gabapentin / Generic mfg. - LARVOL DELTA

Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review. (PubMed, Fundam Clin Pharmacol) - "According to AMSTAR 2, the highest-quality meta-analysis was the one published in the Cochrane Database of Systematic Reviews and concluded that more participants had substantial benefit (at least 50% pain relief or patient global impression change very much improved) with gabapentin at 1200 mg daily or greater than with placebo (in postherpetic neuralgia: RR = 1.8 [95% CI 1.5 to 2.1] and in painful diabetic neuropathy: RR = 1.9 [95% CI 1.5 to 2.3]). One limitation of this work is the inconsistent use of the term neuropathic pain, which may be defined differently across studies."

Journal • Review • Diabetic Neuropathy • Neuralgia • Pain

Understanding the menopause transition in sickle cell disease: An analysis of the implementation of the adapted menopause quick 6 (ASH 2025) - "Treatment use included hydroxyurea (45%mean dose: 1117 ± 444 mg/day; median: 1000), chronic exchange transfusion (10%), L-glutamine (2%),and voxelotor (7%). Half reported chronic opioid use (mean: 113 ± 115 MME/day), and 21% were takingmedications against neuropathic pain (e.g., gabapentin)...Midlife women with SCD report a substantial burden of menopausal symptoms—particularly hot flashes,sleep disturbances, and joint pain. Symptom burden appears influenced by age and hematologicparameters, while disease-modifying therapies may mitigate reported symptoms or individuals withsevere disease may not experience the typical hormonal related menopausal symptoms. These findingslay some foundational groundwork for future studies examining the interplay between disease severity,treatment, and reproductive aging in women with SCD."

CNS Disorders • Genetic Disorders • Hematological Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Sickle Cell Disease • Sleep Disorder • Women's Health

Targeting bcaa metabolism induces synthetic lethality in DNMT3A-mutated acute myeloid leukemia (ASH 2025) - "These findings not only established BCAT1 as a key effector of DNMT3Amutation-driven leukemogenesis but also revealed tRNA charging as a previously unrecognizedmechanism coupling amino acid metabolism to oncogenic translation. The efficacy of Gabapentin anddeficient BCAA supply in suppressing AML progression highlighted the clinical relevance of targetingBCAA metabolism to overcome differentiation arrest and improve outcomes in this high-risk AML subset."

Synthetic lethality • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • BCAT1 • DNMT3A

Pain Reduction Caused by the Combined Treatment of Physiotherapy, Oral Gabapentin and Oral Ibuprofen Arginine. (clinicaltrials.gov) - P4 | N=129 | Completed | Sponsor: Universidad Europea de Madrid | N=35 ➔ 129

Enrollment change • Musculoskeletal Pain • Pain

Gabapentin and Neural Mobilization Pain Reduction Effect Compared to Only Gabapentine (clinicaltrials.gov) - P4 | N=72 | Completed | Sponsor: Universidad Europea de Madrid | N=19 ➔ 72

Enrollment change • Musculoskeletal Pain • Pain

Therapeutic effects of fluorescent gabapentin carbon quantum dots on pentylenetetrazol-induced seizures in rats. (PubMed, J Drug Target) - "The most intense luminescence was in the prefrontal cortex. Our results clearly suggest that GBPCQDs have potential therapeutic advantages in seizure management, and it is a good fluorescent bioimaging material."

Journal • Preclinical • CNS Disorders • Epilepsy

Effect of selumetinib treatment on long-term pain medication utilization in pediatric patients: a retrospective study of a US claims database (SNO 2025) - "Overall, 26 patients were receiving gabapentin in the 12 months prior to selumetinib initiation; 50% (n=13) discontinued use within 12 months of selumetinib initiation. For patients who continued gabapentin (n=13), the average dose declined from 802 mg/day (before selumetinib) to 675 mg/day (after selumetinib).Selumetinib was associated with a consistent and durable reduction in PMU over a follow-up period of up to ~3 years, adding to the long-term and the real-world data supporting its clinical benefits in pediatric patients with neurofibromatosis type 1-related plexiform neurofibroma."

