sulphadiazine / Generic mfg. - LARVOL DELTA

Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort. (PubMed, Environ Health (Wash)) - "In couple-based analyses, sulfaclozine, roxithromycin, sulfamonomethoxine, erythromycin, and penicillin V were positively related to several early IVF reproductive outcomes, while sulfamethoxazole, penicillin G, chlorotetracycline, norfloxacin, florfenicol amine (FFA), sulfadiazine, cyadox, and sulfachloropyridazine were negatively related to early IVF outcomes. The association between parental antibiotic exposure and IVF outcomes requires further validation in a larger cohort of couples. Additionally, the extrapolation of our results to the general childbearing-aged couples requires caution as infertile couples may be more susceptible to antibiotics."

Journal • Preclinical • Gynecology • Infertility

Trapped by Toxoplasma: Ventricular Compromise in a Previously Undiagnosed HIV Patient (SCCM 2026) - "Treatment with sulfadiazine, pyrimethamine and leucovorin was initiated. Early imaging, aggressive critical care management, and timely multidisciplinary coordination were essential to this patient's stabilization and recovery. This case highlights the need for a high index of suspicion for toxoplasmosis in patients with unexplained neurologic decline, even before HIV is confirmed, and supports a multidisciplinary approach to optimize outcomes in severe opportunistic infections."

Clinical • Human Immunodeficiency Virus • Infectious Disease • CD4

Ultrasensitive photoelectrochemical aptasensor for sulfadiazine detection enhanced by taxifolin-boosted 3D porous g-C3N4. (PubMed, Biosens Bioelectron) - "It was successfully applied to detect SDZ residue in Yangtze River water and milk with a recovery of 99.7%-103.2%. This work provides a novel strategy for designing efficient metal-free photoactive materials for monitoring environmental pollutants."

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A two-dimensional nanomaterial-based substrate for the simultaneous SERS detection of three antibiotic substances. (PubMed, Talanta) - "When combined with the optimized pretreatment protocol, the resulting hybrid substrate enables the simultaneous detection of three residual antibiotics-nitrofurantoin, tetracycline, and sulfadiazine-in milk samples within 10 min, achieving a detection limit as low as 8.6-15.3 ng g-1. Compared to national standard methods, the established SERS method enhances analytical efficiency while maintaining detection performance, demonstrating substantial potential for practical application."

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Selective Activation of PMS by a Single-Atom MOF in Confined Space: Hydrogen Bond-Assisted Nonradical Pathway and Continuous Flow Verification. (PubMed, Environ Sci Technol) - "This dual drive mechanism yields nearly complete sulfadiazine removal within 1 min, with nonradical pathways accounting for 80%, PMS utilization above 95%, and high catalytic stability. In a 10 L continuous-flow reactor, cobalt leaching remains below 2.63 μg/L, and a life cycle assessment (LCA) indicates a smaller environmental footprint than a Co3O4/PMS system does, providing design guidance for environmentally relevant nonradical PMS catalysts."

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Ciprofloxacin and sulfadiazine at environmentally relevant concentrations induce a viable but non-culturable state in Escherichia coli. (PubMed, Arch Microbiol) - No abstract available

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TOXOPLASMOSIS SCREENING, PROPHYLAXIS AND TREATMENT PRACTICES ACROSS EBMT CENTERS: A SURVEY ON BEHALF OF THE INFECTIOUS DISEASES WORKING PARTY (EBMT 2026) - "If trimethoprim-sulfamethoxazole is contraindicated, most employed alternatives are atovaquone ± pyrimethamine (45/126, 36%) or nothing (27/126, 21%).In asymptomatic patients, anti-toxoplasma therapy is initiated after a single positive blood PCR in 19/67 (28%) centers, in 2/67 (3%) only if the patient is considered high-risk, in 7/67 (10%) only if the PCR-value is very high...Specific assessments are variably performed: cerebral MRI (49/67, 73%), lung CT (42/67, 63%), ophthalmic examination (43/67, 64%), lumbar puncture (20/67, 30%) and bone marrow assessment (10/67; 15%).Anti-toxoplasma therapy relies on trimethoprim-sulfamethoxazole, pyrimethamine-sulfadiazine and pyrimethamine-clindamycin with similar distribution for infection (73/134, 54%; 49/134, 37%; 10/134, 7%) and disease (66/132, 50%; 54/132, 41%; 9/132, 7%)... This survey highlights significant variability across EBMT centers in toxoplasmosis management, underscoring the need for ongoing harmonization,..."

Bone Marrow Transplantation • Infectious Disease • Ophthalmology • CD4

NURSING MANAGEMENT OF A CHEMOTHERAPY PATIENT WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA AND AN INFECTED LOWER-LIMB WOUND: A CASE STUDY (EBMT 2026) - "The chemotherapy regimen consisted of CHP + VP16 (cyclophosphamide, vincristine, dexamethasone, and etoposide).Wound care focused on infection control and local management, following the principles of "debridement – infection control – moist wound healing." Nursing interventions were adjusted according to the wound-healing stage, with strict aseptic technique throughout.Infection Phase (Day 1–Day 5): Debridement and dressing changes combined with anti-infective therapy: normal saline irrigation, povidone-iodine disinfection, removal of necrotic tissue, repeated saline irrigation; application of a mixture of mupirocin, growth-factor gel, and zinc sulfadiazine in a thick layer; silver-containing dressings, covered with gauze and secured with an elastic bandage.Exudation Phase (Day 6–Day 14): Continued anti-infection treatment with exudate management: saline irrigation → povidone-iodine disinfection → saline irrigation; thick application of a mixture of..."

Case study • Clinical • Glomerulonephritis • Hematological Malignancies • Infectious Disease • Lymphoma • Nephrology • Non-Hodgkin’s Lymphoma • Renal Disease • T Cell Non-Hodgkin Lymphoma

Influence of humic acids on the passive sampling of pharmaceutical compounds by POCIS and DGT. (PubMed, Talanta) - "The sampling of six pharmaceuticals - atenolol (ATE), sulfadiazine (SDZ), trimethoprim (TMP), sulfamethoxazole (SMZ), carbamazepine (CBZ) and diclofenac (DCF) - was compared in the presence and the absence of humic acids at 5, 20 and 50 mgC.L-1 under controlled laboratory conditions. Finally, the sampling of ATE and CBZ was affected only at the highest HA concentration and just for DGT experiments. These findings highlight the importance of accounting for DOM effects when interpreting passive sampler data."

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Novel aminophosphoryl hybridization of natural berberine and heterocyclic azoles with large potential to combat global increasing bacterial resistance. (PubMed, Bioorg Chem) - "Some prepared berberine conjugates effectively inhibited the growth of tested bacteria, particularly, methyloxazolyl aminosulfonylphenyl conjugate I-10b showed stronger antibacterial effects than berberine, norfloxacin and sulfanilamides (sulfamethoxazole, sulfadiazine, sulfacetamide and sulfathiazole). Moreover, conjugate I-10b displayed potent efficacy against S. aureus 25,923 in both G. Mellonella larval and murine wound infection models. These results suggested the potential of the developed azolyl aminophosphoryl berberines as effective antibacterial candidates."

Journal • Hematological Disorders • Infectious Disease • Metabolic Disorders

Use of antiparasitic drugs in the prevention of congenital toxoplasmosis: systematic review and meta-analysis (PubMed, Med Trop Sante Int) - "In the context of preventing congenital Toxoplasma gondii infection, optimizing the use of antiparasitic molecules, such as spiramycin, pyrimethamine-sulfadiazine combinations, cotrimoxazole, and pyrimethamine-sulfadoxine, during the prenatal period is a significant challenge in limiting maternal-fetal transmission and reducing associated effects. The failure rate of standard anti-toxoplasma treatments can be reduced by addressing several recognized risk factors early on. Each healthcare system must strengthen the monitoring and evaluation of treatment policies for primary infection per pregnancy in order to implement a more appropriate secondary prevention strategy."

Journal • Retrospective data • Review • Infectious Disease

Levels of tetracycline and sulphonamide residues in freshwater fish: A systematic review and meta-analysis. (PubMed, Sci Total Environ) - "Pooled mean concentrations for tetracyclines were: tetracycline, 18.13 μg/kg (95% CI: 8.16-28.09; Q(12) = 5148.18, I2 = 99.98%, p < 0.001); oxytetracycline, 104.76 μg/kg (95% CI: -16.09-225.61; Q(14) = 72,693.12, I2 = 100%, p < 0.001); and doxycycline, 47.79 μg/kg (95% CI: -5.92-101.49; Q(6) = 13.15, I2 = 100%, p = 0.02). For sulphonamides, pooled means were: sulphonamerazine, 0.27 μg/kg (95% CI: 0.19-0.35; Q(5) = 76.41, I2 = 81.62%, p < 0.001); sulphadiazine, 29.84 μg/kg (95% CI: -2.36-62.03; Q(8) = 29,816.14, I2 = 100%, p < 0.001); and sulphathiazole, 3.57 μg/kg (95% CI: 0.27-6.87; Q(6) = 6427.72, I2 = 99.91%, p < 0.001)...Collectively, these findings demonstrate persistent antimicrobial contamination in freshwater fish and highlight potential..."

Journal • Retrospective data • Review

Microplastic-mediated antibiotic migration and bioaccumulation in aquaculture: Implications for seafood safety. (PubMed, Food Chem) - "We quantified the adsorption of enrofloxacin (ENR) and sulfadiazine (SDZ) onto polyethylene (PE) and polypropylene (PP) MPs, examining the effects of pH, salinity, particle size, aging, and co-solutes...Notably, ENR bioaccumulated more in MPs-exposed shrimp (16.4 μg/kg) compared to the ENR-only group (12.2 μg/kg). These results define a size-dependent MP-ATB-organism transport pathway with implications for seafood safety and analytical monitoring."

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Developing a slow-release permanganate-persulfate composite gel for the in-situ treatment of sulfonamides in groundwater plumes. (PubMed, J Environ Manage) - "Approximately 99.1% sulfathiazole (STZ) at pH 6, and 83.9% sulfadiazine (SDZ), 92.4% sulfachloropyridazine (SCP) and 92.4% sulfamethoxazole (SMX) at pH 5, were degraded within 24 min by 1.25 g P-PGSR at 2.0 mL min-1 flow rate using 0.01 M NaCl as background solution...Radical quenching experiments illustrated that ∙OH was the primarily reactive species for the degradation of STZ and SMX, while SO4∙- played an important role in the degradation of SDZ, STZ and SCP. The intermediate products of SDZ, STZ and SMX indicated that aniline moiety oxidation, hydroxylation, deamination, and smiles-type rearrangement to produce SO2 extrusion were involved in the degradation pathways of SAs by treatment with P-PGSR."

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Dual heteroatom engineering-modulated cobalt catalysts for peracetic acid activation realized superior sulfadiazine degradation in water. (PubMed, J Environ Manage) - "Based on these results, five primary degradation pathways for SDZ were proposed, and the results of ecotoxicity analysis showed that the transformation products were less toxic. Overall, this work provides significant insights into the development of high-performance dual-heteroatom-doped catalysts to form the PAA-mediated AOP for wastewater treatment."

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Sulfadiazine Interface Layer-Multisite Passivation and Energy Level Regulation for Inverted Perovskite Solar Cells. (PubMed, ACS Appl Mater Interfaces) - "Furthermore, the target devices demonstrate excellent thermal stability. This study indicates that using SD as an interface layer is an effective strategy for enhancing the efficiency and stability of PSCs."

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Dual-signal cross-validation via ECL quenching and DPV oxidation on a MIP sensor: ultrasensitive detection of sulfadiazine in complex food matrices with a CD-COF core. (PubMed, Food Chem) - "Validation in food matrices demonstrates exceptional accuracy and reliability, yielding recoveries of 91-110%. This study not only provides a robust tool for trace SDZ monitoring but also establishes a new paradigm for CD-COF-powered MIP sensors integrating dual-mode signals for highly reliable contaminant analysis in real-world samples."

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Template derivatization-mediated synthesis of highly ordered paper-based imprinted chip for enhanced sulfadiazine analysis. (PubMed, Food Chem) - "A colorimetric sensor based on FP@B-MOF@MIP was further successfully constructed for the visual determination of trace SDZ in food samples with a low detection limit of 0.0048 mg L-1. This work provides a flexible strategy to improve the performance of MIPs for monitoring trace contaminants in foodstuffs."

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Sulfadiazine-induced crystalline nephropathy: a case report of a reversible cause of acute kidney injury in advanced HIV. (PubMed, BMC Nephrol) - No abstract available

Journal • Acute Kidney Injury • Human Immunodeficiency Virus • Infectious Disease • Nephrology • Renal Disease

Severe congenital toxoplasmosis with isolated central hypothyroidism: A rare case report. (PubMed, J Neonatal Perinatal Med) - "Treatment included pyrimethamine, sulfadiazine, folinic acid, and levothyroxine replacement. Early recognition and hormone replacement therapy are essential to prevent further neurological impairment. Systematic endocrine evaluation is recommended in neonates with severe central nervous system involvement due to congenital toxoplasmosis."

Journal • Cataract • CNS Disorders • Endocrine Cancer • Endocrine Disorders • Genetic Disorders • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis • Ventriculomegaly

Suspect List-Guided High-Throughput Screening (SLIG-HTS) Identifies Environmental Substances Associated with Advanced Embryonic Developmental Timing. (PubMed, Environ Sci Technol) - "Notable, the sulfonamide antibiotics sulfadiazine (SDZ) and sulfamethoxazole (SMZ) exhibited pronounced effects at environmentally relevant concentrations (from ng/L to low μg/L)...Furthermore, eight additional sulfonamides produced comparable effects, suggesting a potential class-wide phenomenon. Together, our integrated approach identified a set of environmental substances associated with advanced embryonic developmental timing at environmentally relevant levels and highlighted their potential ecological relevance."

Journal • Cardiovascular

Designing interfacial built-in electric field-driven S-scheme cadmium tungstate/bismuth tungstate heterojunction for boosting photocatalytic performance. (PubMed, J Colloid Interface Sci) - "As a result, the optimized CdWO4/Bi2WO6 heterojunction degraded 84% of sulfadiazine (SDZ) within 180 min, and the kobs is 1.62 and 10.2 times higher than pure Bi2WO6 and CdWO4, respectively...Moreover, through a combination of density functional theory (DFT) calculations and liquid chromatography-mass spectrometry (LC-MS) analysis, the pathways of SDZ degradation involving S-N/N-C cleavage and Smile rearrangement were elucidated. These findings offer insights into the design of efficient S-scheme heterojunctions driven by engineering interfacial built-in electric field for the photocatalytic oxidization of SDZ."

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Successful treatment of pulmonary melioidosis in an Australian dog. (PubMed, Aust Vet J) - "Antimicrobial therapy included amoxicillin clavulanic-acid (AMC) (day 1-21, then day 28-84), trimethoprim sulfadiazine (day 8-28), enrofloxacin (day 2-16) and doxycycline (day 8-16). There was no evidence of recurrence during the follow-up period, and the dog died of unrelated causes 785 days after the original presentation. This case is the first description of successful treatment of canine pulmonary melioidosis in a region not previously associated with high endemicity."

Journal • Infectious Disease • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases

Antiproliferative Plaque Assay for Screening in vitro Bioactive Molecules against Toxoplasma gondii Tachyzoites. (PubMed, J Vis Exp) - "Since the early 1950s, the first-line treatment of this disease has relied on the combination of sulfadiazine, pyrimethamine, and folinic acid. This work describes an optimized plaque assay protocol designed for screening active molecules against intracellular tachyzoites of T. gondii in vitro. This protocol utilizes inexpensive materials and a straightforward laboratory setup, yielding rapid and reproducible results that facilitate the identification of new active molecules against this parasite by various research groups."

Journal • Preclinical • Infectious Disease

Structural and functional insights into glycosyltransferase from Nocardia asteroides NCTC11293 and structure-guided discovery of marine and phytochemical leads through pharmacokinetic screening and molecular dynamics studies. (PubMed, J Mol Graph Model) - "Although initial drugs like sulfadiazine and sulfisoxazole were used, their poor tissue penetration and the requirement for prolonged therapy have led to their exclusion from current treatment regimens...Molecular dynamics (MD), essential dynamics (ED) analyses, including PCA-based FEL, and DSSP assessments reinforced the structural stability of the glycosyltransferase-phytochemical complexes. These computational findings suggest that the identified molecules represent promising therapeutic candidates for the treatment of nocardiosis."

Journal • PK/PD data • Infectious Disease • Respiratory Diseases