Secnizol DS (secnidazole) / Incepta Pharma - LARVOL DELTA

Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole (clinicaltrials.gov) - P4 | N=1200 | Recruiting | Sponsor: Tulane University | Not yet recruiting ➔ Recruiting

Enrollment open • Gynecology • Infectious Disease • Vaginitis

Once Weekly Secnidazole Granules for the Treatment of Recurrent Bacterial Vaginosis (ACOG 2025) - "Twenty-four patients enrolled. Four patients were ineligible. Five patients failed initial therapy and were not eligible for suppressive therapy."

Infectious Disease • Vaginitis

Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates. (PubMed, Microbiol Spectr) - "We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Drug Administration-approved 5-nitroimidazoles (metronidazole [MTZ], tinidazole [TDZ], and secnidazole [SEC]) against MTZ-susceptible and MTZ-resistant Trichomonas vaginalis clinical isolates. Additionally, comprehensive investigations can help inform public health strategies and reduce transmission rates. Ultimately, prioritizing research in this area is essential for improving patient outcomes and safeguarding reproductive health."

Journal • Preclinical • Infectious Disease

Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights. (PubMed, Drug Dev Res) - "In Vitro assays evaluated the effects of representative nitroimidazoles, metronidazole (MET) and secnidazole (SEC), on QS-controlled phenotypes, including violacein production in Chromobacterium violaceum and biofilm formation and protease activity in Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella enterica, and Proteus mirabilis...These findings position nitroimidazoles as dual-function agents; antimicrobial at bactericidal doses and anti-virulence at sub-MICs. Their validated efficacy across In Silico, In Vitro, and In Vivo models underscores their potential as adjunctive therapies, bridging the gap between drug repurposing and next-generation anti-infective development."

Journal • Preclinical • Infectious Disease

How to proceed with easily recrystallizing secnidazole in designing polyelectrolyte complex-based films for periodontitis treatment? (PubMed, Eur J Pharm Sci) - "The impact of utilized polymeric composition and polyelectrolyte complex structures as well as secnidazole form (crystalline/amorphous) on the films performance was observed. The increased temperature of drying enhanced secnidazole-polymers miscibility, which resulted in desirable drug loading improvement and also significantly prolonged secnidazole release to the artificial saliva."

Journal • Dental Disorders • Infectious Disease • Periodontitis

Simultaneous determination of five nitroimidazole antimicrobials in pharmaceuticals using HPLC-ESM and QAMS methods. (PubMed, BMC Chem) - "A green, rapid, and simple HPLC-External standard method (ESM) and a quantitative analysis of multi- components with a single-marker (QAMS) method were established for the simultaneous determination of five nitroimidazole antimicrobials (Metronidazole sodium chloride injection, Tinidazole injection, Ornidazole sodium chloride injection, Morinidazole sodium chloride injection, Secnidazole tablets) in pharmaceutical preparations...In addition, the analytical greenness (AGREE) and blue applicability grade index (BAGI) metric tools were used to evaluate the greenness and environmental friendliness of the developed methods. AGREE scores of QAMS and EMS were 0.66 and 0.59, and BAGI scored 82.5 and 77.5, respectively."

Journal

Low-cost and portable 3D-printed sensor for the determination of secnidazole in pharmaceutical and seized drug samples. (PubMed, Anal Methods) - "The obtained results were statistically similar (95% confidence level) to the values obtained by HPLC. These findings demonstrate that the 3D-printed electrodes developed in this study provide a cost-effective, facile, and highly sensitive platform for on-site SCZ analysis, presenting significant potential for future forensic applications."

Journal

Sunlight-mediated environmental risks of tinidazole in seawater: A neglected ocular toxicity of photolysis mixtures. (PubMed, J Hazard Mater) - "Herein, the photochemical reactivity of TNZ and four other typical nitroimidazoles (i.e., metronidazole, ornidazole, dimetridazole, and secnidazole) were quantified for multiple photoreactive species...This work reported the first comprehensive assessment of the photolysis-mediated environmental fate and secondary risks of TNZ in seawater. The findings highlighted the necessity of including complex photolysis mixtures under solar irradiation in future chemical risk assessments of marine environments."

Journal

Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis. (PubMed, Front Cell Infect Microbiol) - "The clinical cure rate of oral ornidazole was better than clindamycin (RR 16.08; 95%-CI 1.72-150.47), Secnidazole (RR 8.17; 95%-CI 1.66-40.25) and probiotics. The clinical cure rate of vaginal application of sucrose was better than metronidazole (RR 1.12; 95%-CI 1.03-1.21) and metronidazole had a lower clinical cure rate than probiotics (RR 0.68; 95%-CI 0.52-0.88). The results of this systematic review and network meta-analysis suggest that ornidazole may be an effective alternative for the treatment of BV, and that sucrose and probiotics are potential BV treatments that need to be validated by more high-quality clinical studies in the future."

Clinical • Journal • Retrospective data • Review • Vaginitis

Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products. (PubMed, Anal Bioanal Chem) - "Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China's State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health."

Journal

Silver secnidazole nano-hybrid emulsion-based probiotics as a novel antifungal formula against multidrug-resistant vaginal pathogens. (PubMed, Biotechnol Appl Biochem) - "TEM photographs showed that C. auris cells treated with Ag-Secn-NHE-based probiotic formula revealed severe deformations and distored ultrastructural changes. furthermore, results indicated that the Gamma radiation up to 15 kGy increases production of Ag-Secn-NHE in comparison with non-irradiated one."

Journal • Candidiasis • Infectious Disease • Vaginitis

ε-Poly-l-lysine: A Naturally Occurring Biodegradable Polypeptide for Selective Detection of 5-Nitroimidazole Antibiotics in Animal Products and Living Cells via Fluorescence. (PubMed, ACS Appl Bio Mater) - "The 5-nitroimidazole (5-NI) class of antibiotics, such as metronidazole, ornidazole, secnidazole, and tinidazole, are widely used to prevent bacterial infection in humans and livestock industries...Furthermore, ε-PL could detect 5-NI antibiotics in living 3T3-L1 mouse fibroblast cells via cellular imaging. Taken together, the present work demonstrates the detection of 5-NI antibiotics using a biocompatible natural polypeptide, ε-PL, and represents a simple and inexpensive analytical tool for practical application."

Journal • Infectious Disease

trans-Di-chlorido-bis-(secnidazole-κN 3)copper(II). (PubMed, IUCrdata) - "There is a hydrogen-bonded framework based on inter-molecular O-H⋯Cl inter-actions, characterized by H⋯Cl separations of 2.28 (4) Å and O-H⋯Cl angles of 175 (3)°. The resulting supra-molecular network is based on R2 2 (18) ring motifs, forming chains in the [010] direction."

Journal • Infectious Disease

In vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentration for Secnidazole that Correlates with Treatment Success. (PubMed, Sex Transm Dis) - "We determined the in vitro minimum lethal concentration (MLC) of secnidazole (SEC) and assessed correlation with clinical susceptibility among T. vaginalis isolates obtained from 71 women, of whom 66 were successfully treated with this medication. An MLC ≤12.5 μg/ml correlated with clinical susceptibility in this study."

Journal • Preclinical

Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole (clinicaltrials.gov) - P4 | N=1200 | Not yet recruiting | Sponsor: Tulane University

New P4 trial • Gynecology • Infectious Disease • Vaginitis

Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics. (PubMed, Inorg Chem) - "Whereas an outstanding 90% quenching efficiency was observed for antibiotics, tetracycline (TC) and secnidazole (SD). The mechanistic investigations of this luminescence quenching suggest that this might be primarily occurring via the Fourier resonance energy transfer (FRET) and photoinduced electron transfer (PET) mechanisms, which might be assisted by the competitive absorption and host-guest interactions. The π-electron-rich framework structure of sensor Zn-MOF activates this mechanism."

Journal

Drug resistance patterns and genotype associations of Trichomonas gallinae in meat pigeons (Columba livia): insights from Guangdong Province, China. (PubMed, Front Vet Sci) - "The results revealed that 25.3% (20/79) of the isolates were resistant to one or more of the four nitroimidazole drugs tested, namely, metronidazole, dimetridazole, secnidazole, and tinidazole...This study also found the growth characteristics of different Trichomonas isolates to be influenced by their genotypes and initial inoculum concentrations. These findings underscore the urgent need for effective measures to control and prevent drug-resistant T. gallinae infections in pigeons, thus ensuring the stable development of the pigeon industry."

Journal • Infectious Disease

Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment. (PubMed, Eur J Pharm Sci) - "Hydrogels with 5% secnidazole were selected as effective antimicrobial compositions with the highest cytocompatibility. They might be considered as promising for oromucosal application with special attention given to SEC as an alternative locally administered antimicrobial agent."

Journal • Dental Disorders • Periodontitis

Treatment of Dientamoeba fragilis: A retrospective Finnish analysis of faecal clearance and clinical cure comparing four antiprotozoal drugs. (PubMed, New Microbes New Infect) - "Faecal clearance, strongly associated with clinical cure, is most effectively achieved with a course of paromomycin, followed by metronidazole, secnidazole and doxycycline. Our findings will be useful in devising treatment guidelines for adults with symptomatic D. fragilis infection."

Journal • Retrospective data • Infectious Disease

A fluorescence-based assay for Trichomonas vaginalis drug screening. (PubMed, Parasit Vectors) - "This study presents a robust TSF assay that has the potential to facilitate high-throughput, automated in vitro anti-trichomoniasis susceptibility testing for drug resistance monitoring and drug development. In comparison to the standard MLC method, this assay offers the advantages of reduced labor and elimination of subjective examination."

Journal • Infectious Disease

Selective and sensitive colorimetric detection of endocrine disrupter fungicide carbendazim through secnidazole capped silver nanoparticles. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "SEC-AgNPs were tested for CARB sensing under the presence of several pesticides with negligible interference thus verifying its exclusive selectivity for the targeted analyte. This SEC-AgNPs was further applied to find out the concentration of CARB in real samples of tap water and human blood plasma with reference to standard addition method."

Journal

Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole. (PubMed, BMC Microbiol) - "Metformin, N-acetylcysteine, and secnidazole inhibited the virulence of Klebsiella pneumoniae. Besides combating resistant Klebsiella pneumoniae, the tested drugs could also serve as an adjuvant to traditional antibiotics."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance. (PubMed, PLoS One) - "In this study, three screening tools were used on 292 samples of ciprofloxacin and metronidazole collected in Cameroon...Seven additional samples from the nitro-imidazole (secnidazole, ornidazole, tinidazole) and the fluoroquinolone (levofloxacin, ofloxacin, norfloxacin, moxifloxacin) families were analyzed to mimic falsified medicines...The advantages and drawbacks of each screening tool were highlighted. They are promising means in the frame of early detection of SF medicines and they can increase the speed of decision about SF medicines in the context of pharmaceutical post-marketing surveillance."

Journal • P4 data

Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data. (PubMed, BMJ Open) - P3 | "Single-dose oral secnidazole 2 g was highly efficacious in curing trichomoniasis in women co-infected with BV. Appropriate and effective treatment options for co-infection are essential for reducing transmission and reinfection. Secnidazole is the only single-dose medication approved by the Food and Drug Administration for the treatment of BV in women and trichomoniasis in women and men."

Journal • P3 data • Retrospective data • Gynecology • Human Immunodeficiency Virus • Infectious Disease • Vaginitis

Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis. (PubMed, Int J Pharm) - "Although short-term cure rates following treatment with frontline antibiotics (most notably oral metronidazole (MNZ), clindamycin vaginal cream, and MNZ vaginal gel) are generally high, longer term recurrence rates are an issue...Here, we report the manufacture and preclinical testing of matrix-type vaginal rings offering sustained release of four 5-nitroimidazole antimicrobial drugs either being used clinically or having potential in treatment of BV - MNZ, tinidazole (TNZ), secnidazole (SNZ) and ornidazole (ONZ)...The relative merits of SNZ and ONZ over MNZ (the current reference treatment) are discussed. The data support development of vaginal rings for sustained release of 5-nitroimidazole compounds for treatment of BV."

Journal • Vaginitis