acyclovir / Generic mfg. - LARVOL DELTA

Managing refractory herpes simplex keratitis. (PubMed, Br J Ophthalmol) - "The emergence of acyclovir-resistant HSV-1 strains, particularly in immunocompromised or long-term treated patients, represents an increasing concern. In these situations, alternative agents such as trifluridine, foscarnet or more recently, helicase-primase inhibitors, including amenamevir, have demonstrated clinical efficacy. The new strategies outlined here will all provide benefit in treating the drivers of refractory HSK, to quickly resolve and reduce risk of recurrence, providing new opportunities to prevent vision loss in refractory and antiviral-resistant cases."

Journal • Review • Dry Eye Disease • Herpes Simplex • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

EFFICACY OF INTRALESIONAL ACYCLOVIR VERSUS CRYOTHERAPY FOR TREATMENT OF PLANTAR WARTS (EADV 2026) - No abstract available

Clinical • Dermatology

Chronic recurrent urticaria in patient with recurrent herpes labialis: complete remission after administration with Aciclovir and Antihistamines (EADV 2026) - No abstract available

Clinical • Dermatology • Immunology • Urticaria

Efficacy of Intralesional Acyclovir versus Quadrivalent Human Papillomavirus Vaccine for Treatment of Recalcitrant Cutaneous Warts: A Clinical Trial (EADV 2026) - No abstract available

Clinical • Dermatology

Role of Acyclovir in Severe Adult Hand, Foot, and Mouth Disease: A Case Report (EADV 2026) - No abstract available

Case report • Clinical • Infectious Disease

Acute Herpes Zoster-Like Eruption in a Free Flap after Reconstruction of Post-Burn Hand Contracture: A Case Report. (PubMed, Hand Surg Rehabil) - "Intravenous acyclovir was initiated...Herpes simplex virus testing was negative, but varicella-zoster virus testing was unavailable; therefore, involvement of the flap could not be virologically confirmed. This unusual temporal sequence highlights viral reactivation as a differential consideration when vesicular lesions appear during early free-flap monitoring, while standard assessment for vascular compromise must continue."

Journal • Dermatology • Herpes Simplex • Herpes Zoster • Pruritus • Varicella Zoster

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report. (PubMed, Hum Vaccin Immunother) - "Intravenous acyclovir was administered, resulting in complete clinical resolution. Although causality cannot be established, the close temporal relationship between influenza vaccination and the onset of HSV-1 infection is noteworthy, while alternative explanations cannot be excluded. This case highlights the importance of considering HSV infection in the differential diagnosis of multifocal mucocutaneous lesions occurring after influenza vaccination without implying a causal relationship."

Journal • Herpes Simplex • Infectious Disease • Influenza • Respiratory Diseases

Efficacy and Safety of Pritelivir vs Foscarnet for the Treatment of Acyclovir-Refractory Herpes Simplex Virus Infection in Immunocompromised Adults: A Randomized, Open-Label Phase 2 Trial. (PubMed, Open Forum Infect Dis) - "In Part B, the median time to healing was 19.0 days, with a 63% healing rate. Pritelivir demonstrated encouraging efficacy and favorable safety in immunocompromised adults with limited treatment options, supporting Phase 3 evaluation for the treatment of refractory HSV infection in this population."

Clinical • Journal • P2 data • Herpes Simplex • Infectious Disease

Pritelivir for treatment of resistant/refractory HSV in stem cell transplant patients: Real-world experience from a single centre tertiary hospital (TTS 2026) - "Salvage therapies including foscarnet and cidofovir, are limited by nephrotoxicity, cytopenias, and the need for intravenous administration...Pritelivir, a novel first-in-class helicase-primase inhibitor that blocks viral DNA synthesis, offers activity against aciclovir- and foscarnet-resistant HSV...Case 1: A 68-year-old female allogeneic HSCT recipient for pre-B acute lymphoblastic leukaemia developed refractory perianal HSV-2 ulcers despite high-dose valaciclovir, IV foscarnet, and topical imiquimod... In a phase 3 trial, pritelivir demonstrated superior healing of refractory/ resistant HSV lesions compared to standard therapies. Although optimal durations of pritelivir could not be completed in our cases due to transplant related morbidity, there was evidence of initial clinical improvement. Early consideration of pritelivir may help mitigate significant morbidity associated with refractory or resistant HSV ulceration."

Clinical • Real-world • Real-world evidence • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Herpes Simplex • Immunology • Infectious Disease • Leukemia • Myelodysplastic Syndrome • Septic Shock • Transplantation

A Fatal Herpes Simplex Encephalitis with a Normocellular Cerebrospinal Fluid: A Case Report. (PubMed, J Clin Med) - "Despite the prompt initiation of acyclovir after suspicion of encephalitis with MRI, together with corticosteroid therapy, anticonvulsants, and supportive treatment, the clinical course was fatal...The absence of CSF pleocytosis does not exclude HSE, although the timing of CSF sampling should be considered when interpreting this finding. Early MRI and molecular CSF diagnostics remain essential for establishing an accurate diagnosis and ensuring timely treatment."

Journal • Cardiovascular • CNS Disorders • Herpes Simplex • Infectious Disease • Inflammation • Ischemic stroke

Rare bilateral optic neuritis following herpes zoster ophthalmicus in an immunocompetent adult: A case report. (PubMed, IDCases) - "After admission, oral valacyclovir was switched to intravenous acyclovir, and oral corticosteroid therapy was initiated...Corticosteroid treatment was therefore escalated to intravenous methylprednisolone pulse therapy...This case highlights the fulminant course of herpes zoster ophthalmicus-associated optic neuritis and shows that bilateral optic nerve involvement may occur even in immunocompetent patients. Early recognition, close monitoring of both eyes, and prompt escalation of therapy are critical when optic nerve involvement is suspected."

Journal • Herpes Zoster • Immunology • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Varicella Zoster

Early Access Program (EAP) Experience of Pritelivir in the Treatment of Acyclovir- and Foscarnet-Refractory Herpes Simplex Virus (HSV) Infection in Immunocompromised (IC) Patients (IDWeek 2026) - No abstract available

Clinical • Herpes Simplex • Infectious Disease

One in Seventy: The Diagnostic and Antiviral Stewardship Imperative of Neonatal HSV Testing in 1,322 Acyclovir-Treated Infants (IDWeek 2026) - No abstract available

Infectious Disease

A Clinical and Laboratory Comparison of Varicella-Zoster Virus (VZV) and Epstein-Barr Virus (EBV): Two Cases of Herpesvirus Meningitis in Immunocompetent Adults and a Literature Review. (PubMed, Cureus) - "The patient with VZV meningitis experienced rapid clinical improvement following acyclovir therapy and developed a vesicular rash two days after symptom onset, whereas the patient with EBV meningitis presented with a broader range of systemic and neurological symptoms and showed a more gradual recovery. Despite a shared lymphocytic CSF pattern, the two cases demonstrated distinct clinical and laboratory profiles. These findings highlight the importance of molecular testing for definitive diagnosis and support consideration of both viruses in the differential diagnosis of aseptic meningitis in immunocompetent patients."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Herpes Zoster • Infectious Disease • Varicella Zoster

Rashless varicella-zoster virus encephalitis diagnosed by metagenomic next-generation sequencing: two case reports. (PubMed, BMC Neurol) - "Rashless VZV encephalitis may be diagnostically challenging because early clinical, CSF, and neuroimaging findings are nonspecific. CSF mNGS can support etiological diagnosis, and careful follow-up is needed to detect delayed vascular and lumbosacral nerve root complications."

Biomarker • Journal • Next-generation sequencing • Back Pain • CNS Disorders • CNS Lymphoma • Dermatology • Epilepsy • Gastrointestinal Disorder • Hematological Malignancies • Herpes Zoster • Immunology • Infectious Disease • Inflammatory Bowel Disease • Lumbar Back Pain • Lymphoma • Musculoskeletal Pain • Non-Hodgkin’s Lymphoma • Oncology • Pain • Primary Central Nervous System Lymphoma • Varicella Zoster

When Immune System and Herpes Virus Infection Collide: A Case of Severe Stromal Herpetic Keratitis in a Patient with Rheumatoid Arthritis Under Methotrexate. (PubMed, Int Med Case Rep J) - "A recurrent episode of HSVK was diagnosed, and treatment with 3 times daily oral acyclovir, 4 times daily 0.15% ganciclovir ophthalmic gel, and 3 times daily 0.15% topical dexamethasone was started. This case underscores how systemic immunomodulatory treatment may play a clinically relevant role in patients with recurrent HSVK. In selected cases, a conservative, surgery‑sparing approach through the optimization of systemic therapy can help promoting viral load control and corneal healing."

Journal • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Keratitis • Ocular Inflammation • Ophthalmology • Pain • Rheumatoid Arthritis • Rheumatology

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand. (PubMed, Intern Med J) - "Institutional preferences and medicine funding drives variability in ANZ practice. This leaves potential for healthcare inequity since newer antiviral agents are inconsistently used, contrasting with international guidelines."

Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Pediatrics • Transplantation

Ganglioside Antibodies as Formidable Neurologic Mimickers: A Case Report of Dual Anti-GQ1b and Asialo-GM1 Antibody Syndrome. (PubMed, Cureus) - "She was discharged with prednisone and acyclovir for presumed idiopathic Bell's palsy. A ganglioside antibody panel was positive for anti-GQ1b and asialo-GM1 antibodies.  This case highlights an unusual presentation of concurrent anti-GQ1b and asialo-GM1 antibody positivity manifesting as unilateral facial palsy and limb weakness initially attributed to Bell's Palsy. Recognition of ganglioside antibody syndromes as potential mimickers of Bell's palsy is essential to ensure prompt diagnosis and treatment, thereby reducing the risk of neurological morbidity."

Journal • Ataxia • Back Pain • CNS Disorders • Complement-mediated Rare Disorders • Movement Disorders • Musculoskeletal Pain • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Treatment of Herpes simplex encephalitis with the helicase-primase inhibitor pritelivir in an immunocompromised patient. (PubMed, NPJ Antimicrob Resist) - "After 1.5 months, while still on valacyclovir prophylaxis, HSE relapsed, confirmed by Magnetic Resonance Imaging (MRI) and HSV1 DNA detection in cerebrospinal fluid (CSF). Following transient response to acyclovir and foscarnet, combined pritelivir/acyclovir treatment was initiated in this comatose patient with cerebral edema and necrosis...Pritelivir plasma and CSF concentrations exceeded the 50% effective concentration for HSV1. This case highlights the potential of pritelivir for treating HSE."

Journal • Bone Marrow Transplantation • CNS Disorders • Herpes Simplex • Infectious Disease • Transplantation

Adjunctive corticosteroids in herpes simplex virus encephalitis: a meta-analysis of randomized and observational studies. (PubMed, J Neurol) - "Available evidence does not support the routine use of adjunctive corticosteroids in unselected patients with HSVE. Clinically meaningful benefit or harm cannot be excluded, because the evidence is limited and imprecise. The evidence is insufficient to determine the benefits or harms of corticosteroids in selected patients with life-threatening cerebral edema, because this indication was not specifically evaluated. Future adequately powered, multicenter randomized trials should use standardized treatment protocols and prespecify severity- and edema-defined subgroups."

Clinical • Journal • Observational data • Retrospective data • Review • CNS Disorders • Epilepsy • Herpes Simplex • Inflammation • Vascular Neurology

Managing Infections, Hypogammaglobulinemia, and Neutropenia During Treatment With Teclistamab in Relapsed/Refractory Multiple Myeloma: Nurse-Led Experience From the MajesTEC-1 Study (IMW 2023) - "At our institutions, all patients treated with teclistamab were up to date with vaccinations (eg, COVID-19, influenza, and pneumococcal) and received acyclovir or valacyclovir prophylaxis; additional antimicrobials (eg, sulfamethoxazole/trimethoprim for Pneumocystis jirovecii pneumonia prophylaxis) were given per individual center guidelines. Teclistamab should not be given in case of any active infection; therefore, partnership between nurses, physicians, and patients is essential to facilitate prompt identification, monitoring, and management of infections, including appropriate use of antimicrobial prophylaxis, IVIG, and G-CSF. In particular, we recommend that patients are educated on the importance of reporting early signs and symptoms of infections, and that nurses and care teams are prepared and trained to implement appropriate infection management strategies."

Cough • Cytomegalovirus Infection • Hematological Disorders • Hematological Malignancies • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Influenza • Multiple Myeloma • Neutropenia • Novel Coronavirus Disease • Oncology • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Use of fomepizole as a novel approach for preventing aciclovir-induced neurotoxicity. (PubMed, J Antimicrob Chemother) - No abstract available

Journal

Anti-N-methyl-D-Aspartate Receptor Autoimmune Encephalitis Due to Ovarian Teratoma in a 17-Year-Old Young Woman: Case Report and Review of the Literature. (PubMed, EJIFCC) - "In the absence of a definitive diagnosis, midazolam was administered to treat tonic-clonic seizures, while ceftriaxone and acyclovir were started for suspected infection. When clinical suspicion remains high despite negative initial instrumental and laboratory findings, it is essential to repeat these investigations. In such cases, neuroantibody testing may play a crucial role in establishing the diagnosis."

Journal • CNS Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Oncology • Ovarian Cancer • Pediatrics • Psychiatry

Herpes Zoster Ophthalmicus Complicated by Orbital Apex Syndrome. (PubMed, Neuroophthalmology) - "He was misdiagnosed with cluster headache but later returned with a vesicular rash, prompting treatment with IV acyclovir...OAS involves dysfunction of multiple cranial nerves and may mimic other orbital syndromes but is distinguished by optic nerve involvement. Prompt recognition and aggressive treatment are critical to prevent permanent visual and neurological deficits in HZO-associated OAS."

Journal • Anesthesia • Diabetes • Herpes Zoster • Metabolic Disorders • Ophthalmology • Pain • Type 2 Diabetes Mellitus • Varicella Zoster • Vasculitis

Varicella zoster virus infection. (PubMed, Nat Rev Dis Primers) - "VZV infection is treated with antiviral drugs including oral valacyclovir (drug of choice), famciclovir, acyclovir or amenamevir; for severe or disseminated disease, intravenous acyclovir or foscarnet (when other drugs fail) are used. Critical challenges remain in recognizing and diagnosing atypical presentations, developing novel therapeutics, establishing the causal role of VZV in vascular and neurodegenerative disease, and achieving broader vaccine implementation worldwide."

Journal • Review • Cardiovascular • CNS Disorders • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster