gabapentin / Generic mfg. - LARVOL DELTA

A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty (clinicaltrials.gov) - P1 | N=50 | Active, not recruiting | Sponsor: Ohio State University | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial primary completion date • Aesthetic Medicine • Pain

Zoster Sine Herpete Presenting as Refractory Right Upper Quadrant Abdominal Pain Mimicking Hepatobiliary Disease (ACG 2026) - "Empiric intravenous acyclovir was initiated in the setting of underlying renal disease, and gabapentin continued. Rapid and complete symptom resolution following antiviral therapy further supports the clinical diagnosis and underscores the potential for delayed recognition. Neuropathic causes of abdominal pain, including ZSH, should be considered when hepatobiliary evaluation is unrevealing, and pain is refractory to standard therapy."

Gastrointestinal Disorder • Hepatology • Herpes Zoster • Nephrology • Neuralgia • Pain • Renal Disease • Varicella Zoster

When Hiccups Persist: An Atypical Presentation of Esophageal Candidiasis in an Immunocompetent Patient (ACG 2026) - "Outpatient treatment with baclofen, gabapentin, and pantoprazole failed to improve his symptoms, prompting hospital admission for further evaluation...He was treated with intravenous chlorpromazine, gabapentin, metoclopramide, empiric antibiotics for suspected pneumonia, and pantoprazole for possible reflux esophagitis, however, hiccups persisted...Figure: EGD demonstrating diffuse white plaques consistent with candidal esophagitis in the middle third (left) and lower third (right) of the esophagus. Figure: Hematoxylin and eosin staining demonstrating active esophagitis with acute inflammation (left) and fungal organisms morphologically consistent with Candida species, including budding yeast and pseudohyphae (right)."

Clinical • Candidiasis • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases

Endoscopic Salvage of Massive Gastric Bezoar in Severe GI Dysmotility Using Coca-Cola Dissolution and Pathfinder CR-Assisted Evacuation (ACG 2026) - "Case Description/ A 33-year-old woman with gastroparesis status post pyloroplasty, colonic inertia requiring diverting ileostomy with multiple revisions, and autonomic dysfunction presented with 3 days of abdominal pain, nausea, and emesis following recent increases in clonazepam and gabapentin. (C) Retroflexed view of the fundus before evacuation demonstrating extensive retained debris prior to evacuation. (D) Retroflexed view of the fundus demonstrating near-complete clearance of gastric contents following intervention."

Gastrointestinal Disorder

Ulcerative Colitis Patients With Opiate Use Disorder Have Higher Healthcare Utilization and Higher Mortality: A Propensity-Matched Multicenter Analysis (ACG 2026) - "Cases were UC patients with OUD (identified by ICD-10 codes for OUD, methadone use or buprenorphine/naloxone use, n=38,997), and controls were UC patients without OUD (n=383,178), matched 1:1 by age and gender via propensity score matching (total n=77,994). Cohort demographics and selection are outlined in Figure 1. UC patients with OUD demonstrated higher rates of food insecurity (RR 4.81, 95% CI [4.00, 5.80]) and housing instability (RR 7.26, 95% CI [5.61, 9.38]). They were more likely to use TCAs, SNRIs, acetaminophen, NSAIDs, and gabapentin (Fig."

Clinical • HEOR • Addiction (Opioid and Alcohol) • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Substance Abuse • Ulcerative Colitis

Acamprosate Is Associated With Increased Risk of Hepatic Encephalopathy and Ascites Compared With Gabapentin and Baclofen in Compensated Alcohol-Associated Cirrhosis (ACG 2026) - "After propensity matching, 2,833 patients were included in each acamprosate-gabapentin cohort, 4,840 patients in each acamprosate-baclofen cohort, and 2,470 patients in each gabapentin-baclofen cohort. Compared with gabapentin, acamprosate was associated with increased risk of HE (HR 1.45, 95% CI 1.14â1.84, p=0.002) and ascites (HR 1.56, 95% CI 1.21â2.00, p< 0.001). Compared with baclofen, acamprosate was associated with increased risk of HE (HR 1.38, 95% CI 1.15â1.65, p< 0.001) and ascites (HR 1.39, 95% CI 1.15â1.70, p=0.001)."

Addiction (Opioid and Alcohol) • CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatology • Immunology • Metabolic Disorders • Nephrology • Renal Disease

Hepatic Encephalopathy Masquerading as Dementia, Unmasked by Antibiotic-Associated Diarrhea (ACG 2026) - "Opioids, benzodiazepines, and gabapentin were held without improvement...Secondly, ampicillin-sulbactam may have reduced ammonia-producing gut bacteria, similar to rifaximin therapy...Diagnosis was supported by cirrhosis on CT abdomen, asterixis, prior HE, lactulose nonadherence, and lack of improvement after sedatives were held...Although AAD is not a therapeutic strategy, clinicians should recognize that cathartic diarrhea during antibiotic therapy may incidentally benefit patients with undertreated HE. This case emphasizes that in patients labeled with dementia or unexplained cognitive decline, occult or undertreated HE should remain on the differential."

Acute Kidney Injury • Alzheimer's Disease • CNS Disorders • Dementia • Fibrosis • Gastroenterology • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

A Hiccup in the System â Corrected Manually (ACG 2026) - "Multiple pharmacologic therapies, including baclofen, metoclopramide, chlorpromazine, and gabapentin, were trialed but discontinued due to sedation and lack of symptomatic improvement. Accordingly, this case underscores the potential role of OMT for symptomatic relief of benign but troubling conditions such as hiccups. Figure: Doming of the Diaphragm"

Endocrine Disorders • Metabolic Disorders

Effects of Kalanchoe pinnata, exercise, and stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a Wistar-rat model. (PubMed, World J Exp Med) - "KP alleviated neuropathic pain, and the enhancement with exercise and VNS highlights the potential of multimodal strategies targeting cortical pain-control networks. This therapeutic approach demonstrates potential as a multimodal preclinical strategy for neuropathic pain management and warrants further investigation."

Journal • Preclinical • B Cell Lymphoma • Immunology • Inflammation • Lymphoma • Neuralgia • Oncology • Pain • BCL2 • BDNF • CASP3 • HMOX1 • IL10 • IL6 • KEAP1 • TNFA

Medical and non‑medical gabapentinoid use in fatal drug poisonings in Norway: Linked postmortem toxicology and prescription data. (PubMed, Forensic Sci Int) - "Gabapentinoids were increasingly detected in fatal drug poisonings in Norway. Non-medical use became more common over time, particularly for pregabalin. Because 24% of cases were not captured by the standard EUDA definition, the contribution of gabapentinoids to drug-related mortality may be underestimated."

Journal

Gabapentin as an add-on analgesic to morphine in paediatric patients with chronic pain. (PubMed, Br J Clin Pharmacol) - P2 | "A weight-banded dosing regimen results in consistent exposure to gabapentin and morphine across different age groups while ensuring acceptable safety margins. In addition, these results offer a rational basis for future clinical trials aiming to reduce opioid burden and optimize pain control in children."

Journal • Pain • Pediatrics

EASE-TAR: Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Northwestern University

New P4 trial • Gastroenterology • Pain

Prediction analysis for delayed discharge following gastric bypass surgery. (PubMed, J Gastrointest Surg) - "The best predictive variables for delayed discharge included were asthma, preoperative weight, gastroesophageal reflux disease (GERD), gabapentin use, preoperative BMI, preoperative anticoagulant use, chronic pain, obstructive sleep apnea (OSA), dyslipidemia, chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). Conclusions A prediction model including preoperative BMI, obesity-related comorbidities and medication use was generated. This model has the potential to support hospital resource management and triaging patients suitable for short-stay and increase the efficiency of resource allocation for gastric bypass."

Journal • Asthma • Chronic Kidney Disease • Diabetes • Dyslipidemia • Gastroenterology • Gastroesophageal Reflux Disease • Genetic Disorders • Immunology • Metabolic Disorders • Nephrology • Obesity • Obstructive Sleep Apnea • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • Sleep Disorder • Type 2 Diabetes Mellitus

Integrated bioinformatics and molecular docking identify novel key genes, pathways, and potential candidate drugs in papillary thyroid carcinoma. (PubMed, J Genet Eng Biotechnol) - "According to docking analysis, Olysio, Gabapentin, Naldemedine, Imatinib and Enzacamene were drugs that exhibited strong interactions with the target proteins. The findings of the current study offer that FN1, DPP4, CD36, KIT, ITGA2 and hsa-miR-124-3p may be novel biosignatures and therapeutic targets for PTC. In addition, it was demonstrated that discovered pharmaceuticals may be employed as prospective PTC treatments."

Journal • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • CD36 • ITGA2 • MIR124-2 • MIR124-3 • SCARB1

Pharmacovigilance analysis of immune checkpoint inhibitor-associated optic nerve toxicity based on the FAERS database. (PubMed, Front Pharmacol) - "FAERS reports from the first quarter of 2004 to the second quarter of 2025 were screened for optic nerve toxicity associated with five ICIs: pembrolizumab, nivolumab, atezolizumab, durvalumab, and ipilimumab...Among concomitant medications, gabapentin showed a relatively strong association; among comorbidities, erosive gastritis and hypophysitis were more commonly reported...Age and sex were key associated factors. These findings support closer ophthalmic monitoring during ICI therapy."

