MEDI-578 / AstraZeneca - LARVOL DELTA

Pain behaviour assessments by gait and weight bearing in surgically induced osteoarthritis and inflammatory arthritis. (PubMed, Physiol Behav) - "The pain-like behaviour detected is mainly due to inflammation and not to the same degree to structural changes in the joint. Behavioural effects after ACLT were too small for pharmacological evaluation of pain relief. In contrast, the inflammation after CFA injection caused a long-lasting effect on pain-like behaviours such as weight bearing and gait, which could be attenuated by administration of an anti NGF antibody."

Journal • Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Pain • Rheumatology