sertraline / Generic mfg. - LARVOL DELTA

Clinical outcomes in patients with multiple myeloma and antidepressant use: A retrospective cohort study (ASH 2025) - "Adult patients with multiple myeloma since 2010 and prescribed antidepressants (sertraline, escitalopram, citalopram, paroxetine, fluoxetine, fluvoxamine, venlafaxine, duloxetine, trazodone, mirtazapine, or bupropion) were identified using ICD-10 diagnostic and RxNorm codes. While some associations were modest in magnitude, the consistent pattern of increased risk suggests that pre-existing depression and its treatment may identify a more vulnerable subgroup of multiple myeloma patients. Further prospective studies are needed to clarify underlying mechanisms and to evaluate the potential impact of early psychiatric intervention."

Clinical data • Retrospective data • Chronic Kidney Disease • CNS Disorders • Depression • Hematological Malignancies • Infectious Disease • Major Depressive Disorder • Multiple Myeloma • Musculoskeletal Diseases • Nephrology • Renal Disease

Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

Journal

Suicide attempt by cutting an LVAD wire: psychiatric complications in patients with heart failure. (PubMed, BMJ Case Rep) - "He was admitted for cardiac stabilisation and psychiatric evaluation and started on sertraline for treatment of generalised anxiety and depression...Learning points include the need for early psychiatric evaluation and integration of palliative care in patients receiving life-sustaining cardiac devices. Routine screening for demoralisation, depression and suicidal ideations in this population could prevent catastrophic outcomes and improve patient dignity and quality of life."

Journal • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Mood Disorders • Palliative care • Psychiatry • Suicidal Ideation

Efficacy and mechanism of Shugan Jieyu combined with sertraline in alcohol-dependent patients with depression: A randomized clinical study. (PubMed, World J Psychiatry) - "SJC-sertraline combination therapy accelerates depressive symptom relief (by 2 weeks) and improves response rates (+16.7%) in alcohol-dependent patients, without increasing adverse events. Clinical outcomes suggest potential synergistic mechanisms, though no biomarker analyses were performed."

Clinical • Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

Exploratory analysis of symptom-specific efficacy of transcranial magnetic stimulation in adolescent depression. (PubMed, World J Psychiatry) - "This study identified four distinct symptom clusters with differential responses to rTMS treatment. The findings demonstrate that rTMS shows greatest efficacy for improving subjective mood symptoms, guiding targeted therapeutic approaches."

Journal • CNS Disorders • Depression • Insomnia • Major Depressive Disorder • Mood Disorders • Psychiatry • Sleep Disorder

Attentional capacity and PTSD treatment response: prolonged exposure alone or combined with sertraline. (PubMed, Psychother Res) - "Impaired sustained attention may be one moderator to consider towards treatment optimization. Research should examine specific in-session attentional mechanisms impacting outcomes such as reduced engagement with trauma-related stimuli during exposure."

Journal • CNS Disorders • Depression • Post-traumatic Stress Disorder • Psychiatry • Vascular Neurology

Anxiety disorders following percutaneous coronary intervention for acute myocardial infarction: A comprehensive review of clinical manifestations and interventions. (PubMed, World J Psychiatry) - "Heart-specific cognitive behavioral therapy (SMD = -0.72), selective serotonin reuptake inhibitors (especially sertraline), and integrated cardiac rehabilitation programs that incorporate both psychological and physical elements are among the beneficial interventions that have been supported by evidence...Digital initiatives have the potential to increase access, especially in underprivileged areas. Early identification of high-risk patients and implementation of timely, targeted interventions represent crucial strategies for improving both psychological and cardiovascular outcomes in this vulnerable population."

Journal • Review • Cardiovascular • CNS Disorders • Cognitive Disorders • Depression • Mood Disorders • Myocardial Infarction • Psychiatry

Adjustment for dispensed doses does not explain higher antidepressant concentrations in post-mortem toxicology. (PubMed, Br J Clin Pharmacol) - "Dose adjustment generally did not improve the separation of poisoning vs non-poisoning suicides, indicating that post-mortem concentrations may not have clear dose-concentration relationships."

Journal

The impact of antidepressant use on antibiotic treatment outcomes in urinary tract infections and pneumonia: A population-based cohort study. (PubMed, Psychiatry Clin Neurosci) - "Antidepressants are associated with a modest rise in UTI treatment failure risk, possibly due to antibiotic resistance or other mechanisms. Despite this, their essential role in mental health management outweighs the small risk, emphasizing the need for judicious use, particularly in females and older adults. Further research is warranted to clarify underlying mechanisms."

Journal • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs. (PubMed, Basic Clin Pharmacol Toxicol) - "The greater the individual weight loss, the greater the concentration increase in hydrophilic drugs that undergo glomerular filtration, for example, pregabalin and gabapentin, suggesting that this reflects decreased glomerular hyperfiltration. By contrast, for highly lipophilic drugs, for example, mirtazapine and sertraline, the greater the individual creatinine and cystatin C loss, the greater the decrease in drug concentration, interpreted as increased drug metabolism based on decreased liver inflammation and steatosis. Venlafaxine/O-desmethylvenlafaxine displayed a complicated pattern suggesting the involvement of both glomerular filtration and metabolism. Serum concentrations of modestly lipophilic drugs, for example, duloxetine and (es)citalopram, were not significantly affected by the diet. In conclusion, hydrophilicity- and lipophilicity-related changes in drug concentrations over the diet period covary with markers of changes in hyperfiltration and metabolism,..."

Journal • Genetic Disorders • Inflammation • CST3

Lack of Generalizability of PTSD Treatment Trials: The Recent Brexpiprazole-Sertraline Trials as an Example. (PubMed, J Clin Psychiatry) - "As a result, we remain uncertain about the medications' effectiveness for most patients treated in clinical practice. We urge regulatory agencies to require industry to conduct studies that better reflect the patient populations seen in clinical practice."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Sertraline-Associated Riboflavin-Responsive Lipid Storage Myopathy: Report of Two Case. (PubMed, Muscle Nerve) - "Although riboflavin therapy is often reserved for genetically confirmed patients, our findings support its efficacy in sertraline-associated, genetically negative MADD. These cases underscore the importance of recognizing medication-associated metabolic myopathies and the potential for targeted riboflavin therapy."

Journal • Metabolic Disorders • Myositis • Rare Diseases

Sertraline Hydrochloride Exposure Leads to Reactive Oxygen Species Burst in Model Microalgae Species (Raphidocelis subcapitata). (PubMed, Environ Sci Technol) - "This probable ROS burst altered cell membrane composition and downregulated genes associated with protoporphyrinogen IX and heme biosynthesis pathways. This research highlights the molecular mechanisms underlying pharmaceutical-induced chlorosis in a model microalgae species and demonstrates the utility of integrating metabolomics and transcriptomics for assessing the potential ecological risks of SSRIs."

Journal

When migraine meets maternity: A case highlighting the risks of non-selective β-blockers in pregnancy (EHF-EHC 2025) - "A healthy 30-year-old woman with migraine without aura since age 20, previously on propranolol 40 mg/day for prophylaxis and sertraline 50 mg/day, had propranolol continued during the preconception period - following a risk-benefit discussion - due to frequent migraine attacks. This case highlights the need for individualized treatment planning. In cases using non-selective agents like propranolol, fetal risks - particularly IUGR - must be considered and monitored carefully."

Clinical • CNS Disorders • Migraine • Pain

Middle meningeal artery lidocaine infusion for refractory migraine: First case report in Portugal (EHF-EHC 2025) - "Various pharmacologic classes were tried without benefit: antihypertensives and calcium channel blockers (propranolol, candesartan, flunarizine), antiepileptics (valproic acid, topiramate, oxcarbazepine), antidepressants (amitriptyline, nortriptyline, venlafaxine, fluvoxamine, sertraline, clomipramine), other preventives (prednisolone, oxitriptan, melatonin), cycles of botulinum toxin (PREEMPT protocol), monoclonal antibodies (galcanezumab, fremanezumab, erenumab), and atogepant. At the time of the procedure, the patient was on eptinezumab 100 mg and botulinum toxin every three months but continued to have daily headaches, with severe intensity and reliance on eletriptan for acute relief...It constitutes an invasive therapeutic approach that should be considered only as a rescue option for carefully selected patients with severely refractory migraine. Further studies and long-term follow-up are needed to assess efficacy and safety."

Case report • Clinical • Anorexia • CNS Disorders • Migraine • Pain

Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors. (PubMed, BMC Med) - "In this cohort study, based on data from US healthcare claims databases, initiating citalopram, escitalopram, fluoxetine, or paroxetine while on hydrocodone was associated with an increased risk of opioid overdose compared with sertraline. No substantial risk differences were observed across SSRIs other than sertraline."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • CNS Disorders • CYP3A4

The role of empathy in antidepressant withdrawal. (PubMed, Ther Adv Psychopharmacol) - "Part of a larger prospective cohort study in major depressive disorder patients using sertraline or citalopram recruited through university medical centres and connected general practitioners, pharmacies and mental health institutions. Perceived empathy was positively associated with subjective success and negatively associated with the negative effects of discontinuation. Although we could not demonstrate an association of perceived empathy and objective discontinuation, we consider the finding of a relation between subjective success as relevant because a successful experience regarding antidepressant discontinuation may positively influence the initiation of future attempts."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Determination of Nitrosamine Drug Substance-Related Impurities Derived from Nortriptyline and Sertraline Using LC-MS/MS: A Comparative Evaluation of Chromatographic Separation and Pharmaceutical Application. (PubMed, Pharmaceuticals (Basel)) - "The application of this method to commercial products subjected to accelerated stress testing revealed NNORT formation in NORT products with an average concentration of 190 ng/g, as well as NSERT formation in SERT products resulted in an average concentration of 172 ng/g. This validated method provides a reliable tool for routine quality control, thereby enabling pharmaceutical manufacturers and regulatory agencies to ensure safety and compliance with widely used antidepressant medications."

Journal

The impact of sertraline treatment on obesity, inflammation, blood pressure, and lipid profiles: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Diabetol Metab Syndr) - No abstract available

Journal • Retrospective data • Review • CNS Disorders • Depression • Genetic Disorders • Inflammation • Obesity • Psychiatry

Current evidence of randomized clinical trials on hospice-eligible patients with agitation and dementia: A narrative review. (PubMed, Palliat Support Care) - "There is a critical gap in high-quality and generalizable evidence to guide agitation management at the end of life for patients with dementia. Addressing this gap is essential to improving not only symptom control but also to preserving dignity and reducing caregiver distress in hospice care. Future trials must include diverse populations, incorporate home-based hospice settings, and rigorously evaluate both pharmacologic and nonpharmacologic interventions to support compassionate, patient-centered care.This review highlights urgent gaps in research and care delivery, underscoring the need for inclusive and scalable intervention designs to address agitation at the end of life."

Clinical • Journal • Review • Alzheimer's Disease • CNS Disorders • Dementia

Gender and organ responsiveness in Dreissena polymorpha exposed to the antidepressant sertraline: from uptake to effects. (PubMed, Environ Res) - "Moreover, sertraline exposure modulated monoamine oxidase (MAO) activity, reduced total antioxidant capacity (TAC), and altered markers of oxidative stress, inflammation and apoptosis, especially at intermediate to high concentrations. These findings highlight sertraline's potential to induce neurotoxic, immunotoxic, and metabolic stress responses in non-target freshwater organisms, emphasizing the need for further ecotoxicological assessments of SSRIs in aquatic environments."

Journal • Inflammation • Metabolic Disorders

Comparative gastrointestinal effects of antidepressants for the acute treatment of adults with major depressive disorder: a network and dose‒response meta-analysis. (PubMed, Transl Psychiatry) - "Commonly used antidepressants have different gastrointestinal effects. Duloxetine, levomilnacipran, and vilazodone carry a higher risk of inducing nausea and vomiting, whereas trazodone, amitriptyline, agomelatine, and mirtazapine tend to be better tolerated. Amitriptyline, clomipramine, and reboxetine are more prone to induce constipation. Diarrhoea is more commonly associated with vilazodone, fluvoxamine, and sertraline. Amitriptyline, reboxetine, and duloxetine are more likely to cause anorexia. Amitriptyline, reboxetine, and trazodone are related to causing dry mouth. Compared with the placebo, amitriptyline, fluoxetine, and paroxetine were associated with a greater incidence of dyspepsia."

Journal • Retrospective data • Review • Anorexia • CNS Disorders • Constipation • Depression • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Major Depressive Disorder • Mood Disorders • Psychiatry • Xerostomia

Clinical and sociodemographic characterization of Patients with Psychiatric Disorders and Epilepsy admitted to a reference psychiatric hospital (AES 2025) - "Among antiseizure medications, valproate (20.2%), carbamazepine (14.6%), and phenobarbital (12.4%) were most frequently prescribed. The most utilized psychiatric medications were risperidone (18%), haloperidol (15.73%), levomepromazine (9%), and sertraline (9%)... The findings indicate a high prevalence of psychiatric and behavioral comorbidities among institutionalized individuals with epilepsy, emphasizing the significant use of psychoactive substances and aggressive manifestations. The medication profile underscores the necessity for integrated clinical and psychiatric management, highlighting the importance of multidisciplinary approaches to optimize seizure control, reduce complications, and enhance quality of life."

Clinical • Late-breaking abstract • Behavior Disorders • CNS Disorders • Depression • Epilepsy • Insomnia • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia • Sleep Disorder • Suicidal Ideation

Associations of polymorphic variants of CYP2C19*2, *17 with effectiveness and safety of sertraline in adolescents with a depressive episode and suicidal tendencies (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "Carriers of the polymorphic variant of CYP2C19*17 more often reported adverse reactions compared to carriers of «wild» genotypes. The result is paradoxical compared to previous studies in adult patients."

Journal • CNS Disorders • Depression • Psychiatry • CYP2C19 • CYP2C9

Serotonin syndrome induced by Bromfed DM in a patient on sertraline. (PubMed, SAGE Open Med Case Rep) - "It is commonly linked to combinations of serotonergic prescription drugs; however, over-the-counter or prescription cold medications containing dextromethorphan (DM) or first-generation antihistamines may also pose a risk. This case underscores the importance of recognizing the serotonergic potential of common cold medications and the risk of SS even at therapeutic doses, particularly in patients on selective serotonin reuptake inhibitors (SSRIs). Prompt identification and cessation of the causative agents are critical to avoid complications."

Journal • Cough • Respiratory Diseases