captopril / Generic mfg. - LARVOL DELTA

Identification of antihypertensive peptides from doenjang-meju, Korean fermented soybean, and their effects on the renin-angiotensin system. (PubMed, Food Chem) - "Both peptides significantly reduced blood pressure in high-fat diet-induced hypertensive mice, with efficacy comparable to captopril...In addition, B. velezensis-fermented soybean attenuated hypertension more effectively than non-fermented soybean. These findings identify SAGPV and GDSM as antihypertensive peptides generated during B. velezensis fermentation and provide mechanistic evidence that targeted microbial fermentation can enhance the cardiovascular benefits of soybean foods."

Journal • Cardiovascular • Hypertension

The Leaf Aqueous and Ethanolic Extracts of Tricalysia okelensis Hiern. (Rubiaceae) Reverse L-NAME-Induced Hypertension, Cardiac, and Vascular Remodeling in Rats. (PubMed, Adv Pharmacol Pharm Sci) - "L-NAME administration was continued either alone or with captopril (20 mg/kg/day, p.o.), AETO, or EETO at doses of 85 and 170 mg/kg/day for another 3 consecutive weeks, while the naive group received the vehicle for 6 weeks...LC-MS/MS-based molecular networking enabled the putative annotation of several polyphenolic metabolites, including chlorogenic acid, neochlorogenic acid, rutin, quercetin derivatives, kaempferol derivatives, isorhamnetin, avicularin, and guaijaverin...AETO and EETO reversed these alterations and also inhibited L-NAME-induced immune cell infiltration, fibrosis, cardiac and vascular eNOS downregulation, and iNOS overexpression, as well as ANP upregulation in heart tissue. AETO and EETO exhibit antihypertensive and anti-remodeling effects probably by modulating the renin-angiotensin system, improving endothelial function, and reducing inflammation and fibrosis."

Journal • Preclinical • Cardiovascular • Fibrosis • Hypertension • Immunology • Inflammation • Pulmonary Arterial Hypertension • MPO • NOS3

Analysis of related factors for the occurrence of cardiovascular-renal-metabolic syndrome stage 4 in patients with primary aldosteronism (PubMed, Zhonghua Yi Xue Za Zhi) - " High aldosterone level is a factor associated with progression of CKM to the clinical event phase (CKM stage 4). Among aldosterone-related indicators, 2 h post-captopril aldosterone has the most stable predictive value, and this correlation presents heterogeneity across populations with different genders, ages and PA subtypes."

Journal • Retrospective data • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Coronary Artery Disease • Diabetes • Dyslipidemia • Endocrine Disorders • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Comment on: "Adverse Oral Mucosal Reaction to Sublingual Captopril: A Case Report With Exploratory Insights Into AI-Assisted Clinical Reasoning". (PubMed, Spec Care Dentist) - No abstract available

Journal

Targeting the ACE/Ang II Axis with Captopril Attenuates Neuroinflammation and Cerebral Injury Following Fat Embolism. (PubMed, Cells) - "By inhibiting ACE, captopril effectively modulates this axis, reducing oxidative stress and neuroinflammation. Targeting the ACE/Ang II pathway represents a promising therapeutic strategy for managing the neurological complications of FE syndrome."

Journal • CNS Disorders • Inflammation • Musculoskeletal Diseases • Orthopedics • Vascular Neurology • HIF1A

Adverse Oral Mucosal Reaction to Sublingual Captopril: A Case Report With Exploratory Insights Into AI-Assisted Clinical Reasoning. (PubMed, Spec Care Dentist) - No abstract available

Journal

Navigating the Unknown: Scleroderma Renal Crisis and a Fatal Cardiac Complication in a Young Patient With MCTD With Coexisting Anti-U3 RNP and Anti-RNA Polymerase III Antibodies. (PubMed, Case Rep Rheumatol) - "Despite treatment with captopril and hemodialysis, she ultimately died of cardiac arrest. This case highlights the complexity and risks in managing patients with overlapping autoantibodies and underscores the need for close monitoring and cautious use of steroids in such high-risk individuals."

Journal • Cardiovascular • Dermatomyositis • Fibrosis • Hypertension • Immunology • Myositis • Rheumatology • Scleroderma • Systemic Sclerosis

Dual Thiol Drug-Induced Insulin Autoimmune Syndrome in a Non-Asian Patient Carrying HLA-DRB1*04:06: A Case Report and Literature Review. (PubMed, Clin Med Insights Case Rep) - "Management comprised immediate discontinuation of both captopril and ALA (captopril replaced with losartan) and dietary measures (frequent small low-carbohydrate meals). To our knowledge, this is the first reported case of IAS temporally associated with concurrent captopril and ALA exposure in a non-Asian carrier of HLA-DRB1*04:06. The case highlights the need to review both prescription drugs and supplements when investigating hyperinsulinemic hypoglycemia, that IAS can occur outside typical ethnic groups when permissive HLA alleles are present, and that prompt withdrawal of offending agents with conservative measures often leads to spontaneous remission."

Journal • Hypoglycemia • Immunology • Solid Tumor • HLA-DRB1

Investigating the Therapeutic Potential of Compound Fufangteng Oral Liquid in Chronic Heart Failure: Efficacy in a Multifactorial Model. (PubMed, Comb Chem High Throughput Screen) - "CFFOL shows potential for heart failure treatment, particularly in qi deficiency syndrome. Further clinical studies are needed."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • Inflammation • IL17A • TGFB1 • TNFA

Antihypertensive Agent Alleviates Sodium Hypochlorite-Induced Lung Injury. (PubMed, Antioxid Redox Signal) - "Together, these findings indicate that captopril holds promise as a potent antioxidant agent to alleviate NaClO-induced lung injury. Antioxid. Redox Signal. 00, 000-000."

IO biomarker • Journal • Asthma • B Cell Lymphoma • Immunology • Infectious Disease • Lymphoma • Novel Coronavirus Disease • Oncology • Pulmonary Disease • Respiratory Diseases • BAX • CASP3

Captopril Enables the Inhibition of tRNA-Mediated Tau Aggregation. (PubMed, Langmuir) - "Moreover, captopril (CAP) effectively inhibits both general and tRNA-induced tau aggregation, positioning CAP as a potential therapeutic candidate. This work offers an avenue for treating aberrant phase separation-induced tau aggregation using small-molecule compounds."

Journal

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson's Disease in Swiss Albino Mice. (PubMed, Ann Afr Med) - "RAS modulators demonstrated significant neurobehavioral protection in MPTP-induced Parkinsonism, suggesting their potential as adjunct therapeutic agents in PD."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • RAS

Prehospital medical treatment of hypertensive emergencies in patients with suspected acute coronary syndrome or heart failure – a pilot real-world observational study (ESC 2026) - "Patients frequently received only sublingual captopril (n=1,906, 20.6%) or nitroglycerin (n=1,750, 18.9%). For cases requiring intravenous drug treatment, the nitroglycerin-furosemide-morphine combination was the most preferred (n=1,411, 15.3%)... Although guidelines for managing hypertensive emergencies primarily recommend intravenous medications, our observational study revealed that non-intravenous antihypertensive agents may also be valuable during prehospital care. If the initial therapy is ineffective, timely escalation of treatment is essential. Further targeted investigations and complex statistical analyses are necessary to determine the target blood pressure, taking into account the duration of the prehospital period, and whether sublingual antihypertensive medications can effectively manage some hypertensive patients presenting to ambulance care with chest pain or heart failure until hospital admission."

Clinical • Observational data • Real-world • Real-world evidence • Acute Coronary Syndrome • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension

Pediococcus acidilactici JP-10 fermented silkworm pupa peptides: antihypertensive effects and bioinformatic identification of potential ACE inhibitory peptides. (PubMed, Biochimie) - "After the model was successfully established, different doses of silkworm pupa ACE inhibitory peptides (SPPs) and captopril were administered to hypertensive rats by gavage at regular intervals...The mixture regulated the RAS system, alleviated hypertension-triggered inflammatory responses and pathological damage in the kidney and heart, and exerted antihypertensive effects by modulating intestinal flora balance to promote short-chain fatty acid production. These findings provide a scientific basis for the development of SPPs as potential antihypertensive functional food ingredients."

Journal • Cardiovascular • Diabetes • Hypertension • Inflammation • Metabolic Disorders • Myocardial Infarction

Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease. (PubMed, Mol Nutr Food Res) - "The co-treatment reduced inflammation by inhibiting the AhR-NF-κB signaling pathway and TNF-α expression. These findings demonstrate that DHA in combination with captopril mitigates IAA-induced cardiovascular damage in CKD and represents a promising adjunct strategy to reduce cardiovascular complications in uremic condition."

Journal • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease • CAT • TNFA

Formulation and Characterization of Captopril-Loaded Chitosan Mucoadhesive Buccal Films with Different Permeation-Enhancing Components. (PubMed, Pharmaceutics) - " These findings demonstrate that chitosan ascorbate and lactate salts effectively improve the buccal permeability of captopril while maintaining good film properties and biocompatibility. This work highlights the potential of chitosan ascorbate- and lactate-based mucoadhesive films as an efficient platform for the buccal delivery of CAP."

