SL-601 / Menarini - LARVOL DELTA

Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model. (PubMed, Genes (Basel)) - "Interestingly, changes induced by LSL60101 in the 5XFAD model were validated for several genes. These results suggest that treatment with LSL60101 in the 5XFAD model reverses the inflammatory process during the development of AD."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Immunology • Inflammation

Benzofuranyl-2-imidazoles as imidazoline I receptor ligands for Alzheimer's disease. (PubMed, Eur J Med Chem) - "In vivo studies in the familial Alzheimer's disease 5xFAD murine model with the representative compound, revealed significant decreases in the protein expression levels of antioxidant enzymes superoxide dismutase and glutathione peroxidase in hippocampus. Overall, LSL60101 plays a neuroprotective role by reducing apoptosis and modulating oxidative stress."

Journal • Alzheimer's Disease • CNS Disorders • FADD

Disease-modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: A Comparative study with donepezil. (PubMed, Br J Pharmacol) - "Our results suggest that chronic low dose treatment with selective I2-IR ligands can be an effective treatment for AD and provide insights into combination treatments of symptomatic and disease-modifying drugs."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Immunology • Inflammation • Mood Disorders • Psychiatry • GFAP • SYP

Exploring the antidepressant-like potential of the selective I-imidazoline receptor ligand LSL 60101 in adult male rats. (PubMed, Pharmacol Rep) - "These results add to the existing literature by suggesting that not all I ligands might be capable of displaying an antidepressant-like potential, and that particularities in the chemical structure of each compound might help explain these discrepancies and deserve future studies."

Journal • CNS Disorders • Pain • Psychiatry • FADD • MAPK8