BT-115
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- LARVOL DELTA
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March 14, 2023
Therapeutic vulnerability of MTAP-deleted nasopharyngeal carcinoma by MAT2A inhibitors
(AACR 2023)
- "Selective sensitivity of MTAP-deleted NPC to the treatment of MAT2A inhibitors including FIDAS-5 and BT115386 was demonstrated. To facility its growth inhibitory effects, the compounds targeted PRMT5 activity, subsequently modulated multiple cellular mechanisms and induced EBV lytic reactivation. The potent antitumor effect of BT115386 was demonstrated in the in vivo MTAP-deleted NPC mouse models."
Head and Neck Cancer • Nasopharyngeal Carcinoma • Oncology • Solid Tumor • MAT2A • MTAP • PRMT5
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