etodolac / Generic mfg. - LARVOL DELTA

Comparative in silico evaluation of selective and preferential COX-2 inhibitors: Insights from molecular docking, molecular dynamics, ADMET, and toxicity profiling. (PubMed, Comput Biol Chem) - "Using an integrative multi-scale computational workflow that includes docking, MM-GBSA, Molecular Dynamics (MD), ADMET, and toxicity profiling, this study differentiates highly selective inhibitors (celecoxib, etoricoxib) from preferential agents (meloxicam, etodolac). These results suggest that scaffold rigidity and specific side-pocket bonding are the primary determinants of isoform exclusivity. This study provides a structure-guided mechanistic framework for elucidating the pharmacological diversity and safety of COX-2 inhibitors."

Journal • Inflammation

Comparative effects of thiocolchicoside and etodolac on fracture healing in a rat femur model. (PubMed, J Orthop Surg Res) - No abstract available

Journal • Preclinical • Musculoskeletal Diseases • Orthopedics

Nonsteroidal Anti-Inflammatory Drug Use in Orthopaedic Surgery Practice is Increasing: A Review of Medicare Part D Claims from 2013 to 2021 (AAOS 2026) - "The use of ketorolac, meloxicam, diclofenac, celecoxib, and ibuprofen significantly increased with time while the use of naproxen, nabumetone, etodolac, sulindac, piroxicam, and indomethacin significantly decreased (Table 2). Outpatient NSAID prescriptions by orthopaedic surgery providers increased between 2013 and 2021and is likely underestimated by these data as the majority of NSAIDs are available as over the counter medications. Further study is needed to identify if these practice patterns represent rising use in the setting of fracture surgery as historically this has been the subspecialty where their use was most limited."

Medicare • Reimbursement • Review • Surgery • US reimbursement • Musculoskeletal Diseases • Orthopedics

Optimization and validation of an HPLC method for the quantification of Etodolac in liposomes and assessment of its pharmacokinetic profile. (PubMed, Wiad Lek) - " The developed and validated method of HPLC was successfully applied to determine Etodolac in bulk and liposomes for routine quantitative analysis."

Journal • PK/PD data

A unified framework combining linear and 3D molecular features for robust drug-protein interaction prediction. (PubMed, Cell Rep Methods) - "We demonstrate improved performance over several state-of-the-art (SOTA) methods, including increased accuracy in dealing with unseen molecules. Four predicted drug-protein interactions (DPIs) are experimentally validated at both mRNA and protein levels, highlighting the therapeutic potential of adenosine in inflammatory diseases, ondansetron and etodolac in neurological diseases, and neuroprotective action for dopamine."

Journal • CNS Disorders • Inflammation

Antibacterial activity of new azole derivatives incorporating Etodolac. (PubMed, Wiad Lek) - " The results of this research suggest that incorporating Etodolac into the synthesis of azole derivatives can lead to potent antimicrobial agents. Further exploration of these compounds is warranted to fully understand their potential therapeutic applications."

Journal

Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis (clinicaltrials.gov) - P2 | N=30 | Not yet recruiting | Sponsor: Pharos University in Alexandria

New P2 trial • Immunology • Osteoarthritis • Pain • Rheumatology

How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac? (PubMed, Pharmaceutics) - " The optimized SD formulation for ETD contained PVP/VA and/or poloxamer as carriers and was obtained via lyophilization. This SD formulation exhibited the most favorable properties, enhanced the solubility and dissolution of ETD in aqueous media and effectively reduced its crystallinity."

Journal

Multifocal bullous fixed-drug eruption caused by etodolac mimicking autoimmune bullous diseases: a case report. (PubMed, Eur J Dermatol) - No abstract available

Journal • Immunology

Evaluating in-depth potential of Pluronic F127-tailored complex micellar systems of etodolac for the therapeutic management of uveitis: A comprehensive preclinical study. (PubMed, Int J Pharm) - "The HCF cell line studies and ocular compliance experiments using HET-CAM test construed the biocompatible nature of the CMs. The studies, overall, explicitly testify the therapeutic promise of CMs-based Etodolac formulation in treating ocular inflammatory disorders like uveitis."

Journal • Preclinical • Cardiovascular • Glaucoma • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis • IL6 • TNFA

Restorative Neurostimulation of lumbar multifidus muscles in a patient with severe degenerative lumbar scoliosis. (ASRA-FALL 2025) - "Current medication regimen includes gabapentin, etodolac, acetaminophen, cyclobenzaprine and tramadol Known severe degenerative scoliosis MRI confirmed grade 2 (>50%) multifidus atrophy For management of symptoms, Reactiv8 regenerative neurostimulation device implanted Outcome: 12 day post operative visit: No complications. Therapy sessions initiated 10 week follow up: Subjective improvement in pain and functionality, requiring less etodolac and acetaminophen, Left-sided lead activated, Reports ongoing right leg pain 15 month follow up: Patient undergoes right total hip arthroplasty for management of right leg pain 19 month follow up: Ongoing relief of back pain, Patient able to discontinue use of tramadol Discussion Restorative neurostimulation shows promise as pain management strategy for patients with scoliosis and MD. Further research is needed to determine overall safety, feasibility and efficacy"

Clinical • Back Pain • Lumbar Back Pain • Muscular Atrophy • Musculoskeletal Pain • Orthopedics

A new approach for the development of Etodolac emulgels for rheumatic arthritis cure: In vitro and in vivo assessments. (PubMed, Drug Dev Ind Pharm) - "The modified emulgels did not show any sign of irritation on rats' dorsal skin. The obtained results highlighted the promising application of topical ETD emulgels as an alternative anti-inflammatory drug delivery system."

Journal • Preclinical • Immunology • Rheumatoid Arthritis • Rheumatology

Safety of COX-2 Inhibitor NSAIDs in Inflammatory Bowel Disease: A Propensity-Matched Cohort Study Using Real-World Data (ACG 2025) - "Selective COX-2: celecoxib; preferential COX-2: meloxicam, nabumetone, etodolac. Across four matched cohorts (two in UC and two in CD), sample sizes ranged from 805 to 3,009 per group. In UC, the primary composite outcome occurred in 5.2%–5.8% of patients across comparisons, with no significant differences observed. In CD, the primary outcome ranged from 5.9%–7.0%, also without significant associations."

Clinical • Real-world • Real-world evidence • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Systematic review and meta-analysis of analgesic treatment options in patients with rheumatoid arthritis related pain. (PubMed, Adv Rheumatol) - "Several therapies demonstrated substantial pain relief, but heterogeneity, publication bias, and varying study quality limit generalizability. High-quality, long-term trials with standardized pain assessments are needed to guide personalized rheumatoid arthritis pain management."

Clinical • Journal • Retrospective data • Review • Immunology • Inflammation • Inflammatory Arthritis • Musculoskeletal Pain • Pain • Rheumatoid Arthritis • Rheumatology

Systemic Metabolic Alterations Induced by Etodolac in Healthy Individuals. (PubMed, Pharmaceuticals (Basel)) - "These selective metabolic alterations complement its COX-2 inhibition and may contribute to its anti-inflammatory effects. This study provides new insights into Etodolac's metabolic impact under healthy conditions and may inform future therapeutic strategies targeting inflammation."

Journal • Inflammation • Metabolic Disorders • Pain

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

Biological Activities of Etodolac-Based Hydrazone, Thiazolidinone and Triazole Derivatives on Breast Cancer Cell Lines MCF-7 and MDA-MB-231. (PubMed, J Biochem Mol Toxicol) - "The results of this study suggest that, in comparison to a healthy control group, the thiazolidinone derivative SGK 206 and the thiazolidinone derivative SGK 217 are more effective than etodolac when it comes to the breast cancer cell lines MCF-7 and MDA-MB-231. SGK 206 exhibits a low IC50 value, a distinct dose-response relationship, and strong apoptotic effects, particularly on MDA-MB-231 cells."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • PTGS2

Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach. (PubMed, Sci Rep) - "Drug-gene interaction analysis identified nine therapeutic compounds, including etodolac targeting NFE2L2 and PTGS2. A strong positive correlation (r = 0.72, p < 0.001) between NFE2L2 and PTGS2 expression was observed. This study establishes senescence-related genes as promising biomarkers and therapeutic targets for IS, particularly through NFE2L2-PTGS2 interactions, providing a foundation for developing immunomodulatory and targeted therapies."

