ivermectin topical / Generic mfg. - LARVOL DELTA

Eosinophilia Associated with Elranatamab in Patients with Multiple Myeloma: A Multi-Institutional Analysis (IMS 2026) - " We retrospectively evaluated multiple myeloma patients treated with elranatamab (elra; n=181), teclistamab (tec; n=138), and linvoseltamab (linvo; n=44) as monotherapy across three academic centers (n=363)... Prophylactic medications, including sulfamethoxazole/trimethoprim, were standard across institutions and BCMA TCE products... Elra demonstrated a distinct eosinophilic toxicity profile among BCMA-TCE, characterized by higher incidence, greater severity, and infrequent but severe systemic inflammatory manifestations often independent of rash and generally not meeting criteria for DRESS. While the mechanism is unknown, recognition of this syndrome is clinically important. Continued elra dosing with corticosteroids in asymptomatic and/or low-grade cases appears feasible and effective."

Clinical • Eosinophilia • Gastrointestinal Disorder • Hematological Malignancies • Multiple Myeloma • Myeloproliferative Neoplasm

Influence of Major Histocompatibility Complex (MHC) Diversity on Immune Modulation, Pathogenesis, and Control of Lumpy Skin Disease Virus. (PubMed, Recent Adv Antiinfect Drug Discov) - "Lumpy Skin Disease continues to pose a major threat to global cattle health and livestock economies. Advances in molecular diagnostics, genomic surveillance, antiviral drug discovery, and BoLA-guided vaccine design provide promising opportunities for improved disease control. Understanding the interaction between LSDV and the bovine MHC system is essential for developing next-generation vaccines, immunotherapeutics, and precision disease-management strategies. Future research should prioritise experimental validation of predicted epitopes, large-scale vaccine trials, and mechanistic studies on host-virus immune interactions to establish effective and sustainable global control programs for LSDV."

IO biomarker • Journal • Dermatology • Dermatopathology • Immune Modulation • Immunology • Infertility • Sexual Disorders

Clinical Efficacy of a Soothing Dermocosmetic Cream as Adjunctive Care for Rosacea Patients Treated with Topical Ivermectine or Metronidazole. (EADV 2026) - No abstract available

Clinical • Dermatology • Rosacea

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. (PubMed, Neuroprotection) - "In this review, we critically examine the therapeutic potential of selected antimicrobial classes, including tetracyclines (e.g., minocycline), macrolides (e.g., azithromycin), antimalarial agents (e.g., chloroquine/hydroxychloroquine), sulfones (e.g., dapsone), and antiparasitic agents (e.g., ivermectin), in non-infectious neurological diseases...Despite the encouraging evidence, we must carefully manage challenges such as antimicrobial resistance, off-target effects, and regulatory considerations. Further well-designed clinical trials are essential to validate their long-term safety and efficacy in neurodegenerative and neuroinflammatory diseases."

Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Epilepsy • Infectious Disease • Inflammation • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Vascular Neurology

Ultrasound diagnosis of cutaneous furuncular myiasis in a nonendemic area. (PubMed, Radiol Case Rep) - "CT was obtained as an adjunct to ultrasonography to examine the extent of regional inflammation and the larva's relationship to adjacent vascular and deep soft-tissue structures. This case highlights the role of targeted ultrasound in the identification of cutaneous myiasis in a nonendemic, emergency setting, to help avoid misclassification and treatment delay."

Journal • Inflammation

Sepsis Secondary to Crusted Scabies Following Iatrogenic Treatment for Hansen's Disease in an Indigenous Amazonian Patient: A Case Report. (PubMed, Case Rep Infect Dis) - "He was treated with oral ivermectin, topical 5% permethrin, and systemic antibiotics, with gradual tapering and discontinuation of corticosteroids. This case highlights the critical importance of early recognition of crusted scabies and the risks associated with misdiagnosis and inappropriate immunosuppressive therapy. Prompt diagnosis and treatment are essential to prevent severe complications such as sepsis, particularly in resource-limited and endemic settings."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pruritus • Septic Shock

A Study Comparing Ivermectin Cream 1%, Soolantra Cream 1%, PrROSIVER Cream1% to Placebo Control in the Treatment of Moderate to Severe Facial Rosacea. (clinicaltrials.gov) - P1 | N=865 | Completed | Sponsor: Sun Pharmaceutical Industries, Inc.

New P1 trial • Dermatology • Rosacea

Hidden in the Crypts: Strongyloides Hyperinfection Syndrome Overshadowed by Concurrent H. pylori Gastritis (ACG 2026) - "Ivermectin and albendazole were initiated...Figure: (Histology, H&E 200x): Gastric biopsy demonstrating Strongyloides stercoralis larvae within gastric crypts (arrows), with marked active chronic inflammation and reactive epithelial changes. Figure: (EGD): Endoscopic view demonstrating diffuse severe gastritis with mucosal erythema, friability, erosions, and ulceration throughout the gastric body."

Cardiovascular • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Infectious Disease • Inflammation • Metabolic Disorders • Peptic Ulcer • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

Strongyloidiasis Presenting as Steroid-Refractory Colitis Years After Remote Travel to an Endemic Region (ACG 2026) - "She was treated with IV methylprednisolone and mesalamine for presumed IBD flare without improvement...Colonoscopy demonstrating (A) erythema and small superficial ulcerations in the terminal ileum and (B) diffusely irregular mucosa characterized by mucosal erythema, edema, friability, and ulceration in the transverse to splenic flexure region. Findings initially attributed to Crohn disease prior to diagnosis of Strongyloides stercoralis infection."

Crohn's disease • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Type 2 Diabetes Mellitus • Ulcerative Colitis

Biopsy-Proven Pluvicto (Lutetium-177 Vipivotide Tetraxetan)-Induced Colitis in a Patient With Metastatic Prostate Cancer: A Case Report (ACG 2026) - "Case Description/ A 60-year-old man with stage IVB metastatic prostate adenocarcinoma (BRCA2-mutated), previously treated with radiotherapy and docetaxel, began lutetium-177 vipivotide tetraxetan therapy at an outside institution...Budesonide 9 mg daily led to rapid symptom improvement...No granulomas or viral cytopathic effect is identified Figure: Colonic mucosa demonstrates focally active chronic colitis with cryptitis, mixed inflammatory infiltrates in the lamina propria, and mild and focal crypt architectural distortion. No granulomas or viral cytopathic effect is identified"

Biopsy • Case report • Clinical • Metastases • Castration-Resistant Prostate Cancer • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor • BRCA2

Diffuse Colonic Ulcerations and Hematochezia Mimicking Ischemic Colitis in a Post-Hematopoietic Cell Transplant Patient With Strongyloides stercoralis Infection (ACG 2026) - "Case Description/ A 69-year-old male with IgA Kappa MM status post autologous HCT receiving daratumumab, pomalidomide, and dexamethasone presented with progressive weakness and failure to thrive over several months...Figure: Figure 1: Colonoscopy demonstrating erythema and ulceration at the hepatic flexure. Figure: Figure 2: Colonic biopsy demonstrating parasitic organisms (arrows) within the mucosa, with associated eosinophilic inflammation and giant cells involving the crypts and lamina propria."

Clinical • Atrial Fibrillation • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypotension • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Multiple Myeloma • Transplantation

Strongyloidiasis Presenting as Recurrent Eosinophilic Ascites, Pleural Effusion, and Severe Gastrointestinal Dysmotility: A Diagnostic Challenge (ACG 2026) - "Prolonged inflammation may have resulted in irreversible dysfunction. Serologic testing is most sensitive to diagnose chroni strongyloidiasis."

Pleural effusion • Constipation • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Leukopenia • Respiratory Diseases

Strongyloides stercoralis Masquerading as Crohn's Disease (ACG 2026) - "Patient was started on budesonide while pathology reports were pending, which did not improve his symptoms...There are documented cases of hyper infection after courses of steroids for six days and with oral prednisolone doses as low as 20 mg daily...Figure: Figure 2. Colonoscopy revealing patchy colitis with erosions in descending colon, initially raising concern for Crohn's colitis."

Cardiovascular • Coronary Artery Disease • Crohn's disease • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

Topical treatment of rosacea: update and outlook. (PubMed, Int J Pharm) - "Attention is focused on evaluation of formulations with either in vitro permeation testing or in vivo studies. Finally, the limitations of studies published to date are highlighted as well as the likely barriers hindering translation of novel therapies from the laboratory to the market."

Journal • Review • Dermatology • Rosacea

The Combination of Nirmatrelvir and Ivermectin Exerts Strongly Synergistic Antiviral and Anti-Inflammatory Effects Against Murine Coronavirus Infection of Macrophages. (PubMed, Int J Mol Sci) - "Conversely, the combinations of Nirmatrelvir with Azithromycin or Doxycycline exhibited only additive or mildly additive effects, with alterations in certain cytokine levels. These findings support the potential of Nirmatrelvir-Ivermectin as a promising novel combination therapy with both antiviral and anti-inflammatory benefits, warranting further in vivo validation and clinical investigation."

Journal • Preclinical • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • IL1B • IL6 • TNFA

Pharmacokinetics and Efficacy Assessment of Long-Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship. (PubMed, J Vet Pharmacol Ther) - "Skin scrapings confirmed mite clearance in treated dogs by Day 56. These findings suggest that prolonged ivermectin administration is safe and effective for treating canine demodicosis."

Clinical data • Journal • PK/PD data • Dermatology • Inflammation • ABCB1

Comparison of two doxycycline dosages on inflammatory and stress response in dogs naturally infected with Dirofilaria immitis. (PubMed, Parasit Vectors) - "Doxycycline administered at 5 mg/kg every 12 h for 30 days showed a comparable short-term biomarker response to the standard 10 mg/kg regimen during the pre-adulticidal phase. Lower doxycycline dosages may represent a potential alternative with possible benefits in terms of tolerance, compliance, and antimicrobial stewardship, although these aspects were not directly evaluated in the present study."

Clinical • Journal • Inflammation • CRP

An Unusual Perioral Presentation of Pityriasis Folliculorum Mimicking Periorificial Dermatitis. (PubMed, Cureus) - "The condition persisted despite treatment with topical metronidazole, topical tretinoin, and topical antifungal therapy. Given the lack of response to topical therapies, a potassium hydroxide (KOH) skin scraping was performed and demonstrated numerous Demodex mites, with rapid resolution following the initiation of topical ivermectin. This case highlights the importance of considering Demodex‑related disease in the evaluation of perioral papulopustular eruptions when standard therapies are ineffective. Early recognition can help guide appropriate management and prevent prolonged symptoms."

Journal • Dermatitis • Dermatology • Immunology

In Vivo Acaricidal Effect of Linoleic Acid and Olive Oil Against Psoroptes cuniculi Mites in Experimentally Infested Rabbits. (PubMed, Acta Parasitol) - "These findings demonstrate that EVOO and LA exhibit substantial acaricidal activity against P. cuniculi under controlled experimental conditions and support their potential as alternative treatments for further investigation."

Journal • Preclinical • Dermatology • Infectious Disease • Inflammation • Otorhinolaryngology

Duodenal Strongyloidiasis Mimicking Inflammatory Bowel Disease: A Case Report of a 52-Year-Old Immunocompetent Woman. (PubMed, Clin Med Insights Case Rep) - "The patient was treated with oral ivermectin plus adjunctive albendazole...This case emphasizes the clinical and histopathological overlap between duodenal strongyloidiasis and IBD, particularly when stool parasitology is unrevealing. The novelty of this report lies primarily in its didactic value for clinicians in endemic regions: Strongyloides should remain in the differential diagnosis of IBD-like presentations with unexplained eosinophilic mucosal inflammation before immunosuppressive therapy is considered."

