X-339 / Betta Pharma - LARVOL DELTA

Production of polyhydroxybutyrate from wheat straw hydrolysate using a low-salt requiring and alkaliphilic Halomonas nigrificans X339 under non-sterile open condition. (PubMed, Bioresour Technol) - "Additionally, whole genome of X339 was sequenced to identify candidate genes related to carbon source utilization. Our findings will benefit researchers in developing a suitable chassis for Next Generation Industrial Biotechnology, and offer a sustainable and eco-friendly solution for bio-based products."

Journal

Increases in Physiological Fluid Shear Enhance Mechanotransductive Pathogenic Phenotypes and Reveal Molecular Regulatory Mechanisms in Multidrug Resistant Salmonella (ASM Microbe 2023) - "We previously showed low fluid shear force relevant to that in the intestinal tract is a novel environmental signal that increased virulence, stress responses, and reprogrammed gene expression in classical gastrointestinal disease-causing Salmonella Typhimurium (x3339)...Our data suggest that D23580 responds dynamically to a range of physiological fluid shear levels to modulate pathogenesis-related stress resistance, colonization, and gene expression. This is the first demonstration that incremental changes in fluid shear alter stress responses and gene expression in any ST313 strain, and provides mechanistic insight into our previous study showing increased virulence in mice infected with D23580 grown in high fluid shear."

Gastroenterology • Gastrointestinal Disorder • Infectious Disease