sertraline / Generic mfg. - LARVOL DELTA

Acneiform Eruption as A Reported Adverse Effect of Antidepressants: A Systematic Review (AAD 2026) - "Out of 13 studies selected, 10 (76.9%) reported acneiform eruptions in patients using amineptine. The remaining studies each reported acneiform eruptions associated with sertraline (7.7%), escitalopram, (7.7%) and desvenlafaxine (7.7%)...Further research into antidepressant-associated acneiform eruptions and whether there is a difference in risk between classes of widely used antidepressants such as SSRIs and SNRIs is required. In the meantime, physicians should be aware and vigilant for acneiform eruptions in patients treated with antidepressants to better counsel patients as these reactions can potentially lead to worsening depression and reduced compliance with medications."

Adverse events • Review • Acne Vulgaris • CNS Disorders • Depression • Dermatology

Treatment of Recurrent Facial Ulcerations from Trigeminal Trophic Syndrome with Vagal Nerve Stimulation (AAD 2026) - "Management included naltrexone 50 mg daily, sertraline 25 mg, gabapentin 300 mg, N-acetylcysteine 1000 mg, and biweekly human skin allografts. This represents the first reported case of successful VNS treatment for refractory TTS, potentially mediated through reduced glutamate in the trigeminal nucleus caudalis. VNS may act as a valuable adjunctive therapy for resistant cases."

Cardiovascular • Keratitis • Ocular Inflammation

Antidepressant-Induced Apathy in Adolescents with a Depressive Episode While Taking Sertraline: Results of 8-Week Observational Study with Pharmacogenetic Testing for CYP2C19. (PubMed, Biomedicines) - "There was no increase in emotional blunting according to the ODQ score among adolescents with depression who took sertraline for eight weeks. No significant correlations were found between the carrier status of CYP2C19 gene variants and the development of apathy induced by antidepressants."

Biomarker • Journal • Observational data • CNS Disorders • Depression • Psychiatry • CYP2C19

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

SSRI-Induced Galactorrhea in Adolescents. (PubMed, J Child Adolesc Psychopharmacol) - "Reports show that SSRI-induced galactorrhea and hyperprolactinemia, though uncommon, can occur in adolescents. Clinicians should be aware that SSRI-related galactorrhea may occur even when prolactin levels are normal or mildly elevated and should actively inquire about this adverse effect. Further research is needed to clarify prevalence, risk factors, and mechanisms involved."

Journal

Efficacy of sertraline combined with low-dose antipsychotics in first-episode schizophrenia. (PubMed, Eur Arch Psychiatry Clin Neurosci) - No abstract available

Journal • CNS Disorders • Psychiatry • Schizophrenia

Drugs for dementia. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Movement Disorders • Parkinson's Disease

NALFURAFINE FOR REFRACTORY UREMIC AND CHOLESTATIC PRURITUS IN A HEMODIALYSIS PATIENT: A CASE REPORT (ISN-WCN 2026) - "During her course, she experienced recurrent spontaneous bacterial peritonitis (pathogen: vancomycin-resistant Enterococcus faecium) necessitating multiple courses of broad-spectrum antibiotics (including cefoperazone-sulbactam, meropenem, daptomycin, linezolid)...Initially suspected as a drug allergy, all potential culprit medications were discontinued, and prednisone was administered...Despite trials of various standard therapies including antihistamines, intensified hemodialysis with hemoperfusion, gabapentin, ursodeoxycholic acid, sertraline, topical tacrolimus ointment, and achieving targets for phosphate and parathyroid hormone control, the generalized pruritus remained refractory...This outcome underscores its mechanistic advantage and potential therapeutic value in challenging clinical scenarios involving mixed-origin pruritus.Conclusion In conclusion, nalfurafine presents a promising therapeutic option for refractory pruritus of mixed uremic and cholestatic..."

Case report • Clinical • Chronic Kidney Disease • Dermatology • Fibrosis • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Liver Failure • Nephrology • Pruritus • Renal Disease • Urticaria

EFFICACY OF SUBCUTANEOUS LIDOCAINE INFUSION FOR CKD-ASSOCIATED PRURITUS (CKD-AP) (ISN-WCN 2026) - "Furthermore, CKM patients have difficulty accessing intravenous difelikefalin, which is only approved for haemodialysis patients...Other skin conditions were excluded following dermatology review and multiple therapies had been trialled, including regular aqueous emollients, topical capsaicin, pregabalin (up to doses of 150mg BD), methylprednisone 0.1% ointment, sertraline, evening primrose oil and doxepin...No side-effects were observed. The response was sustained for 6 weeks, after which the patient deteriorated from underlying kidney failure and end of life care was provided.Conclusion Subcutaneous lidocaine infusion may be an effective and safe alternative treatment option for cases of refractory CKD-aP.I have potential conflict of interest to disclose.Dr Kelly Li receives honoraria from CSL SeqirusI did not use generative AI and AI-assisted technologies in the writing process."

Clinical • Alzheimer's Disease • Chronic Kidney Disease • CNS Disorders • Dementia • Depression • Dermatology • Diabetic Nephropathy • Insomnia • Nephrology • Pruritus • Sleep Disorder

Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis. (PubMed, Sex Med) - "Comparative analysis of antidepressant-related adverse events in the FAERS database showed that while sexual dysfunction was associated with all studied SSRIs/SNRIs (sertraline, citalopram/escitalopram, paroxetine, fluoxetine, venlafaxine, and duloxetine), symptom profiles varied markedly. But the limitation is FAERS' passive surveillance nature, which may involve underreporting or insufficient clinical context, restricting causal inference. While previous studies have not fully elucidated antidepressant-related sexual dysfunction, our findings delineate distinct sexual adverse effect profiles between SSRIs and SNRIs, contributing valuable evidence for personalized treatment approaches."

Adverse events • Journal • Sexual Disorders

Transfer of Bromazepam to Cord Blood and Breast Milk: A Case Series of Bromazepam Serum Levels and Outcomes in Newborns and Breastfed Infants. (PubMed, J Hum Lact) - "Bromazepam transfers into the placenta and breast milk, with no serious outcomes in neonates and infants, but one infant had unexplained lethargy. Further cases are needed."

Journal • CNS Disorders • Mental Retardation • Psychiatry

Transient frontal spectral events from EEG predict antidepressant response to sertraline in depression. (PubMed, J Psychiatr Res) - "We found that pre-treatment frontopolar beta duration was significantly correlated with depression score change, with greater degree of symptom response linked to shorter beta events at baseline. This finding replicates prior work on frontopolar beta duration as a possible biomarker of antidepressant response in rTMS and raises the possibility that beta events may be a cross-modal therapeutic biomarker in antidepressant treatment."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Three-Year Follow-Up of children and adolescents with OCD Who Did Not Respond to Initial Cognitive-Behavioral Therapy (CBT): Outcomes of Continued CBT vs. Sertraline. (PubMed, Eur Child Adolesc Psychiatry) - No abstract available

Journal • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Early Epigenetic Alterations in Cardiac Tissue Following Perinatal Sertraline Exposure in Mice (PAS 2026) - No abstract available

Preclinical • Cardiovascular

TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children (clinicaltrials.gov) - P4 | N=180 | Recruiting | Sponsor: Poznan University of Medical Sciences

New P4 trial • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Sertraline safety in adolescents experiencing a depressive episode during first 3 weeks: added anxiolytic matters more than CYP2C19 polymorphisms. (PubMed, Front Pharmacol) - "The use of anxiolytics (alimemazine and hydroxyzine) was significantly associated with an increased number of vegetative/somatic, and mental ADRs on day 7, as well as an increased total number of ADRs by day 21. Linear regression analysis confirmed that anxiolytics were the most significant predictors of ADR development on day 21 (Estimate = 0.86, 95% CI 0.32-1.41, p = 0.002). Polypharmacy (particularly, adding a non-benzodiazepine anxiolytic) was a more significant risk factor for ADRs when taking sertraline, compared to the carrier status of CYP2C19 gene polymorphisms."

Journal • CNS Disorders • Depression • Psychiatry • CYP2C19

Therapeutic Use of Melatonin for Gastrointestinal Motility and Hypersomnolence in a Patient With Pineal Cyst Pathology. (PubMed, Am J Case Rep) - "Amantadine and sertraline were used in conjunction with melatonin. The report is limited by being a single case with lack of a control group, and use of concurrent medications. Larger, controlled studies are needed to further explore the mechanisms involved in the relationships between melatonin, GI functioning, and sleep dysregulation."

Journal • CNS Disorders • Mood Disorders • Psychiatry

Pseudo-Cheilitis: An Underreported Condition (AAD 2026) - "Treatment with topical Clobetasol, Tacrolimus, Clotrimazole, and oral Doxycycline showed no improvement...Based on this, treatment with Sertraline, a selective serotonin reuptake inhibitor (SSRI), was initiated, resulting in a marked improvement of cheilitis within 2 months...This may result from repeated, subconscious lip trauma during periods of stress. Clinicians should consider this differential diagnosis when expected therapeutic responses are not observed"

Atopic Dermatitis • CNS Disorders • Depression • Immunology • Mood Disorders

Acquired Multiple Acyl-Coenzyme A Dehydrogenase Deficiency Associated With Sertraline in Sweden-A Nationwide Population-Based Study. (PubMed, Eur J Neurol) - "Acquired MADD associated with sertraline is the most common type of adult-onset MADD in Sweden. The disease is generally responsive to riboflavin treatment. Patients presenting with muscle symptoms during sertraline therapy should undergo adequate evaluation to exclude MADD."

Journal • Retrospective data • Fatigue • Genetic Disorders • Metabolic Disorders • Myositis • Rare Diseases

Prevalence and risk factors associated with anxiety and depression in patients with acute ischemic stroke who receive mechanical thrombectomy. (PubMed, J Stroke Cerebrovasc Dis) - "Poststroke anxiety and depression are prevalent issues in patients with AIS who receive mechanical thrombectomy. Meanwhile, younger age, lower BMI, and hypertension were independently associated with poststroke anxiety."

Journal • Cardiovascular • CNS Disorders • Depression • Hypertension • Ischemic stroke • Mood Disorders • Psychiatry

The Effects of Sertraline on Dialysis-Induced Hypotension: A Systematic Review and Meta-Analysis. (PubMed, Healthcare (Basel)) - " Sertraline significantly improves hemodynamic stability during hemodialysis with a favorable safety profile. It represents a promising option for DIH, particularly in patients with comorbid depression or contraindications to midodrine."

Journal • Retrospective data • Review • Chronic Kidney Disease • CNS Disorders • Depression • Hypotension • Nephrology • Psychiatry • Renal Disease

Reply to the Complex Etiology of Sertraline-Induced Lipid Storage Myopathy and Acquired Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)-like Syndromes: Hidden Genetic Variation, Nutritional Deficiency, and Mitochondrial Vulnerability. (PubMed, Muscle Nerve) - No abstract available

Journal • Metabolic Disorders • Myositis

Postorgasmic illness syndrome (POIS) in two patients responding to sertraline: a case report. (PubMed, J Sex Med) - No abstract available

Journal

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland. (PubMed, Acta Ophthalmol) - "Our large nested case-control study suggests that certain systemic medications may increase the incidence of surgically treated cataract, but with the possibility of residual confounding."

Journal • Cataract • Diabetes • Metabolic Disorders • Ophthalmology