HSP60-Treg / Sangamo Therap - LARVOL DELTA

Chronic stress-induced brain-derived small extracellular vesicles promote colorectal cancer through Treg differentiation. (PubMed, Clin Transl Med) - "Chronic stress promotes the differentiation of regulatory T cells (Treg) in the tumour microenvironment through brain-derived small extracellular vesicles (BD-sEVs) to inhibit antitumour immunity. Mechanistically, BD-sEV-induced phorbol-12-myristate-13-acetate-induced protein 1 (NOXA) binds heat shock protein 60 (HSP60) and inhibits its chaperone activity, triggering mitochondrial DNA (mtDNA) release and activation of the cyclic GMP‒AMP synthase (cGAS)‒stimulator of interferon genes (STING) pathway to drive Treg differentiation. The stress‒BD-sEV‒NOXA‒HSP60‒Treg axis is a key pathway that connects psychological stress with peripheral tumour immunosuppression. The expression of NOXA and Forkhead box P3 (FOXP3) in clinical tumour samples correlates with the level of anxiety and may serve as potential prognostic biomarkers."

Journal • Colorectal Cancer • Hematological Malignancies • Leukemia • Mood Disorders • Oncology • Psychiatry • Solid Tumor • CD4 • CGAS • FOXP3 • HSPD1 • L1CAM • MCL1 • MIR15A • MIR342 • MIR381 • PMAIP1 • STING