bisoprolol / Generic mfg. - LARVOL DELTA

Spontaneous coronary artery dissection in a male patient with haemophilia A: a case report. (PubMed, Eur Heart J Case Rep) - "The patient, with no bleeding complications, was conservatively treated with medications, including aspirin and bisoprolol. CCTA at 8 months detected the disappearance of the previously seen intramural haematoma. We revealed two important clinical issues: (i) SCAD in a male patient with haemophilia and (ii) the usefulness of CCTA in observing SCAD lesions."

Journal • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease • Diabetes • Hematological Disorders • Hemophilia • Hemophilia A • Hemophilia B • Metabolic Disorders • Myocardial Infarction • Pain • Rare Diseases • Type 2 Diabetes Mellitus

Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care. (PubMed, Pharmacol Res Perspect) - "A significantly higher concentration-to-dose ratio and a significantly lower weight-adjusted apparent clearance were demonstrated in patients with reduced cardiac function, reduced renal function, and taking the combination with amiodarone. These patients may be more prone to overdose with bisoprolol."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Recurrent syncope attributed to torsade de pointes induced by worsened long QT interval after switching from peritoneal dialysis to hemodialysis: A case report. (PubMed, J Cardiol Cases) - "Evocalcet was discontinued because it is known to induce long QT, and bisoprolol was initiated. The worsening of long QT is mainly attributed to fluctuation in potassium levels before and after HD. Thus, carefully monitoring the QT interval and changes in the serum potassium level is crucial, particularly, when initiating HD."

Journal • Cardiovascular • Chronic Kidney Disease • Renal Disease

Anomalous left coronary artery from the pulmonary artery: A case report of ALCAPA syndrome with bicuspid aortic valve. (PubMed, Medicine (Baltimore)) - "This case emphasizes the importance of recognizing ALCAPA in adults, particularly in patients presenting with minimal symptoms despite significant congenital anomalies. In select cases with adequate collateral circulation, medical management may be a viable alternative to surgical intervention, underscoring the need for individualized treatment approaches based on the patient's anatomical and functional profile."

Journal • Cardiovascular • Heart Failure • Pain • Thrombosis

J.B. Chemicals & Pharmaceuticals Ltd receives ANDA approval from USFDA for Bisoprolol Tablets USP (Equitybulls) - "J.B. Chemicals & Pharmaceuticals Limited has received approval from United States Food and Drug Administration (US FDA) for its Abbreviated New Drug Application (ANDA), Bisoprolol Tablets USP, 5 mg, and 10 mg, the generic version of Zebeta (Teva), which is indicated in the management of hypertension."

ANDA • Cardiovascular • Hypertension

A Case of Ventricular Premature Contractions With Multiple Morphologies Reproduced by a Single Ventricular Extrastimulus With Different Coupling Intervals. (PubMed, J Cardiovasc Electrophysiol) - "This case illustrated how a single focus VPC could exhibit multiform morphology due to varying fusion with intrinsic conduction and the importance of coupling interval-matched extrastimuli in identifying the origin."

Journal • Cardiovascular

Aortic dissection type A, common carotid artery occlusion, and stroke after dapsone for 20 years. (PubMed, J Family Med Prim Care) - "He underwent aortic valve and aortic replacement and achieved a modified Ranking score of 2 after administration of phenprocumon, bisoprolol, atorvastatin, and sertraline and intensive rehabilitation. This case demonstrates that long-term use of dapsone may contribute to vascular pathology that ultimately leads to aortic dissection. Unless necessary, dapsone should not be given for years."

Journal • Atopic Dermatitis • Cardiovascular • Dermatology • Immunology • Ischemic stroke

JB Chemicals Gets USFDA Nod For Generic Hypertension Drug (NDTV) - "JB Chemicals and Pharmaceuticals Ltd. on Friday said it has received approval from the US health regulator to market a generic medication to treat high blood pressure...The company has received approval from the US Food and Drug Administration for Bisoprolol tablets in strengths of 5 mg and 10 mg, the company said in a regulatory filing....The company's product is the generic version of Teva's Zebeta tablets, which are indicated for the management of hypertension."

ANDA • Hypertension

Comparison between bisoprolol and carvedilol in functional class in heart failure (HEART FAILURE 2025) - No abstract available

Cardiovascular • Congestive Heart Failure • Heart Failure

Early onset development of hypertrophic cardiomyopathy in less than 1 year in a patient with familial Friedrich's ataxia: Case report. (PubMed, Radiol Case Rep) - "She was prescribed bisoprolol and dapagliflozin, with significant improvement at her latest checkup. No cardiac abnormalities were detected in her younger brother or parents. Friedreich's hypertrophic cardiomyopathy has been reported as the most significant cause of mortality, especially among younger patients with early onset disease manifestations."

Journal • Ataxia • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Fibrosis • Friedreich ataxia • Heart Failure • Hypertrophic Cardiomyopathy • Immunology • Metabolic Disorders • Movement Disorders • Non-obstructive Hypertrophic Cardiomyopathy • Pulmonary Disease

β-Adrenergic Blockers Increase cAMP and Stimulate Insulin Secretion Through a PKA/RYR2/TRPM5 Pathway in Pancreatic β-Cells In Vitro. (PubMed, Pharmacol Res Perspect) - "Unexpectedly, high concentrations (100 μM) of β-blockers (propranolol and bisoprolol) paradoxically increased cAMP levels 5-10 fold, enhanced Ca2+ influx, and stimulated a 2-4 fold increase in glucose- and glimepiride-induced insulin secretion in MIN6-K8 clonal β-cells and isolated mouse pancreatic islets. CICR then activates transient receptor potential cation channel subfamily M member 5 (TRPM5), resulting in increased Ca2+ influx via voltage-dependent Ca2+ channels. These effects contradict the conventional understanding of the pharmacology of β-blockers, highlighting the variability in β-blocker actions depending on the experimental context."

Journal • Preclinical

Development and validation of a highly sensitive HPLC method for quantifying cardiovascular drugs in human plasma using dual detection. (PubMed, Sci Rep) - "This research introduces an innovative, sustainable HPLC-FLD method for the concurrent determination of bisoprolol (BIS), amlodipine besylate (AML), telmisartan (TEL), and atorvastatin (ATV) within human plasma. The extraction of sample was carried by liquid-liquid extraction (LLE) and analyzed by LC-fluorescence detector. The chromatographic run was short (less than10 min) which is a greet economical value."

Journal • Acute Myelogenous Leukemia • Cardiovascular

DANBLOCK: Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction (clinicaltrials.gov) - P4 | N=2760 | Active, not recruiting | Sponsor: Bispebjerg Hospital | Trial completion date: Apr 2025 ➔ Dec 2035

Trial completion date • Cardiovascular • Congestive Heart Failure • Myocardial Infarction

STAMI-BAS: STunning in Acute Myocardial Infarction - BAS (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Vastra Gotaland Region | Not yet recruiting ➔ Recruiting | Initiation date: Sep 2024 ➔ Jan 2025

Enrollment open • Trial initiation date • Cardiovascular • Myocardial Infarction • TNNI3

RARELY PERFORMED: SURGICAL MYECTOMY FOR SYMPTOM RELIEF IN MID LV OBSTRUCTION, WITH A MYSTERIOUS DIAGNOSIS OF THICKENED LV AS THE SILENT INTRUDER - Piyachat Pipatpongsopon (ACC 2025) - "Despite therapy with bisoprolol and disopyramide, her chest pain persisted, and her mid-LV gradient stayed elevated at 103mmHgDecision-making: Multimodality imaging was used to rule out HCM mimickers... Mid cavitary obstruction can be managed with myectomy safely with significant improve symptom. This case highlights unexpected myocardial glycogen accumulation, raising questions about its pathophysiology."

Cardiomyopathy • Cardiovascular • Fibrosis • Immunology • Metabolic Disorders • Obstructive Hypertrophic Cardiomyopathy • Pain

HYPERTROPHIC CARDIOMYOPATHY - Nelson Acosta (ACC 2025) - "Treated with Bisoprolol 2.5mg, with favorable response... A 5-year risk of sudden death of 3.85% was calculated, equal to a low risk; Therefore, implantation of an automatic defibrillator as primary prevention is not indicated. Estimation of the risk of sudden death, family screening and appropriate medical therapy were tools used for the comprehensive management of this disease."

Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Pain

TICAGRELOR INDUCED BRADYARRHYTHMIA AND COMPLETE HEART BLOCK IN PATIENT WITH ST ELEVATION MYOCARDIAL INFARCTION: A RARE BUT SERIOUS CASE REPORT - Turki A. Asiri (ACC 2025) - "She received a loading dose of aspirin 300 mg, ticagrelor 180 mg, and heparin 5000 IU IV bolus, followed by urgent coronary angiography revealing severe RCA occlusion, treated with PCI and DES...The electrophysiology team was consulted, and advised withholding bisoprolol and sending her to the CCU for close observation.Decision-making: After reviewing her medication history, we found that she had been on propranolol for a long time without any complications...Therefore, it was stopped and switched to clopidogrel... Clinicians must be aware of this rare side effect of Ticagrelor particularly when initiating treatment in patient with inferior wall MI. Carful history taking and vigilant assessment of drug related conditions should be considered to identify iatrogenic causes and thus, avoiding unnecessary invasive treatments."

Case report • Clinical • Acute Coronary Syndrome • Cardiovascular • Myocardial Infarction • Pain

A Rapid and Sensitive Method for the Determination of Bisoprolol in Human Plasma by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry. (PubMed, Biomed Chromatogr) - "The method was fully validated including whole blood stability and reinjection reproducibility and successfully applied to the pharmacokinetic study of 5-mg bisoprolol in healthy volunteers, which 93.1% incurred samples reanalysis (ISR) met the criteria. Compared with the reported methods, this method had the highest sensitivity and fast analysis speed."

Journal

Association between beta-1-adrenoceptor blockade and risk of Raynaud's phenomenon: Mendelian randomisation study. (PubMed, J Scleroderma Relat Disord) - "The effect of beta-1-adrenoceptor blockers (e.g. bisoprolol, atenolol) on Raynaud's phenomenon remains unclear. We found no genetic evidence to support a causal association between beta-1-adrenoceptor blockade and Raynaud's phenomenon risk in either direction. Randomised controlled trials are required to confirm the safety of beta-1-adrenoceptor blockers in people with Raynaud's phenomenon."

Journal • Cardiovascular • Immunology • Rheumatology • Scleroderma • Systemic Sclerosis

PROPORTION OF HEART FAILURE PATIENTS RECEIVING GUIDELINE RECOMMENDED DOSES OF BETA BLOCKERS IN GEORGIA: A STUDY ON TITRATION AND TOLERABILITY. (PubMed, Georgian Med News) - "The inability to use beta-blockers, one of the most important medications for heart failure, is a major problem in Georgia, as only 25.67% of patients were able to take the recommended dose of the medication. Since 24.17% of patients were able to titrate to a higher dose of beta blockers, we can conclude that with long-term and careful control of heart failure some patients may be able to titrate to a higher dose of beta blockers through adaptation to the medication and to the cardiac function. It is also possible that patients were not receiving optimal medication treatment at the time of medication initiation and the medication could actually have been titrated to a higher dose. This fact highlights the importance of attempting to titrate to a higher dose of beta blockers, as 24.17% of patients saw improvement in their prescribed medication over the course of the study."

Journal • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Hypotension • Pulmonary Disease

POLYPHARMACY, DRUG RELATED NITROSAMINE CONTAMINATION (BISOPROLOL/PROPAFENONE) AND THE LINK TO LICHEN PLANUS/SUBSEQUENT DEVELOPMENT OF KERATINOCYTE AND MUCOSAL CANCER/ORAL LEUKOPLAKIA: PRESENTATION OF THE FIRST CASE AND UPDATE ON THE NEW PATHOGENETIC VISION. (PubMed, Georgian Med News) - "The association between drug-induced lichen planus - whether oral/mucosal or solely cutaneous - involves a diverse range of drugs, including ACE inhibitors, diuretics, and beta blockers, as well as quinidine, NSAIDs, hydroxychloroquine, antiretroviral medications for HIV, penicillamine, TNF inhibitors, and certain medications for type 2 diabetes. We present for the first time in the medical literature, a case of a 91-year-old patient with a 2-year history of oral lichen planus and subsequent oral leukoplakia following 2-year beta-blocker (bisoprolol) and/or anti-arrhythmic (propafenone) administration, with no history of smoking and alcohol consumption, and discuss the possible role of nitrosamines as a cofactor in the malignant transformation of ulcerative lichenoid lesions to oral leukoplakia/mucosal carcinoma. The adverse effects of these medications may be categorized into those related to 1) the active substance - potentially triggering lichen planus and those 2)..."

Journal • Dermatology • Dermatopathology • Diabetes • Human Immunodeficiency Virus • Infectious Disease • Lichen Planus • Metabolic Disorders • Oncology • Oral Cancer • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Type 2 Diabetes Mellitus

A Quantitative Analysis of Aspirin, Telmisartan, and Bisoprolol in Spiked Human Plasma Using Green Spectrofluorimetric Analysis. (PubMed, Luminescence) - "However, direct fluorescence detection of aspirin and telmisartan proved challenging because their native emission spectra at 406 and 375 nm overlapped. The method's greenness was further evaluated using the Green Analytical Procedure Index and the Analytical GREEnness metrics. The results showed that the employed procedure was environmentally friendly."

Journal

Bioequivalence of China- and Germany-manufactured bisoprolol (Concor®) tablets in fasted and fed healthy Chinese participants: a randomized, open-label, two-way, crossover study. (PubMed, Front Pharmacol) - "This study compared the bioequivalence of bisoprolol 5-mg tablets manufactured in China to that of the tablets manufactured in Germany among healthy Chinese adults. identifier CTR20230391."

Journal

Prediction Factors for Quality Risks in the Pharmaceutical Development of Tablets Bisoprolol Fumarate with Indapamide. (PubMed, Curr Comput Aided Drug Des) - "The developed algorithm and mathematical model for predicting tablet quality risks, proposed for the first time, are highly informative and qualitative. It makes it possible to assess and predict risks related to the quality of tablets, arising from the influence of multiple factors."

Journal

TEMPO II: Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Morten Steen Kvistholm Jensen | Trial completion date: Jun 2027 ➔ Dec 2027 | Trial primary completion date: Jun 2025 ➔ Apr 2027

Trial completion date • Trial primary completion date • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Hypertrophic Cardiomyopathy • Non-obstructive Hypertrophic Cardiomyopathy