Adverse events • Checkpoint inhibition • Journal • Gastrointestinal Disorder • Oncology • Ophthalmology

Cannabis Assessment in Oncology Patients - Evaluation Survey: Understanding Usage Patterns in a Rural Radiation Cohort in Kentucky. (PubMed, Oncologist) - "Self-administration of unprescribed medicinal cannabis use was common across demographic groups and was primarily directed toward symptom management. This study demonstrates the feasibility of fully tablet-based research in rural oncology populations and provides novel data from an opioid-endemic region."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Mood Disorders • Oncology • Pain • Psychiatry • Sleep Disorder

Multimodal Pharmacologic Strategies for Chronic Cancer Pain: A Systematic Review. (PubMed, Cureus) - "In one trial, duloxetine was associated with clinically meaningful pain-response rates, although its primary mean pain-score analysis was not statistically significant. Low-dose gabapentin plus imipramine reduced pain and rescue-morphine use. Pregabalin reduced the morphine dose required to maintain pain control in one crossover trial, while other pregabalin studies showed numerical or non-significant benefits. Neither nabiximols trial met its primary efficacy endpoint, and nefopam did not significantly improve pain response or morphine consumption...Overall, the evidence remains heterogeneous and insufficient to support a standard multimodal pharmacological regimen. Selected antidepressant and gabapentinoid strategies, particularly in neuropathic cancer pain, may benefit selected patients."

Journal • Review • Addiction (Opioid and Alcohol) • Oncology • Pain

Potential Histological Benefits of Gabapentin in Experimental Facial Nerve Crush Injury in Rats: Increased Myelinated Axons and S100-Positive Schwann Cells. (PubMed, Iran J Otorhinolaryngol) - "These findings suggest that gabapentin may support structural nerve repair after FN injury. Further functional evaluation and cellular and molecular studies are needed."

Journal • Preclinical • Anesthesia

KYNA-3M: Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Plovdiv Medical University | Initiation date: Sep 2019 ➔ Oct 2017

Biomarker • Trial initiation date • Inflammation • Pain • Psychiatry

Gabapentin-Induced Severe Vivid Nightmares: A Case Series and Brief Review. (PubMed, Psychopharmacol Bull) - "Management strategies included medication discontinuation and transition to pregabalin. Both patients experienced resolution of nightmares following intervention. This report reviews the existing literature on gabapentin's effects on sleep architecture and discusses potential mechanisms, clinical implications, and management approaches."

Journal • Review • CNS Disorders • Musculoskeletal Pain • Neuralgia • Pain • Psychiatry • Sleep Disorder

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data. (PubMed, EBioMedicine) - "20 widely used medications may be associated with reduced progression from MCI to ADRD and represent promising candidates for clinical evaluation as repurposed therapies for dementia."

Journal • Real-world evidence • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Pain

Bilateral Sphenopalatine Ganglion Blocks in Adult Tonsillectomy and Uvulopalatopharyngoplasty: A Matched Retrospective Cohort Study (AAO-HNSF 2026) - "SPG block patients trended toward higher non-opioid analgesic use including acetaminophen (p=0.12), celecoxib (p=0.17), and gabapentin (p=0.10). There was no significant difference in hydromorphone, fentanyl, oxycodone, or morphine requirements between groups... SPG blocks in adults undergoing sleep surgery were safe and associated with trends toward increased non-opioid analgesic use. While immediate PACU pain scores did not differ, fewer block patients reported uncontrolled postoperative pain and/or required opioid refills after discharge, suggesting that SPG blocks may provide longer-lasting benefit beyond the immediate postoperative period."

Retrospective data

Healthcare providers' perspectives on headache care in Azerbaijan: results of a national cross-sectional survey. (PubMed, Front Neurol) - "The most commonly reported preventive medications were amitriptyline (75.7%), magnesium (51.1%), gabapentin (24.6%), and valproate (24.3%). Because the survey was based on healthcare providers' perceptions derived from a convenience sample, the findings should be interpreted as complementary to, rather than substitutes for, patient-level or administrative health-system data. Future nationally representative studies are needed to guide the development of structured, evidence-based headache services."

Journal • CNS Disorders • Migraine • Pain • Pediatrics

Benzodiazepine-Sparing Alcohol Withdrawal Protocol Pilot in Postsurgical Head and Neck Cancer Patients. (PubMed, Clin Neuropharmacol) - "In patients with significant medical comorbidities, the utilization of a benzodiazepine-sparing protocol is protective against withdrawal. We have found benefit from proactive utilization of a benzodiazepine-sparing protocol versus a traditional CIWA-based reactive treatment model for alcohol withdrawal."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Head and Neck Cancer • Oncology • Solid Tumor

Benzodiazepines in Epilepsy: A US Perspective on Clinical Use, Pharmacology, Abuse Methods, and Public Health Considerations. (PubMed, Neurol Ther) - "Particularly in combination with other central nervous system depressants (e.g., opioids, gabapentin, and alcohol), misuse and abuse of BZDs are linked to serious and potentially fatal complications...The objective of this paper is to identify a practical balance between ensuring access to these essential medications for those who experience clinical benefit while also supporting safe prescribing of BZDs to minimize misuse and abuse. Findings from the present review support continued research, drug utilization policies, and patient education."

Journal • Review • CNS Disorders • Epilepsy