SO286
/ Keio University
- LARVOL DELTA
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October 15, 2025
Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation.
(PubMed, EMBO J)
- "Furthermore, the small compound SO286 inhibited both UBQLN2 self-association and its interaction with α-syn by binding to the STI1 domain, thereby suppressing α-syn aggregation. These findings demonstrate that UBQLN2 droplets catalyze α-syn fibrillization and suggest that small molecules targeting fibril-catalyzing proteins such as UBQLN2 may represent a promising therapeutic approach for neurodegenerative diseases."
Journal • CNS Disorders • Movement Disorders • Parkinson's Disease
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