Journal • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Mucositis • Thrombocytosis

Scabies Exacerbation With Eosinophilia As Immune Reconstitution Inflammatory Syndrome in a Patient With AIDS and Pneumocystis Pneumonia: A Case Report. (PubMed, Cureus) - "Initially, he was suspected of having IRIS of PCP with eosinophilia, but he was ultimately diagnosed with scabies, which was thought to be exacerbated by IRIS. He recovered completely from his symptoms and eosinophilia after combination therapy of ivermectin and sulfur formulations."

Journal • Eosinophilia • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Respiratory Diseases • CD4

Erythrodermic crusted scabies-a diagnostic pitfall and mini-review: a case report. (PubMed, Front Med (Lausanne)) - "Treatment with oral ivermectin and topical scabicidal therapy resulted in marked clinical improvement...This is particularly relevant in primary care and general practice settings, where initial management decisions are often made. Knowledge of various scabies manifestations, especially its erythrodermic presentation, could further improve disease management and control, particularly in endemic and resource-limited areas."

Journal • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Oncology • Pruritus • Psoriasis • Seborrheic Dermatitis

Drug repurposing as a promising therapeutic strategy against renal cell carcinoma. (PubMed, Cancer Chemother Pharmacol) - "This review article summarizes and shows the effectiveness and potential of repurposed drugs including metabolic and cardiovascular modulators (metformin, simvastatin), antimicrobial and antiparasitic agents (artesunate, ivermectin, ketoconazole, chloroquine, hydroxychloroquine, niclosamide, doxycycline, pentamidine), mTOR inhibitors (temsirolimus, everolimus, rapamycin), anti-inflammatory and analgesic agents (aspirin, celecoxib), and agents with other mechanisms of action (acetazolamide, disulfiram). These agents exert their anticancer effects against RCC by modulating multiple signaling pathways, including PI3K/AKT/mTOR, AMPK, JAK2/STAT3, ERK1/2, Wnt/β-catenin, and RhoA/ROCK, as well as by inducing autophagy inhibition, ferroptosis, oxidative stress, and mitochondrial dysfunction, highlighting their utility in RCC therapy and emphasizing their clinical relevance."

Journal • Review • Cardiovascular • Genito-urinary Cancer • Kidney Cancer • Metabolic Disorders • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor • AMPK • CTNNB1 • JAK2 • RHOA • STAT3

Isolated colonic strongyloidiasis presenting as iron deficiency anemia with negative duodenal biopsies and stool studies. (PubMed, IDCases) - "Negative stool studies and unrevealing duodenal biopsies did not exclude infection, with diagnosis established only through colonic histopathology. Strongyloidiasis should be considered in patients with unexplained eosinophilia, iron deficiency anemia, or eosinophilic colitis despite negative stool studies and unrevealing upper gastrointestinal biopsies."

Journal • Anemia • Dermatology • Eosinophilia • Fatigue • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation

Crusted Scabies Mimicking Psoriasis in a Patient With Down Syndrome: A Case Report. (PubMed, Cureus) - "The patient was successfully treated with a combination of oral ivermectin, topical benzyl benzoate, and keratolytic agents, alongside environmental decontamination and the treatment of close contacts. This case underscores the diagnostic challenge of crusted scabies in cognitively impaired patients and highlights the risk of misdiagnosis, particularly as psoriasis, which may delay appropriate treatment and increase the risk of outbreaks. Early recognition, microscopic confirmation, and aggressive multidrug therapy are essential for effective management."

Journal • Alzheimer's Disease • Cognitive Disorders • Dermatology • Developmental Disorders • Genetic Disorders • Immunology • Infectious Disease • Psoriasis