KDT501 / KinDex Pharma - LARVOL DELTA

Bitter taste receptor ligand improves metabolic and reproductive functions in a murine model of PCOS. (PubMed, Endocrinology) - "Pioglitazone, a PPARγ agonist, also improved metabolic and reproductive function, though not to the same degree as KDT501. Interestingly, the ovaries were found to express Tas2R 108 suggesting a potential regulation of ovarian steroidogenesis through this chemosensory receptor family. In summary, this study suggests that a therapeutic strategy for PCOS can include direct influences on ovarian steroidogenesis that are independent from gonadotrophic hormone regulation."

Journal • Preclinical

Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits. (PubMed, Mol Metab) - "Activation of Tas2r108 in the gut results in a remodeling of enteroendocrine hormone release and bile acid metabolism that ameliorates multiple features of metabolic syndrome. Targeting extraoral bitter taste receptors may be useful in metabolic disease."

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