SO286 / Keio University - LARVOL DELTA

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation. (PubMed, EMBO J) - "Furthermore, the small compound SO286 inhibited both UBQLN2 self-association and its interaction with α-syn by binding to the STI1 domain, thereby suppressing α-syn aggregation. These findings demonstrate that UBQLN2 droplets catalyze α-syn fibrillization and suggest that small molecules targeting fibril-catalyzing proteins such as UBQLN2 may represent a promising therapeutic approach for neurodegenerative diseases."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease