ivermectin topical / Generic mfg. - LARVOL DELTA

Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages. (PubMed, Biomedica) - "Ivermectin is effective against T. canis larvae during early migratory stages but shows limited efficacy against late-stage larvae."

Journal • Preclinical • Infectious Disease • Inflammation

Letter: A Case of Propylene Glycol Allergic Contact Dermatitis Associated With Soolantra. (PubMed, Dermatitis) - No abstract available

Journal • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Insurance Coverage of Rosacea Topicals: A Cross-Sectional Review (AAD 2026) - " Azelaic acid gel, oxymetazoline hydrochloride cream, ivermectin cream, sulfacetamide sodium–sulfur cleanser, metronidazole gel, minocycline foam, brimonidine gel, and Epsolay benzoyl peroxide (BPO) cream were reviewed across UnitedHealth Group, Elevance (Anthem), CVS Health (Aetna), Cigna, Health Care Service Corporation Blue Cross Blue Shield (BCBS), Kaiser Permanente, BCBS Florida, BCBS Michigan, Centene, and Blue Shield of California. Only two rosacea topicals were consistently covered by major commercial insurers, and many plans imposed quantity limits and step therapy barriers. Interestingly, metronidazole, identified as less effective than the uncovered topicals, was the most covered agent. [5] This disconnect between evidence-based rosacea treatments and insurer restrictions underscores the need for reform and improved access."

Reimbursement • Review • US reimbursement • Dermatology • Inflammation • Rosacea

EFFUSIVE-CONSTRICTIVE PERICARDITIS SECONDARY TO STRONGYLOIDIASIS (ACC 2026) - "Strongyloides stercoralis is a rare but significant cause of ECP that remains underreported in the literature. Travel history and consideration of parasitic infections are essential for prompt identification and treatment."

Cardiovascular • Eosinophilia • Fibrosis • Immunology • Infectious Disease • Inflammation • Respiratory Diseases

Innovative naringin-ivermectin combination for improved scabies management and dermal healing in rabbits. (PubMed, Vet Parasitol) - "The anti-inflammatory potential of NGNPs was confirmed by a significant downregulation of the transcript levels of NF-κB, TNF-α, and IL-1β alongside weak expression of both iNOS and CD3 in the skin tissues. The study concluded that the daily oral supplementation of NGNPs can act as a powerful cofactor for IVM to completely eliminate the parasite from rabbits, accelerate skin healing, enhance rabbits' immunity, protect many organs from damage, and therefore increase their growth performance."

Journal • Preclinical • Dermatitis • Dermatology • Immunology • Infectious Disease • IL1B • NFKB1 • TNFA

Treatment of redness in rosacea with potassium-titanyl-phosphate (KTP) 532 nm laser with and without topical 1% ivermectin cream: a randomized split-face trial. (PubMed, J Dermatolog Treat) - P2 | "The combination is well tolerated, suggesting a potential adjunctive role for topical ivermectin in laser-based rosacea therapy. clinicalTrials.gov (NCT06033352)."

Journal • Dermatology • Rosacea

Avian Mite Dermatitis Caused by Microlichus sp. in the Great Kiskadee (Pitangus sulphuratus). (PubMed, Acta Parasitol) - "This case highlights the relevance of integrating clinical and parasitological investigations in wildlife rehabilitation settings and contributes to expanding current knowledge on the host range and potential health impacts of epidermoptid mites in free-ranging Neotropical birds."

Journal • Dermatitis • Dermatology • Immunology

An Itch on the Move: A Diagnostic Dilemma of Cutaneous Serpiginous Eruption. (PubMed, Cureus) - "The patient responded well to systemic albendazole with adjunctive topical ivermectin. This case highlights that cutaneous larva migrans should be kept in the differential of a creeping migratory lesion irrespective of site."

Journal • Dermatology

Evaluation of the Efficacy of Anthelmintic Drugs Against Trichinella spiralis Larvae. (PubMed, Antibiotics (Basel)) - "Background: Albendazole, mebendazole, and ivermectin are effective against adult Trichinella spiralis but show limited efficacy against encapsulated muscle stage larvae... Seven antiparasitic drugs, albendazole (ABZ), miltefosine (MLT), ivermectin (IVM), tribendimidine (TBD), praziquantel (PZQ), artesunate (ART), and mefloquine (MEQ), were evaluated for in vitro activity against T. spiralis muscle larvae...In vivo, TBD treatment significantly reduced larval burdens in diaphragm and gastrocnemius muscles and was associated with reduced collagen capsule thickness, inflammation, and fibrosis compared with ABZ-treated controls. This study validated an assay for quantitative evaluation of T. spiralis muscle larvae and demonstrates robust in vitro and in vivo activity of TBD against this stage."

Journal • Fibrosis • Immunology • Inflammation

Combinations of Favipiravir with Doxycycline, Azithromycin or Ivermectin Exert Synergistic Effects Against Influenza A H3N2 Virus Replication. (PubMed, Pathogens) - "Specific combinations of Favipiravir with Artesunate or Andrographolide revealed additive effects by inhibiting influenza virus titers by about 2 or 1.5 log10, respectively. Our findings indicate that specific drug combinations show promising efficacy and potential in the treatment of influenza and warrant further studies using influenza models of human cell, tissue and animal infection."

Journal • Infectious Disease • Influenza • Respiratory Diseases • IFNG • IL1B • IL6 • TNFA

Dermoscopic Response Predictors in Papulopustular Rosacea Treated with Topical Ivermectin and Metronidazole: A Prospective Observational Comparative Study. (PubMed, Clin Cosmet Investig Dermatol) - "Ten patients received ivermectin 10 mg/g cream and 13 received metronidazole 1% gel (non-randomized, based on physician preference), applied once daily for 8 weeks. PFPs in dermoscopy of moderate-to-severe PPR serve as positive predictors for optimal response to topical ivermectin, but not metronidazole. This observation warrants validation in larger controlled trials."

Journal • Observational data • Dermatology • Rosacea

Comparison of the Effectiveness of Ivermectin 1% Cream and Ketoconazole 2% Cream in Treating Facial Seborrheic Dermatitis: A Double-Blind, Randomized, Controlled Clinical Trial. (PubMed, Health Sci Rep) - "Ivermectin cream is a safe and effective treatment for facial SD, and is as effective as topical ketoconazole in reducing SEDASI score, erythema index, itch score, and DLQI score of SD patients. Topical ivermectin could be added to the therapeutic armamentarium of SD.(Iranian Registry of Clinical Trials registration No: IRCT20210222050452N1)."

Clinical • Journal • Dermatitis • Dermatology • Immunology • Pruritus • Seborrheic Dermatitis

Galectin-3 binds to the RGD-binding site in a glycan-independent manner and to the allosteric site and activates integrins αvβ3, αIIbβ3, and α5β1. (PubMed, bioRxiv) - "RGDfV or eptifibatide inhibited Gal3 binding to αvβ3 and αIIbβ3, respectively, but lactose, pan-galectin inhibitor, did not inhibit Gal3 binding to integrins...Known anti-inflammatory agents, Ivermectin, NRG1, and FGF1 inhibited integrin activation induced by Gal3 in αvβ3 and αIIbβ3. These findings suggest that Gal3 binding to site 2 may be a potential mechanism of pro-inflammatory and pro-thrombotic action of Gal3."

Journal • Oncology • IL6 • LGALS3 • NRG1

Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation. (PubMed, CNS Neurosci Ther) - "LIPUS mitigates LPS-induced neuroinflammation, neuronal apoptosis, and depression-like behavior by targeting microglial P2X4R and activating the BDNF/TrkB pathway. The findings provide mechanistic insights and demonstrate that LIPUS is a promising non-pharmacological intervention for depression, underscoring the translational potential of P2X4R as a therapeutic target."

IO biomarker • Journal • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry • BAX • BCL2 • BDNF • IL1B • IL6 • TNFA

MARKED PERIPHERAL EOSINOPHILIA IN THE SETTING OF MILIARY GOUT: A CASE REPORT (WRMC 2026) - "His hospital course was complicated by persistent fevers and eosinophilias unresponsive to scheduled NSAIDs and acetaminophen, and with discontinuation of allopurinol and antibiotics...Proposed mechanisms include MSU crystal–driven cytokine signaling, though not well defined. This case represents rare gout-associated eosinophilia mimicking DRESS, underscoring the need for broad workup and consideration of gout on the differential for peripheral eosinophilia."

Case report • Clinical • Addiction (Opioid and Alcohol) • Dermatology • Eosinophilia • Gout • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Musculoskeletal Pain • Rheumatology

the Efficacy of Ivermectin Alone or With Microneedling in Treatment of Cutaneous Warts. (clinicaltrials.gov) - P1 | N=88 | Not yet recruiting | Sponsor: Assiut University

New P1 trial • Dermatology

Nasal Rhinomyiasis Caused by Cochliomyia hominivorax Complicated by a Parapharyngeal Abscess: A Case Report. (PubMed, Cureus) - "Treatment included ivermectin for myiasis, clindamycin and cefotaxime for the abscess, and functional endoscopic sinus surgery (FESS) for cleaning and debridement. The patient's clinical course was favourable after multidisciplinary treatment, and she was discharged after improvement."

Journal • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Evaluating the Impact of Prophylactic Administration of Ivermectin on the Fecal Microbiome of Healthy C57BL/6J Mice (Mus musculus). (PubMed, J Am Assoc Lab Anim Sci) - "Animals received either ivermectin-impregnated feed (12 ppm, ad libitum for 4 weeks), weekly topical ivermectin solution (2.0 mg/kg for 4 weeks), or no treatment (controls)...These findings demonstrate that ivermectin administration induces measurable and persistent changes in the fecal microbiome of healthy mice. Researchers should consider these effects when designing experiments, and institutions must weigh the benefits of colony protection against potential microbiome-related confounding variables."

