acyclovir / Generic mfg. - LARVOL DELTA

Viral encephalitis related to adalimumab in a 16-year-old Crohn's disease patient: case report and literature review. (PubMed, Front Immunol) - "Following discontinuation of ADA and treatment with acyclovir, the child's symptoms largely subsided. This report presents the first pediatric CD patient with treatment of ADA, during which VE manifested. Although neurological adverse events associated with ADA are infrequent in pediatrics, vigilant monitoring for neurological symptoms, particularly for infections, remains critical."

Journal • Review • CNS Disorders • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Pediatrics

PREVALENCE AND ASSOCIATED FACTORS OF HOSPITALIZED INFECTION IN LUPUS NEPHRITIS: A FIVE-YEAR SINGLE-CENTER STUDY (ISN-WCN 2026) - "Three patients had herpes infection (skin infection, gingivostomatitis, and meningitis) with no to 400-mg acyclovir prophylaxis. Four infection-related deaths occurred (pathogen: Salmonella, Escherichia coli, tuberculosis, and fungi), in whom IS regimens included only prednisolone to steroid combined with mycophenolate mofetil 2000mg/day and hydroxychloroquine.Table 1 Unadjusted and adjusted odds ratios of various factors for hospitalized infection in lupus nephritis...Unlike this higher dose, the use of any dose of any dose of trimethoprim/sulfamethoxazole (single strength or double strength) was not a significantly protective factor for hospitalized infection, even in adjusted analysis.Download: Download high-res image (502KB)Download: Download full-size imageConclusion Prescribing IS, especially higher dose prednisolone, in LN patients with risk factors for hospitalized infection requires careful decision and vigilant monitoring to balance risk-benefit for the best..."

Clinical • Chronic Kidney Disease • CNS Disorders • Diabetes • Diabetic Nephropathy • Glomerulonephritis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Metabolic Disorders • Nephrology • Pneumonia • Respiratory Diseases • Tuberculosis

ACYCLOVIR-INDUCED NEPHROPATHY AND ENCEPHALOPATHY IN FIVE ELDERLY FEMALE CASES: A CASE SERIES (ISN-WCN 2026) - "Introduction Acyclovir is an antiviral drug that is excreted by the kidneys. Valaciclovir (225 Da, low protein binding, Vd 0.6 L/kg) is easily removable by HD (45% removed in 3h). Blood purification therapy can improve these toxicities by removing the drug."

Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Herpes Zoster • Immunology • Nephrology • Renal Disease • Rheumatoid Arthritis • Scleroderma • Systemic Sclerosis • Varicella Zoster

Herpes Zoster in a 9-Month-Old Infant Following Maternal Varicella Infection: A Rare Case Report. (PubMed, Clin Cosmet Investig Dermatol) - "The patient presented with dermatomally distributed vesicular lesions on the left anterior chest and back. Treatment included intravenous acyclovir, oral antiviral therapy, semiconductor laser therapy, boric acid compresses, and traditional Chinese herbal fumigation."

Journal • Herpes Zoster • Infectious Disease • Varicella Zoster

Severe Varicella Pneumonia in an Immunocompetent Adult Requiring Intensive Care Management: A Case Report. (PubMed, Cureus) - "Early treatment with intravenous acyclovir followed by oral valacyclovir resulted in favorable clinical and radiological outcomes. This case emphasizes the importance of early recognition and prompt antiviral therapy to improve prognosis, even in immunocompetent adults without classical risk factors."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Varicella Zoster

Atypical Bilobed Lymphocytes in CSF: Diagnostic Insights into Varicella Zoster Virus Meningitis and Herpes Zoster with Temporal Presentations. (PubMed, Infect Drug Resist) - "The first case involved a 19-year-old man with HIV who presented with meningitis symptoms, followed by the appearance of a dermatomal rash three days after initiation of acyclovir, consistent with herpes zoster...Although previously associated with primary VZV infection, such cytological findings may also occur in reactivation and should prompt consideration of VZV as an etiology, even in the absence of cutaneous lesions. Early recognition facilitates timely antiviral therapy and favorable clinical outcomes."

Journal • CNS Disorders • Herpes Zoster • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pain • Systemic Lupus Erythematosus • Varicella Zoster

PARKINSONISM FOLLOWING VARICELLA-ZOSTER VIRUS (SHINGLES) INFECTION: A CASE REPORT (ADPD 2026) - "She received two courses of oral valacyclovir after recurrence but never IV acyclovir...Sinemet improved most symptoms except foot dystonia... The relationship between parkinsonism and VZV is uncertain, with evidence suggesting but not confirming an association. A veteran cohort study found no increased Parkinson's disease risk after VZV exposure, whereas a meta-analysis and systematic review reported a significant association (1,3). Another study linked higher anti-VZV antibody levels with Parkinson's risk (6)."

Case report • Clinical • CNS Disorders • Dystonia • Gastrointestinal Disorder • Herpes Zoster • Infectious Disease • Movement Disorders • Parkinson's Disease • Varicella Zoster

When Treatment Mimics Disease: A Case of Aciclovir-induced Neurotoxicity in a Patient with VZV-Positive CSF (ESCMID Global 2026) - No abstract available

Clinical

Amenamevir for acyclovir-resistant genital HSV-2 infection in people living with HIV (ESCMID Global 2026) - No abstract available

Human Immunodeficiency Virus • Infectious Disease

Helicase-primase inhibitor adibelivir (IM-250) shows potent antiviral activity against HSV clinical and acyclovir-resistant isolates and achieves therapeutic exposure in phase I/Ib studies (ESCMID Global 2026) - No abstract available

Clinical • P1 data

Natural polymorphisms in UL23 thymidine kinase of herpes simplex virus type 1 associated with a decreased susceptibility to acyclovir (ESCMID Global 2026) - No abstract available

Herpes Simplex

Subretinal parasitic lesion mimicking viral retinitis managed with combined medical therapy and laser photocoagulation. (PubMed, IDCases) - "She was previously diagnosed with acute retinal necrosis and treated with corticosteroids and acyclovir, but her condition continued to decline...This case highlights that parasitic infections should be considered in the differential diagnosis of infectious uveitis that does not respond to initial treatment in regions where parasitic infections are common. Combining focal laser photocoagulation with medical therapy may help control inflammation and preserve vision when a distinct extramacular subretinal parasite is detected."

Journal • Genetic Disorders • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Differentiating Verrucous Herpes from Neoplastic Processes (AAD 2026) - "Treatment typically includes antiviral medications such as acyclovir, valacyclovir, and famciclovir, although some patients might need intralesional or surgical treatment. Patients in an immunocompromised state may not respond to standard anti-herpetic agents such as acyclovir, thus possibly needing escalation of treatment. This case highlights the importance of maintaining a broad differential diagnosis when evaluating cutaneous lesions in immunocompromised patients."

Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Squamous Cell Carcinoma • CD4

Generalized vesicles in a renal transplant patient: Varicella relapse, an underrecognized condition. (AAD 2026) - "We present the case of a patient with renal transplant due to advance chronic kidney disease with IgA nephropathy as the etiology, on immunosuppressive management with tacrolimus, mycophenolate, and prednisolone in whom varicella without organic involvement was diagnosed, and treatment was initiated with intravenous acyclovir (10 mg/kg every 8 hours for 14 days), with resolution of the skin lesions. However, 10 days after finishing the treatment, the patient presented a recurrence of generalized vesicles, without prodromal symptoms, no dermatomal distribution, or pain, with confirmation of herpetic infection through a Tzanck test and skin biopsy, together considered as a varicella relapse. The search in literature suggests that this is one of the first reported cases of varicella relapse in a patient with renal transplant without documented systemic complications, highlighting the importance of considering this diagnosis not only in patients with HIV and underlying..."

Clinical • Chronic Kidney Disease • Glomerulonephritis • Herpes Zoster • Human Immunodeficiency Virus • IgA Nephropathy • Infectious Disease • Nephrology • Renal Disease • Transplantation • Varicella Zoster

Neonatal varicella and early-onset herpes zoster following maternal infection at term: a case report. (PubMed, J Med Case Rep) - "This case highlights that neonatal varicella can occur despite intravenous immunoglobulin prophylaxis and strict isolation, and early-onset herpes zoster may follow perinatal exposure. Close follow-up of exposed neonates is crucial, and further research is needed to better understand the protective efficacy of intravenous immunoglobulin and the mechanisms of early varicella zoster virus reactivation in infancy."

Journal • Critical care • Developmental Disorders • Herpes Zoster • Infectious Disease • Varicella Zoster

ACICLOVIR-RESISTANT HERPES SIMPLEX VIRUS IN PEDIATRIC PATIENTS UNDERGOING ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANT: A CASE SERIES (EBMT 2026) - "All patients were treated with second-line antivirals (foscarnet and/or cidofovir), and three patients were treated with third-line antivirals (pritelivir). Aciclovir-resistant HSV infection in pediatric HSCT recipients is associated with high morbidity and mortality, limited therapeutic options, and significant treatment-related toxicity. Early recognition, resistance testing, timely initiation of second-line therapy and weaning of immunosuppression are critical for disease control. Emerging therapies, such as helicase-primase inhibitors and adoptive T-cell therapy, hold promise but remain limited by access and pediatric data."

Clinical • Bone Marrow Transplantation • Gastrointestinal Disorder • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Keratitis • Leukemia • Myelodysplastic Syndrome • Ocular Inflammation • Ophthalmology • Pediatrics • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • Sickle Cell Disease • Transplantation • Transplantation Associated Thrombotic Microangiopathy

PRITELIVIR DEMONSTRATED SUPERIOR EFFICACY COMPARED TO INVESTIGATOR'S CHOICE TREATMENT FOR REFRACTORY HERPES SIMPLEX VIRUS INFECTIONS IN IMMUNOCOMPROMISED PATIENTS: PRIOH-1, PHASE 3 SAFETY AND EFFICACY (EBMT 2026) - P3 | " In this randomized (1:1), controlled, open label trial, 101 IC patients (≥16 years) with R±R HSV mucocutaneous infection received oral pritelivir (100 mg daily; 400 mg loading dose) or ICT (IV foscarnet, IV/topical cidofovir, or topical imiquimod) for up to 28 days, extendable to 42 days. Eligibility criteria included hematopoietic cell transplant, solid organ transplant, HIV, malignancy, or chronic use of immunosuppressive treatment with refractory/clinical failure (defined as no clinical improvement of lesions after ≥7 days of standard of care nucleoside analogue therapy or confirmed acyclovir resistance)... Pritelivir met the Phase 3 primary endpoint, demonstrating statistically superior efficacy compared with ICT, with a favorable safety and tolerability profile. These findings support pritelivir as a promising oral agent to address the unmet needs of refractory HSV infections in IC patients.Table 1 Incidence of TEAEs (≥ 10%): Pritelivir vs...."

Clinical • P3 data • Herpes Simplex • Human Immunodeficiency Virus • Immunology • Infectious Disease • Primary Immunodeficiency • Solid Organ Transplantation

Herpes Simplex Encephalitis Mimicking a Stroke With Favorable Response to Adjuvant Corticosteroids (SCCM 2026) - "Despite the effectiveness of intravenous Acyclovir, a subset of patients may deteriorate due to intense cerebral inflammation, leading to cerebral edema...Antibiotics were discontinued, and intravenous dexamethasone and hypertonic saline were initiated to manage cerebral edema...The initial misdiagnosis of ischemic stroke delayed the initiation of antiviral therapy and the development of cerebral edema. The subsequent use of corticosteroids and hypertonic saline therapy was associated with rapid clinical improvement, suggesting a beneficial role in managing HSVE-related inflammation and edema."

Clinical • Cardiovascular • CNS Disorders • Cognitive Disorders • Herpes Simplex • Inflammation • Ischemic stroke • Thrombosis

Navigating the Challenges of Managing Lupus Cerebritis in the Intensive Care Setting (SCCM 2026) - "The patient was then started on IV Acyclovir...Despite multiple rounds of compressions and epinephrine administration, the patient could not be resuscitated and passed away after 12 days of admission. This case highlights the unique challenges associated with managing SLE and lupus cerebritis in the critical care setting, especially with regards to hematologic management. The patient ultimately expired due to a pulmonary embolism that could not be therapeutically coagulated due to ongoing parenchymal hemorrhage and thrombocytopenia. Furthermore, we emphasize the need for active collaboration between intensivists and other specialists to navigate the multisystem complications of SLE."

Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Critical care • Epilepsy • Hematological Disorders • Herpes Zoster • Hypotension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pulmonary Embolism • Respiratory Diseases • Systemic Lupus Erythematosus • Thrombocytopenia • Varicella Zoster

West Nile Neuroinvasive Disease (WNND) After a Natural Disaster in a Kidney Transplant Recipient (SCCM 2026) - "Her immunosuppression included mycophenolate, prednisone, and letermovir.Over six days, her condition rapidly worsened, developing flaccid paralysis in all extremities and loss of airway protection requiring intubation...She was empirically started on doxycycline, zosyn, and acyclovir.Twelve days after symptom onset, WNV IgM returned positive (2.1; cutoff >1.11), with negative IgG, confirming acute infection...It also raises an important question: should solid organ transplants be delayed during early hurricane season in high-risk regions? Education and preventive mosquito measures are critical for transplant recipients in hurricane-prone areas."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Solid Organ Transplantation • Transplantation • Type 2 Diabetes Mellitus

Austrian Syndrome: A Triple Threat (SCCM 2026) - "Empiric treatment with ceftriaxone, vancomycin, ampicillin, and acyclovir was given for severe sepsis with suspected meningitis.Her course was complicated by new-onset atrial fibrillation and respiratory failure requiring intubation. Due to its high mortality, clinicians should maintain a strong index of suspicion in any patient presenting with altered mentation, a new or changing murmur, and S. pneumoniae bacteremia, regardless of typical risk factors. Early diagnosis, prompt imaging, timely empiric antibiotics, and consideration of surgical intervention are critical to improving outcomes in these rare but life-threatening cases"

Atrial Fibrillation • Breast Cancer • CNS Disorders • Cough • Hypertension • Infectious Disease • Musculoskeletal Pain • Pneumonia • Respiratory Diseases • Septic Shock • Solid Tumor

Hemophagocytic lymphohistiocytosis directly triggered by peginterferon alfa-2b in a patient with chronic hepatitis B. (PubMed, Front Immunol) - "He responded well to etoposide and dexamethasone. Both complications were managed successfully with intravenous immunoglobulin and acyclovir, respectively. This case highlights PegIFN-α-2b as a rare direct trigger of HLH in CHB and underscores the critical risk of opportunistic infections during immunosuppressive therapy, demonstrating the pivotal role of mNGS in diagnosing elusive infections in immunocompromised hosts."

Journal • CNS Disorders • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatitis B • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Rare Diseases • IFNA1 • IL2 • ISG20

How to interpret low-dose valacyclovir for postherpetic neuralgia in the Zoster Eye Disease Study-a randomized clinical trial. (PubMed, Ann Transl Med) - No abstract available

Clinical • Journal • Herpes Zoster • Keratitis • Neuralgia • Ocular Inflammation • Ophthalmology • Pain • Uveitis • Varicella Zoster

A Complex Case of Erythema Multiforme Major in a Patient with Recalcitrant HSV and Superimposed MRSA Infection (AAD 2026) - "Treatment included methylprednisolone taper, escalation to valacyclovir 800mg three times daily, systemic linezolid 600mg twice daily, and topical mupirocin ointment resulting in gradual improvement with residual post-inflammatory changes...The patient's persistence of lesions despite suppressive acyclovir underscores the potential need for alternative antivirals or immunomodulatory agents in select cases... Dermatologists play a central role in recognizing the interplay of HSV reactivation, EM Major presentation, and comorbid infections. Comprehensive management incorporating antivirals, antimicrobials, and immunomodulators can optimize outcomes in severe, recalcitrant cases."

Clinical • Dermatitis • Dermatology • Hematological Disorders • Herpes Simplex • Immunology • Infectious Disease • Mucositis

Varicella-zoster virus expression following fractional Thulium laser treatment for skin rejuvenation: the first case report. (PubMed, J Cosmet Laser Ther) - "The treatment proposed involved a combination of phototherapies as an adjunctive local strategy, alongside systemic acyclovir therapy...Varicella-zoster virus expression should be considered following aesthetic skin treatments with fractional Thulium laser, and the need for prophylaxis with antiviral agents may be appropriate for certain cases. Moreover, the combination of phototherapies proposed herein seemed to be beneficial for accelerating the resolution of such a condition."

Journal • Herpes Zoster • Varicella Zoster