Oxy210 / MAX BioPharma - LARVOL DELTA

Targeting the ARF6-dependent recycling pathway to alter lipid rafts and reduce inflammation. (PubMed, J Lipid Res) - "Using Oxy210, a synthetic oxysterol, we observed significant anti-inflammatory effects both in vivo and in vitro...This impaired lipid raft recycling to the cell surface and simultaneously reduced ABCA1 internalization. These findings highlight a novel approach to modulating lipid raft-dependent pathological pathways, with potential applications in treating inflammation, neurodegeneration, and infectious diseases."

Journal • CNS Disorders • Infectious Disease • Inflammation • ABCA1

Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro. (PubMed, Cells) - "These findings further support the potential therapeutic effects of Oxy210 mediated in part through inhibition of senescence-driven hepatic fibrosis and inflammation in MASH and perhaps in other senescence-associated fibrotic diseases."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Cystic Fibrosis • Fibrosis • Genetic Disorders • Heart Failure • Hepatology • Idiopathic Pulmonary Fibrosis • Immunology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Solid Tumor • Transplantation • APOE • TGFB1

Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells. (PubMed, Cells) - "These findings suggest that Oxy210 could be a drug candidate for targeting both NASH and atherosclerosis, as well as chronic inflammation associated with the manifestations of metabolic syndrome."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Dyslipidemia • Fibrosis • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • Peripheral Arterial Disease • APOE • CCL2 • IL1B • IL6 • TNFA • VCAM1

Oxy210, a Semi-Synthetic Oxysterol, Inhibits Profibrotic Signaling in Cellular Models of Lung and Kidney Fibrosis. (PubMed, Pharmaceuticals (Basel)) - "In human primary small airway epithelial cells (HSAECs) and renal tubular epithelial cells, Oxy210 significantly inhibited TGF-β target gene expression associated with epithelial-mesenchymal transition (EMT). Oxy210 also inhibited the proliferation of fibroblasts, pericytes, and mesangial cells in a dose-dependent and statistically significant manner."

Journal • Chronic Kidney Disease • Fibrosis • Hepatology • Idiopathic Pulmonary Fibrosis • Immunology • Liver Cirrhosis • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • COL1A1 • CTGF • FN1 • TGFB1

Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer. (PubMed, Cell Biosci) - "The oxysterols Oxy186 and Oxy210 both possess inhibitory activity towards WNT/β-catenin signaling, and Oxy186 is also a potent inhibitor of NSCLC tumor growth."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • TGFB1

Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization. (PubMed, Int J Mol Sci) - "The anti-inflammatory effects of Oxy210 are correlated with the inhibition of macrophage polarization. We propose that Oxy210 and its structural analogs may be attractive candidates for future therapeutic development for targeting inflammatory diseases."

IO biomarker • Journal • Addiction (Opioid and Alcohol) • Atherosclerosis • Cardiovascular • Dermatology • Dyslipidemia • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Non-alcoholic Steatohepatitis • Obesity • Osteoarthritis • Pain • Psoriasis • Psoriatic Arthritis • Rheumatoid Arthritis • Rheumatology • APOE • CD68 • IL6 • TLR4

Oxy210, a novel inhibitor of hedgehog and TGF-β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice. (PubMed, Endocrinol Diabetes Metab) - "Oxy210 effectively ameliorated hepatic fibrosis and inflammation and improved hypercholesterolemia in mice. Our findings suggest that Oxy210 and related analogues are a new class of drug candidates that may serve as potential therapeutics candidates for NASH."

Journal • Preclinical • Dyslipidemia • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Metabolic Disorders • Non-alcoholic Fatty Liver Disease • Non-alcoholic Steatohepatitis • Transplantation • TGFB1

Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro. (PubMed, Int J Mol Sci) - "Mechanistic studies suggest that Oxy210 reduced replication of SARS-CoV-2 by disrupting the formation of double-membrane vesicles (DMVs); intracellular membrane compartments associated with viral replication. Our study warrants further evaluation of Oxy210 and Oxy232 as a safe and reliable oral medication, which could help protect vulnerable populations with increased risk of developing COVID-19."

Journal • Preclinical • Fibrosis • Immunology • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling. (PubMed, Cells) - "Combining Oxy210 with Carboplatin (CP) increases the anti-proliferative response to CP and inhibits TGFβ-induced resistance to CP in A549 NSCLC cells. In addition, Oxy210 displays encouraging drug-like properties, including chemical scalability, metabolic stability and oral bioavailability in mice. Unlike other known inhibitors, Oxy210 antagonizes TGFβ and Hh signaling independently of TGFβ receptor kinase inhibition and downstream of Smoothened, respectively."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer