resolvin E1 (RX-10001) / Resolvyx - LARVOL DELTA

Resolvin E1 (RE) attenuates LPS induced inflammation and subsequent atrophy in C2C12 myotubes. (PubMed, J Cell Biochem) - "These findings demonstrate, in our model of endotoxin induced inflammation in skeletal muscle, that REhas pro-resolving properties in this cell type. Our data provides rationale for further investigation into the mechanistic action of REin skeletal muscle, with the vision of having potential benefits for the prevention/resolution of in-vivo skeletal muscle atrophy."

Journal • Biosimilar • Immunology • Ophthalmology

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23. (PubMed, Psychopharmacology (Berl)) - "The results of this study demonstrate that (1) RvE1/RvE2 produce antidepressant effects likely via ChemR23, (2) mTORC1 signaling mediates the antidepressant effect of RvE1, and (3) mPFC and DG are the key brain regions involved in these actions. RvE1/RvE2 and their receptors may be promising targets for the development of novel antidepressants."

Journal • Biosimilar • CNS Disorders • Depression