JNJ-28312141 / J&J - LARVOL DELTA

PET/CT imaging of CSF1R in a mouse model of tuberculosis. (PubMed, Eur J Nucl Med Mol Imaging) - "[C]JNJ-28312141 binds specifically to CSF1R + macrophages and delineates granulomatous foci of disease in a murine model of pulmonary TB."

Journal • Preclinical • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CSF1R

Colony stimulating factor 1 inhibition decreases tumor growth and macrophage infiltration, and increases neutrophil infiltration in xenograft mice models of glioblastoma (SNO 2019) - "We tested two CSF-1R inhibitors (AZD 7507 and JNJ-28312141) alone and in combination with VEGF inhibition to prevent macrophage infiltration in xenograft GBM mouse models. Detailed characterization of TAN population and polarization in patient tumors are ongoing. Our findings revealed that CSF-1 and VEGF inhibition reduced macrophage infiltration and tumor growth, but significantly increased TAN infiltration which will likely hamper the potential therapeutic benefit of anti-CSF1-directed inhibitors."

Preclinical • CD15 • CHI3L1 • CSF1 • ITGAM