ecothiopate iodide (MI 100) / Makindus - LARVOL DELTA

Evaluation of Echothiophate in Pediatric Patients With Refractory Amblyopia (clinicaltrials.gov) - P2 | N=20 | Not yet recruiting | Sponsor: University of Oklahoma

New P2 trial • CNS Disorders • Ophthalmology • Pediatrics

Proposal on incorporating consolidation-to-tumor ratio into the clinical T1 classification in patients with invasive lung adenocarcinoma. (PubMed, Transl Lung Cancer Res) - "The CTR-incorporated stratification scheme clearly classified the prognosis of PSNs (LCSS: T1mi: 100%, T1a: 99.1%, T1b: 89.4%, T1c: 75.3%; RFS: T1mi: 100%, T1a: 98.2%, T1b: 87.6%, T1c: 66.9%). CTR had a significant effect on the prognosis of PSNs, even when the solid component sizes were similar. An exploratory staging model incorporating CTR showed potential for improving risk stratification over the current T1 classification, but warrants external validation in future studies."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Associations of angiopoietin-like protein 7 with coronary collateral circulation and prognosis of patients with severe coronary artery stenosis. (PubMed, Front Cardiovasc Med) - "Additionally, ANGPTL7 enhanced endothelial cell proliferation, migration and capillary-like structure formation, indicating a proangiogenic effect in vitro. ANGPTL7 serves as a predictive biomarker for CCC levels and the prognosis of patients with SCS, which probably attributed to its proangiogenic properties."

Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Myocardial Infarction

Echothiophate Iodide for the Prevention of Progression of Myopia (clinicaltrials.gov) - P4 | N=0 | Withdrawn | Sponsor: Danbury Eye Physicians & Surgeons, PC | N=33 ➔ 0 | Unknown status ➔ Withdrawn

Enrollment change • Trial withdrawal • Ophthalmology

Utility of PET CT in CT stage IA non-small cell lung cancer: the New Zealand Te Whatu Ora Northern region experience (BTS WM 2024) - "The percentage of lesions upstaged on FDG PET-CT that remained Stage 1A was 100% in T1mi, 100% in T1a, 47.1% in T1b, and 40.7% in T1c groups...Conclusion Our data suggests that FDG PET-CT is indicated for T1b and T1c lesions but is of limited utility in Tis, T1mi and T1a lesions. Omitting FDG PET-CT in these early stage lung cancers could significantly shorten the diagnostic pathway, reduce unnecessary investigations, improve accessibility for patients in whom FDG PET-CT is essential for their diagnostic pathway and potentially yield financial savings."

Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Utility of FDG PET-CT in CT Stage IA non-small cell lung cancer: The New Zealand Te Whatu Ora Northern region experience. (PubMed, J Med Imaging Radiat Oncol) - "Our data suggests that FDG PET-CT is indicated for T1b and T1c lesions but is of limited utility in Tis, T1mi and T1a lesions. Adopting a more targeted approach and omitting FDG PET-CT in patients with Tis, T1mi, and T1a lesions may benefit all patients with lung cancer by improving accessibility and treatment timelines."

FDG PET • Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor

The Effect of Exercise Intensity on Carbohydrate Sparing Postexercise: Implications for Postexercise Hypoglycemia. (PubMed, Int J Sport Nutr Exerc Metab) - "Six physically active participants completed 1 hr of low-intensity (LI; 50% lactate threshold) or moderate-intensity (MI; 100% lactate threshold) exercise on separate days following a randomized counterbalanced design...In summary, CHO oxidation during exercise increases with exercise intensity but there is a preference for CHO sparing (and fat oxidation) during recovery from MI exercise compared with LI exercise. This exercise intensity-dependent shift in substrate oxidation during recovery is explained, in part, by the pattern of change of key glucoregulatory hormones including catecholamines and growth hormone and plasma fatty acid concentrations."

Journal • Hypoglycemia

Point-of-Care Ultrasound Transmission for Remote Interpretation in Austere Environments. (PubMed, Wilderness Environ Med) - "Slow-scan television image transmission is a viable option for transmitting ultrasound images in remote areas where more modern forms of communication are unavailable or not practical. Slow-scan television may have potential as another data transmission option in the wilderness, such as electrocardiogram tracings."

Journal

Hypoglycosylated Follistatin-Like 1 Attenuates the Loss of Coronary and Cerebral Vascular Functional Capacity in Ossabaw Swine with Cardiometabolic Heart Failure with Reduced Ejection Fraction. (PubMed, FASEB J) - "In coronary arterioles, the NS-1619 induced vasodilatory capacity was increased ~18-fold in MI+FSTL1 animals relative to MI (100 ± 13% vs. 1832 ± 3% in MI and MI+FSTL1, respectively) in the remote region of the heart (interaction effect), but not the infarct nor border regions. In cerebral arterioles, the vasoconstrictor capacity in response to U46619 was increased ~2-fold in MI+FSTL1 relative to MI animals (100 ± 19% vs. 213 ± 25% in MI and MI+FSTL1, respectively; interaction effect). In conclusion, FSTL1 partially attenuates the loss of functional capacity in both coronary and cerebral arterioles, demonstrating its potential to improve vascular function in an experimental setting of cardiometabolic HFrEF."

Journal • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Immunology • Inflammation • Metabolic Disorders • Myocardial Infarction • FSTL1

Nerolidol attenuates isoproterenol-induced acute myocardial infarction in rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "CK total, creatine kinase total; CK-MB, creatine kinase myocardial band; LDH, lactate dehydrogenase; SOD, superoxide dismutase; CAT, catalase. CTR (vehicle group), MI (100 mg/kg of isoproterenol), ISO + NRD 50 (50 mg/kg of nerolidol), and ISO + NRD 100 (100 mg/kg of nerolidol)."

Journal • Preclinical • Cardiovascular • Myocardial Infarction • CAT

Patient-reported outcome measures after mitral valve repair: a comparison between minimally invasive and sternotomy. (PubMed, Interact Cardiovasc Thorac Surg) - "MI surgery was associated with faster recovery and less pain; treatment satisfaction and safety profiles were similar."

Clinical • Journal • Patient reported outcomes • Pain

Midterm results of different treatment methods for myocardial bridging in patients after septal myectomy. (PubMed, J Card Surg) - "Surgical MB treatment could be beneficial and performed safely during septal myectomy. Myocardial unroofing is the recommended treatment for MB, and unroofing when technically possible may be preferable for long-term outcomes."

Clinical • Journal • Cardiomyopathy • Cardiovascular • Myocardial Infarction

Meta-analysis of re-do stenting versus endarterectomy for in-stent stenosis following carotid artery stenting. (PubMed, J Vasc Surg) - "Re-do carotid artery stenting is commonly used to treat patients with severe and/or symptomatic ISR after primary CAS. Although endovascular approach is a less invasive procedure, both rCAS and CEA can be performed safely with similar short- and mid-term outcomes of stroke, death, and surgery-related complications."

Journal • Retrospective data • Review • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Hypertension • Metabolic Disorders • Myocardial Infarction

[VIRTUAL] HIGHER RATE OF HEMORRHAGIC STROKE AMONG BLACK PATIENTS WITH HISTORY OF MYOCARDIAL INFARCTION (ACC 2020) - "Hemorrhagic stroke was identified using the Myocardial Infarction Data Acquisition System (MIDAS), a validated statewide database of all hospitalizations for cardiovascular disease in New Jersey for the period 1995 to 2015 using ICD-9 codes 430.xx to 432.xx. Within one year of follow-up after the index MI, 100 of 23,964 black patients and 545 of 206,045 white patients suffered a hemorrhagic stroke (adjusted HR 1.52, 95% CI 1.21-1.90; Figure). Black patients were more likely to develop hemorrhagic stroke than white patients within a year after hospitalization for acute MI. This could be due to insufficient treatment of hypertension, a strong predictor of hemorrhagic stroke."

Clinical

Contrast-Enhanced Mammography and Radiomics Analysis for Noninvasive Breast Cancer Characterization: Initial Results. (PubMed, Mol Imaging Biol) - "Radiomics analysis with CEM has potential for noninvasive differentiation of tumors with different degrees of invasiveness, hormone receptor status, and tumor grade."

Journal • Retrospective data

Improvements in left ventricular regional and global systolic function following treatment with S100A4-shRNA after myocardial infarction in mice. (PubMed, Quant Imaging Med Surg) - "...A total of 48 mice were randomly assigned to sham+S100A4-shRNA, sham+scrambled (Scr) sequence-shRNA, MI+S100A4-shRNA, and MI+Scr-shRNA groups (n=12 per group) and underwent intramyocardial injection of target agents after MI was produced by left anterior descending ligation...S100A4-shRNA can be utilized as a therapeutic target to improve regional deformation and attenuate cardiac fibrosis following MI. Two-dimensional STE is useful in the early and comprehensive assessment of LV systolic function in mice."

Journal

The influence of non-alcoholic fatty liver disease on a two year prognosis of the patients with stable coronary heart disease depending on SYNTAX score II (EASL-ILC 2019) - "...Survival analysis based on Kaplan-Meier curves was evaluated by a two-year cumulative proportion surviving (%), the difference between groups was determined by Cox's F and Gehan's Wilcoxon tests. A two-year cumulative proportion surviving was the highest in pts without NAFLD: by reoccurring myocardial infarction (MI)-100.0% (Group IA) vs. 100.0% (Group IIA); by ischemic stroke-93.5% (Group IA) vs. 85.4% (Group IIA) (p > 0.05); by death from cardiovascular causes-96.8% (Group IA) vs. 88.9% (Group IIA) (p < 0.05); by re-revascularization-98.4% (Group IA) vs. 85.8% (Group IIA) (p < 0.05)... The course of stable CHD in pts who underwent coronary artery stenting depends on the NAFLD presence and its severity and is the most prognostically unfavorable in pts with NASH. The severe course of NAFLD forms a high risk of major cardiovascular events by SS II values and causes a significant decrease of a two-year cumulative proportion surviving in pts with stable..."

Clinical