aspirin/ketamine (VTS-K) / Vitalis - LARVOL DELTA

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression (clinicaltrials.gov) - P4 | N=15 | Completed | Sponsor: Maimonides Medical Center | Active, not recruiting ➔ Completed | Trial completion date: Oct 2024 ➔ May 2024 | Trial primary completion date: Oct 2024 ➔ May 2024

Trial completion • Trial completion date • Trial primary completion date • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression (clinicaltrials.gov) - P4 | N=20 | Active, not recruiting | Sponsor: Maimonides Medical Center | Recruiting ➔ Active, not recruiting | Trial completion date: Oct 2023 ➔ Oct 2024 | Trial primary completion date: Oct 2023 ➔ Oct 2024

Enrollment closed • Trial completion date • Trial primary completion date • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression (clinicaltrials.gov) - P4 | N=20 | Recruiting | Sponsor: Maimonides Medical Center | Trial primary completion date: Jun 2023 ➔ Oct 2023

Trial primary completion date • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression (clinicaltrials.gov) - P4 | N=20 | Recruiting | Sponsor: Maimonides Medical Center

New P4 trial • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry

Oral Aspirin/ketamine versus oral ketamine for emergency department patients with acute musculoskeletal pain. (PubMed, Am J Emerg Med) - P4 | "The administration of an oral combination of VTS-Aspirin ™ and ketamine resulted in less analgesia compared to oral ketamine alone, for the short-term treatment of moderate to severe acute musculoskeletal pain in the ED."

Journal • Fatigue • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Analgesic Efficacy of Oral Aspirin/Ketamine Combination for Management of Acute Musculoskeletal Pain in the Emergency Department - A Proof of Concept Pilot Study. (PubMed, J Emerg Med) - "We demonstrated that administration of an oral combination of VTS-Aspirin and ketamine to adult ED patients with acute MSK pain resulted in clinically significant pain relief in 80% of enrolled subjects."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Analgesic Efficacy of Orally Administered VTS-K for Pain Management (clinicaltrials.gov) - P=N/A | N=25 | Completed | Sponsor: Antonios Likourezos | Recruiting ➔ Completed

Trial completion • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain (clinicaltrials.gov) - P4; N=60; Completed; Sponsor: Antonios Likourezos; Active, not recruiting ➔ Completed

Clinical • Trial completion • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain (clinicaltrials.gov) - P4; N=60; Active, not recruiting; Sponsor: Antonios Likourezos; Recruiting ➔ Active, not recruiting

Clinical • Enrollment closed • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Analgesic Efficacy of Orally Administered VTS-K for Pain Management (clinicaltrials.gov) - P=N/A; N=25; Recruiting; Sponsor: Antonios Likourezos; Trial completion date: Sep 2021 ➔ Dec 2021

Clinical • Trial completion date • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Analgesic Efficacy of Orally Administered VTS-K for Pain Management (clinicaltrials.gov) - P=N/A; N=25; Recruiting; Sponsor: Antonios Likourezos; Trial completion date: Jun 2021 ➔ Sep 2021; Trial primary completion date: Mar 2021 ➔ Jun 2021

Clinical • Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain (clinicaltrials.gov) - P4; N=60; Recruiting; Sponsor: Antonios Likourezos

Clinical • New P4 trial • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Analgesic Efficacy of Orally Administered VTS-K for Pain Management (clinicaltrials.gov) - P; N=25; Recruiting; Sponsor: Antonios Likourezos

Clinical • New trial • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

First Patient Dosed in Pilot Study of Vitalis’ VTS-K for Acute Musculoskeletal Pain (GlobeNewswire) - "Top-line Data Expected First Quarter 2021...Vitalis...today announced the dosing of the first patient in a pilot study evaluating safety and preliminary analgesic efficacy of VTS-K in patients with acute musculoskeletal pain. VTS-K is an oral combination of Vitalis’ patented VTS-Aspirin and ketamine, a non-competitive N-methyl-D-aspartate (NMDA)/glutamate receptor complex antagonist that decreases pain by diminishing central sensitization, hyperalgesia, and 'wind-up' phenomenon at the level of the spinal cord and central nervous system."

P2 data • Trial status • CNS Disorders • Musculoskeletal Pain • Pain