Claims database • Retrospective data • Genetic Disorders • Neurofibromatosis • Pain • Pediatrics • Solid Tumor

Effect of selumetinib treatment on long-term pain medication utilization in pediatric patients: a retrospective study of a US claims database (SNO 2025) - "Overall, 26 patients were receiving gabapentin in the 12 months prior to selumetinib initiation; 50% (n=13) discontinued use within 12 months of selumetinib initiation. For patients who continued gabapentin (n=13), the average dose declined from 802 mg/day (before selumetinib) to 675 mg/day (after selumetinib).Selumetinib was associated with a consistent and durable reduction in PMU over a follow-up period of up to ~3 years, adding to the long-term and the real-world data supporting its clinical benefits in pediatric patients with neurofibromatosis type 1-related plexiform neurofibroma."

Claims database • Retrospective data • Genetic Disorders • Neurofibromatosis • Pain • Pediatrics • Solid Tumor

Oral Gabapentin and Median Nerve Mobilization in the Treatment of Carpal Tunnel Syndrome (clinicaltrials.gov) - P4 | N=126 | Completed | Sponsor: Universidad Europea de Madrid | N=46 ➔ 126

Enrollment change • Musculoskeletal Pain

Pain Reduction and Changes in Upper Limb Function Produced by Different Treatments in Carpal Tunnel Syndrome (clinicaltrials.gov) - P4 | N=196 | Completed | Sponsor: Francisco Unda Solano | N=87 ➔ 196

Enrollment change • Musculoskeletal Pain • Pain

Effectiveness of gabapentin in combination therapy for phenobarbital-responsive sialadenosis in a Toy Poodle. (PubMed, J Vet Med Sci) - "Residual hypersalivation and retching almost completely resolved within 24 hr after gabapentin (GBP) addition, with only mild hypersalivation (about 10% of the initial level) remaining. No recurrence was observed during a 3-year follow-up, during which PB (3.6 mg/kg administered orally twice daily [PO BID]) and GBP (15 mg/kg PO BID) were continued at the same doses."

Journal • Movement Disorders • Pain

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol. (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

Management of Small Fiber Neuropathy: A Clinical Perspective. (PubMed, Muscle Nerve) - "First-line medications include amitriptyline, nortriptyline, gabapentin, and pregabalin. Second-line treatments can include serotonin-norepinephrine reuptake inhibitors and selective serotonin reuptake inhibitors such as duloxetine and venlafaxine, as well as lidocaine patches and capsaicin."

Journal • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Neuralgia • Pain

Gabapentinoids-Induced Rhabdomyolysis/Myopathy: Clinical Characteristics, Management, Outcomes, and Critical Safety Alerts. (PubMed, J Pain Res) - "This study provides the first evidence-based framework for gabapentinoid myotoxicity monitoring, emphasizing renal function-guided dosing, early CPK surveillance, and drug interaction vigilance. Clinicians should consider gabapentinoid cessation in unexplained myalgia with CK >3×ULN, particularly in high-risk populations."

Journal • Review • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Musculoskeletal Pain • Myositis • Neuralgia • Pain • Renal Disease

Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis. (PubMed, J Pain Res) - "Duloxetine was generally associated with increased CV risks, while a lower risk of AMI and no significant increase in mortality were observed compared to gabapentin. Our subgroup analysis further suggests that when potential confounding from preexisting CVDs was minimized, duloxetine was associated with incident CV complications in patients without prior CVDs."

Journal • Cardiovascular • Cerebral Hemorrhage • Congestive Heart Failure • Heart Failure • Hematological Disorders • Immunology • Ischemic stroke • Musculoskeletal Pain • Myocardial Infarction • Osteoarthritis • Pain • Rheumatology

Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

Journal

Gabapentin repurposing for glioblastoma therapy: Real-world data analyses augmented by use of active comparators. (PubMed, Neuro Oncol) - No abstract available

Journal • Real-world evidence • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief (clinicaltrials.gov) - P=N/A | N=240 | Completed | Sponsor: Muhammad Aamir Latif

New trial • Pain

Impact of pregabalin reclassification as a controlled substance in Egypt on gabapentinoid and opioid utilization: A repeated cross-sectional study. (PubMed, PLoS One) - "Reclassifying pregabalin effectively reduced its utilization but prompted a shift to gabapentin use. Our findings highlight the complexity of drug policy interventions, underscoring the need for continuous monitoring to mitigate unintended substitution effects and better understand policy impacts of the treatment of pain."

