NDT-05-1040 / Nitto Denko - LARVOL DELTA

A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-driven Non-small Cell Lung Cancer. (PubMed, Mol Cancer Ther) - "The lead drug product candidate (NBF-006) is a proprietary siRNA-based lipid nanoparticle (LNP) comprising GSTP siRNA (NDT-05-1040). Additionally, in a surgically implanted orthotopic lung tumor model, the survival rate of the NBF-006 treatment group was significantly prolonged (P <0.005) as compared to the vehicle control group. Together, these preclinical studies supported advancement of NBF-006 into clinical studies."

Journal • Lipid Nanoparticle • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • KRAS • PARP1 • PCNA