Secnizol DS (secnidazole) / Incepta Pharma - LARVOL DELTA

Simultaneous determination of five nitroimidazole antimicrobials in pharmaceuticals using HPLC-ESM and QAMS methods. (PubMed, BMC Chem) - "A green, rapid, and simple HPLC-External standard method (ESM) and a quantitative analysis of multi- components with a single-marker (QAMS) method were established for the simultaneous determination of five nitroimidazole antimicrobials (Metronidazole sodium chloride injection, Tinidazole injection, Ornidazole sodium chloride injection, Morinidazole sodium chloride injection, Secnidazole tablets) in pharmaceutical preparations...In addition, the analytical greenness (AGREE) and blue applicability grade index (BAGI) metric tools were used to evaluate the greenness and environmental friendliness of the developed methods. AGREE scores of QAMS and EMS were 0.66 and 0.59, and BAGI scored 82.5 and 77.5, respectively."

Journal

Low-cost and portable 3D-printed sensor for the determination of secnidazole in pharmaceutical and seized drug samples. (PubMed, Anal Methods) - "The obtained results were statistically similar (95% confidence level) to the values obtained by HPLC. These findings demonstrate that the 3D-printed electrodes developed in this study provide a cost-effective, facile, and highly sensitive platform for on-site SCZ analysis, presenting significant potential for future forensic applications."

Journal

Sunlight-mediated environmental risks of tinidazole in seawater: A neglected ocular toxicity of photolysis mixtures. (PubMed, J Hazard Mater) - "Herein, the photochemical reactivity of TNZ and four other typical nitroimidazoles (i.e., metronidazole, ornidazole, dimetridazole, and secnidazole) were quantified for multiple photoreactive species...This work reported the first comprehensive assessment of the photolysis-mediated environmental fate and secondary risks of TNZ in seawater. The findings highlighted the necessity of including complex photolysis mixtures under solar irradiation in future chemical risk assessments of marine environments."

Journal

Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis. (PubMed, Front Cell Infect Microbiol) - "The clinical cure rate of oral ornidazole was better than clindamycin (RR 16.08; 95%-CI 1.72-150.47), Secnidazole (RR 8.17; 95%-CI 1.66-40.25) and probiotics. The clinical cure rate of vaginal application of sucrose was better than metronidazole (RR 1.12; 95%-CI 1.03-1.21) and metronidazole had a lower clinical cure rate than probiotics (RR 0.68; 95%-CI 0.52-0.88). The results of this systematic review and network meta-analysis suggest that ornidazole may be an effective alternative for the treatment of BV, and that sucrose and probiotics are potential BV treatments that need to be validated by more high-quality clinical studies in the future."

Clinical • Journal • Retrospective data • Review • Vaginitis

Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products. (PubMed, Anal Bioanal Chem) - "Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China's State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health."

Journal

Silver secnidazole nano-hybrid emulsion-based probiotics as a novel antifungal formula against multidrug-resistant vaginal pathogens. (PubMed, Biotechnol Appl Biochem) - "TEM photographs showed that C. auris cells treated with Ag-Secn-NHE-based probiotic formula revealed severe deformations and distored ultrastructural changes. furthermore, results indicated that the Gamma radiation up to 15 kGy increases production of Ag-Secn-NHE in comparison with non-irradiated one."

Journal • Candidiasis • Infectious Disease • Vaginitis

ε-Poly-l-lysine: A Naturally Occurring Biodegradable Polypeptide for Selective Detection of 5-Nitroimidazole Antibiotics in Animal Products and Living Cells via Fluorescence. (PubMed, ACS Appl Bio Mater) - "The 5-nitroimidazole (5-NI) class of antibiotics, such as metronidazole, ornidazole, secnidazole, and tinidazole, are widely used to prevent bacterial infection in humans and livestock industries...Furthermore, ε-PL could detect 5-NI antibiotics in living 3T3-L1 mouse fibroblast cells via cellular imaging. Taken together, the present work demonstrates the detection of 5-NI antibiotics using a biocompatible natural polypeptide, ε-PL, and represents a simple and inexpensive analytical tool for practical application."

Journal • Infectious Disease

trans-Di-chlorido-bis-(secnidazole-κN 3)copper(II). (PubMed, IUCrdata) - "There is a hydrogen-bonded framework based on inter-molecular O-H⋯Cl inter-actions, characterized by H⋯Cl separations of 2.28 (4) Å and O-H⋯Cl angles of 175 (3)°. The resulting supra-molecular network is based on R2 2 (18) ring motifs, forming chains in the [010] direction."

Journal • Infectious Disease

In vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentration for Secnidazole that Correlates with Treatment Success. (PubMed, Sex Transm Dis) - "We determined the in vitro minimum lethal concentration (MLC) of secnidazole (SEC) and assessed correlation with clinical susceptibility among T. vaginalis isolates obtained from 71 women, of whom 66 were successfully treated with this medication. An MLC ≤12.5 μg/ml correlated with clinical susceptibility in this study."

Journal • Preclinical

Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole (clinicaltrials.gov) - P4 | N=1200 | Not yet recruiting | Sponsor: Tulane University

New P4 trial • Gynecology • Infectious Disease • Vaginitis

Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics. (PubMed, Inorg Chem) - "Whereas an outstanding 90% quenching efficiency was observed for antibiotics, tetracycline (TC) and secnidazole (SD). The mechanistic investigations of this luminescence quenching suggest that this might be primarily occurring via the Fourier resonance energy transfer (FRET) and photoinduced electron transfer (PET) mechanisms, which might be assisted by the competitive absorption and host-guest interactions. The π-electron-rich framework structure of sensor Zn-MOF activates this mechanism."

Journal

Drug resistance patterns and genotype associations of Trichomonas gallinae in meat pigeons (Columba livia): insights from Guangdong Province, China. (PubMed, Front Vet Sci) - "The results revealed that 25.3% (20/79) of the isolates were resistant to one or more of the four nitroimidazole drugs tested, namely, metronidazole, dimetridazole, secnidazole, and tinidazole...This study also found the growth characteristics of different Trichomonas isolates to be influenced by their genotypes and initial inoculum concentrations. These findings underscore the urgent need for effective measures to control and prevent drug-resistant T. gallinae infections in pigeons, thus ensuring the stable development of the pigeon industry."

Journal • Infectious Disease

Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment. (PubMed, Eur J Pharm Sci) - "Hydrogels with 5% secnidazole were selected as effective antimicrobial compositions with the highest cytocompatibility. They might be considered as promising for oromucosal application with special attention given to SEC as an alternative locally administered antimicrobial agent."

Journal • Dental Disorders • Periodontitis

Treatment of Dientamoeba fragilis: A retrospective Finnish analysis of faecal clearance and clinical cure comparing four antiprotozoal drugs. (PubMed, New Microbes New Infect) - "Faecal clearance, strongly associated with clinical cure, is most effectively achieved with a course of paromomycin, followed by metronidazole, secnidazole and doxycycline. Our findings will be useful in devising treatment guidelines for adults with symptomatic D. fragilis infection."

Journal • Retrospective data • Infectious Disease

A fluorescence-based assay for Trichomonas vaginalis drug screening. (PubMed, Parasit Vectors) - "This study presents a robust TSF assay that has the potential to facilitate high-throughput, automated in vitro anti-trichomoniasis susceptibility testing for drug resistance monitoring and drug development. In comparison to the standard MLC method, this assay offers the advantages of reduced labor and elimination of subjective examination."

Journal • Infectious Disease

Selective and sensitive colorimetric detection of endocrine disrupter fungicide carbendazim through secnidazole capped silver nanoparticles. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "SEC-AgNPs were tested for CARB sensing under the presence of several pesticides with negligible interference thus verifying its exclusive selectivity for the targeted analyte. This SEC-AgNPs was further applied to find out the concentration of CARB in real samples of tap water and human blood plasma with reference to standard addition method."

Journal

Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole. (PubMed, BMC Microbiol) - "Metformin, N-acetylcysteine, and secnidazole inhibited the virulence of Klebsiella pneumoniae. Besides combating resistant Klebsiella pneumoniae, the tested drugs could also serve as an adjuvant to traditional antibiotics."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance. (PubMed, PLoS One) - "In this study, three screening tools were used on 292 samples of ciprofloxacin and metronidazole collected in Cameroon...Seven additional samples from the nitro-imidazole (secnidazole, ornidazole, tinidazole) and the fluoroquinolone (levofloxacin, ofloxacin, norfloxacin, moxifloxacin) families were analyzed to mimic falsified medicines...The advantages and drawbacks of each screening tool were highlighted. They are promising means in the frame of early detection of SF medicines and they can increase the speed of decision about SF medicines in the context of pharmaceutical post-marketing surveillance."

Journal • P4 data

Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data. (PubMed, BMJ Open) - P3 | "Single-dose oral secnidazole 2 g was highly efficacious in curing trichomoniasis in women co-infected with BV. Appropriate and effective treatment options for co-infection are essential for reducing transmission and reinfection. Secnidazole is the only single-dose medication approved by the Food and Drug Administration for the treatment of BV in women and trichomoniasis in women and men."

Journal • P3 data • Retrospective data • Gynecology • Human Immunodeficiency Virus • Infectious Disease • Vaginitis

Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis. (PubMed, Int J Pharm) - "Although short-term cure rates following treatment with frontline antibiotics (most notably oral metronidazole (MNZ), clindamycin vaginal cream, and MNZ vaginal gel) are generally high, longer term recurrence rates are an issue...Here, we report the manufacture and preclinical testing of matrix-type vaginal rings offering sustained release of four 5-nitroimidazole antimicrobial drugs either being used clinically or having potential in treatment of BV - MNZ, tinidazole (TNZ), secnidazole (SNZ) and ornidazole (ONZ)...The relative merits of SNZ and ONZ over MNZ (the current reference treatment) are discussed. The data support development of vaginal rings for sustained release of 5-nitroimidazole compounds for treatment of BV."

Journal • Vaginitis

Development of an anti-infective urinary catheter composed of polyvinyl alcohol/sodium alginate/methylcellulose/polyethylene glycol by using a pressure-assisted 3D-printing technique. (PubMed, Int J Biol Macromol) - "The release models suggest the Quasi-Fickian diffusion mechanism from the system. Moreover, the secnidazole 3D printed catheter disrupted biofilms and suppressed all the Quorum sensing mediated virulence factors of two important keystone pathogens causing urinary tract infections."

Journal • Infectious Disease • Nephrology

Where do tinidazole and secnidazole fit in with the treatment of trichomoniasis? (PubMed, Sex Transm Dis) - No abstract available

Journal • Infectious Disease

Porphyrin-based hypercrosslinked polymers as sorbents for efficient extraction of nitroimidazoles from water, honey and chicken breast. (PubMed, J Chromatogr A) - "Among them, the HCP-TPP-BCMBP, which was prepared by using TPP as the monomer and with 4,4'-Bis(chloromethyl)-1,1'-biphenyl (BCMBP) as the cross-linking agent, had the best adsorption capability for the enrichment of the nitroimidazoles of dimetridazole, ronidazole, secnidazole, metronidazole, and ornidazole...The analytes recoveries by the method in fortified samples fell in the range from 91.1% to 102.7% for environmental water, from 83.2% to 105.0% for honey, and from 85.9% to 103.0% for chicken breast samples, and the relative standard deviations for the determination were less than 10%. It shows that the HCP-TPP-BCMBP has a strong adsorption capability for some polar compounds."

Journal

Suppressive Antibacterial Therapy With Once-Weekly Secnidazole Granules to Prevent Recurrent Bacterial Vaginosis; A Pilot Study (clinicaltrials.gov) - P2/3 | N=20 | Completed | Sponsor: Indiana University | Recruiting ➔ Completed | N=50 ➔ 20 | Trial completion date: Jun 2023 ➔ Oct 2022 | Trial primary completion date: Mar 2023 ➔ Oct 2022

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Vaginitis

In Vitro Susceptibility and Resistance of Mycoplasma genitalium to Nitroimidazoles. (PubMed, Antimicrob Agents Chemother) - "genitalium infections are increasingly difficult to treat due to poor efficacy of doxycycline and acquired resistance to azithromycin and moxifloxacin. A recent clinical trial suggested that metronidazole may improve cure rates for women with pelvic inflammatory disease and reduced the detection of M. genitalium when included with standard doxycycline plus ceftriaxone treatment. As data regarding susceptibility of mycoplasmas to nitroimidazoles are lacking in the scientific literature, we determined the in vitro susceptibility of 10 M. genitalium strains to metronidazole, secnidazole, and tinidazole...The presence of oxygen did not affect MICs of wild-type M. genitalium, but a nitroimidazole-resistant mutant was defective for growth under anaerobic conditions, suggesting that resistant mutants may have a fitness disadvantage in anaerobic genital sites. Clinical studies are needed to determine if nitroimidazoles, especially tinidazole, are effective for eradicating M...."

Journal • Preclinical • Infectious Disease • Inflammation