interferon alpha-5 (IFN alpha 5) / Digna Biotech - LARVOL DELTA

Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling. (PubMed, Circ Heart Fail) - "cRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5. Differential biologic pathway activation by sex in cRM may contribute to the female predominance of HFpEF and holds promise for identification of new therapeutic avenues for prevention and treatment of HFpEF."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension