TP-271 / Innoviva - LARVOL DELTA

Cultivation of Anabaena sp. at Different Phosphorus Excess Concentrations: Growth Parameters, Value-Added Metabolites, and Microcystin-LR Production. (PubMed, Physiol Plant) - "In this study, the effects of different phosphorus concentrations, including 7.10 (control treatment), 7.74, 8.38, and 9.66 mg L-1 (CP230, TP250, TP271, and TP312, respectively), on growth, valuable biochemicals, as well as the toxicity potential of Anabaena sp...The findings of the current research indicated that Anabaena sp. not only produces cyanotoxins but also beneficial chemicals, positioning it as a potential new target for antibacterial and antioxidant drug development."

Journal

A kinetic study of the photolysis of sulfamethoxazole with special emphasis on the photoisomer. (PubMed, Photochem Photobiol Sci) - "In a competitive reaction to the formation of ISO from SMX, the degradation product TP271 is formed...In real samples in a northern German surface water in summer 2021 mean concentrations of SMX were found in the range of 120 ng/L. In agreement with the pH-dependent yields, concentrations of ISO were low in the range of 8 ng/L."

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A Phase 1 TP-271 Oral PK Single Ascending Dose Study (clinicaltrials.gov) - P1; N=56; Completed; Sponsor: Tetraphase Pharmaceuticals, Inc.; Active, not recruiting ➔ Completed

Clinical • Trial completion • Infectious Disease

A Phase 1 Safety and PK Study of IV TP-271 (clinicaltrials.gov) - P1; N=40; Completed; Sponsor: Tetraphase Pharmaceuticals, Inc.; Active, not recruiting ➔ Completed

Clinical • Trial completion • Infectious Disease

Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence. (PubMed, J Exp Pharmacol) - "Delafloxacin, omadacycline and lefamulin are the most recently approved antibiotics for CAP...New antimicrobials, such as solithromycin and nemonoxacin, are currently being studied in Phase III clinical trials...These include zabofloxacin, aravofloxacin, nafithromycin, TP-271, gepotidacin, radezolid, delpazolid, and CAL02. The preliminary results of these clinical trials allow us to assure that most of these drugs may play a role in the future treatment of CAP."

Journal • Review • Infectious Disease • Pneumonia • Respiratory Diseases

Safety, tolerability and pharmacokinetics of multiple doses of TP-271, a novel fluorocycline, in normal healthy subjects (ECCMID 2019) - "Multiple IV and oral doses of TP-271 were well tolerated. Plasma exposure increased with dose and high exposures were achieved. This study was funded by a NIAID HHSN272201100028C award."

Clinical • PK/PD data

The Novel Fluorocycline TP-271 is Efficacious in a Nonhuman Primate Model of Inhalation Anthrax (ASM Microbe 2018) - "TP-271 was efficacious when administered therapeutically to cynomolgus monkeys after aerosol exposure to Ba; 21 days of therapy produced complete protection and development of an immunologic response. TP-271 shows promise as a countermeasure for the treatment of inhalation anthrax."

Preclinical • Biosimilar • Immunology

A Phase 1 Safety and PK Study of IV TP-271 (clinicaltrials.gov) - P1; N=40; Active, not recruiting; Sponsor: Tetraphase Pharmaceuticals, Inc.; Trial completion date: Oct 2018 ➔ Feb 2019

Trial completion date • Biosimilar

A Phase 1 Safety and PK Study of IV TP-271 (clinicaltrials.gov) - P1; N=40; Active, not recruiting; Sponsor: Tetraphase Pharmaceuticals, Inc.; Recruiting ➔ Active, not recruiting

Enrollment closed • Biosimilar • Immunology

A Phase 1 TP-271 Oral PK Multiple Ascending Dose Study (clinicaltrials.gov) - P1; N=40; Completed; Sponsor: Tetraphase Pharmaceuticals, Inc.; Recruiting ➔ Completed; Trial primary completion date: Aug 2018 ➔ Dec 2018

Clinical • Trial completion • Trial primary completion date

Effect of alpha-hydroxy acids on transformation products formation and degradation mechanisms of carbamazepine by UV/HO process. (PubMed, Sci Total Environ) - "The identification of TP253a, TP253b, TP271a, TP271b, TP226, and TP180 in the absence and presence of GA and LA were performed by HPLC-MS/MS and two main degradation pathways were presented. Tailing peaks of all TPs caused by GA and LA inevitably resulted in the toxicity of the treated effluent of UV/HO process even when CBZ was decomposed completely. Therefore, alpha-hydroxy acids play important roles in determining the fate and transformation of refractory pharmaceuticals in AOPs treatment."

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Identification of transformation products of carbamazepine in lettuce crops irrigated with Ultraviolet-C treated water. (PubMed, Environ Pollut) - "4 of the TPs identified in peat (iminostilbene, TP 271B, TP 285A-B); and 3 in leaves (10-11 dihydrocarbamazepine, TP 271A-B) were not previously reported in soils or edible parts of crops, respectively. UVC treatment did not contribute to the formation of different TPs than those generated by transformation or metabolism of CBZ in peat or plant material. This research improves the current knowledge on the fate of CBZ TPs in agricultural systems because of reuse practices."

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