Biomarker • Journal • Cardiovascular • Gene Therapies • Ischemic stroke • HIF1A • PACERR • PTGS2 • TGFB1

The M&M Trial: Evaluating micronutrients and mindfulness for emotional dysregulation in children: A community-based randomised placebo-controlled trial (ANZCTR) - P=N/A | N=160 | Recruiting | Sponsor: Professor Julia Rucklidge | Not yet recruiting ➔ Recruiting

Enrollment open

Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study. (PubMed, Front Neurosci) - "Notably, both WMH categories share common metabolites, particularly polyunsaturated fatty acids (PUFA), while PVWMH-specific metabolites were primarily carnitine derivatives, and DWMH-specific metabolites were prostaglandin E2 and etodolac...However, the cross-sectional nature of the study does not allow for causal conclusions. Future longitudinal studies are needed to validate the temporal relationships between metabolic perturbations and WMH progression."

Journal • Atherosclerosis • CNS Disorders • Metabolic Disorders

Enhanced skin adhesion of transdermal drug delivery systemviaa semi-IPN strategy:in vitro/in vivoevaluation and drug release mechanism. (PubMed, Colloids Surf B Biointerfaces) - "Meanwhile, rivastigmine, etodolac, ketoprofen, propranolol, pirfenidone, and zolmitriptan were used to evaluate drug release rates from the semi-IPN PSA. The release rates of different drugs were negatively correlated with drug polarizability, suggesting dipole-dipole interactions as the key mechanism. In summary, the semi-IPN strategy offers a robust solution for high-performance transdermal patches by improving adhesion without compromising drug release."

Journal • Preclinical

lodine-131 combined with plasma exchange treatment in Graves' hyperthyroidism patients with severe liver injury (APASL 2025) - "Our study enrolled Graves' hyperthyroidism patients with severe liver injury whose total bilirubin reached the definition of liver failure, and shows that liver function test can recover on about 3 months treated iodine-131 combined with PE therapy. Table and Figure:Figure 1.The level of bilirubin before and after iodine-131 treatment."

Clinical • Endocrine Disorders • Grave’s Disease • Hepatology • Liver Failure

Global Perspectives on China's lodine Dietary Reference Intakes: Revisions, Public Health Implications, and Future Strategies. (PubMed, J Nutr) - "By comparing iodine intake recommendations worldwide, this review aims to provide a comprehensive understanding of iodine nutrition and its impact on public health. It also identifies gaps in current research and offers insights into future directions for ensuring optimal iodine intake through updated guidelines and public health interventions."

Journal • Endocrine Disorders

Impact of high lodine and fluoride intake on children's IQ in rural China. (PubMed, Eur J Nutr) - "High levels of both fluoride and iodine intake negatively affect the IQ of school-age children. Monitoring and regulating these elements in children's diets is essential to prevent cognitive impairment."

Journal • Alzheimer's Disease • Cognitive Disorders

Quality of Life Outcomes Following Radioactive lodine 131 Therapy in Hyperthyroid Patients: Insights from the Thyroid Patient-Reported Outcome Questionnaire. (PubMed, Mol Imaging Radionucl Ther) - "These findings support the use of RAI 131 as a primary treatment for hyperthyroidism, highlighting the importance of personalized treatment approaches for optimizing patient outcomes. Future research should focus on long-term QoL outcomes and refine therapeutic strategies."

HEOR • Journal • Endocrine Disorders • Grave’s Disease