Ganfule / China Medical System - LARVOL DELTA

Mechanistic insights into the Ganfule capsule in alleviating alcoholic liver disease. (PubMed, Bioorg Chem) - "GFL capsule exerts a protective effect against ALD in mice and hepatocytes, potentially through the inhibition of inflammation, oxidative stress and apoptosis. This study provides a solid theoretical foundation for the potential application of GFL capsule in the prevention and clinical management of ALD."

Journal • Hepatology • Inflammation • Liver Cancer • Metabolic Disorders • Oncology • Solid Tumor • CYP2E1 • IL17A • IL17RA • IL6

Ganfule capsule alleviates AFB1-induced toxic liver injury via inhibiting oxidative stress, inflammatory response, and apoptosis. (PubMed, Ecotoxicol Environ Saf) - "Molecular docking analysis, molecular dynamics simulation, and in vitro experiments suggest that quercetin (QCT) mediates its effects through specifically binding to IL6 and STAT3, resulting in the subsequent inhibition of the IL6/STAT3 signaling pathway. This study elucidates the pharmacological mechanism of GFL in treating AFB1-induced toxic liver injury, providing theoretical evidence for its clinical application."

Journal • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cancer • Liver Failure • Oncology • Solid Tumor • IL6 • KEAP1

Systems Biology Approach to Unraveling Transcriptomic Mechanisms of Ganfule Capsules in Ameliorating Nonalcoholic Fatty Liver Disease. (PubMed, Comb Chem High Throughput Screen) - "This study enhances understanding of GFL's efficacy and identifies potential biomarkers for NAFLD treatment. Optimizing GFL's efficacy and elucidating its mechanism provides a methodological reference for traditional Chinese medicine exploration."

Journal • Genetic Disorders • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity • ABCG1 • FABP4 • IGFBP1 • LEP • PDK4 • SOCS3 • STAT3

The molecular and network mechanisms of antilipidemic potential effects of Ganfule capsules in nonalcoholic fatty liver disease. (PubMed, Heliyon) - "GFL improved the histopathological features of NAFLD rats by regulating lipid metabolism as well as reducing hepatocyte apoptosis and hepatocellular steatosis. These findings offer insights into the biochemical mechanism of action of GFL and support its use in the treatment for NAFLD."

Journal • Fibrosis • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • PIK3CG • PPARA • PRKACA

Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism. (PubMed, Front Pharmacol) - " This study confirms the protective effect of GFL on liver injury and shows that GFL inhibits glutamine metabolism, which was correlated with the NF-κB pathway, and eventually alleviates liver fibrosis. These results are conducive to the development of new therapeutic drugs for liver fibrosis."

Journal • Preclinical • Fibrosis • Gastroenterology • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Immunology • Liver Cancer • Liver Cirrhosis • Liver Failure • Metabolic Disorders • Oncology • Solid Tumor • GLS1 • RELA

Chinese Herbal Medicine for Primary Liver Cancer Therapy: Perspectives and Challenges. (PubMed, Front Pharmacol) - "We also summarize the latest in vivo, in vitro, and clinical studies of CHM-derived compounds against PLC: icaritin and ginsenoside Rg3. Dilemmas facing the development of CHMs, such as drug toxicity and low oral availability, and future developments are also discussed. This review provides a deeper the understanding of CHMs as PLC treatments and provides ideas for the development of new natural drugs against PLC."

Journal • Review • Gastrointestinal Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor

Effects of Ganfule Capsule on microbial and metabolic profiles in anti-hepatocellular carcinoma. (PubMed, J Appl Microbiol) - "This study is the first to report the anti-HCC effect of GFL associated with gut microbiota and plasma metabolites. GFL may improve the gut microbiota structure, such as increasing probiotics - Lactobacillus. It also provides a new strategy for the scientific demonstration of the modernization of traditional Chinese medicine."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Metabolic Disorders • Oncology • Solid Tumor • BAX • BCL2

Network Meta-analysis of oral Chinese patent medicine for adjuvant treatment of primary liver cancer (PubMed, Zhongguo Zhong Yao Za Zhi) - "In terms of the effective rate, 1-year survival rate, 2-year survival rate, KPS score improvement rate and reduced adverse reaction incidence, the optimal treatment measures were Shenyi Capsules, Cidan Capsules, Pingxiao Capsules, Huaier Granules and Huisheng Oral Liquid in turn. However, due to the limitations of the research, the current level of evidence is not high, and clear conclusions and evi-dence strength still need to be further verified and improved by high-quality researches."

Journal • Retrospective data • Gastrointestinal Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor