quinine sulphate / Generic mfg. - LARVOL DELTA

The Role of Quinine to Prevent Ventricular Fibrillation and ICD Shocks in Early Repolarization Syndrome. (PubMed, JACC Case Rep) - "This case highlights the possible role of quinine in suppression of short-coupled premature ventricular complexes and ventricular fibrillation in patients with ERS."

Journal • Cardiovascular • Genetic Disorders

CH3/CF3 substituent dependent tunable fluorescence and thermofluorochromism triphenylamine-acetophenone fluorophore. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "1-CH3 and 1-CF3 showed solvent polarity dependent tunable fluorescence between 489 and 564 nm (quantum yield (ϕF) = 0.258 (toluene) compared to quinine sulfate)...1-CF3-polmer exhibited complete disappearance of fluorescence upon heating and reversed to initial upon cooling at -15 °C for a minute. Thus, the present work elucidated the role of substituent group for developing functional fluorescent molecules for reversible temperature dependent fluorescence switching applications."

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Investigation of Fluorescence Sensing Capabilities in Boron-Nitrogen Co-Doped Carbon Quantum Dots Towards Fe (III) and Hg(II) Ions. (PubMed, J Fluoresc) - "BN-CQDs exhibited a particle size below 5 nm, abundant surface functional groups, and photoluminescence (PL) with a quantum yield of 3.4% against quinine sulphate...The detection limits of 0.081 µM for Fe(III) and 0.025 µM for Hg(II), and quantification limits of 0.25 µM (Fe(III)) and 0.075 µM (Hg (II)) present the ability of detection of these metal ions by fluorometric sensor. This study underscores the potential of BN-CQDs as eco-friendly and effective sensors for environmental monitoring."

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Fast multicomponent synthesis of highly fluorescent diorganotin complexes derived from plastic waste (ACS-Fall 2025) - "The resulting molecular materials exhibit strong blue fluorescence, both solid and solution state with a maxima emission wavelength centered around 470 nm with a fluorescent quantum value around 50% relative to quinine sulfate used as internal reference in this study. Terephthalic dihydrazide monomers were obtained from poly(ethylenethereftalate) waste by aminolysis assisted ultrasound irradiation at room temperature without solvent. Additionally, the strategic route allows the formation selective of two new heterocyclic systems containing nitrogen, oxygen and tin atoms inside the expected structure as indicative by 119Sn spectrum (1:-323; 2:-250 ppm) and 1H in the range of 8.25 to 9.28 ppm, respectively."

Quinine Sulfate for Muscle Cramps in Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind Crossover Trial. (PubMed, Muscle Nerve) - "Our findings suggest the potential efficacy of quinine sulfate in reducing muscle cramp intensity and frequency in ALS patients. However, the small sample size (n = 7) limits generalizability. Larger, multicenter studies are needed to confirm these results and fully assess its safety, serious adverse events, and therapeutic potential."

Clinical • Journal • Amyotrophic Lateral Sclerosis • CNS Disorders • Otorhinolaryngology

Surfactant-rescued gelation: Stabilizing P123-chitosan hydrogels in blood-isotonic aqueous solutions for controlled drug delivery. (PubMed, Int J Biol Macromol) - "Quinine sulfate release studies showed sustained drug release without burst effects. Kinetic modeling indicated a predominantly non-Fickian transport mechanism, governed by both diffusion and polymer relaxation. This surfactant-rescued gelation strategy stabilizes chitosan-based hydrogels in physiological conditions, making them promising candidates for controlled drug delivery."

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The Evolution of Sunscreen from Ancient Egypt to Modern Day: A historical perspective (AAD 2025) - "In 1891, Friedrich Hammer developed the first chemical sunscreen using quinine sulfate...By the 1990s, SPF ratings of 15 to 30 were standard, reflecting sunscreen's central role in preventing UV-induced skin damage and skin cancer. This review highlights sunscreen's evolution from ancient protective mixtures to a fundamental aspect of modern oncological dermatology, emphasizing sunscreen's growing significance in public health."

Dermatology • Genetic Disorders • Oncology • Skin Cancer

Determining Fluorescence Quantum Yield for 5-(2-(Dimethylamino)-6-Methoxypyrimidin-4-yl)-Furan-2-Carbaldehyde Using Simultaneous Absorption and Fluorescence Emission (SAFE) Method. (PubMed, J Fluoresc) - "In a second set of excitation wavelengths (λ₂) at 273, 335, and 397 nm, the corresponding QY values were determined to be 13.091, 29.153, and 27.354, with quinine sulfate serving as the reference standard at λ₁ (299 nm) and λ₂ (310 nm). These findings demonstrate the effectiveness of the SAFE method in accurately determining fluorescence quantum yields, offering significant utility for characterizing luminescent compounds and evaluating pharmacological substances."

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Luminescence Properties of Hoechst 33258 in Polyvinyl Alcohol Films. (PubMed, Int J Mol Sci) - "Its fluorescence quantum yield is notably high (~0.74), as determined relative to a quinine sulfate standard...Notably, we observed that direct triplet-state excitation at longer wavelengths (beyond the primary absorption band) produces highly polarized RTP. We believe this possibility of direct triplet-state excitation opens new avenues for studying RTP in polymer-immobilized molecules."

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Efficacy and Safety of Antimalarial as Repurposing Drug for COVID-19 Following Retraction of Chloroquine and Hydroxychloroquine. (PubMed, Clin Pharmacol) - "The results showed 3 antimalarial drugs, namely Quinine Sulfate (QS), Atovaquone (AQ), and Artemisinin-Piperaquine (AP), had gone through clinical trial to assess efficacy and safety against COVID-19 patients. Furthermore, the intervention group took 10.6 days, and the control group took 19.3 days (p=0.001). Based on this review, AP showed significant potential as a therapy in the fight against COVID-19."

Journal • Review • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Ultrasensitive turn-off fluorescent sensor for estimation of the new influenza antiviral prodrug baloxavir marboxil in its pharmaceutical formulation. (PubMed, R Soc Open Sci) - "The generated N,S-CQDs yielded strong fluorescence emission at λ em 430.0 nm after excitation at λ ex 360.0 nm, with a relatively high quantum yield of 41.3% utilizing quinine sulfate as a reference fluorescent compound. Considering the optimal conditions, the fluorescence intensity reduction of N,S-CQDs exhibited a 'turn-off' response to BXM at concentrations of 10.0-100.0 ng ml-1, with detection limits of 1.88 ng ml-1 and quantitation limits of 5.69 ng ml-1, respectively. The proposed method determined BXM successfully in its tablet dosage form and further expanded to confirm the content uniformity of the tablet units in agreement with USP guidelines."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Fluorescent Probe-Based Fiber Optic Sensor for Real-Time Monitoring of Chloride Ions in Coastal Concrete Structures. (PubMed, Sensors (Basel)) - "The findings confirm that the designed fiber optic sensor based on quinine sulfate enables real-time monitoring of chloride ions in concrete structures, offering high sensitivity (0.1% in concentration and 2.7 mm in terms of penetration depth), unique selectivity (as it is immune to other ions whose concentrations are 10 times higher than those of Cl-), and a compact size (10 × 20 mm). These attributes render it promising for practical engineering applications."

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A simple light path modifying device to reduce scattering in front-face fluorescence spectra. (PubMed, Methods Appl Fluoresc) - "The spectra obtained with the LPM were much clearer, and distortion of the fluorescence peaks was avoided. Scans of quinine sulphate complied well with reference spectra.&#xD."

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Propeller shaped triarylamine acid: An ultra-sensitive fluorescence probe for distinguishing propanol isomers and water sensing in organic solvents. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "TPA-C exhibited strong solvent polarity dependent tunable fluorescence (Φf = 0.01 to 0.11 compared to quinine sulphate standard) but Cz-C was non-emissive in the solution state...The LOD of IPA sensing in n-PA is 0.05 % and indicated the very efficient sensing and distinguishing propanol isomers. Thus, simple triphenylamine acid showed excellent water sensing and propanol isomers discrimination that could be attributed to the twisted intramolecular charge transfer (TICT) formation."

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Deep blue emitting dual state fluorescent triphenylamine-dicyclohexylurea derivative: Multi-stimuli responsive fluorescence switching and methanol/water sensing. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "NCDPB also exhibited strong solvent polarity dependent tunable emission in solution (λmax = 402-462 nm, Φf = 1.15 (compared to quinine sulphate))...The water sensitive fluorescence modulation of NCDPB in organic solvents was used to sensing water contamination in common organic solvents. Thus, integration of twisted TPA with H-bonding urea produced dual state emitting organic fluorophore with multi-responsive fluorescence switching and solvent sensing."

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Solid-phase fluorescence: Reproducibility and comparison with the solution states. (PubMed, Talanta) - "The developed cell is applied to proteins (ovalbumin, BSA, gliadin, gluten, powdered collagen, casein), amino acids (tryptophan, tyrosine, and phenylalanine), soybean ingredients (daidzein, and genistein), and fluorescent chemicals (rhodamine B, fluorescein sodium salt, pyrene, and quinine sulfate dihydrate) and their spectra are compared with those in the solution states...Powdered rhodamine B and fluorescein sodium salt do not exhibit fluorescence, possibly due to the inner-filter effect (IFE). Some non-colored molecules also exhibit loss of fluorescence or a remarkable difference between the solid and solution states, possibly due to the interaction of the fluorescent structure with the surrounding local environment, similar to the solvent effect, which is possibly affected by the molecular proximity, three-dimensional structure, and moisture absorption capacity."

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Chronological development of functional fluorophores for bio-imaging. (PubMed, Chem Commun (Camb)) - "After the discovery of quinine sulfate and subsequent elucidation of the fluorescence mechanism by Sir George Stokes, research in the field of fluorescence gained momentum...Furthermore, we speculate on the potential prospects and significant challenges of existing fluorophores and their potential biomedical research applications. By addressing these aspects, we intend to illuminate the compelling advancements in fluorescent probe development and their potential influence across various fields."

Journal • Review

Quinine for the treatments of muscle cramps in amyotrophic lateral sclerosis; a randomized, placebo controlled, double-blind cross-over trial (ALS-MND 2023) - "Quinine sulphate is effective in reducing muscle cramp frequency and intensity specifically in ALS patients. This was more pronounced during day times. Quinine sulphate was well tolerated and safe."

Clinical • Amyotrophic Lateral Sclerosis • CNS Disorders

The Study of the Effect of Dimethylsulfoxide (or Diethylsulfoxide) on Quinine Sulfate-DNA Binding by UV-Vis and Steady-State Fluorescence Spectroscopies. (PubMed, J Fluoresc) - "The obtained results show that quantum yield of QS in sulfoxides is lower compared with that in water and aqueous solution of 0.1 M HSO. QS forms ground state complexes with both DMSO and DESO that are stronger fluorophores compared with free QS molecules."

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Evaluation of cancer drug infusion devices prior to the implementation of a compounding robot. (PubMed, J Oncol Pharm Pract) - "Our results showed that the new infusion device complied with current standards. However, the presence of contamination emphasizes the need for operators to use the recommended personal protective equipment. Further studies of contamination with cancer drugs are required."

Journal • Oncology

LOW-DOSE BELIMUMAB AND ANTIMALARIAL AGENTS PREVENT RENAL FLARES IN SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS FROM FOUR RANDOMISED CLINICAL TRIALS (EULAR 2023) - "Additionally, we classified patients as AMA users if they had received hydroxychloroquine, chloroquine, mepacrine, or quinine sulphate in stable doses for at least 30 days prior to the trial commencement. The protective effect of IV belimumab against renal flares appeared optimal when belimumab was combined with AMA. The prominent effect of low-dose belimumab motivates investigation of the efficacy of intermediate doses of belimumab."

Clinical • Chronic Kidney Disease • Glomerulonephritis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Systemic Lupus Erythematosus

Palatability Profile In Spontaneously Hypertensive Rats. (PubMed, Chem Senses) - "Here, we investigated the palatability of SHRs (n=8-10) and normotensive Holtzman rats (n=8-10) to sucrose and quinine sulphate infused intraorally in the same conditions that NaCl palatability was increased in SHRs...They also showed a more intense aversive response in SHRs to bitter taste compared to normotensives. This suggests that the enhanced response of SHRs to taste rewards does not correspond to a decreased response to a typical aversive taste."

Journal • Preclinical • Cardiovascular • Hypertension

Carbazole fluorophore with an imidazole/thiazole unit: contrasting stimuli-induced fluorescence switching, water-sensing and deep-blue emission. (PubMed, RSC Adv) - "Carbazole integrated with imidazole (Cz-I) and carbazole integrated with thiazole (Cz-T) showed strong fluorescence in solution (quantum yield (Φ ) = 0.18 (Cz-I) and 0.14 (Cz-T) compared with the standard quinine sulfate) and solid-state (Φ = 8.0% (Cz-I) and 14.6% (Cz-T))...Computational studies indicated that thiazole integration improved the electron-withdrawing characteristics compared with imidazole and contributed to contrasting fluorescence responses. Thus, a simple change of nitrogen with sulfur produced contrasting self-assembly in the solid-state that led to different functional properties and stimuli-induced fluorescence switching."

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Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 ) (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: Universitas Padjadjaran

New trial • Infectious Disease • Novel Coronavirus Disease

Reverse phase liquid chromatography for separation of illicit drugs utilizing water-rich mobile phases (ACS-Sp 2023) - "The preliminary testing samples include caffeine, vanillin, quinine sulfate, and acetylsalicylic acid. The illicit substance samples currently include methamphetamine, amphetamine, and MDEA...Additionally, plans are being discussed to develop a basic buffer with higher pH in an attempt to be in favor of the basic drugs. Once separation in a mixed sample is achieved, the 1-butanol concentration will be altered to various levels to observe the level of effectiveness; this process of optimization will allow for the limit of detection and the limit of quantification to be calculated and represented."