Journal • Preclinical

Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial. (PubMed, BMJ) - P3 | "The results of this cluster randomised trial of classic scabies, confirmed by dermoscopy, did not show the non-inferiority of oral ivermectin compared with 5% permethrin cream, given on days 0 and 10, in achieving clinical cure of scabies on day 28 in index cases and their household members. Conversely, the trial showed the statistical superiority of 5% permethrin cream."

Clinical • Journal • Infectious Disease

From signal to strategy: a disproportionality analysis of dupilumab-associated rosacea in FAERS with a summary of reported clinical cases. (PubMed, J Dermatolog Treat) - "Most patients improved with rosacea-directed therapy (topical ivermectin or metronidazole; anti-inflammatory-dose doxycycline). However, dechallenge or rechallenge patterns and the need for dose-interval extension, temporary interruption, or switching biologic (e.g., lebrikizumab, upadacitinib) in a subset support a drug-related pattern at the reporting level. DAR represents a distinct clinical entity from dupilumab-associated head and neck dermatitis, which is eczematous and typically responds to antifungals or calcineurin inhibitors. While disproportionality signals indicate association rather than incidence or causality and are subject to reporting bias, clinicians should be aware of this potential adverse event to ensure appropriate management."

Journal • Review • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Rosacea

ISSC: Ivermectin Safety in Small Children (clinicaltrials.gov) - P2 | N=240 | Completed | Sponsor: University of Oxford | Recruiting ➔ Completed | N=399 ➔ 240 | Trial completion date: Dec 2024 ➔ Apr 2025 | Trial primary completion date: Dec 2024 ➔ Apr 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Infectious Disease

CD21 Things can only get redder! Two cases of allergic contact dermatitis to topical brimonidine tartrate gel. (PubMed, Br J Dermatol) - "Allergic contact blepharitis to brimonidine eye drops is recognized and, more recently, case reports have described patients developing ACD to topical brimonidine gel [Bangsgaard N, Fischer LAN, Zachariae C. Sensitization to and allergic contact dermatitis caused by Mirvaso® (brimonidine tartrate) for treatment of rosacea - 2 cases...He had been using topical Elocon cream daily (mometasone furoate 0.1%) and was diagnosed with steroid-induced rosacea. He was prescribed oral doxycycline, ivermectin cream and brimonidine gel...We would like to raise awareness that in addition to rebound erythema, topical brimonidine gel is also a cause of severe facial ACD. Patch testing to the patient's own medicaments should be performed in suspected cases."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Dry Eye Disease • Immunology • Ocular Inflammation • Ophthalmology • Rosacea • CD21

PA01 Treating scabies with oral ivermectin in infants: series of 12 cases. (PubMed, Br J Dermatol) - "Early treatment with oral ivermectin should be emphasized, along with reiteration of the importance of treating contacts to reduce chances of recurrence. Additionally, existing data suggest that oral ivermectin in children weighing < 15 kg is safe, which is also supported by our study."

Journal • Retrospective data • Atopic Dermatitis • CNS Disorders • Dermatology • Epilepsy • Immunology • Infectious Disease • Pruritus

BI21 Intermittent and progressive pustular psoriasis during chemotherapy cycles in a toddler. (PubMed, Br J Dermatol) - "Just before his next chemotherapy cycle (cisplatin and etoposide), the rash recurred as a pruritic pustular eruption across the frontal and retroauricular scalp; skin biopsy suggested nonspecific subacute eczematous dermatitis...Topical ivermectin and ketoconazole did not help...A second biopsy was taken due to clinical suspicion of psoriasis, and 10 days of oral prednisolone was given to try to clear his skin for autologous stem cell transplantation (HSCT)...He was treated with topical calcipotriol and mometasone 0.1%, with consideration of acitretin should he not improve. Fortunately, the rash settled with topical therapy and time. After completing proton radiotherapy prior to tumour resection, he had six cycles of maintenance immunotherapy (dinutuximab) with no recurrence of the rash, despite monthly GCSF, and good cell counts, and has now completed his oncological therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Contact Dermatitis • Dermatitis • Dermatology • Epstein-Barr Virus Infections • Herpes Simplex • Herpes Zoster • Immunology • Neuroblastoma • Oncology • Psoriasis • Pustular Psoriasis • Solid Tumor • Transplantation • Varicella Zoster

BI36 A case study of hypereosinophilic syndrome in a patient with atopic dermatitis on dupilumab therapy and Strongyloides infection. (PubMed, Br J Dermatol) - "Despite topical treatments and ciclosporin, his eczema persisted, leading to the initiation of dupilumab...This is a case of hypereosinophilic syndrome with colitis secondary to dupilumab in a patient with positive Strongyloides serology. This case demonstrates the diagnostic difficulty in Strongyloides-positive patients, given that both hypereosinophilic syndrome and Strongyloides hyperinfection can present with colitis, and there is a theoretical risk of disseminated Strongyloides and hyperinfection in patients immunosuppressed with dupilumab."

Journal • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Metabolic Disorders • Oncology • Pain • Pulmonary Disease • Respiratory Diseases