ONO-1600586 / Ono Pharma - LARVOL DELTA

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis. (PubMed, Res Pract Thromb Haemost) - "Additionally, we compared thrombus formation induced by endothelial denudation and stenosis or stasis in the jugular vein and skin bleeding time and volume between rabbits treated with direct FXIa inhibitors (ONO-1600586) and FXa inhibitors (rivaroxaban). The pathologic findings of human DVT suggest FXI's role in human DVT. FXIa inhibitors may inhibit less fibrin formation than FXa inhibitors and may explain the minor role of FXIa in hemostasis."

Journal • Cardiovascular • Hematological Disorders • Thrombosis • Venous Thromboembolism

[VIRTUAL] ONO-1600586, an Oral Direct Factor XIa Inhibitor, Suppresses Thrombus Formation in Rabbit Jugular Vein without Bleeding Tendency (ISTH 2020) - "ONO-1600586 may be a safer anticoagulant targeting FXIa for venous thromboembolism."

Hematological Disorders • Ischemic stroke • Reperfusion Injury • Thrombosis • Venous Thromboembolism • F2