ivermectin topical / Generic mfg. - LARVOL DELTA

CD21 Things can only get redder! Two cases of allergic contact dermatitis to topical brimonidine tartrate gel. (PubMed, Br J Dermatol) - "Allergic contact blepharitis to brimonidine eye drops is recognized and, more recently, case reports have described patients developing ACD to topical brimonidine gel [Bangsgaard N, Fischer LAN, Zachariae C. Sensitization to and allergic contact dermatitis caused by Mirvaso® (brimonidine tartrate) for treatment of rosacea - 2 cases...He had been using topical Elocon cream daily (mometasone furoate 0.1%) and was diagnosed with steroid-induced rosacea. He was prescribed oral doxycycline, ivermectin cream and brimonidine gel...We would like to raise awareness that in addition to rebound erythema, topical brimonidine gel is also a cause of severe facial ACD. Patch testing to the patient's own medicaments should be performed in suspected cases."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Dry Eye Disease • Immunology • Ocular Inflammation • Ophthalmology • Rosacea • CD21

PA01 Treating scabies with oral ivermectin in infants: series of 12 cases. (PubMed, Br J Dermatol) - "Early treatment with oral ivermectin should be emphasized, along with reiteration of the importance of treating contacts to reduce chances of recurrence. Additionally, existing data suggest that oral ivermectin in children weighing < 15 kg is safe, which is also supported by our study."

Journal • Retrospective data • Atopic Dermatitis • CNS Disorders • Dermatology • Epilepsy • Immunology • Infectious Disease • Pruritus

BI21 Intermittent and progressive pustular psoriasis during chemotherapy cycles in a toddler. (PubMed, Br J Dermatol) - "Just before his next chemotherapy cycle (cisplatin and etoposide), the rash recurred as a pruritic pustular eruption across the frontal and retroauricular scalp; skin biopsy suggested nonspecific subacute eczematous dermatitis...Topical ivermectin and ketoconazole did not help...A second biopsy was taken due to clinical suspicion of psoriasis, and 10 days of oral prednisolone was given to try to clear his skin for autologous stem cell transplantation (HSCT)...He was treated with topical calcipotriol and mometasone 0.1%, with consideration of acitretin should he not improve. Fortunately, the rash settled with topical therapy and time. After completing proton radiotherapy prior to tumour resection, he had six cycles of maintenance immunotherapy (dinutuximab) with no recurrence of the rash, despite monthly GCSF, and good cell counts, and has now completed his oncological therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Contact Dermatitis • Dermatitis • Dermatology • Epstein-Barr Virus Infections • Herpes Simplex • Herpes Zoster • Immunology • Neuroblastoma • Oncology • Psoriasis • Pustular Psoriasis • Solid Tumor • Transplantation • Varicella Zoster

BI36 A case study of hypereosinophilic syndrome in a patient with atopic dermatitis on dupilumab therapy and Strongyloides infection. (PubMed, Br J Dermatol) - "Despite topical treatments and ciclosporin, his eczema persisted, leading to the initiation of dupilumab...This is a case of hypereosinophilic syndrome with colitis secondary to dupilumab in a patient with positive Strongyloides serology. This case demonstrates the diagnostic difficulty in Strongyloides-positive patients, given that both hypereosinophilic syndrome and Strongyloides hyperinfection can present with colitis, and there is a theoretical risk of disseminated Strongyloides and hyperinfection in patients immunosuppressed with dupilumab."

Journal • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Metabolic Disorders • Oncology • Pain • Pulmonary Disease • Respiratory Diseases

Effectiveness of Oral Ivermectin Treatment in Cases Unresponsive to Classical Demodex Blepharitis Treatment. (PubMed, Turkiye Parazitol Derg) - "OSDI scoring mean ± SD values before classical Demodex blepharitis treatment and after oral ivermectin treatment were 77.47±5.74 and 6.69±4.71, respectively. In the treatment of Demodex related blepharitis, the use of oral ivermectin is an effective treatment option in cases that do not respond to classical treatment."

Journal • Dry Eye Disease • Ocular Inflammation • Ophthalmology • Seborrheic Dermatitis

Effect of Moringa oleifera and ivermectin nanoparticles on the immunopathological response during experimental trichinosis in mice. (PubMed, Gut Pathog) - "Treatment with nanoparticle formulations of IVM and MOL modulated macrophage-related immune responses by reducing the pro-inflammatory markers iNOS, TNF-α and NF-κB, while increasing the relative gene expression of the anti-inflammatory cytokine IL-10. Combination therapy exhibited superior efficacy in decreasing parasite burden and mitigating intestinal pathology compared to monotherapy."

Journal • Preclinical • Infectious Disease • ARG1 • IL10 • TNFA

PF4 Autoantibody Complexes Cause Activation of Integrins αIIbβ3 and αvβ3 and Possible Subsequent Thrombosis and Autoimmune Diseases. (PubMed, Int J Mol Sci) - "When plasma PF4 tetramer is increased, active PF4 monomer is generated by autoanti-PF4 and plays a role in disease pathogenesis. Notably, anti-inflammatory cytokine neuregulin-1 and anti-inflammatory ivermectin bind to site 2 and suppress integrin activation induced by RTO/PF4 complex, suggesting that neuregulin-1 and ivermectin are potentially useful to suppress PF4/anti-PF4-mediated inflammatory signals."

Journal • Cardiovascular • Hematological Disorders • Immunology • Thrombosis • CXCL12 • NRG1

Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma. (PubMed, Biomater Res) - "In combination with anti-PD-L1 antibody and LD, IMN effectively inhibited tumor growth in orthotopic, subcutaneous, and metastatic HCC mouse models. Our study underscores the crucial role of IMN in amplifying the NLRP3 inflammasome cascade in DCs during ICD, presenting a promising strategy to enhance the efficacy of HCC chemoimmunotherapy."

IO biomarker • Journal • Hepatocellular Cancer • Oncology • Solid Tumor • CD73 • ENTPD1 • NLRP3 • NT5E

Targeted Management of Severe Myocarditis and Myositis in Drug-Induced Hypersensitivity Syndrome Using Precision Medicine (AHA 2025) - "He was ultimately diagnosed with DiHS/DRESS (attributable to ibuprofen use), started on dexamethasone, and discharged on prednisone...The patient was started on solumedrol, cyclosporine, and IVIG...To avoid further loss of functionality and potentially life-threatening consequences, the patient was started on tofacitinib with, surprisingly, a notable improvement in clinical symptoms.DiscussionCardiac involvement and skeletal muscle myositis are under-recognized manifestations of DiHS/DRESS, with immune-mediated necrotizing myositis/myocarditis representing the most severe form. Due to the high morbidity and mortality associated with these complications, patients should be aggressively treated with high-dose systemic corticosteroids to avoid fibrosis of the myocardium and irreversible damage. The use of precision medicine can be critical, particularly in treatment-resistant patients, to improving clinical outcomes and providing expedited targeted medical therapy."

Atopic Dermatitis • Cardiovascular • Dental Disorders • Dermatology • Eosinophilia • Fibrosis • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Myositis • Stomatitis

A Wormy Surprise: Unmasking Strongyloides in Eosinophilic Colitis (ACG 2025) - "The patient was started on omeprazole 40 mg BID indefinitely and ivermectin...Classification of eosinophilic colitis into primary and secondary subtypes highlighting associated mechanisms and etiologies.Figure: A, B. Multiple 1 mm white spots noted in the cecum and ascending colon, respectively. C, D. H&E sections of colon biopsies show benign colonic mucosa with a marked lamina propria infiltrate of eosinophils [H&E x200]."

Barrett Esophagus • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • KIT

Schistosomiasis or Ulcerative Colitis? Unraveling the Overlap Between Parasitic Infection and IBD (ACG 2025) - "He was started on mesalamine and prednisone...Symptom improvement following praziquantel and albendazole may reflect parasite clearance, but concurrent steroid use makes it unclear whether recovery was due to anti-parasitic therapy, immunosuppression, or both...Endoscopic image of the rectum showing continuous moderate inflammation consistent with ulcerative colitis, with loss of vascular pattern, erythema, friability, and superficial ulcerations (Mayo 2).Figure: Figure 2. Left colon biopsy: Colonic mucosa with increased lamina propria eosinophils, eosinophilic microabscess, and parasite ova/larva."

Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Gastro-Duodenal Strongyloidiasis as a Cause of Upper Gastrointestinal Bleeding in an Immunocompetent Patient With Poorly Controlled Diabetes (ACG 2025) - "Patient received a 2-week course of oral ivermectin, with no further bleeding...Absence of eosinophilia is common in the hyperinfection phase of Strongyloidiasis. Strongyloidiasis should be ruled out in immunocompromised patients presenting with gastrointestinal bleeding and endoscopic findings of multiple gastric ulcers with friable mucosa.Figure: Figure 1: Endoscopic images (1A: Body of stomach, 1B: Duodenal Bulb, 1C: Second portion of duodenum) showing friable mucosa and diffuse ulceration secondary to Strongyloides stercoralis.Figure: Figure 2: Histopathology slides demonstrating Strongyloides stercoralisFigures 2A, 2B: Gastric mucosa containing numerous cross sections of Strongyloides larvae (Filariform larvae); Figures 2C, 2D: Duodenal mucosa with ulcer, reactive changes, and numerous Strongyloides larvae)."

Clinical • Addiction (Opioid and Alcohol) • Anemia • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Metabolic Disorders • Peptic Ulcer • Type 2 Diabetes Mellitus

Strongyloides: A Case Report (ACG 2025) - "Treatment for strongyloides is ivermectin, after which the patient had significant improvement of his symptoms. (4)Figure: EGD with evidence of diffuse severely friable mucosa in the duodenum"

Case report • Clinical • Fatigue • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Nephrology • Peptic Ulcer

Strongyloidiasis: A Mimicker of Recurrent Colitis and Failure to Thrive (ACG 2025) - "She received two days course of oral ivermectin with symptomatic improvement. This case illustrates the diagnostic ambiguity as strongyloidiasis mimics recurrent colitis, asthma exacerbations, pulmonary embolism.Diagnosing strongyloidiasis requires a high index of suspicion due to nonspecific presentations, intermittent larvae shedding in stool.Initial testing may not reveal strongyloidiasis hence recurrent presentations and delayed diagnosis...The overlapping features of parasitic infection, inflammatory colitis, and malignancy require careful consideration. Steroid can trigger severe strongyloidiasis necessitating repeat testing before use."

Asthma • Cardiovascular • Diabetes • Dyslipidemia • Embryonal Tumor • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Inflammatory Bowel Disease • Metabolic Disorders • Novel Coronavirus Disease • Pulmonary Embolism • Respiratory Diseases • Respiratory Syncytial Virus Infections • CEACAM5

Severe Iron Deficiency Anemia Due to a Strongyloides-Induced Duodenal Ulcer in the Setting of Warfarin Therapy (ACG 2025) - "Warfarin was switched to apixaban due to its lower risk of exacerbating GI bleeding. He was discharged on pantoprazole with stabilization of the anemia during follow-up. This case highlights the importance of considering Strongyloides stercoralis infection in unexplained iron deficiency anemia and eosinophilia, particularly when evaluating individuals from endemic regions...B) Longitudinal section with filariform larvae seen within the inflamed lamina propria. Villous blunting and mucosal inflammation are present throughout both images."

Anemia • Atrial Fibrillation • Cardiovascular • Eosinophilia • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Inflammation • Mucositis • Peptic Ulcer

Except if It's Strongyloides (ACG 2025) - "Stronglyloides is one of the few parasites capable ofautoinfection, with hyperinfection syndrome carrying high mortality in immunosuppressed hosts. Early recognition and treatment are critical.Figure: Crypt-based Strongyloides stercoralis larva in small intestinal mucosa with surrounding eosinophilic inflammation (H&E)"

Gastric Adenocarcinoma • Gastric Cancer • Gastrointestinal Disorder • Infectious Disease • Solid Tumor

Beyond IBS: An Unusual Case of Eosinophilic Gastroenteritis (ACG 2025) - "Conservative management was started, infectious disease recommended treatment with a dose of oral albendazole 400 mg and ivermectin 200 mcg/kg...Given the negative infectious workup, we initiated prednisone 20 mg with a taper over four weeks...This represents an important functional cause of obstruction. We highlight how corticosteroids can be beneficial after completing a hematology-oncology workup and ruling out infectious causes."

Clinical • Constipation • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Rare Diseases

When scabies mimics atopic dermatitis in Twins: diagnostics pitfall (ISAD-RAJKA 2025) - "A combined treatment involving a contact scabicide, oral ivermectin (200ug/kg for adults) and environmental decontamination was initiated for the entire family...This diagnosis vigilance is especially important in pediatric populations, where management delays perpetuate both individual suffering and community transmission. The case serves as a reminder that in the global landscape of dermatological practice, common parasitic infestations may wear the convincing disguise of more familiar inflammatory conditions like atopic dermatitis."

Atopic Dermatitis • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Pediatrics • Pruritus

The Hidden Passenger: Schistosomiasis as a Silent Contributor in Colorectal Neoplasia (ACG 2025) - "He was treated with praziquantel for two separate 3 day courses over 3 months as well as ivermectin due to concern for concomitant Strongyloides infection...Within the literature one study has shown that the 5-year survival rate amongst patients with CRC cancer with concomitant schistosomiasis is around 45.6% compared to 50.9% of non-infected patients with further studies supporting this finding. These findings highlight the importance of recognizing patients at increased risk and underscore the need for further research evaluating association between schistosomiasis and CRC cancer.Figure: A.) Ileocecal valve view in colonoscopy, yellow arrow denotes nodular mucosa B.) Villous, infiltrative, and ulcerated mass found in the sigmoid colon C.) Low powered view of sigmoid colon mass demonstrating invasive focus with desmoplastic reaction and dysmorphic glands D.) High powered view of sigmoid mass demonstrating helminth eggs consistent with schistosomiasis"

Addiction (Opioid and Alcohol) • Anemia • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Solid Tumor • KRAS • TP53

Strongyloides Colitis: An Incidental Finding on a Screening Colonoscopy (ACG 2025) - "Notably, the patient was from an endemic area and had chronic peripheral eosinophilia, which prompted serologic testing and diagnosis of strongyloides infection. This case demonstrates peripheral eosinophilia as a useful clue in diagnosing strongyloides infection, especially in those from an endemic region.Figure: White nodules seen on colonoscopy."

Cardiovascular • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

Uncovering potent natural phytochemicals targeting SARS-COV-2 spike protein variants: molecular dynamics insights. (PubMed, Sci Rep) - "This study evaluated 20 phytocompounds and four approved antiviral drugs, Remdesivir, Favipiravir, Hydroxychloroquine, and Ivermectin, against nine SARS-CoV-2 spike glycoprotein structures, including five wild-type and four variants (Alpha, Beta, Delta, and Omicron)...In contrast, ursolic acid and ivermectin showed unstable binding and higher structural fluctuations during simulation. Overall, the study highlights betulinic acid and β-sitosterol as presumptive SARS-CoV-2 inhibitors, warranting further experimental validation through in vitro and in vivo studies to confirm their therapeutic potential."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

EOSINOPHILIC PLEURAL EFFUSION FROM REACTIVATION OF CHRONIC STRONGYLOIDES INFECTION (CHEST 2025) - "A transesophageal echocardiogram confirmed IE, and he was started on cefazolin... Pleural effusion with an elevated peripheral AEC, positive Strongyloides serology, and relevant risk factors should raise suspicion of Strongyloides pleural effusion. Early thoracentesis should be performed and if fluid studies show evidence of eosinophilia, prompt treatment with ivermectin should be initiated to prevent Strongyloides hyperinfection syndrome."

Pleural effusion • Cardiovascular • Cough • Eosinophilia • Hematological Disorders • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock • Venous Ulcer

Ivermectin modulates macrophage activity and enhances bacterial clearance in Pseudomonas aeruginosa acute pneumonia. (PubMed, Mol Cell Biochem) - "In vivo, however-particularly in TLR4-deficient mice-ivermectin improved bacterial clearance, lung histopathology, and cytokine modulation. These findings highlight a complex, context-dependent immunomodulatory role of ivermectin."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases • IFNG • IL17A • IL6 • TLR4 • TNFA

Ivermectin: a therapeutic strategy to treat patients with resistant epilepsy. (PubMed, Behav Pharmacol) - "These findings align with epidemiological data on onchocerciasis-associated epilepsy and recent controlled trials of IVM formulations in focal epilepsy. While further randomized studies are needed to confirm optimal dosing, safety monitoring, and mechanistic correlates, our results provide real-world evidence that IVM represents a promising adjunctive option for the management of refractory epilepsy."

Journal • CNS Disorders • Epilepsy • Infectious Disease • Inflammation

Efficacy of topical Ivermectin in controlling human Demodex infestation: Evidence from systematic review and meta-analysis. (PubMed, Parasite Epidemiol Control) - "While new therapies like lotilaner, niclosamide, and berberine show promise against D. folliculorum, ivermectin remains widely used for its strong antiparasitic and anti-inflammatory effects. However, the potential for mite repopulation after treatment underscores the importance of ongoing monitoring. Study heterogeneity and the limited number of included trials warrant cautious interpretation of the findings."

Journal • Retrospective data • Dermatology • Dry Eye Disease • Ocular Inflammation • Ophthalmology • Rosacea