sci) - "The present study showed that I-CP-loaded magnesomes can be a beneficial brain-targeting approach for improving the diagnosis and/or radiotherapy of certain brain diseases."

Journal • PK/PD data • Preclinical • CNS Disorders • Oncology

Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery. (PubMed, Pharmaceutics) - "Both gels were significantly more effective than the solution. However, RAMEB was essential not only to promote drug release, but also to reduce drug cytotoxicity and further improve its permeability."

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