RMD1101 / Remedium Bio - LARVOL DELTA

Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis. (PubMed, Curr Gene Ther) - "FGF18 gene therapy treatment of OA joints can provide benefits to both cartilage and subchondral bone, with a high degree of localization and durability."

Gene therapy • Journal • Gene Therapies • Genetic Disorders • Immunology • Obesity • Osteoarthritis • Pain • Rheumatology • FGF18 • PRG4

NOVEL AAV2-FGF18 CHONDROGENIC GENE THERAPY (OARSI 2023) - "Gene therapy is a promising therapeutic modality capable of a high degree of localization, long-term durability, and potential disease modification. In this study, we aimed to compare rhFGF18 protein injections and AAV2-delivered hFGF18 by analyzing effects on cartilage anabolism via primary human chondrocyte proliferation, gene expression, as well as articular and meniscal cartilage generation in vivo."

Gene therapy • Gene Therapies • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology