etodolac / Generic mfg. - LARVOL DELTA

Pulsed Electric Field Ablation for Radioactive lodine-Refractory Metastatic Papillary Thyroid Carcinoma (ATA 2026) - No abstract available

Metastases • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma

Isolated Collagenous Gastritis With Biopsy-Confirmed Histologic Resolution Following Etodolac Cessation in an Adult With Psoriatic Arthritis and Atopic Diathesis (ACG 2026) - "Medication included chronic daily etodolac, adalimumab, and valsartan...An empiric 8-week course of pantoprazole 40mg twice daily failed to improve symptoms...Without an identifiable etiology, etodolac was discontinued, and therapy was transitioned to omeprazole 40mg twice daily...(A) Initial evaluation demonstrating diffuse moderate inflammation with erythema, edema, erosions, and friability of the gastric body. (B) Follow-up endoscopy after etodolac cessation showed a more uniform mucosal surface with reduced erythema and fewer erosive changes."

Biopsy • Clinical • Allergic Rhinitis • Atopic Dermatitis • Celiac Disease • Dermatitis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Isolated Small Bowel Obstruction Complicated by Retained Video Capsule Endoscope: An Uncommon Initial Manifestation of Crohn's Disease (ACG 2026) - "Case Description/ A 57-year-old man with a history of rheumatoid arthritis treated with methotrexate and etodolac presented with severe right lower quadrant abdominal pain...The patient was started on adalimumab with good tolerance and no further complications at this time...Caution must be taken during the choice of diagnostic tests when SBO is present and CD is on the differential. Figure: Retained video capsule endoscope"

Video • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Rheumatoid Arthritis

COXTRANs (CXT): Rationally designed dual COX-2/TP agents with therapeutic potential in inflammation-related pathologies and cancer metastasis | Poster Board #D04 (ACS-Fall 2026) - "Starting from the scaffold of etodolac, a FDA-approved drug, over 50 analogues were synthesized through systematic modifications of the tetrahydropyranindole core...Figure 1. SAR summary and structure of the lead compound CXT29"

Breast Cancer • Oncology • Solid Tumor

Development and Optimization of Sodium Deoxycholate-Stabilised Shellac-Based Polymeric Nanoparticles for Enhanced Pharmacokinetics and Anticancer Activity of Etodolac in Hepatocellular Carcinoma. (PubMed, Polymers (Basel)) - "ETD-SDS-SHNPs formulation offers an enhanced passive, efficient, and safer nanocarrier platform for repurposing etodolac in liver cancer therapy, showing significant promise for improving clinical outcomes in HCC treatment."

Journal • PK/PD data • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Pain Characteristics, Analgesic Use Patterns, and Reliability of the Short-Form McGill Pain Questionnaire in Community-Dwelling Older Adults: A Cross-Sectional Study. (PubMed, Pain Manag Nurs) - "Routine pain assessment and nurse involvement may contribute to more informed analgesic use in older adults. The SF-MPQ may serve as a practical assessment tool in older adults."

Journal • Observational data • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Exosomal gene-based predictive model and therapeutic target identification for Alzheimer's disease: A bioinformatics analysis. (PubMed, PLoS One) - "Our comprehensive analyses successfully established a reliable exosomal gene-based model for predicting AD pathogenesis, and identified relevant pharmacological networks and core molecular docking targets, providing novel insights for AD diagnosis and targeted therapy."

Journal • Alzheimer's Disease • CNS Disorders • CXCR4 • TUBB

NSAID use is associated with lower dementia and Alzheimer's disease prevalence and slower cognitive decline: A retrospective longitudinal analysis of the NACC cohort. (PubMed, medRxiv) - "These findings suggest a compound-specific association between NSAID use and AD, with diclofenac potentially modulating disease progression through anti-inflammatory mechanisms. The observed modulation of longitudinal cognitive decline supports further investigation of inflammatory pathways, including microglial and inflammasome signaling, as therapeutic targets in biomarker-defined AD populations."

Journal • Retrospective data • Alzheimer's Disease • CNS Disorders • Dementia • Inflammation

The impact of ubrogepant on the use of other migraine acute treatments, opioid discontinuation, and healthcare utilization: Results from a pre-post opioid subcohort analysis (AHS 2026) - "Acute medications other than ubrogepant included acetaminophen, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, dihydroergotamine, ergotamine, amobarbital, aprobarbital, butabarbital, butalbital, mephobarbital, metharbital, pentobarbital, phenobarbital, secobarbital, talbutal, barbital, codeine, hydrocodone, meperidine, morphine, oxycodone, propoxyphene, tramadol, aspirin, bromfenac, celecoxib, diclofenac, diflunisal, esomeprazole, etodolac, famotidine, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, sulindac, tolmetin, lasmiditan, Zavegepant, and Rimegepant (<15 pills). Opioid use included acetaminophen/tramadol, oxymorphone, levorphanol, buprenorphine/naloxone, meperidine, morphine, oxycodone, codeine, methadone, oxycodone, hydromorphone, butorphanol, and tapentadol... In patients with a history of opioid use,..."

HEOR • CNS Disorders • Migraine • Pain

Favorable safety outcomes of a perioperative propranolol and etodolac regimen in cancer patients in four randomized controlled trials. (PubMed, Front Pharmacol) - P=N/A, P2, P3 | "These findings suggest the safety of this inexpensive and easy-to-implement perioperative propranolol and etodolac regimen in patients participating in these RCTs. https://clinicaltrials.gov/study/NCT00502684, https://clinicaltrials.gov/study/NCT00888797, https://clinicaltrials.gov/study/NCT03919461, https://clinicaltrials.gov/study/NCT03838029, identifier NCT00502684, NCT00888797, NCT03919461, NCT03838029."

Clinical • Journal • Cardiovascular • Colorectal Cancer • Infectious Disease • Oncology • Pain • Pancreatic Cancer • Solid Tumor

Smart Functionalization of Acupuncture Needle Enables Molecular Subtyping and Personalized Treatment of Osteoarthritis. (PubMed, ACS Biomater Sci Eng) - "The degradation of each segment triggers the controlled release of a corresponding therapeutic agent: Batimastat, Etodolac, and Docetaxel. After implantation, the needle can be retrieved, and the degradation status of each hydrogel segment assessed by fluorescence imaging, providing a post-treatment readout of the dominant OA molecular subtype. Collectively, this multifunctional platform, termed helical-groove acupuncture needle (HGN), represents a promising strategy to curtail OA progression by simultaneously promoting cartilage restoration and inhibiting fibrotic changes."

Journal • Fibrosis • Genetic Disorders • Immunology • Inflammation • Obesity • Osteoarthritis • Pain • Rheumatology • ADAMTS5 • MMP13 • TGFB1

Perioperative psycho-behavioral stress promotes cancer metastasis beyond the impact of surgery: Neuroendocrine and tumor molecular mediating mechanisms. (PubMed, Brain Behav Immun Health) - "In the latter, we also assessed the efficacy of glucocorticoid, β-adrenergic, or COX-2 inhibitors/antagonists (mifepristone, propranolol, or etodolac) in preventing the effects of stress. Overall, psycho-behavioral stress can uniquely contribute to metastatic progression through stress responses and malignant pro-metastatic transcriptional pathways. Thus, in cancer patients, managing perioperative distress may improve long-term cancer outcomes."

Journal • Breast Cancer • Colorectal Cancer • Inflammation • Neuroendocrine Tumor • Oncology • Solid Tumor

Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis (clinicaltrials.gov) - P=N/A | N=120 | Recruiting | Sponsor: Konya Beyhekim Training and Research Hospital

New trial • Musculoskeletal Pain • Neuralgia • Pain

Comparative in silico evaluation of selective and preferential COX-2 inhibitors: Insights from molecular docking, molecular dynamics, ADMET, and toxicity profiling. (PubMed, Comput Biol Chem) - "Using an integrative multi-scale computational workflow that includes docking, MM-GBSA, Molecular Dynamics (MD), ADMET, and toxicity profiling, this study differentiates highly selective inhibitors (celecoxib, etoricoxib) from preferential agents (meloxicam, etodolac). These results suggest that scaffold rigidity and specific side-pocket bonding are the primary determinants of isoform exclusivity. This study provides a structure-guided mechanistic framework for elucidating the pharmacological diversity and safety of COX-2 inhibitors."

Journal • Inflammation

Comparative effects of thiocolchicoside and etodolac on fracture healing in a rat femur model. (PubMed, J Orthop Surg Res) - No abstract available

Journal • Preclinical • Musculoskeletal Diseases • Orthopedics

Nonsteroidal Anti-Inflammatory Drug Use in Orthopaedic Surgery Practice is Increasing: A Review of Medicare Part D Claims from 2013 to 2021 (AAOS 2026) - "The use of ketorolac, meloxicam, diclofenac, celecoxib, and ibuprofen significantly increased with time while the use of naproxen, nabumetone, etodolac, sulindac, piroxicam, and indomethacin significantly decreased (Table 2). Outpatient NSAID prescriptions by orthopaedic surgery providers increased between 2013 and 2021and is likely underestimated by these data as the majority of NSAIDs are available as over the counter medications. Further study is needed to identify if these practice patterns represent rising use in the setting of fracture surgery as historically this has been the subspecialty where their use was most limited."

Medicare • Reimbursement • Review • Surgery • US reimbursement • Musculoskeletal Diseases • Orthopedics

Optimization and validation of an HPLC method for the quantification of Etodolac in liposomes and assessment of its pharmacokinetic profile. (PubMed, Wiad Lek) - " The developed and validated method of HPLC was successfully applied to determine Etodolac in bulk and liposomes for routine quantitative analysis."

Journal • PK/PD data

A unified framework combining linear and 3D molecular features for robust drug-protein interaction prediction. (PubMed, Cell Rep Methods) - "We demonstrate improved performance over several state-of-the-art (SOTA) methods, including increased accuracy in dealing with unseen molecules. Four predicted drug-protein interactions (DPIs) are experimentally validated at both mRNA and protein levels, highlighting the therapeutic potential of adenosine in inflammatory diseases, ondansetron and etodolac in neurological diseases, and neuroprotective action for dopamine."

Journal • CNS Disorders • Inflammation

Antibacterial activity of new azole derivatives incorporating Etodolac. (PubMed, Wiad Lek) - " The results of this research suggest that incorporating Etodolac into the synthesis of azole derivatives can lead to potent antimicrobial agents. Further exploration of these compounds is warranted to fully understand their potential therapeutic applications."

Journal

Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis (clinicaltrials.gov) - P2 | N=30 | Not yet recruiting | Sponsor: Pharos University in Alexandria

New P2 trial • Immunology • Osteoarthritis • Pain • Rheumatology

How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac? (PubMed, Pharmaceutics) - " The optimized SD formulation for ETD contained PVP/VA and/or poloxamer as carriers and was obtained via lyophilization. This SD formulation exhibited the most favorable properties, enhanced the solubility and dissolution of ETD in aqueous media and effectively reduced its crystallinity."

Journal

Multifocal bullous fixed-drug eruption caused by etodolac mimicking autoimmune bullous diseases: a case report. (PubMed, Eur J Dermatol) - No abstract available

Journal • Immunology

Evaluating in-depth potential of Pluronic F127-tailored complex micellar systems of etodolac for the therapeutic management of uveitis: A comprehensive preclinical study. (PubMed, Int J Pharm) - "The HCF cell line studies and ocular compliance experiments using HET-CAM test construed the biocompatible nature of the CMs. The studies, overall, explicitly testify the therapeutic promise of CMs-based Etodolac formulation in treating ocular inflammatory disorders like uveitis."

Journal • Preclinical • Cardiovascular • Glaucoma • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis • IL6 • TNFA

Restorative Neurostimulation of lumbar multifidus muscles in a patient with severe degenerative lumbar scoliosis. (ASRA-FALL 2025) - "Current medication regimen includes gabapentin, etodolac, acetaminophen, cyclobenzaprine and tramadol Known severe degenerative scoliosis MRI confirmed grade 2 (>50%) multifidus atrophy For management of symptoms, Reactiv8 regenerative neurostimulation device implanted Outcome: 12 day post operative visit: No complications. Therapy sessions initiated 10 week follow up: Subjective improvement in pain and functionality, requiring less etodolac and acetaminophen, Left-sided lead activated, Reports ongoing right leg pain 15 month follow up: Patient undergoes right total hip arthroplasty for management of right leg pain 19 month follow up: Ongoing relief of back pain, Patient able to discontinue use of tramadol Discussion Restorative neurostimulation shows promise as pain management strategy for patients with scoliosis and MD. Further research is needed to determine overall safety, feasibility and efficacy"

Clinical • Back Pain • Lumbar Back Pain • Muscular Atrophy • Musculoskeletal Pain • Orthopedics

A new approach for the development of Etodolac emulgels for rheumatic arthritis cure: In vitro and in vivo assessments. (PubMed, Drug Dev Ind Pharm) - "The modified emulgels did not show any sign of irritation on rats' dorsal skin. The obtained results highlighted the promising application of topical ETD emulgels as an alternative anti-inflammatory drug delivery system."

Journal • Preclinical • Immunology • Rheumatoid Arthritis • Rheumatology