Journal • Observational data • Pain

Synchronous Macular Amyloidosis and Brachioradialis Pruritus Successfully Treated With Gabapentin. (PubMed, Case Rep Dermatol Med) - "This case highlights the first reported synchronous presentation of MA and BRP and suggests potential shared pathophysiological mechanisms. The favorable dual therapeutic response to gabapentin provides new insights into management strategies for concurrent presentations of these conditions."

Journal • Amyloidosis • Dermatology • Pruritus

Treatment-induced neuropathy of diabetes overlapping with chronic inflammatory demyelinating polyradiculoneuropathy after rapid glycemic correction: a case report. (PubMed, Front Endocrinol (Lausanne)) - "The patient received insulin pump therapy for glycemic control, along with oral analgesics, including gabapentin and carbamazepine. Additionally, we review the literature on the pathophysiological mechanisms of TIND and discuss its potential relationship with CIDP, aiming to provide clinical insights that may assist in early recognition and diagnosis. To date, cases of coexisting TIND and CIDP in a single patient have rarely been reported in the literature."

Journal • Diabetes • Diabetic Neuropathy • Inflammation • Metabolic Disorders • Pain • Peripheral Neuropathic Pain • Type 1 Diabetes Mellitus

The Use of an Enhanced Recovery Bundle in Surgical Spine Patients to Reduce Opioid Requirements and Improve Patient Comfort. (PubMed, Orthop Nurs) - "Spine patients were receiving preoperative education, a consult with the pre-anesthesia testing clinic, a balanced anesthetic technique, antibiotics, and chlorhexidine gluconate wipes. A preoperative oral carbohydrate drink, and oral acetaminophen and gabapentin were added to make a complete ERAS bundle. This QI project found a statistically significant reduction in total morphine milligram equivalents required in the post-anesthesia recovery unit (PACU)...This QI ERAS bundle is evidence that the use of multimodal analgesia and oral carbohydrate combined with preexisting ERAS spine interventions reduce patients' total amount of narcotics and improve their overall comfort. Individually, these interventions do not appear impactful, but patient outcomes are positively impacted when bundled."

Journal • Anesthesia • Orthopedics

Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs. (PubMed, Basic Clin Pharmacol Toxicol) - "The greater the individual weight loss, the greater the concentration increase in hydrophilic drugs that undergo glomerular filtration, for example, pregabalin and gabapentin, suggesting that this reflects decreased glomerular hyperfiltration. By contrast, for highly lipophilic drugs, for example, mirtazapine and sertraline, the greater the individual creatinine and cystatin C loss, the greater the decrease in drug concentration, interpreted as increased drug metabolism based on decreased liver inflammation and steatosis. Venlafaxine/O-desmethylvenlafaxine displayed a complicated pattern suggesting the involvement of both glomerular filtration and metabolism. Serum concentrations of modestly lipophilic drugs, for example, duloxetine and (es)citalopram, were not significantly affected by the diet. In conclusion, hydrophilicity- and lipophilicity-related changes in drug concentrations over the diet period covary with markers of changes in hyperfiltration and metabolism,..."

Journal • Genetic Disorders • Inflammation • CST3

Feline blood donation via cephalic intravenous catheter: A novel method. (PubMed, Vet Rec) - "Although not possible in all cats, intravenous catheter donation can be a successful method for blood donation."

Journal • Anesthesia • Hematological Disorders

A Comparative Study on the Efficacy, Safety and Cost Effectiveness of Gabapentin and Pregabalin in the Treatment of Neuropathic Pain. (PubMed, Cureus) - "Such comparisons, including expense analysis, are limited in the literature. Our study plays a role in substantiating PG as a better analgesic in many respects for neuropathic pain while also proposing a possibility for evaluating combination therapies and to provide an optimize healthcare resource allocation."

HEOR • Journal • Neuralgia • Pain