Journal

Therapeutic effect of Fuzheng Yixin decoction on cardiac insufficiencythe soluble guanylyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway in a doxorubicin-induced dilated cardiomyopathy rat model. (PubMed, J Tradit Chin Med) - "These findings suggest that the cardioprotective effect of FZYX may be mediated through the restoration of the sGC-cGMP-PKG signaling pathway. FZYX may provide a new strategy for clinical application against DCM."

Journal • Preclinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors. (PubMed, ADMET DMPK) - "Captopril emerges as a promising scaffold for NDM-1 inhibitors and reveals significant structural features associated with NDM-1 inhibitors. Despite limited in vivo data and heterogeneity in assay conditions, the findings provide a rational framework for optimizing captopril-inspired NDM-1 inhibitors."

Journal • Review

An "On-Off-On" Fluorescence Sensing System Based on Nitrogen-Doped Carbon Quantum Dots (N-CQDs) and Ferric Ions (Fe3+) for the Determination of Captopril (CAP) in Real Samples. (PubMed, J Fluoresc) - "The method was successfully applied to the determination of CAP in commercial tablet formulations, with recoveries meeting the acceptance criteria of the Chinese Pharmacopoeia (2020 Edition). The proposed approach offers a simple, rapid, and sensitive strategy for the quantitative analysis of CAP in pharmaceutical products."

Journal

SubPA-DKD: Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease (clinicaltrials.gov) - P1 | N=125 | Active, not recruiting | Sponsor: Brigham and Women's Hospital | Recruiting ➔ Active, not recruiting

Enrollment closed • Chronic Kidney Disease • Diabetes • Endocrine Disorders • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Digital pharmacoepidemiology of angiotensin-converting enzyme inhibitors in Russia. (PubMed, Front Pharmacol) - "Search queries were analyzed for six major ACE inhibitors (captopril, enalapril, lisinopril, perindopril, ramipril, fosinopril), as well as for their brand names (21 drugs in total). The identified digital patterns may indirectly reflect medication-related information needs and potential gaps in the population's health literacy. The infodemiological approach represents a promising tool for monitoring patients' information needs and optimizing clinical communication and preventive programs."

Journal • Cardiovascular • Hypertension

Scleroderma Renal Crisis in Mixed Connective Tissue Disease. (PubMed, Am J Med) - "Management focuses on prompt initiation of angiotensin-converting enzyme inhibitors, particularly captopril, to control blood pressure and prevent irreversible renal injury...Emerging therapies, including endothelin receptor antagonists and complement inhibitors, may offer benefit in refractory cases. Awareness of scleroderma renal crisis in mixed connective tissue disease is crucial for early recognition and timely intervention to improve outcomes."

Journal • Review • Cardiovascular • Chronic Kidney Disease • Hematological Disorders • Hypertension • Immunology • Nephrology • Renal Disease • Rheumatology • Scleroderma • Systemic Sclerosis • Transplantation

Antioxidant and Antihypertensive Activities of Ficus exasperata Vahl Leaves: Integrated In Vitro Evaluation and In Silico Multi-Target Mechanistic Insights. (PubMed, Chem Biodivers) - "Antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, while angiotensin-converting enzyme (ACE) inhibitory activity was compared with captopril...Docking analysis revealed strong affinities with nitric oxide synthase 3 (NOS3) and ACE, and simulations confirmed stable ligand-NOS3 interactions. These findings support the therapeutic potential of F. exasperata in HTN management."

Journal • Preclinical • Cardiovascular • Hypertension • NOS3

Coexistence of primary aldosteronism and micro-pheochromocytoma: a case report with pathological analysis and literature review. (PubMed, Front Med (Lausanne)) - "A mildly elevated aldosterone to renin ratio and an unsuppressed captopril challenge test met the diagnostic criteria for primary aldosteronism...This case highlights the importance of early identification and diagnosis, and it provides experience regarding the diagnostic and treatment protocol for such a rare condition. Pathological findings and the KCNJ5 mutation in APN provide directions for subsequent research on the pathogenesis of concomitant PA and PHEO."

Journal • Cardiovascular • Endocrine Disorders • Hypertension • Oncology • Pain • Solid Tumor

Captopril alleviates vascular endothelial dysfunction by regulating TRPV1 and activating the eNOS pathway. (PubMed, Eur J Pharmacol) - "This study predicted potential targets and pathways through which CAP may act on VED. For the first time, CAP was shown to alleviate diabetic VED in a TRPV1-dependent manner by activating the TRPV1/eNOS pathway, thereby attenuating oxidative stress and restoring endothelial function. These findings highlight CAP as a potential therapeutic agent for mitigating eNOS over-inhibition and endothelial dysfunction in diabetes."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • CDC37 • NOS3 • PPARG • TRPV1